Medicine and Health Sciences Commons^™

On The Potential Therapeutic Roles Of Taurine In Autism Spectrum Disorder, Alberto Rubio-Casillas, Elrashdy M. Redwan, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Contemporary research has found that people with autism spectrum disorder (ASD) exhibit aberrant immunological function, with a shift toward increased cytokine production and unusual cell function. Microglia and astroglia were found to be significantly activated in immuno-cytochemical studies, and cytokine analysis revealed that the macrophage chemoattractant protein-1 (MCP-1), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and transforming growth factor β-1 (TGFB-1), all generated in the neuroglia, constituted the most predominant cytokines in the brain. Taurine (2-aminoethanesulfonic acid) is a promising therapeutic molecule able to increase the activity of antioxidant enzymes and ATPase, which may be protective against aluminum-induced neurotoxicity. …

An Evaluation Of Distributed And Accumulated Reinforcer Arrangements On Skill Acquisition And Preference, Natalie R. Mandel

USF Tampa Graduate Theses and Dissertations

Discrete trial training (DTT), an evidence-based instructional procedure (Wong et al., 2015), is often used to teach skills to individuals with autism. Manipulations to the reinforcement component of DTT have increased its instructional efficiency, resulting in acquisition of skills in less time (e.g., Cividini-Motta & Ahearn, 2013). Results of previous studies (e.g., DeLeon et al., 2014) indicate that some individuals prefer to complete larger work requirements that result in a larger amount of a reinforcer (i.e., accumulated arrangement), rather than receiving access to small amounts of a reinforcer dispersed throughout the work requirement (i.e., distributed arrangement). In addition, accumulated reinforcer …

Case Study: Using A Contingency-Based Delay Procedure To Decrease Tantrums During Periods Of Delayed Reinforcement, Lindsey Snyder

USF Tampa Graduate Theses and Dissertations

Functional Communication Training (FCT) involves reinforcing a functional communicative response (FCR) while placing problem behaviors on extinction (Carr & Durrand, 1985). When reinforcement for the FCR is delayed or unavailable, the individual’s problem behavior may return to previous levels (i.e., resurgence of previously reinforced problem behavior; Briggs et al., 2018) or the participant may exhibit emotional responding consistent with an extinction burst (Lerman & Iwata, 1996). A contingency-based delay procedure was introduced which increased the participant’s percentage of trials without tantrums and decreased the overall duration of tantrums.

Evaluating Video Modeling To Teach Job Seeking Skills: Composing A Professional Email, Scott A. Fontechia Ii

USF Tampa Graduate Theses and Dissertations

Within the disabilities community, individuals with an Autism Spectrum Disorder (ASD) diagnosis consistently have some of the most detrimental employment related statistics. To address this issue, this study evaluated video modeling, an evidence-based procedure, in teaching professional emailing skills to individuals diagnosed with ASD when applying for a job. Results of the study support video modeling research as an effective teaching tool. Significant skill acquisition, in composing a professional email, occurred across all participants. Seventy-five percent of participants concluded the study at mastery level. Implications of this study are immediately impactful on the ASD community as a new evidence-based transition …

The Durational Effects Of A Free Operant Condition On Automatically Maintained Stereotypic Behavior And Discrete Trial Task Responding, Shikika Sade Young

USF Tampa Graduate Theses and Dissertations

This study examined the effects of three fixed-duration free operant access conditions on rates of automatically maintained stereotypic behavior and correct task responding during discrete trial training (DTT) with two children diagnosed with autism. Following a functional analysis, confirming automatic function, interviews/observations were conducted to identify behavioral indicators of satiation and an average satiation level. In this endeavor, participants were exposed to a free operant condition to validate satiation of stereotypic responding. Once satiation level was averaged, two durational conditions were computed: Long (75% access) and Short (25% access). A third condition, Deprivation, involved blocking all attempts at the stereotypic …

Minocycline Treatment And The Necessity To Develop A Novel Outcome Measure For Children With Angelman Syndrome, Joseph Christopher Grieco

USF Tampa Graduate Theses and Dissertations

Angelman syndrome (AS) is a rare genetic disorder affecting 1/10,000 to 1/20,000 births. This disorder arises through the genetic disruption of the maternal UBE3A allele, which when coupled with epigenetic silencing of the paternal allele UBE3A allele, gives rise to an absence of UBE3A protein in the central nervous system. Clinical manifestations of the syndrome vary in severity and include poor motor function, deficits in language and severe intellectual impairments. Previous research in the Angelman syndrome mouse model revealed abnormalities in dendritic spine density and morphology of hippocampal pyramidal cells. As seen in humans with AS, mice show abnormal behavioral …

Using Video Feedback To Increase Eye Contact During Mock Job Interviews For Transition Age Adults With Autism Spectrum Disorders, Alexia Barnes

