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Articles 1 - 30 of 209
Full-Text Articles in Microbiology
The Changing Tumor Microenvironment Of Non-Small Cell Lung Cancer, Mackenzie Hansen, Kim O'Neill, Qin Zhou, Yoko Derose, Magdalena Kovacsovics, Benjamin Brintz, Benjamin L. Witt, Siwen Hu-Lieskovan
The Changing Tumor Microenvironment Of Non-Small Cell Lung Cancer, Mackenzie Hansen, Kim O'Neill, Qin Zhou, Yoko Derose, Magdalena Kovacsovics, Benjamin Brintz, Benjamin L. Witt, Siwen Hu-Lieskovan
Library/Life Sciences Undergraduate Poster Competition 2024
Lung cancer is the leading cause of cancer related death in the United States, and non-small cell (NSCLC) is the most common type. An increasingly prevalent treatment in the last few years for NSCLC has been immunotherapy. However, for immunotherapy to be the most effective, we need to have a better understanding of how the immune system interacts with cancer in all stages. Specifically, we need to know where the immune cells reside, how they interact with each other, and how these populations change as the disease progresses. To define the tumor microenvironment, we stained 27 whole tumor slides with …
Targeting Hsp90: A Novel Approach To Combat Synovial Sarcomas, Peyton Worley, Jared Barrott, Matt Kirkham, Drake Heithoff
Targeting Hsp90: A Novel Approach To Combat Synovial Sarcomas, Peyton Worley, Jared Barrott, Matt Kirkham, Drake Heithoff
Library/Life Sciences Undergraduate Poster Competition 2024
Synovial sarcomas are rare muscle cancers that have very few targeted therapies. HSP90 is a protein upregulated in this form of cancer and many others. A screening of this cancer was done in vitro, using FDA-approved drugs, showing that HSP90 could be a promising treatment option. A novel HSP90 inhibitor was applied to human and mouse synovial sarcoma cell lines and was analyzed after receiving a drug treatment for HSP90.
Carbon-Infiltrated Carbon Nanotube Surfaces Affect Pseudomonas Aeruginosa Biofilm Development, Jenny Finlinson, Lucy C. Bowden, Bradford K. Berges
Carbon-Infiltrated Carbon Nanotube Surfaces Affect Pseudomonas Aeruginosa Biofilm Development, Jenny Finlinson, Lucy C. Bowden, Bradford K. Berges
Library/Life Sciences Undergraduate Poster Competition 2024
• ~30% of surgical implant failure is caused by infection1
• 10-23% of all implant-associated bone and joint infections are caused by gram-negative bacteria2
• Pseudomonas aeruginosa, a gram-negative bacterium, forms biofilms (bacterial communities encased in a matrix) that are extremely difficult to treat
Reducing Food Scarcity: The Benefits Of Urban Farming, S.A. Claudell, Emilio Mejia
Reducing Food Scarcity: The Benefits Of Urban Farming, S.A. Claudell, Emilio Mejia
Journal of Nonprofit Innovation
Urban farming can enhance the lives of communities and help reduce food scarcity. This paper presents a conceptual prototype of an efficient urban farming community that can be scaled for a single apartment building or an entire community across all global geoeconomics regions, including densely populated cities and rural, developing towns and communities. When deployed in coordination with smart crop choices, local farm support, and efficient transportation then the result isn’t just sustainability, but also increasing fresh produce accessibility, optimizing nutritional value, eliminating the use of ‘forever chemicals’, reducing transportation costs, and fostering global environmental benefits.
