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Articles 1051 - 1080 of 1878
Full-Text Articles in Medicine and Health Sciences
Pathogenic Policy: Health-Related Consequences Of Immigrant Policing In Atlanta, Ga, Nolan Sean Kline
Pathogenic Policy: Health-Related Consequences Of Immigrant Policing In Atlanta, Ga, Nolan Sean Kline
USF Tampa Graduate Theses and Dissertations
Multilayered immigration enforcement regimes comprising state and federal statutes and local police practices demand research on their social and health-related consequences. This dissertation explores the multiple impacts of immigrant policing: sets of laws and police activities that make undocumented immigrants more visible to authorities and increase their risk of deportation. Examining immigrant policing through a multi-sited framework and drawing from principles of engaged anthropology, findings from this dissertation suggest how immigrant policing impacts undocumented immigrants' overall wellbeing, health providers' professional practice, and reveals troubles with safety net medical care. Interviews and participant observation experiences suggest how immigrant policing perpetuates a …
Exploring The Underlying Mechanisms Of Comorbid Adhd And Eating Disorders, Jennifer Rebecca Bleck
Exploring The Underlying Mechanisms Of Comorbid Adhd And Eating Disorders, Jennifer Rebecca Bleck
USF Tampa Graduate Theses and Dissertations
Evidence suggests comorbidity of ADHD and eating disorders (EDs) among females. Capitalizing on the comorbidity of ADHD and EDs and subsequent obesity could lead to improved prevention and treatment of all three conditions. However, additional information regarding the comorbidity is necessary to develop such interventions, as little is known about how or why this co-occurrence exists. A comprehensive model of the underlying mechanisms associated with comorbid ADHD and EDs is needed to improve understanding of the development of the comorbidity. Moreover, while there are gender differences within each disorder, literature is limited regarding to the comorbidity among males, leading to …
The Relationship Between Nurses' Emotional Intelligence And Patient Outcomes, Mary Kutash
The Relationship Between Nurses' Emotional Intelligence And Patient Outcomes, Mary Kutash
USF Tampa Graduate Theses and Dissertations
Heart Failure readmissions (HFR) significantly contribute to all cause hospital readmissions rates. Current evidence on the effectiveness of interventions for reduction of HFR is inconclusive. Recent research suggests that nurses’ emotional intelligence (EI) may be associated with better patient outcomes.
The purpose of this study was to examine if nurses’ EI is significantly related to HFR and if that relationship is mediated through patient satisfaction with care. One hundred and thirty six Registered Nurses were recruited from 11 in-patient units at a large teaching hospital in the south eastern United States. Two surveys were mailed to eligible participants; the Bar-On …
Sleep, Depressive Symptoms And Cognition In Older Adults And Caregivers Of Persons With Dementia, Glenna Shemida Brewster
Sleep, Depressive Symptoms And Cognition In Older Adults And Caregivers Of Persons With Dementia, Glenna Shemida Brewster
USF Tampa Graduate Theses and Dissertations
Caregivers of persons with dementia, who are often older adults, report sleep disturbance, high rates of depressive symptoms and may be at risk for impaired cognition. This dissertation examined sleep, depressive symptoms, and cognition in older adults and caregivers of persons with dementia. The aims of the review of literature were to understand, in community dwelling adults 60 years and older, the relationships among sleep parameters (sleep onset latency, wake after sleep onset, sleep efficiency, total sleep time, and general sleep complaints), and the domains of cognition (Executive Function, Attention, Episodic Memory, Working Memory, Processing Speed), and global cognition. Based …
Sexual Functioning And Body Image In Younger Breast Cancer Survivors, Carly Lynn Paterson
Sexual Functioning And Body Image In Younger Breast Cancer Survivors, Carly Lynn Paterson
USF Tampa Graduate Theses and Dissertations
