Biomechanics and Biotransport Commons^™

Real-Time Simulation Of Three-Dimensional Shoulder Girdle And Arm Dynamics, Edward K. Chadwick, Dimitra Blana, Robert F. Kirsch, Antonie J. Van Den Bogert

Antonie J. van den Bogert

Electrical stimulation is a promising technology for the restoration of arm function in paralyzed individuals. Control of the paralyzed arm under electrical stimulation, however, is a challenging problem that requires advanced controllers and command interfaces for the user. A real-time model describing the complex dynamics of the arm would allow user-in-the-loop type experiments where the command interface and controller could be assessed. Real-time models of the arm previously described have not included the ability to model the independently controlled scapula and clavicle, limiting their utility for clinical applications of this nature. The goal of this study therefore was to evaluate …

Dynamic Simulations And Data Mining Of Single-Leg Jump Landing: Implications For Anterior Cruciate Ligament Injury Prevention, Kristin Denise Morgan

Doctoral Dissertations

It is estimated that 400,000 anterior cruciate ligament (ACL) injuries occur in the United States each year with the cost of ACL reconstruction surgery and rehabilitation exceeding $1 billion annually. The majority of ACL injuries are non-contact injuries occurring during cutting and jump landing movements. Because the majority of the injuries are non-contact injuries there is the potential to develop programs to reduce the risk of injury. Given our understanding of the joint kinematics and kinetics that place an individual at high risk for ACL, researchers have developed neuromuscular training programs that focus on improving muscle function in order to …

Development Of Biomechanical Analysis Techniques For Fatigue Of Transtibial Prosthetic Socket And Pylon Interactions, Thomas Z. Sudbury

Honors Theses

The lack of formal, engineering based information is prevalent in the prosthetic industry. Currently, very few prosthetic manufacturing companies can definitively tell their patients how long their products will last. Because of this lack of information, many amputee patients will experience failure of their transtibial prosthetic device during daily activities. One such failure occurs from the fatigue of everyday use. Fatigue failures originate from the repeated application of certain loading conditions. These repeated loads usually occur for millions of cycles before a transtibial prosthetic catastrophically fails. The purpose of this study is to develop a testing procedure and apparatus that …

Application Of Limited Mixing In The Hele-Shaw Geometry In Fabrication Of Janus Hydrogels, Md Mahmudur Rahman

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

It is widely accepted that cells behave differently responding to the stiffness of their extracellular matrix (ECM). Such observations were made by culturing cells on hydrogel substrates of tunable stiffness. However, it was recently proposed that cells may sense how strongly they are tethered to ECM, not the local stiffness of ECM. To investigate both hypotheses, we developed a method to fabricate Janus polyacrylamide (PAAM) gels. We squeeze two drops of different concentrations in the Hele-Shaw geometry to generate radial Stokes flow. When the drops coalesce, limited mixing occurs at the interface due to the narrow confinement, and diffusion normal …

The Development And Application Of A Forearm Simulator To Investigate Radial Head Biomechanics, Brent A. Lanting

Electronic Thesis and Dissertation Repository

The forearm is a complex articular unit, with poorly understood biomechanics. A novel forearm simulator to facilitate physiologic testing of cadavers for multiple clinical scenarios was designed, manufactured and validated. A number of outcome measurements were potentiated including the forearm’s resistance to rotation, radiocapitellar contact pressure and area as well as IOM loads. Testing of changes to forearm biomechanics due to radial head excision and variations of radial head arthroplasty dimensions was conducted. Radial head arthroplasty using the correct radial head length and diameter recreated the biomechanics of an intact forearm. Radial head excision as well an implant of non-anatomic …

Computational Techniques To Predict Orthopaedic Implant Alignment And Fit In Bone, Seyed Kamaleddin Mostafavi Yazdi

Electronic Thesis and Dissertation Repository

Among the broad palette of surgical techniques employed in the current orthopaedic practice, joint replacement represents one of the most difficult and costliest surgical procedures. While numerous recent advances suggest that computer assistance can dramatically improve the precision and long term outcomes of joint arthroplasty even in the hands of experienced surgeons, many of the joint replacement protocols continue to rely almost exclusively on an empirical basis that often entail a succession of trial and error maneuvers that can only be performed intraoperatively. Although the surgeon is generally unable to accurately and reliably predict a priori what the final malalignment …

Biomechanical Investigations Of Medial Opening Wedge High Tibial Osteotomy: Gait Analysis, Materials Testing And Dynamic Radiography, Kristyn Leitch