Imagine Doris, who is …
Engineering And Characterization Of Antibodies Against Cancer Biomarker Thymidine Kinase 1, Joshua Bennett, Kiara V. Whitley, Christopher J. Haynie, Kim O'Neill
Engineering And Characterization Of Antibodies Against Cancer Biomarker Thymidine Kinase 1, Joshua Bennett, Kiara V. Whitley, Christopher J. Haynie, Kim O'Neill
Library/Life Sciences Undergraduate Poster Competition 2023
Engineered antibodies used in immunotherapies have been increasingly successful due to their ability to uniquely target cells expressing specific cancer antigens Thymidine Kinase 1 (TK 1 is a DNA salvage enzyme typically found in the cytosol However, in certain types of cancer, TK 1 is surface expressed, making it a unique cancer biomarker By identifying antibodies with a high binding affinity for TK 1 we can target cancer cells expressing TK 1 on their surface Using cell sorting and a yeast display library expressing 109 human single chain antibody fragments, we have isolated ten unique single chain antibodies scFvs that …
From The Headlines: A Textual Analysis Of Social Polarization And Discord In Times Of Pandemic Across A Century In The United States, Alexa Demarco
From The Headlines: A Textual Analysis Of Social Polarization And Discord In Times Of Pandemic Across A Century In The United States, Alexa Demarco
Undergraduate Honors Theses
Within the past century, three major pandemics have affected the United States – the Spanish Flu, AIDS, and COVID-19. Each of these pandemics has tested the capabilities of the public health sector and the social resilience of the population. Scientists have studied the viruses and implemented public health measures to limit viral transmission, but the social responses to these preventative measures proved to be difficult to predict and control. The dissonance and polarization between the public health initiatives and the response of the general public in the most recent pandemic was apparent. Was this a pattern in other pandemics? Was …
Qualitative Proteomic And Genomic Analysis Of Klebsiella Pneumoniae Bacteriophage Kaomega, Emilee Carr
Qualitative Proteomic And Genomic Analysis Of Klebsiella Pneumoniae Bacteriophage Kaomega, Emilee Carr
Undergraduate Honors Theses
Klebsiella pneumoniae is a Gram-negative Enterobacteriaceae that is a common nosocomial pathogen causing pneumonia, infections in the bloodstream, wound infections, and meningitis. It has developed natural resistance to multiple antibiotics, most notably carbapenems which are often seen as the last line of defense against multi-drug resistant pathogens. Bacteriophages are being investigated as a promising alternative treatment to antibiotics in fighting these resistant pathogens. KaOmega, a Klebsiella pneumoniae bacteriophage, was isolated, sequenced, and annotated to characterize and understand its potential for use in a phage therapy. Characterization included Phyre2 analysis to predict putative protein functions based on structural homology, burst size …
Exploring Melatonin As A Treatment For Oral Ulcers, William H. Sutherland
Exploring Melatonin As A Treatment For Oral Ulcers, William H. Sutherland
Undergraduate Honors Theses
The hormone melatonin is best known for its role in the sleep-wake cycle, but its anti-inflammatory and antioxidant effects have significant implications that have not been fully explored in oral health. Some studies use melatonin to treat gastrointestinal ulcers, including duodenal ulcers and oral mucositis, but we found no study reporting its effects on more common oral ulcers, like aphthous stomatitis. We hypothesize that the anti-inflammatory and antioxidant characteristics of melatonin could effectively prevent and heal oral ulcers. In this paper, we review the literature on melatonin to propose its use as a treatment for oral ulcers. We also include …
Overcoming Detrimental Potato Fungi In Potato Fields With The Secondary Metabolites Of Naturally Occurring Steptomyces, Hansan Jones, Jacob Anderson, Erik Kemp, Brad Geary, Matthew Madsen, Ryan Stewart
Overcoming Detrimental Potato Fungi In Potato Fields With The Secondary Metabolites Of Naturally Occurring Steptomyces, Hansan Jones, Jacob Anderson, Erik Kemp, Brad Geary, Matthew Madsen, Ryan Stewart
Library/Life Sciences Undergraduate Poster Competition 2022
- Fungal disease Silver scurf can cause 13% water loss and give poor aesthetic appeal, both of which reduce farmers profits (1,2).
- Pythium leak can result in up to 50% total loss of potatoes in storage (3)
- Streptomyces is the right candidate to mitigate or eliminate these losses because of its ability to survive in soil (4) and its history as a proven biocontrol for other plant pathogens (5).