Younger breast cancer survivors often report problems related to sexuality following surgical and adjuvant treatment that often lead to sexual distress and body image distress. This research was conducted as an exploratory study within a larger R01 trial with the purpose to evaluate sexual distress and body image related-distress in younger women with breast cancer and to examine the extent to which the Mindfulness-Based Stress Reduction-Breast Cancer (MBSR(BC)) was efficacious in improving distress related to sexuality, i.e. sexual distress and body image related-distress. The aims of this study were to: 1) evaluate the efficacy of the MBSR(BC) program in improving …
Brca1 185delag Mutation Enhances Interleukin-1Β Expression In Ovarian Surface Epithelial Cells, Kamisha T. Woolery, Mai Mohamed, Rebecca J. Linger, Kimberly P. Dobrinski, Jesse Roman, Patricia A. Kruk
Brca1 185delag Mutation Enhances Interleukin-1Β Expression In Ovarian Surface Epithelial Cells, Kamisha T. Woolery, Mai Mohamed, Rebecca J. Linger, Kimberly P. Dobrinski, Jesse Roman, Patricia A. Kruk
Pathology and Cell Biology Faculty Publications
Familial history remains the strongest risk factor for developing ovarian cancer (OC) and is associated with germline BRCA1 mutations, such as the 185delAG founder mutation. We sought to determine whether normal human ovarian surface epithelial (OSE) cells expressing the BRCA1 185delAG mutant, BRAT, could promote an inflammatory phenotype by investigating its impact on expression of the proinflammatory cytokine, Interleukin-1β (IL-1β). Cultured OSE cells with and without BRAT were analyzed for differential target gene expression by real-time PCR, western blot, ELISA, luciferase reporter, and siRNA assays. We found that BRAT cells expressed increased cellular and secreted levels of …
Tp53 And Mdm2 Single Nucleotide Polymorphisms Influence Survival In Non-Del(5q) Myelodysplastic Syndromes, Kathy L. Mcgraw, Thomas Cluzeau, David A. Sallman, Ashley A. Basiorka, Brittany A. Irvine, Ling Zhang, P.K. Epling-Burnette, Dana E. Rollison, Mar Mallo, Lubomir Sokol, Francesc Solé, Jaroslaw Maciejewski, Alan F. List
Tp53 And Mdm2 Single Nucleotide Polymorphisms Influence Survival In Non-Del(5q) Myelodysplastic Syndromes, Kathy L. Mcgraw, Thomas Cluzeau, David A. Sallman, Ashley A. Basiorka, Brittany A. Irvine, Ling Zhang, P.K. Epling-Burnette, Dana E. Rollison, Mar Mallo, Lubomir Sokol, Francesc Solé, Jaroslaw Maciejewski, Alan F. List
Pathology and Cell Biology Faculty Publications
P53 is a key regulator of many cellular processes and is negatively regulated by the human homolog of murine double minute-2 (MDM2) E3 ubiquitin ligase. Single nucleotide polymorphisms (SNPs) of either gene alone, and in combination, are linked to cancer susceptibility, disease progression, and therapy response. We analyzed the interaction of TP53 R72P and MDM2 SNP309 SNPs in relationship to outcome in patients with myelodysplastic syndromes (MDS). Sanger sequencing was performed on DNA isolated from 208 MDS cases. Utilizing a novel functional SNP scoring system ranging from +2 to −2 based on predicted p53 activity, we found statistically significant differences …
Surface Electromyography Of The Forearm Musculature During The Windmill Softball Pitch, D. Trey Remaley, Bryce Fincham, Bryan Mccullough, Kirk Davis, Charles Nofsinger, Charles Armstrong, Julie M. Stausmire
Surface Electromyography Of The Forearm Musculature During The Windmill Softball Pitch, D. Trey Remaley, Bryce Fincham, Bryan Mccullough, Kirk Davis, Charles Nofsinger, Charles Armstrong, Julie M. Stausmire
Orthopaedics and Sports Medicine Faculty Publications
Background: Previous studies investigating the windmill softball pitch have focused primarily on shoulder musculature and function, collecting limited data on elbow and forearm musculature. Little information is available in the literature regarding the forearm. This study documents forearm muscle electromyographic (EMG) activity that has not been previously published.
Purpose: Elbow and upper extremity overuse injuries are on the rise in fast-pitch softball pitchers. This study attempts to describe forearm muscle activity in softball pitchers during the windmill softball pitch. Overuse injuries can be prevented if a better understanding of mechanics is defined.
Study Design: Descriptive laboratory study.
