Microbiology Commons^™

The Changing Tumor Microenvironment Of Non-Small Cell Lung Cancer, Mackenzie Hansen, Kim O'Neill, Qin Zhou, Yoko Derose, Magdalena Kovacsovics, Benjamin Brintz, Benjamin L. Witt, Siwen Hu-Lieskovan

Library/Life Sciences Undergraduate Poster Competition 2024

Lung cancer is the leading cause of cancer related death in the United States, and non-small cell (NSCLC) is the most common type. An increasingly prevalent treatment in the last few years for NSCLC has been immunotherapy. However, for immunotherapy to be the most effective, we need to have a better understanding of how the immune system interacts with cancer in all stages. Specifically, we need to know where the immune cells reside, how they interact with each other, and how these populations change as the disease progresses. To define the tumor microenvironment, we stained 27 whole tumor slides with …

Targeting Hsp90: A Novel Approach To Combat Synovial Sarcomas, Peyton Worley, Jared Barrott, Matt Kirkham, Drake Heithoff

Library/Life Sciences Undergraduate Poster Competition 2024

Synovial sarcomas are rare muscle cancers that have very few targeted therapies. HSP90 is a protein upregulated in this form of cancer and many others. A screening of this cancer was done in vitro, using FDA-approved drugs, showing that HSP90 could be a promising treatment option. A novel HSP90 inhibitor was applied to human and mouse synovial sarcoma cell lines and was analyzed after receiving a drug treatment for HSP90.

Carbon-Infiltrated Carbon Nanotube Surfaces Affect Pseudomonas Aeruginosa Biofilm Development, Jenny Finlinson, Lucy C. Bowden, Bradford K. Berges

Library/Life Sciences Undergraduate Poster Competition 2024

• ~30% of surgical implant failure is caused by infection1

• 10-23% of all implant-associated bone and joint infections are caused by gram-negative bacteria2

• Pseudomonas aeruginosa, a gram-negative bacterium, forms biofilms (bacterial communities encased in a matrix) that are extremely difficult to treat