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Articles 1 - 4 of 4
Full-Text Articles in Microbiology
Isolation, Characterization, And Genomic Comparison Of Bacteriophages Of Enterobacteriales Order, Ruchira Sharma
Isolation, Characterization, And Genomic Comparison Of Bacteriophages Of Enterobacteriales Order, Ruchira Sharma
Theses and Dissertations
According to CDC, every year at least 2 million people are affected and 23,000 dies as a result of antibiotic resistance in U.S. It is considered one of the biggest threats to global health. More and more bacterial infections are becoming harder to treat. One such infection is fire blight, one of the most destructive disease of apple and pear trees. It is caused by bacteria Erwinia amylovora and its outbreaks have been known to destroy entire orchards in a single season. The conventional method of treatments includes use of antibiotics like streptomycin and oxytetracycline but the incidences like presence …
Isolation, Genetic Characterization And Clinical Application Of Bacteriophages Of Pathogenic Bacterial Species, Trever Leon Thurgood
Isolation, Genetic Characterization And Clinical Application Of Bacteriophages Of Pathogenic Bacterial Species, Trever Leon Thurgood
Theses and Dissertations
Bacteriophages (phages) are the smallest biological entity on the planet. They provide vast amounts of valuable knowledge to biologists. Phage genomes are relatively simple compared to the organisms they infect (prokaryotes) and yet continually point to the complexity surrounding molecular- and microbiological mechanisms of life. By studying phages we can learn of the systems of gene expression, protein interaction and DNA organization. Phages are useful not only from an academic perspective, but may also have useful clinical applications. In the face of the rise of antibiotic-resistant bacterial “super pathogens”, scientists and researchers turn to phages as alternative treatments to these …
Bacteriophages For Treating American Foulbrood And The Neutralization Of Paenibacillus Larvae Spores, Thomas Scott Brady
Bacteriophages For Treating American Foulbrood And The Neutralization Of Paenibacillus Larvae Spores, Thomas Scott Brady
Theses and Dissertations
The causative agent of the most devastating honeybee disease, American foulbrood (AFB), is the spore-forming bacterium Paenibacillus larvae. To prevent AFB outbreaks beekeepers prophylactically treat their hives with antibiotics even though it decreases the overall health of uninfected hives. A new treatment for AFB is needed due to recent legislation against using antibiotics, antibiotic resistance developing in P. larvae, and the resilience of P. larvae spores. Bacteriophages, or phages, are an attractive alternative to traditional antibiotics because of their specificity and ability to evolve alongside their target bacterium. In this study, two phage cocktails were developed for the …
Discovery Of Geographical Gene Variants In Related Pseudomonas Aeruginosa Bacteriophages, Emilee Carr, Elise Melhado, Emily Loertscher, Trever Thurgood, Ruchira Sharma, Julianne H. Grose
Discovery Of Geographical Gene Variants In Related Pseudomonas Aeruginosa Bacteriophages, Emilee Carr, Elise Melhado, Emily Loertscher, Trever Thurgood, Ruchira Sharma, Julianne H. Grose
Library/Life Sciences Undergraduate Poster Competition 2019
Antibiotic resistant bacterial strains are a major crisis in the world due to the difficult nature of curing individuals afflicted with them. Phage therapy has been proposed as an alternate treatment for these bacterium. In Dr. Julianne Grose's lab, bacteriophages were against the bacteria, Pseudomonas aeruginosa. To isolate, environmental samples were utilized in enrichment cultures that were ultimately used in serial dilutions, plaque purification, electron microscopy, DNA isolation, sequencing, and genome annotation. The P. aeruginosa phage, TF17, infects a bacterial strain that is highly related to a strain that causes fatalities as an opportunistic infection in patients with cystic fibrosis. …