Methods: Surface EMG …
Controlled Laboratory Comparison Study Of Motion With Football Equipment In A Destabilized Cervical Spine: Three Spine-Board Transfer Techniques, Mark L. Prasarn, Marybeth Horodyski, Matthew J. Dipaola, Christian P. Dipaola, Gianluca Del Rossi, Bryan P. Conrad, Glenn R. Rechtine Ii
Controlled Laboratory Comparison Study Of Motion With Football Equipment In A Destabilized Cervical Spine: Three Spine-Board Transfer Techniques, Mark L. Prasarn, Marybeth Horodyski, Matthew J. Dipaola, Christian P. Dipaola, Gianluca Del Rossi, Bryan P. Conrad, Glenn R. Rechtine Ii
Orthopaedics and Sports Medicine Faculty Publications
Background: Numerous studies have shown that there are better alternatives to log rolling patients with unstable spinal injuries, although this method is still commonly used for placing patients onto a spine board. No previous studies have examined transfer maneuvers involving an injured football player with equipment in place onto a spine board.
Purpose: To test 3 different transfer maneuvers of an injured football player onto a spine board to determine which method most effectively minimizes spinal motion in an injured cervical spine model.
Study Design: Controlled laboratory study.
Methods: Five whole, lightly embalmed cadavers were fitted with shoulder pads and …
Expandable Total Humeral Replacement In A Child With Osteosarcoma, Eric R. Henderson, Jidi Gao, John Groundland, Odion Binitie, G. Douglas Letson
Expandable Total Humeral Replacement In A Child With Osteosarcoma, Eric R. Henderson, Jidi Gao, John Groundland, Odion Binitie, G. Douglas Letson
Orthopaedics and Sports Medicine Faculty Publications
Case. A right-handed 8-year-old female patient presented with a conventional, high-grade osteosarcoma involving her right humerus; through-shoulder amputation was recommended. After consultation, total humerus resection with expandable, total humeral endoprosthesis reconstruction was performed with a sleeve to encourage soft-tissue ingrowth. At three-year follow-up she has received one lengthening procedure and her functional scores are excellent. Conclusion. Total humeral resection and replacement in the pediatric population are rare and although early reports of expandable total humeral endoprosthesis outcomes demonstrate high failure rates, this patient’s success indicates that expandable total humeral replacement is a viable option.
Effect Of Utilization Of Veno-Venous Bypass Vs. Cardiopulmonary Bypass On Complications For High Level Inferior Vena Cava Tumor Thrombectomy And Concomitant Radical Nephrectomy, Ross M. Simon, Timothy Kim, Patrick Espiritu, Tony Kurian, Wade J. Sexton, Julio M. Pow-Sang, Einar Sverrisson, Philippe E. Spiess
Effect Of Utilization Of Veno-Venous Bypass Vs. Cardiopulmonary Bypass On Complications For High Level Inferior Vena Cava Tumor Thrombectomy And Concomitant Radical Nephrectomy, Ross M. Simon, Timothy Kim, Patrick Espiritu, Tony Kurian, Wade J. Sexton, Julio M. Pow-Sang, Einar Sverrisson, Philippe E. Spiess
Urology Faculty Publications
Purpose: To determine if patients with renal cell carcinoma (RCC) with levels III and IV tumor thrombi are receive any reduction in complication rate utilizing veno-venous bypass (VVB) over cardiopulmonary bypass (CPB) for high level (III/IV) inferior vena cava (IVC) tumor thrombectomy and concomitant radical nephrectomy.
Materials and Methods: From May 1990 to August 2011, we reviewed 21 patients that had been treated for RCC with radical nephrectomy and concomitant IVC thrombectomy employing either CPB (n =16) or VVB (n=5). We retrospectively reviewed our study population for complication rates and perioperative characteristics.
Results: Our results are reported using the validated …
Partial Priapism Treated With Pentoxifylline, Meghan A. Cooper, Rafael E. Carrion, Christopher Yang
Partial Priapism Treated With Pentoxifylline, Meghan A. Cooper, Rafael E. Carrion, Christopher Yang
Urology Faculty Publications
Main findings: A 26-year-old man suffering from partial priapism was successfully treated with a regimen including pentoxifylline, a nonspecific phosphodiesterase inhibitor that is often used to conservatively treat Peyronie's disease.
Case hypothesis: Partial priapism is an extremely rare urological condition that is characterized by thrombosis within the proximal segment of a single corpus cavernosum. There have only been 36 reported cases to date. Although several factors have been associated with this unusual disorder, such as trauma or bicycle riding, the etiology is still not completely understood. Treatment is usually conservative and consists of a non-steroidal anti-inflammatory and anti-thrombotic.