USF Tampa Graduate Theses and Dissertations

Abstract

Autism Spectrum Disorders (ASD) are characterized by impairments in social and communicative behaviors. These impairments can impact an individual's ability to obtain employment. The rates of unemployment for individuals with ASD are much higher than those of their peers without ASD. This study used a multiple baseline design across three participants diagnosed with ASD to determine the effectiveness of video feedback in improving eye contact duration during mock job interviews. After video feedback sessions, eye contact duration increased across all participants. On average, participant's eye contact duration was at 30.2% during baseline. These percentages increased to an average of …

Evaluating The Efficacy Of Shaping With A Percentile Schedule To Increase The Duration Of Sustained Interaction Following A Bid For Joint Attention In Children With Autism, Therese Gutbrod

USF Tampa Graduate Theses and Dissertations

This study examined the use of shaping with a percentile schedule to increase the duration of the interaction following a bid for joint attention in children with autism. Specifically, the therapist initiated a bid for joint attention and reinforced longer successive approximations in seconds of sustained interaction with the therapist and activity. A percentile schedule ranked the most recent 10 observations and reinforcement was provided if the current observation equaled the sixth ranking. Most-to-least prompting was used if the child failed to meet the calculated criterion. Shaping with a percentile schedule of reinforcement was effective at increasing the duration of …

Evaluation Of Video Modeling To Teach Children Diagnosed With Asd To Avoid Poison Hazards, Shannon Eileen King

USF Tampa Graduate Theses and Dissertations

Accidental poisonings are one of the leading safety threats for young children, so it is important to teach children to avoid ingesting poisonous substances. Research has shown that behavioral skills training (BST) and in situ training (IST) are effective in teaching children safety skills to prevent gun play, abduction, and poison ingestion. However, little research on safety skills has been conducted with children with autism. Video modeling has been shown to be effective in teaching abduction prevention skills to children diagnosed with Autism Spectrum Disorder (ASD). The purpose of this study was to evaluate the effectiveness of video modeling to …

A Comparison Of A Matrix Programming And Standard Discrete Trial Training Format To Teach Two-Component Tacts, Emily Braff

USF Tampa Graduate Theses and Dissertations

Teaching using matrix programming has been shown to result in recombinative generalization. However, this procedure has not been compared to more standard discrete trial training formats such as DTT. This study compared acquisition and recombinative generalization of two-component tacts using each procedure. Matrix training was found to be more efficient than the DTT format. Half the amount of teaching was required to teach roughly the same number of targets using matrix training as compared to DTT.

Training And Assessment Of Toothbrushing Skills Among Children With Special Needs, Rachel A. Brown

USF Tampa Graduate Theses and Dissertations

The success of applied behavior analysis (ABA) interventions relies heavily on adherence to measures of social importance. One area identified by caregivers, educators, and researchers as having social importance is the area of daily living skills; particularly in populations of children with special needs. A number of studies employed the use of a task analysis to objectively measure toothbrushing, with various training procedures utilized. Behavioral Skills Training (BST) is an effective procedure used to train a variety of skills. Further, research indicates the addition of an in situ assessment promotes generalization of trained skills. The current study examined the use …

Behavioral And Immunological Phenotypes Of Transgenic Mice Overexpressing Human Secreted Amyloid Precursor Protein Alpha: Implications For Autism, Antoinette R. Bailey

USF Tampa Graduate Theses and Dissertations

Autism is a heterogeneous neurodevelopmental disorder that is characterized by impaired social interaction and communication as well as restricted and repetitive behaviors and focused interests. In addition to the cardinal behavioral characteristics observed for diagnosis, autistic individuals exhibit a number of comorbid conditions as well as a variety of aberrant immunological features. Recent studies report that plasma from autistic children contained elevated levels of secreted amyloid precursor protein alpha (sAPP-á), the á-secretase cleavage product of the amyloid precursor protein (APP) which is ubiquitously expressed in the brain, spleen, thymus and other organs. Interestingly, the sAPP-á fragment functions as a neurotrophic …

Comparing Prompt Delay And Total Communication For Training Vocal Intraverbals In Children With Autism, Rosana Pesantez

USF Tampa Graduate Theses and Dissertations

Abstract

Verbal behavior encompasses a wide range of aspects in our everyday lives and in the activities of a society. Many verbal behavior interventions often include programs to teach answering questions, these responses are referred to as intraverbals. Previous research has demonstrated a higher rate of acquisition of verbal targets such as mands and tacts for children with a limited verbal repertoire when a presentation of both sign and vocal prompts occur simultaneously (Total Communication), in comparison to sign-alone or vocal-alone trainings. However, an important variable not often examined in the literature is the comparison of Total Communication (TC) and …