Medicine and Health Sciences Commons^™

Resilience And Health Outcomes Of Sexual Minority Middle-Aged And Older Adults, Christi L. Nelson

USF Tampa Graduate Theses and Dissertations

While research on lesbian, gay, and bisexual (hereafter referred to as sexual minority) middle-aged and older adults has increased over the past decade, there is still a critical need for more research on the health and resilience in this growing subpopulation. Research has provided evidence that sexual minority adults have an increased risk of negative health outcomes when compared to heterosexual adults. Research has also demonstrated possible resilience in sexual minority middle-aged and older adults; however, few studies have measured resilience in middle-aged and older adults. Gaining a better understanding of resilience in sexual minority adults may help identify modifiable …

Immune Modulation As A Therapeutic Target In An Α-Synuclein Model Of Parkinson’S Disease, Meena Subhashini Subbarayan

USF Tampa Graduate Theses and Dissertations

Parkinson’s disease (PD) is the second most common neurodegenerative disorder affecting about 1.5 million people in the United States with more than 60,000 people diagnosed each year. It is classically characterized by four major symptoms: tremor, postural instability, stiffness in joints, and slow movement (bradykinesia). Pathologically PD is characterized by up to 70% loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) of midbrain and accumulation of presynaptic protein called α-synuclein (α-syn) within dopaminergic neurons that extend to the striatum. This disrupts the nigrostriatal pathway leading to the motor symptoms seen in PD patients. Microglia, the innate immune cells …

Assisted Living Facilities In Florida: Examining The Factors Associated With Entries, Closure, And Licensure Change, Joseph W. June

USF Tampa Graduate Theses and Dissertations

Assisted living facilities (ALFs) have become a large provider of long-term care in the United States. Their expansion has been met with interest from older adults who desire to be independent yet receive some services and from state legislators who recently have attempted to increase access. Studies in long-term care have focused extensively on nursing homes, but recent research has examined the effects of ALFs on the long-term care market. Research has been lacking in understanding the unique markets of ALFs. Describing themselves as “communities” and offering multiple options for housing, ALFs have targeted independent and wealthier older adults who …

Indicators Of Mild Cognitive Impairment Associated With Language Processing And Production, Diana Julbe-Delgado

USF Tampa Graduate Theses and Dissertations

The research purpose of the present study was to (1) examine cognitive-linguistic features related to processing and production across a series of tasks that are representative of everyday discourse and (2) compare older adults with and without mild cognitive impairment (MCI) across linguistic features. Twenty-seven participants, including 12 individuals with- and 15 individuals without MCI, were enrolled from a larger study (Hudak et al., 2019). Cognitive status was initially assessed as part of the larger study using the Montreal Cognitive Assessment (MoCA; Nasreddine et al., 2005). Participants who scored ≤ 25 on the MoCA received a standardized neuropsychological evaluation and …

Balance Function: A Potential Early Indicator Of Mild Cognitive Impairment, Karen L. Bell

USF Tampa Graduate Theses and Dissertations

This study examined oculomotor and vestibular function in young adults, cognitively normal older adults (CNOA), and older adults with MCI. Oculomotor and vestibular function were assessed using videonystagmography (VNG), vestibular evoked myogenic potentials (VEMPs), the modified Clinical Test of Sensory Integration and Balance (mCTSIB), and the Fukuda Stepping test. Forty-two participants comprised three groups (young adults, n = 15; CNOA, n = 13; MCI, n = 14). The Montreal Cognitive Assessment ([MoCA]; Nasreddine et al., 2005) was used to assess cognitive status, and a MCI diagnosis was confirmed using standardized neuropsychological testing and a physician’s exam. MANOVA was calculated to …

Mass Spectrometry Discovery-Based Proteomics To Examine Anti-Aging Effects Of The Nutraceutical Nt-020 In Rat Serum, Samantha M. Portis

USF Tampa Graduate Theses and Dissertations

Aging is a complex physiological process that leads to the deterioration of all cells and tissues throughout the body. Aging is a major risk factor for the onset of many degenerative diseases in both the central nervous system (CNS) and the periphery, but even nonpathological aging (“normal” aging) is associated with chronic inflammation, oxidative stress, and decreased stem cell proliferation and regenerative capacity. This decreased regenerative capacity in stem cell niches is thought to be a key component underlying the aging process and many disease states associated with aging.

