Medicine and Health Sciences Commons^™

Craniopharyngioma Causing Bilateral Vision Loss 4 Months After Unremarkable Magnetic Resonance Imaging Of The Brain, Rainy Betts, Curtis E. Margo, Mitchell Drucker

Ophthalmology Faculty Publications

A 65-year-old man developed bilateral vision loss 4 months after magnetic resonance imaging demonstrated no lesion in the vicinity of the optic chiasm, hypothalamus, and suprasellar tissues. Repeat computed tomography 3 months later showed a predominantly cystic mass of the suprasellar cistern with extension into the anterior third ventricle, which histologically was a craniopharyngioma. The clinical course of this case fuels the controversy whether craniopharyngiomas arise from embryonic rests or can be acquired. From a clinical perspective, it raises questions about when to obtain imaging studies dedicated to the chiasm and the appropriate interval in which a scan should be …

Visual Electrodiagnostic Testing In Birdshot Chorioretinopathy, Radouil Tzekov, Brian Madow

Ophthalmology Faculty Publications

Birdshot chorioretinopathy (BSCR) is a rare form of autoimmune posterior uveitis that can affect the visual function and, if left untreated, can lead to sight-threatening complications and loss of central vision. We performed a systematic search of the literature focused on visual electrophysiology studies, including electroretinography (ERG), electrooculography (EOG), and visual evoked potentials (VEP), used to monitor the progression of BSCR and estimate treatment efficacy. Many reports were identified, including using a variety of methodologies and patient populations, which makes a direct comparison of the results difficult, especially with some of the earlier studies using nonstandardized methodology. Several different electrophysiological …

Itraq-Based Proteomic Analysis Of Visual Cycle-Associated Proteins In Rpe Of Rd12 Mice Before And After Rpe65 Gene Delivery, Qinxiang Zheng, Yueping Ren, Radouil Tzekov, Shanshan Hua, Minghan Li, Jijing Pang, Jia Qu, Wensheng Li

Ophthalmology Faculty Publications

Purpose. To investigate the iTRAQ-based proteomic changes of visual cycle-associated proteins in RPE of rd12 mice before and after RPE65 gene delivery. Mehtods. The right eyes of rd12 mice underwent RPE65 gene delivery by subretinal injection at P14, leaving the left eyes as control. C57BL/6J mice were served as a wide-type control group. ERGs were recorded at P42, and RPE-choroid-sclera complex was collected to evaluate the proteomic changes in visual cycle-associated proteins by iTRAQ-based analysis. Western blot was used to confirm the changes in the differentially expressed proteins of interest. Results. ERG parameters improved dramatically at P42 after …

Standardized Training Examinations Among Ophthalmology Residents And The American Board Of Ophthalmology Written Qualifying Examination First Attempt: The Morsani College Of Medicine Experience, Andrew Carey, Mitchell Drucker

Ophthalmology Faculty Publications

Purpose: The aim of the study is to demonstrate whether resident performance on the United States Medical Licensing Exam (USMLE) Step 1 and the Ophthalmology Knowledge Assessment Program (OKAP) correlates to American Board of Ophthalmology Written Qualifying Examination (ABO-WQE).

Design: This is a retrospective cohort study.

Participants: Forty-one residents who completed their postgraduate training between 1999 and 2011 from our institution were included in the study.

Methods: Percentiles on the USMLE Step 1, OKAP, and ABO-WQE first attempt were recorded and analyzed for possible correlations among scores across examinations using Pearson rank correlation, chi-square analysis, Fisher exact test, and Student …

The Role Of Lumbar Puncture And Pressure.Lowering Therapy For Transverse Dural Sinus Thrombosis, Joshua Grant, Andrew Carey, Curtis Margo, Murtagh Reed, Mitchell Drucker

Ophthalmology Faculty Publications

Transverse (lateral) sinus thrombosis is a well-known complication of acute otitis media and mastoiditis in the pediatric and adult population. Thrombosis involving the transverse sinus can ultimately cause elevation of intracranial pressure (ICP) as a result of decreased cerebrospinal fluid absorption. If treatment to lower ICP is not undertaken, it can lead to ophthalmological complications including irreversible vision loss. The following case report describes an 11-year-old girl who was diagnosed with AOM by her pediatrician and subsequently presented to the emergency department complaining of nausea, vomiting, headache, and diplopia.