Electronic Thesis and Dissertation Repository

This thesis aimed to develop and assess biomechanical methods to assist in the evaluation of medial opening wedge high tibial osteotomy (HTO). Five studies using diverse methods were performed, including three-dimensional (3D) gait analysis, materials testing of HTO fixation plates, and dynamic radiography in patients after surgery. Study 1 compared external knee joint moments during walking before and after varus or valgus producing osteotomy in patients with lateral or medial compartment osteoarthritis, and in healthy participants. The results highlighted the importance of alignment on gait biomechanics with changes in frontal plane angular impulse highly correlated to changes in mechanical axis. …

Subtalar Fusion Fixture Design And Test, Nathan Ortiz

Honors Theses

Subtalar arthrodesis is performed when cartilage in the talo-calcaneal (the ankle) joint is degraded in a patient and there are multiple approaches to this surgery. Using synthetic bone material, fixtures were cast from aluminum, using the process of evaporation pattern casting, and epoxy. This casting was used to grip the calcaneus bone of the foot in order to load it mechanically, simulating different scenarios that would be encountered during walking. The relative displacement of the ankle joint was measured using a digital image correlation (DIC) program that was modified to work in both two- and three-dimensional space. This program can …

Development Of An In-Vitro Passive And Active Motion Simulator For The Investigation Of Shoulder Function And Kinematics, Joshua W. Giles

Electronic Thesis and Dissertation Repository

Injuries and degenerative diseases of the shoulder are common and may relate to the joint’s complex biomechanics, which rely primarily on soft tissues to achieve stability. Despite the prevalence of these disorders, there is little information about their effects on the biomechanics of the shoulder, and a lack of evidence with which to guide clinical practice. Insight into these disorders and their treatments can be gained through in-vitro biomechanical experiments where the achieved physiologic accuracy and repeatability directly influence their efficacy and impact.

This work’s rationale was that developing a simulator with greater physiologic accuracy and testing capabilities would improve …

Hand Prosthesis, Tru Nguyen, Aaron Delano, Kyle M. Green, Jorge Maderal, Cody Poland

Thinking Matters Symposium Archive

This project deals with engineering students’ prosthetic hand design, submitted to the University of Southern Maine’s engineering department. The primary goal of the prosthetic hand design is to allow an impaired individual to grasp and hold everyday objects ranging from a toothbrush to a jug of milk. The project consists of three teams each designing their respective portion of the prosthetic device. The teams will deal with three specific design areas; computer aided design of the mechanism, electronic integration, and manufacturing implementation. The design team turns notebook doodles into virtual models in SolidWorks. The electronics team will control a battery …

Developing A Hardware Platform For A Low-Power, Low-Cost, Size-Constrained Biomechanical Telemetry System, Aditya Balasubramanian

Open Access Theses

As sport-related traumatic brain injuries face increasing attention from the media and the general public, the need to be able to detect brain injury quickly, inexpensively and accurately is more important than ever. Commercially-available event-based systems exist that claim to achieve this goal; however, they collect little to no continuous-time data and primarily indicate when a pre-determined acceleration threshold has been exceeded under the unvalidated assumption that a potentially concussive blow has occurred. Recent findings by the Purdue Neurotrauma Group (PNG) have indicated that repeated exposure to both concussive and subconcussive blows can result in cumulative trauma disorder. To track …

Biomechanics And Relaxivity For Functional Imaging Of Articular Cartilage Injury And Degradation, Kateri Elizabeth Fites

Open Access Theses

Osteoarthritis (OA) is a major debilitating health concern and economic burden worldwide, affecting 27 million people in the United States alone. OA often follows tissue injury, and is marked by changes in the structure and biomechanical function of cartilage, including breakdown of extracellular matrix molecules, loss of bulk tissue stiffness, and increase in articular surface friction and wear. Unlike bone and many other tissues, cartilage lacks an intrinsic capacity for regeneration. Advanced OA is typically diagnosed by patient symptoms (e.g. joint pain) and confirmed by radiographic evaluation of joint space narrowing. However, the application of functional imaging to assess cartilage …

Developing An Embedded System Solution For High-Speed, High-Capacity Data Logging For A Size-Constrained, Low-Power Biomechanical Telemetry System And Investigating Components For Optimal Performance, Brandon Blaine Gardner

Open Access Theses

The Purdue Neurotrauma Group (PNG) seeks to develop a biomechanical telemetry system capable of monitoring and storing athletes' head motions with the intention of identifying when a player may be at risk of neurophysiological damage, especially brain damage. A number of commercially-available systems exist with a similar goal; however, each of these systems discards information below an acceleration threshold. Research by PNG indicates that any acceleration may contribute to brain damage and that, because of this, an event-based model is insufficient for a proper understanding of an athlete's neurophysiological health. Continuous-time monitoring of head accelerations is therefore necessary. To facilitate …