While the exact biological mechanisms underlying impaired stem cell proliferation and …

Home-Based Cognitive Monitoring: The Role Of Personality And Predictors Of Adherence And Satisfaction, Nasreen A. Sadeq

USF Tampa Graduate Theses and Dissertations

Over the last several decades, a growing awareness of the benefits of regular screening for common health conditions, such as cancer and cardiovascular diseases, has paved the way for preventative screenings to become routine in medical settings. Given that cognitive impairment is frequently reported as the number one worry of older adults, home-based cognitive monitoring may be an innovative solution that allows middle aged and older adults to take an active role in monitoring an important aspect of their health. Although several home-based cognitive monitoring programs have been validated for use in clinical and home-based settings, the Cogstate Brief Battery …

Effects Of Medications With Anticholinergic Properties And Opioids On Cognitive Function And Neural Volumetric Changes In Elderly Australians, Malinee Neelamegam

USF Tampa Graduate Theses and Dissertations

Introduction: Multiple comorbidities are common among older adults. Pharmaceutical interventions are the most common form of medical management of the multiple health conditions that the older adult population faces. Almost 90% of adults aged 65 years and above take at least one prescription medication. Polypharmacy (5 medication or more) occurs with 50% of the older adult population. Most medications used to treat common ailments affecting the geriatric population have anticholinergic properties. These medications are known to cause a range of side effects from peripheral effects to central nervous system effects. These adverse effects are of particular concern in the older …

Small Heat Shock Proteins, Big Impact On Protein Aggregation In Neurodegenerative Disease, Jack M. Webster, April L. Darling, Vladimir N. Uversky, Laura J. Blair

Molecular Medicine Faculty Publications

Misfolding, aggregation, and aberrant accumulation of proteins are central components in the progression of neurodegenerative disease. Cellular molecular chaperone systems modulate proteostasis, and, therefore, are primed to influence aberrant protein-induced neurotoxicity and disease progression. Molecular chaperones have a wide range of functions from facilitating proper nascent folding and refolding to degradation or sequestration of misfolded substrates. In disease states, molecular chaperones can display protective or aberrant effects, including the promotion and stabilization of toxic protein aggregates. This seems to be dependent on the aggregating protein and discrete chaperone interaction. Small heat shock proteins (sHsps) are a class of molecular chaperones …

Factors Related To Hearing Aid Use Among Older Adults From Hispanic/Latino Backgrounds: Findings From The Hispanic Community Health Study/Study Of Latinos, Michelle L. Arnold

USF Tampa Graduate Theses and Dissertations

The purpose of this dissertation was to understand perceived hearing loss and hearing health care use among older adults from Hispanic/Latino backgrounds using the Andersen model of health care utilization as a framework. A cross sectional analysis of audiometric and survey data from the Hispanic Community Health Study/Study of Latinos was used to estimate factors that characterize perceived hearing handicap and hearing aid use, and to determine hearing aid use rates in a large group of older Hispanic/Latino adults. Data came from 6970 adults aged 45 to 76. Results revealed that self-perceived hearing handicap is significantly correlated to measured hearing …

Astaxanthin Attenuates Mptp Induced Neurotoxicity And Modulates Cognitive Function In Aged Mice, Beth Grimmig

USF Tampa Graduate Theses and Dissertations

Parkinson’s disease is the second common neurodegenerative disease and is most frequently diagnosed in individuals over 60. There are no available medications that can prevent or restore the loss of neurons that correspond to motor impairments in patients. Identifying novel therapeutic compounds that are capable of slowing and reversing the extensive neurodegeneration that occurs in PD remains an important goal of the field. While basic research has identified potential therapeutic agents, studies often use young model organisms to demonstrate efficacy of the target compound. This approach ignores the impact of the aged CNS on the disease process, and likely contributes …