Promising future …
Reduction Corporoplasty, Tariq S. Hakky, Daniel Martinez, Christopher Yang, Rafael E. Carrion
Reduction Corporoplasty, Tariq S. Hakky, Daniel Martinez, Christopher Yang, Rafael E. Carrion
Urology Faculty Publications
Objective: Here we present the first video demonstration of reduction corporoplasty in the management of phallic disfigurement in a 17 year old man with a history sickle cell disease and priapism.
Introduction: Surgical management of aneurysmal dilation of the corpora has yet to be defined in the literature. Materials and Methods: We preformed bilateral elliptical incisions over the lateral corpora as management of aneurysmal dilation of the corpora to correct phallic disfigurement.
Results: The patient tolerated the procedure well and has resolution of his corporal disfigurement.
Conclusions: Reduction corporoplasty using bilateral lateral elliptical incisions in the management of aneurysmal dilation …
A Novel Approach For The Treatment Of Radiation-Induced Hemorrhagic Cystitis With The Greenlight™ Xps Laser, Daniel Roberto Martinez, Cesar E. Ercole, Juan Gabriel Lopez, Justin Parker, Mary K. Hall
A Novel Approach For The Treatment Of Radiation-Induced Hemorrhagic Cystitis With The Greenlight™ Xps Laser, Daniel Roberto Martinez, Cesar E. Ercole, Juan Gabriel Lopez, Justin Parker, Mary K. Hall
Urology Faculty Publications
Introduction: The treatment of pelvic malignancies with radiotherapy can develop severe sequelae, especially radiation-induced hemorrhagic cystitis. It is a progressive disease that can lead to the need for blood transfusion, hospitalizations, and surgical interventions. This tends to affect the quality of life of these patients, and management can at times be difficult. We have evaluated the GreenLight Xcelerated Performance System (XPS) with TruCoag, although primarily used for management of benign prostatic hypertrophy (BPH), for the treatment of radiation-induced hemorrhagic cystitis.
Materials and Methods: After International Review Board (IRB) approval, a retrospective chart review was performed in addition to a literature …
Distal Spermatic Cord Peritoneal Stripping: An Adjunct Technique During Inguinal Orchiopexy, Hubert S. Swana, Rikin Patel, Mark A. Rich
Distal Spermatic Cord Peritoneal Stripping: An Adjunct Technique During Inguinal Orchiopexy, Hubert S. Swana, Rikin Patel, Mark A. Rich
Urology Faculty Publications
No abstract provided.
Bilateral Ureteral-Iliac Artery Fistula In A Patient With Chronic Indwelling Ureteral Stents: A Case Report And Review, Arash Rafiei, Timothy A. Weber, Michael Kongnyuy, Raul Ordorica
Bilateral Ureteral-Iliac Artery Fistula In A Patient With Chronic Indwelling Ureteral Stents: A Case Report And Review, Arash Rafiei, Timothy A. Weber, Michael Kongnyuy, Raul Ordorica
Urology Faculty Publications
Ureteral-arterial fistula (UAF) is an exceedingly rare but life-threatening condition warranting emergent intervention. Prompt recognition and management of UAF in suspect patients presenting with gross hematuria are required for a successful outcome. We report a rare subset of UAF involving the bilateral common iliac arteries. The patient underwent successful endovascular stent-grafting to correct the arterial defect and delayed open repair of the ureteral strictures. Timely management has benefited from the collaboration of the involved medical teams, which included emergency medicine, urology, and interventional radiology.
A Rare Case Of A Renal Cell Carcinoma Confined To The Isthmus Of A Horseshoe Kidney, Michael Kongnyuy, Daniel Martinez, Anthony Park, Barrett Mccormick, Justin Parker, Mary Hall
A Rare Case Of A Renal Cell Carcinoma Confined To The Isthmus Of A Horseshoe Kidney, Michael Kongnyuy, Daniel Martinez, Anthony Park, Barrett Mccormick, Justin Parker, Mary Hall
Urology Faculty Publications
Horseshoe kidney (HSK) is the most common renal anomaly. Reports of the incidence of renal cell carcinoma (RCC) in HSK are conflicting. Very few cases of isthmus-located RCC have been reported in the literature. We report a unique case of an isthmus-located RCC. Proper vascular and tumor imaging prior to surgery is key to successful tumor removal.