Characteristics Of Fibrous Tissue At High Rates Of Tensile Loading, Benjamin J. Claus

Open Access Theses

The mechanical behavior of fibrous tissue is generally characterized at very low strain rates. However, many injuries occur at high rates of loading, such as those encountered in sporting events or vehicle accidents. An understanding of injury behavior requires the injury process to be recorded at high strain rates. Even at low rates of loading, the injury/failure within tissues occurs quickly. Furthermore, using conventional imaging systems, the surface of a specimen may be well documented throughout an experiment. However, damage formation does not necessarily begin at the surface of the specimen or even on the surface exposed to a camera. …

Vicon Motion System, Arezoo Eshraghi

AREZOO ESHRAGHI

No abstract provided.

Relationships Of Long-Term Bisphosphonate Treatment With Measures Of Bone Microarchitecture And Mechanical Competence, Jonathan Joseph Ward

Theses and Dissertations--Biomedical Engineering

Oral bisphosphonate drug therapy is a common and effective treatment for osteoporosis. Little is known about the long-term effects of bisphosphonates on bone quality. This study examined the structural and mechanical properties of trabecular bone following 0-16 years of bisphosphonate treatment. Fifty-three iliac crest bone samples of Caucasian women diagnosed with low turnover osteoporosis were identified from the Kentucky Bone Registry. Forty-five were treated with oral bisphosphonates for 1 to 16 years while eight were treatment naive. A section of trabecular bone was chosen from a micro-computed tomography (Scanco µCT 40) scan of each sample for a uniaxial linearly elastic …

Biomechanical Analysis Of Concealed Pack Load Influences On Terrorist Gait Signatures Derived From Gröbner Basis Theory, Sean S. Kohles, Anum Barki, Kimberly D. Kendricks, Ronald F. Tuttle

Biology Faculty Publications and Presentations

This project examines kinematic gait parameters as forensic predictors of the influence associated with individuals carrying concealed weighted packs up to 20% of their body weight. An initial inverse dynamics approach combined with computational algebra provided lower limb joint angles during the stance phase of gait as measured from 12 human subjects during normal walking. The following paper describes the additional biomechanical analysis of the joint angle data to produce kinetic and kinematic parameters further characterizing human motion. Results include the rotational velocities and accelerations of the hip, knee, and ankle as well as inertial moments and kinetic energies produced …

Novel Computational Approaches Characterizing Knee Physiotherapy, Wangdo Kim, Antonio P. Veloso, Duarte Araújo, Sean S. Kohles

Biology Faculty Publications and Presentations

A knee joint’s longevity depends on the proper integration of structural components in an axial alignment. If just one of the components is abnormally off-axis, the biomechanical system fails, resulting in arthritis. The complexity of various failures in the knee joint has led orthopedic surgeons to select total knee replacement as a primary treatment. In many cases, this means sacrificing much of an otherwise normal joint. Here, we review novel computational approaches to describe knee physiotherapy by introducing a new dimension of foot loading to the knee axis alignment producing an improved functional status of the patient. New physiotherapeutic applications …

Design And Validation Of A Computational Model For Study Of Scapholunate Joint Kinematics, Edward J. Tremols

Theses and Dissertations

As computational power has increased, computational modeling has become a very promising tool to model the biomechanics of complex joint systems. Musculoskeletal computational models have become more complex when compared to original iterations which utilized a number of simplifications. This thesis utilized a three-dimensional computational model of the wrist joint structure to investigate scapholunate kinematics. The model accurately represented the bony anatomy of the wrist and hand and represented soft tissue structures such as ligaments, tendons, and other surrounding tissues. Creation of the model was done using commercially available computer-aided design and medical image processing software, and utilized the rigid …

Analysis And Modeling Of The Roles Of Actin-Myosin Interactions In Bladder Smooth Muscle Biomechanics, Seyed Omid Komariza

Theses and Dissertations

Muscle mechanical behavior potentially plays an important role in some of the most common bladder disorders. These include overactive bladder, which can involve involuntary contractions during bladder filling, and impaired contractility or underactive bladder, which may involve weak or incomplete contractions during voiding. Actin-myosin cross-bridges in detrusor smooth muscle (DSM) are responsible for contracting and emptying the bladder. The total tension produced by muscle is the sum of its preload and active tensions. Studies suggest that actin-myosin cross-links are involved in adjustable preload stiffness (APS), which is characterized by a preload tension curve that can be shifted along the length …