Potential Regulation Of Breast Cancer Invasion By Thymidine Kinase 1, Eliza E. Bitter, Rachel M. Morris, Toni O. Mortimer, Kai Barlow, Abigail Schekall, Michelle H. Townsend, Jonathan Skidmore, Brett E. Pickett, Kim L. O'Neill
Potential Regulation Of Breast Cancer Invasion By Thymidine Kinase 1, Eliza E. Bitter, Rachel M. Morris, Toni O. Mortimer, Kai Barlow, Abigail Schekall, Michelle H. Townsend, Jonathan Skidmore, Brett E. Pickett, Kim L. O'Neill
Library/Life Sciences Undergraduate Poster Competition 2022
Breast cancer is the most common cancer in women and is largely treatable within the early stages of the disease. However, patient mortality drastically declines as the tumor begins to invade other tissues and metastasize, making aggressive phenotypes especially problematic to treat. Such treatment typically requires an aggressive and decisive multidisciplinary approach. The recent expansion of immunotherapy as a viable treatment option has greatly improved treatment outcomes, especially with aggressive breast cancer phenotypes. Thymidine kinase 1 (TK1) is a DNA salvage pathway enzyme that is highly expressed during S phase and involved in cell cycle repair. Past studies indicated that …
The Role Of Cd5 In Cd4+ T Cell Metabolism, Joshua Bennett, Kiara Whitley, Claudia Freitas Phd, Christopher Haynie, Carlos Moreno, Scott Weber
The Role Of Cd5 In Cd4+ T Cell Metabolism, Joshua Bennett, Kiara Whitley, Claudia Freitas Phd, Christopher Haynie, Carlos Moreno, Scott Weber
Library/Life Sciences Undergraduate Poster Competition 2022
T cells serve a key role in the immunological response in the adaptive system. Different receptors present on the T cell have certain roles and are able to either inhibit or stimulate signaling which consequently regulates the function and metabolism of the cell. CD5 is an inhibitory co receptor expressed on the surface of T cells known to regulate thymocyte selection and TCR signaling . Our goal is to better understand the effects of CD5 regulation in metabolism. Using metabolic flux assays, we found that CD5KO naïve T cells have increased glycolysis and mitochondrial respiration in comparison to wild type …
Genes Critical For Flagellar Motility In Agrobacterium Fabrum, Audrey Memmott, Joel Griffitts
Genes Critical For Flagellar Motility In Agrobacterium Fabrum, Audrey Memmott, Joel Griffitts
Library/Life Sciences Undergraduate Poster Competition 2022
The flagellum contains 24 structural proteins that are vital for bacterial motility and virulence (Liu). Additionally, these structural proteins must be assembled in the correct order and orientation for a bacterium to be motile via its flagellum (Armitage). Our current knowledge regarding the flagellum is limited, however, because the majority of it comes from studies focused on Escherichia coli. To increase existing knowledge regarding the flagellum and the genes vital for its functionality, we attempted to define all the genes vital for flagellar motility in A. fabrum by analyzing motility when specific genes are disrupted.
On The Relationship Of Diabetes And Sleep Apnea: Evolution And Epigenetics, Nancy Wilson
On The Relationship Of Diabetes And Sleep Apnea: Evolution And Epigenetics, Nancy Wilson
Undergraduate Honors Theses
This thesis gives an overview of the relationship between diabetes, sleep apnea, obesity, and heart disease. It then addresses evidence that the traditional understanding of this relationship is incomplete or misleading. In the process, there is a brief discussion of the evolutionary rationale for the development and retention of sleep apnea in light of blood sugar dysregulation, as an adaptive mechanism in response to environmental stressors, followed by a brief overview of the general concepts of epigenetics. Finally, this paper presents the results of a literature search on the epigenetic marks and changes in gene expression found in sleep apnea …
Sunflower Seedlings Fail To Remove Uranium Pollution In The Navajo Nation: Participatory Science As A Path To Build Community And Address Environmental Injustice, Zak R. Webber
Undergraduate Honors Theses
Mid-20th century mining on Naabeehó Bináhásdzo (Navajo Nation) polluted groundwater with high concentrations of uranium and arsenic. The Navajo Nation and other rural residents of this region use groundwater for drinking, livestock, and irrigation. However, many individuals and communities must purchase and transport treated water from locations that are often hours away. Sunflowers have been shown to preferentially take up heavy metals, including uranium and arsenic, potentially representing a tool to improve water quality through on-site, low-cost phytoremediation. We carried out a collaborative research project with a high school class on the Navajo Nation in 2018 and 2019. The students …