Frataxin Levels In Peripheral Tissue In Friedreich Ataxia, Michael Lazaropoulos, Yina Dong, Elisia Clark, Nathaniel R. Greeley, Lauren A. Seyer, Karlla W. Brigatti, Carlton Christie, Susan L. Perlman, George R. Wilmot, Christoper M. Gomez, Katherine D. Mathews, Grace Yoon, Theresa Zesiewicz, Chad Hoyle, Sub H. Subramony, Alicia F. Brocht, Jennifer M. Farmer, Robert B. Wilson, Eric C. Deutsch, David R. Lynch
Frataxin Levels In Peripheral Tissue In Friedreich Ataxia, Michael Lazaropoulos, Yina Dong, Elisia Clark, Nathaniel R. Greeley, Lauren A. Seyer, Karlla W. Brigatti, Carlton Christie, Susan L. Perlman, George R. Wilmot, Christoper M. Gomez, Katherine D. Mathews, Grace Yoon, Theresa Zesiewicz, Chad Hoyle, Sub H. Subramony, Alicia F. Brocht, Jennifer M. Farmer, Robert B. Wilson, Eric C. Deutsch, David R. Lynch
Neurology Faculty Publications
No abstract provided.
Anti-Nmda Receptor Encephalitis In A Patient With Previous Psychosis And Neurological Abnormalities: A Diagnostic Challenge, R. David Heekin, Maria C. Catalano, Alfred T. Frontera, Glenn Catalano
Anti-Nmda Receptor Encephalitis In A Patient With Previous Psychosis And Neurological Abnormalities: A Diagnostic Challenge, R. David Heekin, Maria C. Catalano, Alfred T. Frontera, Glenn Catalano
Neurology Faculty Publications
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune disorder characterized by IgG autoantibodies directed against the NR1 subunit of the NMDA glutamate receptor. Psychiatric symptoms are common and include psychosis, mania, depressed mood, aggression, and speech abnormalities. Neurological symptoms such as seizures, decreased responsiveness, dyskinesias, and other movement abnormalities and/or autonomic instability are frequently seen as well. We present the case of a woman who was followed up at our facility for over 14 years for the treatment of multiple neuropsychiatric symptoms. Initially, she presented with paresthesias, memory loss, and manic symptoms. Nine years later, she presented to our facility again, …
Mobile Stroke Unit (Msu): The Future Of Acute Stroke Treatment, Waldo R. Guerrero
Mobile Stroke Unit (Msu): The Future Of Acute Stroke Treatment, Waldo R. Guerrero
Neurosurgery and Brain Repair Faculty Publications
No abstract provided.
Dendritic And Langerhans Cells Respond To Aβ Peptides Differently: Implication For Ad Immunotherapy, Jiang Cheng, Xiaoyang Lin, David Morgan, Marcia Gordon, Xi Chen, Zhen-Hai Wang, Hai-Ning Li, Lan-Jie He, Shu-Feng Zhou, Chuanhai Cao
Dendritic And Langerhans Cells Respond To Aβ Peptides Differently: Implication For Ad Immunotherapy, Jiang Cheng, Xiaoyang Lin, David Morgan, Marcia Gordon, Xi Chen, Zhen-Hai Wang, Hai-Ning Li, Lan-Jie He, Shu-Feng Zhou, Chuanhai Cao
Molecular Pharmacology & Physiology Faculty Publications
Both wild-type and mutated beta-amyloid (Aβ) peptides can elicit an immune response when delivered subcutaneously. However, only mutated forms of Aβ can sensitize dendritic cells when administered intravenously or intraperitoneally. To understand the role of mutation and delivery routes in creating immune responses, and the function of dendritic cells as therapeutic agents, we used fluorescent-conjugated WT Aβ1-40 (WT40) and artificially mutated Aβ1-40 (22W40) peptides to treat dendritic and Langerhans cells from young and/or old mice at different time points. The cell types were analyzed by flow cytometry and confocal microscopy to identify differences in function and antigen presentation, and Luminex …
Craniopharyngioma Causing Bilateral Vision Loss 4 Months After Unremarkable Magnetic Resonance Imaging Of The Brain, Rainy Betts, Curtis E. Margo, Mitchell Drucker
Craniopharyngioma Causing Bilateral Vision Loss 4 Months After Unremarkable Magnetic Resonance Imaging Of The Brain, Rainy Betts, Curtis E. Margo, Mitchell Drucker
