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Full-Text Articles in Microbiology
The Effect Of The Overexpression Of Irf% In B-Cells On Inflammatory And Co-Stimulatory Activity, Reika Takita, Brian Poole
The Effect Of The Overexpression Of Irf% In B-Cells On Inflammatory And Co-Stimulatory Activity, Reika Takita, Brian Poole
Journal of Undergraduate Research
Systemic Lupus Erythematosus is a chronic autoimmune disease characterized by inflammatory tissue damage inflicted by the body's rogue immune system (1). Although treatment is available for the disease, the pathogenesis of SLE remains unclear (2). However, researchers suspect the disease to be associated with environmental, genetic, and hormonal factors (1).
Pharmacologic Immunomodulation Of Macrophage Activation By Caffeine, Ryan Perry Steck
Pharmacologic Immunomodulation Of Macrophage Activation By Caffeine, Ryan Perry Steck
Theses and Dissertations
Caffeine is one of the most widely used neurostimulants in the world and there is considerable debate on its effect in immune cells. One of its main targets is proposed to be adenosine receptors which mediate an anti-inflammatory switch in activated immune cells while another target is phosphodiesterase where it acts as an inhibitor. In macrophages, caffeine has been shown to cause both pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes. If the primary effect of caffeine on macrophages were to antagonize adenosine receptors we would expect cells exposed to caffeine to have a prolonged M1 response. However, we show that caffeine …
An Infection Model For Examining The Effects Of Gender And Diabetic State On Proinflammatory Cytokine Secretion By Phagocytic Cells In Response To Infection With Burkholderia Pseudomallei, Laura L. Dickey
Theses and Dissertations
Burkholderia pseudomallei is an opportunistic soil pathogen that causes melioidosis, a life-threatening human disease prevalent in Southeast Asia, northern Australia, the Middle East, Africa, and South America. The organism also causes disease in plants and animals. Persons with severe melioidosis usually die of septicemia. Relatively little is known regarding the virulence mechanisms of B. pseudomallei; however, several putative virulence determinants have been identified. The organism is able to invade and replicate within phagocytic cells and is particularly pathogenic in males with diabetes mellitus. B. thailandensis is closely related to B. pseudomallei, but is not pathogenic. This study examines various in …