Evaluation And Improvement Of A Novel Method For Rapid Promoter Characterization In A Zebrafish Model, Hunter Giles
Evaluation And Improvement Of A Novel Method For Rapid Promoter Characterization In A Zebrafish Model, Hunter Giles
Undergraduate Honors Theses
This thesis examines a novel technique for characterizing promoters using a zebrafish model. The proximal upstream cis-regulatory elements, also known as promoters or promoter regions, are essential for the precise regulation and timing of gene expression. Often the characterization of these regions relies on imprecise methods involving large deletions or bioinformatic predictions rather than experimental data. However, high-throughput sequencing technology could potentially allow large libraries containing hundreds of thousands of variants of a single promoter to be simultaneously analyzed. We have been working to develop a novel method for promoter characterization that takes advantage of this technology. We tested this …
Functional Implications Of Nlrp1 Variants For Autoimmune Disease, Laura J. Westhoff
Functional Implications Of Nlrp1 Variants For Autoimmune Disease, Laura J. Westhoff
Undergraduate Honors Theses
NLRP1 is a protein-coding human gene that plays a crucial role in the NLRP1 inflammasome. Variants to the NLRP1 gene have been associated with autoimmune and autoinflammatory diseases. We examined the effects of polymorphisms at two SNPs on cytokine levels and NLRP1 gene expression in 50 human volunteers without diagnosed autoimmune disease. NLRP1 was genotyped at SNPs rs2670660 and rs12150220 and individuals who were homozygous at one or more SNP were selected for further analysis. Serum IL-18 and IL-1β levels were quantified using ELISA. NLRP1 gene expression was measured using real-time PCR. A strong linkage was found between genotypes of …
Improving And Modeling Bacteria Recovery In Hollow Disk System, Clifton Anderson
Improving And Modeling Bacteria Recovery In Hollow Disk System, Clifton Anderson
Theses and Dissertations
Identifying antibiotic resistance in blood infections requires separating bacteria from whole blood. A hollow spinning disk rapidly removes suspended red blood cells by leveraging hydrodynamic differences between bacteria and whole blood components in a centrifugal field. Once the red cells are removed, the supernatant plasma which contains bacteria is collected for downstream antibiotic testing. This work improves upon previous work by modifying the disk design to maximize fractional plasma recovery and minimize fractional red cell recovery. V-shaped channels induce plasma flow and increase fractional plasma recovery. Additionally, diluting a blood sample spiked with bacteria prior to spinning it increased the …
Heterotrophic Protists As Useful Models For Studying Microbial Food Webs In A Model Soil Ecosystem And The Universality Of Complex Unicellular Life, Andrew Robert Thompson
Heterotrophic Protists As Useful Models For Studying Microbial Food Webs In A Model Soil Ecosystem And The Universality Of Complex Unicellular Life, Andrew Robert Thompson
Theses and Dissertations
Heterotrophic protists, consisting largely of the Cercozoa, Amoebozoa, Ciliophora, Discoba and some Stramenopiles, are a poorly characterized component of life on Earth. They play an important ecological role in soil communities and provide key insights into the nature of one of life’s most enigmatic evolutionary transitions: the development of the complex unicell. Soil ecosystems are crucial to the functioning of global biogeochemical cycles (e.g. carbon and nitrogen) but are at risk of drastic change from anthropogenic climate change. Heterotrophic protists are the primary regulators of bacterial diversity in soils and as such play integral roles in biogeochemical cycling, nutrient mobilization, …
Bottom-Up Controls (Micronutrients And N And P Species) Better Predict Cyanobacterial Abundances In Harmful Algal Blooms Than Top-Down Controls (Grazers), Scott Andrew Collins
Bottom-Up Controls (Micronutrients And N And P Species) Better Predict Cyanobacterial Abundances In Harmful Algal Blooms Than Top-Down Controls (Grazers), Scott Andrew Collins
Theses and Dissertations
The initiation, bloom, and bust of harmful Cyanobacteria and algae blooms (HAB) in lakes are controlled by top-down and bottom-up ecological controls. Excess phosphorous and nitrogen inputs from anthropogenic sources are primary to blame, but eukaryotic grazers may also promote or curb Cyanobacteria dominance. We tracked shifts in bacterial composition, lake chemistry, and eukaryotic grazing community weekly or bi-weekly through spring and summer and modeled the causes of specific Cyanobacterial species blooms and busts across three lakes in Utah, USA, with differing lake trophic states. Regardless of trophic status, all three lakes experienced blooms of varying composition and duration. Aphanizomenon …