Ophthalmology Faculty Publications
A 65-year-old man developed bilateral vision loss 4 months after magnetic resonance imaging demonstrated no lesion in the vicinity of the optic chiasm, hypothalamus, and suprasellar tissues. Repeat computed tomography 3 months later showed a predominantly cystic mass of the suprasellar cistern with extension into the anterior third ventricle, which histologically was a craniopharyngioma. The clinical course of this case fuels the controversy whether craniopharyngiomas arise from embryonic rests or can be acquired. From a clinical perspective, it raises questions about when to obtain imaging studies dedicated to the chiasm and the appropriate interval in which a scan should be …
Visual Electrodiagnostic Testing In Birdshot Chorioretinopathy, Radouil Tzekov, Brian Madow
Visual Electrodiagnostic Testing In Birdshot Chorioretinopathy, Radouil Tzekov, Brian Madow
Ophthalmology Faculty Publications
Birdshot chorioretinopathy (BSCR) is a rare form of autoimmune posterior uveitis that can affect the visual function and, if left untreated, can lead to sight-threatening complications and loss of central vision. We performed a systematic search of the literature focused on visual electrophysiology studies, including electroretinography (ERG), electrooculography (EOG), and visual evoked potentials (VEP), used to monitor the progression of BSCR and estimate treatment efficacy. Many reports were identified, including using a variety of methodologies and patient populations, which makes a direct comparison of the results difficult, especially with some of the earlier studies using nonstandardized methodology. Several different electrophysiological …
Itraq-Based Proteomic Analysis Of Visual Cycle-Associated Proteins In Rpe Of Rd12 Mice Before And After Rpe65 Gene Delivery, Qinxiang Zheng, Yueping Ren, Radouil Tzekov, Shanshan Hua, Minghan Li, Jijing Pang, Jia Qu, Wensheng Li
Itraq-Based Proteomic Analysis Of Visual Cycle-Associated Proteins In Rpe Of Rd12 Mice Before And After Rpe65 Gene Delivery, Qinxiang Zheng, Yueping Ren, Radouil Tzekov, Shanshan Hua, Minghan Li, Jijing Pang, Jia Qu, Wensheng Li
Ophthalmology Faculty Publications
Purpose. To investigate the iTRAQ-based proteomic changes of visual cycle-associated proteins in RPE of rd12 mice before and after RPE65 gene delivery. Mehtods. The right eyes of rd12 mice underwent RPE65 gene delivery by subretinal injection at P14, leaving the left eyes as control. C57BL/6J mice were served as a wide-type control group. ERGs were recorded at P42, and RPE-choroid-sclera complex was collected to evaluate the proteomic changes in visual cycle-associated proteins by iTRAQ-based analysis. Western blot was used to confirm the changes in the differentially expressed proteins of interest. Results. ERG parameters improved dramatically at P42 after …
“In-Plant” Nmr: Analysis Of The Intact Plant Vesicularia Dubyana By High Resolution Nmr Spectroscopy, Viktor P. Kutyshenko, Peter Beskaravayny, Vladimir N. Uversky
“In-Plant” Nmr: Analysis Of The Intact Plant Vesicularia Dubyana By High Resolution Nmr Spectroscopy, Viktor P. Kutyshenko, Peter Beskaravayny, Vladimir N. Uversky
Molecular Medicine Faculty Publications
We present here the concept of “in-plant” NMR and show that high-resolution NMR spectroscopy is suitable for the analysis of intact plants and can be used to follow the changes in the intraorganismal molecular composition over long time periods. The NMR-based analysis of the effect of different concentrations of heavy water on the aquatic plant Vesicularia dubyana revealed that due to the presence of specific adaptive mechanisms this plant can sustain the presence of up to 85% of D2O. However, it dies in 100% heavy water.