How Did I Get Here? Testing The Translation Of The Morris Water Maze And The Influence Of Hemoglobin A1c On Spatial Navigation Performance, Colleen Pappas

USF Tampa Graduate Theses and Dissertations

Changes in cognitive status occur with aging and significant attention has been placed on developing interventions to possibly delay cognitive decline and identifying risk factors that exacerbate cognitive deficits. One issue that arises when studying interventions is that they do not always effectively translate from animal models to human subjects. When testing potentially modifiable risk factors related to cognitive impairment, more sensitive metrics could help in identifying targets for intervention at earlier time-points. Therefore, the aims of the current dissertation were twofold. The first study examined the ability to translate between species using a common behavioral paradigm, the Morris water …

Pain And Physical Function In A Socioeconomically Diverse Sample Of Black And White Adults, Angela Sardina

USF Tampa Graduate Theses and Dissertations

Musculoskeletal pain alters physiological function and these changes may be evidenced as early as middle age. Previous research has concluded that middle-aged adults are a high-risk group for chronic pain and report functional limitations similar to older adults. However, few studies have explored the unique individual factors (e.g., sociodemographic, health, and psychosocial characteristics) that may drive the pain experience; and more research is needed that examines the relationships between musculoskeletal pain and physical function, using objective performance measures, in a sample of racially and socioeconomically diverse adults.

Data from the Healthy Aging in Neighborhoods of Diversity across the Life Span …

Mass-Spectrometry Based Proteomics Of Age-Related Changes In Murine Microglia, Antwoine Flowers

USF Tampa Graduate Theses and Dissertations

The last century has seen a steady increase in the extension of the average lifespan. This has concomitantly produced higher incidences of age-related chronic degenerative diseases like Alzheimer’s and Parkinson’s diseases. Age is the single greatest risk factor for the development of not just these degenerative conditions but cancer as well. The aged niche undergoes a number of maladaptive changes that allow underlying conditions to present and progress. Exactly which changes, contribute to the progression of which disease is currently an area of intense study. However, these answers often present therapeutic targets for disease prevention. Age is characterized by a …

Moderation Analysis Of Bowel Function Among Nutrients And Physical Function Or Depression, As Well As Whether Bowel Function Is Related To Cognition In Older Adults, Jessie Alwerdt

USF Tampa Graduate Theses and Dissertations

As we age, the risk for gut issues, such as smooth muscle tone, may be an underlying indirect or direct cause or risk factor for many age-related issues, such as frailty. Consequences of decreased motility and depleted epithelial barrier may result in nutrient deficiencies that may increase the risk for malnutrition (Brownie, 2006). Further, there is increasing evidence that there is a gut-brain-axis relationship that may influence cognition and mental health issues, such as depression and anxiety. While there are relationships established, the interconnections of these factors have yet to be fully understood.

This dissertation examined several relationships specific to …

Large Cross-Sectional Study Of Presbycusis Reveals Rapid Progressive Decline In Auditory Temporal Acuity, Erol J. Ozmeral, Ann C. Eddins, Robert Frisina Sr., David A. Eddins

Communication Sciences and Disorders Faculty Publications

The auditory system relies on extraordinarily precise timing cues for the accurate perception of speech, music, and object identification. Epidemiological research has documented the age-related progressive decline in hearing sensitivity that is known to be a major health concern for the elderly. Although smaller investigations indicate that auditory temporal processing also declines with age, such measures have not been included in larger studies. Temporal gap detection thresholds (TGDTs; an index of auditory temporal resolution) measured in 1071 listeners (aged 18–98 years) were shown to decline at a minimum rate of 1.05 ms (15%) per decade. Age was a significant predictor …

Genetic Moderators Of Cognitive Decline In The Health And Retirement Study, Shannon K. Runge

USF Tampa Graduate Theses and Dissertations

The current dissertation used a gene x environment (G x E) approach to examine the independent and interactive effects of specific genetic variants and participation in physical and cognitive/social activities (PA and CSA) on cognitive performance in 4,764 participants of the Health and Retirement Study. Using three-wave data, three sets of multi-level growth models were conducted to examine baseline, longitudinal, and interactive effects of genotype (i.e., ApoE, COMT, and BDNF) and CSA/PA on performance across five cognitive measures: immediate, delayed and total word recall, and serial 7s and backwards counting.