Bioaerosols Associated With Evaporative Cooler Use In Low-Income Homes In Semi-Arid Climates, Ashlin Elaine Cowger
Bioaerosols Associated With Evaporative Cooler Use In Low-Income Homes In Semi-Arid Climates, Ashlin Elaine Cowger
Theses and Dissertations
Asthma is the leading chronic illness in children in the United States. Since children in the U.S. spend a majority of their time indoors there is an increased need to understand key sources of daily asthma triggers in the home. Bacterial endotoxin, dust mite allergens and β-D-glucan have been shown to be potent inducers of asthma attacks, and high levels of these allergens in homes can trigger attacks in those with asthma. We aim to better understand the risks to those with asthma that might be associated with evaporative cooler (EC) use in low-income homes. ECs are often promoted because …
Isolation, Characterization, And Genomic Comparison Of Bacteriophages Of Enterobacteriales Order, Ruchira Sharma
Isolation, Characterization, And Genomic Comparison Of Bacteriophages Of Enterobacteriales Order, Ruchira Sharma
Theses and Dissertations
According to CDC, every year at least 2 million people are affected and 23,000 dies as a result of antibiotic resistance in U.S. It is considered one of the biggest threats to global health. More and more bacterial infections are becoming harder to treat. One such infection is fire blight, one of the most destructive disease of apple and pear trees. It is caused by bacteria Erwinia amylovora and its outbreaks have been known to destroy entire orchards in a single season. The conventional method of treatments includes use of antibiotics like streptomycin and oxytetracycline but the incidences like presence …
Isolation, Genetic Characterization And Clinical Application Of Bacteriophages Of Pathogenic Bacterial Species, Trever Leon Thurgood
Isolation, Genetic Characterization And Clinical Application Of Bacteriophages Of Pathogenic Bacterial Species, Trever Leon Thurgood
Theses and Dissertations
Bacteriophages (phages) are the smallest biological entity on the planet. They provide vast amounts of valuable knowledge to biologists. Phage genomes are relatively simple compared to the organisms they infect (prokaryotes) and yet continually point to the complexity surrounding molecular- and microbiological mechanisms of life. By studying phages we can learn of the systems of gene expression, protein interaction and DNA organization. Phages are useful not only from an academic perspective, but may also have useful clinical applications. In the face of the rise of antibiotic-resistant bacterial “super pathogens”, scientists and researchers turn to phages as alternative treatments to these …
Geological And Geochemical Controls On Non-Tuberculous Mycobacterium Transmission: Examples From Hawaii, Schuyler Thomas Robinson
Geological And Geochemical Controls On Non-Tuberculous Mycobacterium Transmission: Examples From Hawaii, Schuyler Thomas Robinson
Theses and Dissertations
The opportunistic environmental microbes, non-tuberculous Mycobacterium (NTM), pose an increasing risk of disease and death in both immunodeficient and immunocompetent individuals in the USA and across the world. NTM lung disease is particularly prevalent in Hawaii, although the modes of NTM acquisition and transport in Hawaii are not fully understood. This study evaluated 149 soil and 50 water samples across the Hawaiian Islands to determine geochemical factors controlling NTM. Non-metric multidimensional scaling (NMDS) and principal component analyses (PCA) of modern soils show variables such as Total Organic Carbon (TOC), pH, P, mafic silicate minerals, and Pb seem to control NTM …
You Are What You Eat At Any Age: Carbon And Nitrogen Analysis Of Mummies From An Ancient Egyptian Necropolis, Stephen Funk, R. Paul Evans
You Are What You Eat At Any Age: Carbon And Nitrogen Analysis Of Mummies From An Ancient Egyptian Necropolis, Stephen Funk, R. Paul Evans
Library/Life Sciences Undergraduate Poster Competition 2019
The BYU Egypt Project at Fag el-Gamus necropolis and adjacent Seila Pyramid has studied over 700 mummies excavated over the past 30 years. The necropolis includes an open area with densely located vertical burial shafts and a hill with horizontal burial shafts. The chronological and dietary history of the mummies was assessed using stable isotopy and 14C analysis of accessible biological samples.
