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Full-Text Articles in Microbiology
Pas Kinase And Tor, Controllers Of Cell Growth And Proliferation, Brooke Jasmyn Cozzens
Pas Kinase And Tor, Controllers Of Cell Growth And Proliferation, Brooke Jasmyn Cozzens
Theses and Dissertations
Nutrient sensing kinases lie at the heart of cellular health and homeostasis, allowing cells to quickly adapt to changing environments. Target of Rapamycin (TOR) and PAS kinase (PASK, or PASKIN) are two such nutrient kinases, conserved from yeast to man. In yeast, these kinases each have paralogs. The two TOR paralogs in yeast mimic the mammalian TORC1 and TORC2 complexes, except both Tor1 and Tor2 may contribute to TORC1 or TORC2 function. The two PAS kinase paralogs are paired with the TOR paralogs, meaning that both Psk1 and Psk2 regulate TORC1, while Psk2 suppresses a temperature-sensitive allele of Tor2. Herein …
The Role Of Pas Kinase And Cbf1 In Cellular Metabolism, Jenny Adele Pattison, Julianne H. Grose
The Role Of Pas Kinase And Cbf1 In Cellular Metabolism, Jenny Adele Pattison, Julianne H. Grose
Journal of Undergraduate Research
The most recent National Institute of Health report concludes that 68.8% of American adults are considered to be overweight or obese1. With this trend in obesity, metabolic diseases such as heart disease, stroke, cancer, and diabetes are on the rise. The critical yet basic function of cellular homeostasis is a central component in controlling these diseases. Sensory protein kinases are essential in the phosphorylation of many protein substrates, allowing them to control several metabolic functions and appropriately allocate glucose, maintaining homeostasis in cells. PAS kinase is a sensory protein kinase that is highly conserved and plays a crucial role in …
The Role Of Pas Kinase And The Gut Microbiome In Metabolism And Diabetes Onset In Mice, Andrew Rees, Laura Bridgewater
The Role Of Pas Kinase And The Gut Microbiome In Metabolism And Diabetes Onset In Mice, Andrew Rees, Laura Bridgewater
Journal of Undergraduate Research
Diabetes and obesity are among the most prevalent health concerns in the modern world. However, prevention of their onset and control of their symptoms are still largely limited by our understanding of how these diseases arise. Recent research has indicated that the composition of the gut microbiome is one of the important factors in development of these diseases (5). However, current thinking is not definitive on the relative importance of genetic factors, diet and the gut microbiome, among other factors (5,6). PAS Kinase provided a model through which we could compare the relative affects of genetics, gut microbiome and diet …
Identifying And Characterizing Yeast Pas Kinase 1 Substrates Reveals Regulation Of Mitochondrial And Cell Growth Pathways, Desiree Demille
Identifying And Characterizing Yeast Pas Kinase 1 Substrates Reveals Regulation Of Mitochondrial And Cell Growth Pathways, Desiree Demille
Theses and Dissertations
Glucose allocation is an important cellular process that is misregulated in the interrelated diseases obesity, diabetes and cancer. Cells have evolved critical mechanisms for regulating glucose allocation, one of which is sensory protein kinases. PAS kinase is a key sensory protein kinase that regulates glucose allocation in yeast, mice and man; and is a novel therapeutic target for the treatment of metabolic diseases such as obesity, diabetes and cancer. Despite its importance, the molecular mechanisms of PAS kinase function are largely unknown. Through large-scale protein-interaction studies, we have identified 93 novel binding partners for PAS kinase which help to expand …