Fendiline Inhibits Proliferation And Invasion Of Pancreatic Cancer Cells By Interfering With Adam10 Activation And Β-Catenin Signaling, Neha Woods, Jose Trevino, Domenico Coppola, Srikumar Chellappan, Shengyu Yang, Jaya Padmanabhan
Fendiline Inhibits Proliferation And Invasion Of Pancreatic Cancer Cells By Interfering With Adam10 Activation And Β-Catenin Signaling, Neha Woods, Jose Trevino, Domenico Coppola, Srikumar Chellappan, Shengyu Yang, Jaya Padmanabhan
Molecular Medicine Faculty Publications
ADAM10 (A Disintegrin and Metalloprotease Domain 10) affects the pathophysiology of various cancers, and we had shown that inhibition of ADAM10 sensitizes pancreatic cancer cells to gemcitabine. ADAM10 is activated in response to calcium influx, and here we examined if calcium channel blockers (CCB) would impede ADAM10 activation and affect biology of pancreatic cancer cells. We find that the CCB, fendiline, significantly reduces proliferation, migration, invasion, and anchorage independent growth of pancreatic cancer cells. This was associated with ADAM10 inhibition and its localization at the actin-rich membrane protrusions. Further, fendiline-treated cells formed cadherin-catenin positive tight adherens junctions and elicited defective …
Does Intrinsically Disordered Caldesmon Bind Calmodulin Via The “Buttons On A String” Mechanism?, Sergei E. Permyakov, Eugene A. Permyakov, Vladimir N. Uversky
Does Intrinsically Disordered Caldesmon Bind Calmodulin Via The “Buttons On A String” Mechanism?, Sergei E. Permyakov, Eugene A. Permyakov, Vladimir N. Uversky
Molecular Medicine Faculty Publications
We show here that chicken gizzard caldesmon (CaD) and its C-terminal domain (residues 636-771, CaD136) are intrinsically disordered proteins. The computational and experimental analyses of the wild type CaD136 and series of its single tryptophan mutants (W674A, W707A, and W737A) and a double tryptophan mutant (W674A/W707A) suggested that although the interaction of CaD136 with calmodulin (CaM) can be driven by the non-specific electrostatic attraction between these oppositely charged molecules, the specificity of CaD136-CaM binding is likely to be determined by the specific packing of important CaD136 tryptophan residues at the CaD136-CaM interface. It is suggested that this interaction can be …
Does Intrinsically Disordered Caldesmon Bind Calmodulin Via The “Buttons On A String” Mechanism?, Sergei E. Permyakov, Eugene A. Permyakov, Vladimir N. Uversky
Does Intrinsically Disordered Caldesmon Bind Calmodulin Via The “Buttons On A String” Mechanism?, Sergei E. Permyakov, Eugene A. Permyakov, Vladimir N. Uversky
Molecular Medicine Faculty Publications
We show here that chicken gizzard caldesmon (CaD) and its C-terminal domain (residues 636-771, CaD136) are intrinsically disordered proteins. The computational and experimental analyses of the wild type CaD136 and series of its single tryptophan mutants (W674A, W707A, and W737A) and a double tryptophan mutant (W674A/W707A) suggested that although the interaction of CaD136 with calmodulin (CaM) can be driven by the non-specific electrostatic attraction between these oppositely charged molecules, the specificity of CaD136-CaM binding is likely to be determined by the specific packing of important CaD136 tryptophan residues at the CaD136-CaM interface. It is suggested that this interaction can be …
An Assessment Of Retractions As A Measure Of Scientific Misconduct And Impact On Public Health Risks, Alison J. Abritis
An Assessment Of Retractions As A Measure Of Scientific Misconduct And Impact On Public Health Risks, Alison J. Abritis
USF Tampa Graduate Theses and Dissertations
Research misconduct has been generally considered a limited issue, occurring in a small percentage of research studies. Studies of the number of article retractions use retraction percentages to perpetuate the idea that research misconduct is not a common event, and use information in the retraction notice to quantify types of research misconduct and types or research error. However, retractions appear to be the wrong variable with which to assess misconduct rates and characteristics. Using final misconduct findings in hard science research from the Office of Research Integrity (ORI) for investigations closed from 1993 through 2013, the number of publications and …
Theoretically Guided Examination Of Caregiver Strain And Its Relationship With School-Based Mental Health Services Utilization And Parent Engagement In Services, Amy Lynn Green
USF Tampa Graduate Theses and Dissertations
Broadly, the purpose of this study was to address the gaps in the knowledge base of caregiver strain through an examination of this and other theoretically related constructs in a sample of parents of high-risk youth. In the last two decades, a growing body of research has pointed to the significance of strain that can result from this caregiving experience, particularly as it relates to patterns of mental health services utilization. Despite the fact that the majority of children who receive mental health receive them from the school, few studies have examined caregiver strain in the context of school-based mental …