Evaluating Fungal Pathogen Inoculum Loads In Field Seed Banks, Taryn Lori Williamson
Evaluating Fungal Pathogen Inoculum Loads In Field Seed Banks, Taryn Lori Williamson
Theses and Dissertations
Quantification of soilborne pathogen inoculum loads is important in both agricultural and wildland settings. Quantitative Polymerase Chain Reaction (qPCR) methods using SYBR Green chemistry have been shown to be useful for quantifying fungal inoculum loads in environmental samples. The purpose of this study was to develop a method to quantify fungal pathogen inoculum loads in soil seed banks using a qPCR method with SYBR Green chemistry. The invasive annual grass Bromus tectorum was chosen for this seed bank study. There were three objectives: 1) to design target-specific primers for three fungal pathogens known to be important in Bromus tectorum seed …
Further Understanding Of Bacteriophages That Infect The Bacterial Family Enterobacteriaceae, Paul Flake
Further Understanding Of Bacteriophages That Infect The Bacterial Family Enterobacteriaceae, Paul Flake
Undergraduate Honors Theses
Despite the eclectic nature of bacteriophage genomes, nucleotide comparison is an effective method for grouping phages into cluster and subcluster classifications. This process is facilitated by making preliminary cluster assignations based on the identity of the major capsid protein. As more phages continue to be sequenced and integrated into cluster/subcluster groupings, adjustments may need to be made to the genomic similarity percentages that have previously defined cluster/subcluster classifications. Implementing proteomic comparison in addition to nucleotide homology may provide added clarity to this process. Protein conservation and diversity among lytic phages that infect the bacterial family Enterobacteriaceae is discussed and the …
Pas Kinase And Tor, Controllers Of Cell Growth And Proliferation, Brooke Jasmyn Cozzens
Pas Kinase And Tor, Controllers Of Cell Growth And Proliferation, Brooke Jasmyn Cozzens
Theses and Dissertations
Nutrient sensing kinases lie at the heart of cellular health and homeostasis, allowing cells to quickly adapt to changing environments. Target of Rapamycin (TOR) and PAS kinase (PASK, or PASKIN) are two such nutrient kinases, conserved from yeast to man. In yeast, these kinases each have paralogs. The two TOR paralogs in yeast mimic the mammalian TORC1 and TORC2 complexes, except both Tor1 and Tor2 may contribute to TORC1 or TORC2 function. The two PAS kinase paralogs are paired with the TOR paralogs, meaning that both Psk1 and Psk2 regulate TORC1, while Psk2 suppresses a temperature-sensitive allele of Tor2. Herein …
Galleria Mellonella As An Alternate Infection Model For Burkholderia Species And A Comparison Of Suspension And Surface Test Methods For Evaluating Sporicidal Efficacy, Joseph D. Thiriot
Galleria Mellonella As An Alternate Infection Model For Burkholderia Species And A Comparison Of Suspension And Surface Test Methods For Evaluating Sporicidal Efficacy, Joseph D. Thiriot
Theses and Dissertations
Melioidosis is a neglected tropical disease that continues unabated in many countries, particularly in Southeast Asia. There is no vaccine and antimicrobial treatment is expensive and complicated. Virulence models are important tools used to investigate genes involved in pathogenesis. Galleria mellonella is the larvae of the wax worm moth that has been used to model various infections. Based on previous studies, we attempted to establish an infection model using Burkholderia pseudomallei and Burkholderia thailandensis, a related species which is avirulent in humans. Injections of various forms of these species (fresh and frozen) were used to develop Kaplan-Meier plots. We …
The Antimicrobial Properties Of Honey And Their Effect On Pathogenic Bacteria, Shreena Himanshu Mody
The Antimicrobial Properties Of Honey And Their Effect On Pathogenic Bacteria, Shreena Himanshu Mody
Theses and Dissertations
Honey has been used to heal wounds since ancient times. There are many references in ancient literature that cite honey for its medicinal uses. It is used as an alternative agent to cure infections of wounds, burns, ulcers etc. Researchers have shown some of the antimicrobial properties of honey when used as an ointment. When applied to an affected area, it helps to promote the growth of healthy tissue. One of the factors on which the quality of the honey depends, is its geographical origin. Based on the location, honey types can vary as much as 100-fold from each other …
The Effect Of The Overexpression Of Irf% In B-Cells On Inflammatory And Co-Stimulatory Activity, Reika Takita, Brian Poole
The Effect Of The Overexpression Of Irf% In B-Cells On Inflammatory And Co-Stimulatory Activity, Reika Takita, Brian Poole
Journal of Undergraduate Research
Systemic Lupus Erythematosus is a chronic autoimmune disease characterized by inflammatory tissue damage inflicted by the body's rogue immune system (1). Although treatment is available for the disease, the pathogenesis of SLE remains unclear (2). However, researchers suspect the disease to be associated with environmental, genetic, and hormonal factors (1).