At baseline, the ApoE ε4 allele predicted …

Lipoproteins And Health Outcomes: Cognitive And Physical Function In Older Adults, Marianne Chanti-Ketterl

USF Tampa Graduate Theses and Dissertations

Cardiovascular health is a major determinant of quality of life and mortality, especially in older adulthood. With the world’s oldest population increasing at expedited rates, challenges from cardiovascular conditions and its implications are spawning. Although it is well known that dyslipidemia may lead to cardiac events, less is known about the effects on cognitive and physical function in older adults. Epidemiological studies show that optimizing current preventive strategies even at older ages may reduce the incidence of cardiovascular comorbidity (e.g. hypertension, stroke) and increase quality of life. Determining the association between lipoproteins and cognitive and functional performance in older adults …

Word Recognition In Noise Among Young And Older Listeners: A Combined Behavioral And Electrophysiological Study, Victoria Ann Williams-Sanchez

USF Tampa Graduate Theses and Dissertations

Word recognition is based on the complex interplay of bottom up processing of acoustic input and corresponding top-down processing based on linguistic redundancies (i.e., contextual cues). Friedrich and Kotz (2007) investigated the timeline of integrating top-down and bottom-up processes among young adults with normal hearing using sentences presented in quiet. As a follow-up study, also with young adults with normal hearing (Experiment 1 of this dissertation), we used sentences embedded in multi-talker background noise and found similar results to Friedrich and Kotz (2007); but, with the use of principal component analysis (PCA) unveiled additional effects of phonological and semantic integration …

Sugar Consumption And Cognitive Aging In The Swedish Adoption/Twin Study Of Aging, Shyam Seetharaman

USF Tampa Graduate Theses and Dissertations

Abstract

Consumption of foods high in sugar content has been linked with the development of metabolic abnormalities such as cardiovascular disease and type II diabetes, major sources of global health concerns. Although the detrimental consequences of high intake of sugar on abnormal metabolic processes are established, it is not known how this association affects (or accelerates) cognitive aging.

The current project was based on data from the Swedish Adoption/Twin Study of Aging (SATSA) to test the hypothesis that high refined sugar intake contributes to accelerated trajectories of cognitive decline assessed longitudinally. Trajectories of cognitive change were assessed as a function …

Semantic Feature Distinctiveness And Frequency, Katherine Marie Lamb

USF Tampa Graduate Theses and Dissertations

Lexical access is the process in which basic components of meaning in language, the lexical entries (words) are activated. This activation is based on the organization and representational structure of the lexical entries. Semantic features of words, which are the prominent semantic characteristics of a word concept, provide important information because they mediate semantic access to words. An experiment was conducted to examine the importance of semantic feature distinctiveness and feature frequency in accessing the lexical representations of young and older adults in an off-line task using features of animals. The McRae, Cree, Seidenberg, and McNorgan (2005) feature norm corpus …

Subjective And Objective Napping And Sleep In Older Adults: Are Evening Naps “Bad” For Nighttime Sleep?, Natalie D. Dautovich, Christina S. Mccrae, Meredeth A. Rowe

Nursing Faculty Publications

Objectives: To compare objective and subjective measurements of napping, and to examine the relationship between evening napping and nocturnal sleep in older adults.

Design: For twelve days, participants wore actigraphs and completed sleep diaries.

Setting: Community

Participants: 100 individuals who napped, 60–89 years (including good and poor sleepers with typical age-related medical comorbidities).

Measurements: Twelve days of sleep diary and actigraphy provided subjective and objective napping and sleep data.

Results: Evening naps (within 2 hours of bedtime) were characteristic of the sample with peak nap time occurring between 20:30–21:00 (average nap time occurred between 14:30–15:00). Two categories of nappers were …