Other Physics Commons^™

Design And Characterization Of A Novel Eef2k Degrader With Potent Therapeutic Efficacy Against Triple-Negative Breast Cancer, Changxin Zhong, Rongfeng Zhu, Ting Jiang, Sheng Tian, Xiaobao Zhao, Xiaoya Wan, Shilong Jiang, Zonglin Chen, Rong Gong, Linhao He, Jin-Ming Yang, Na Ye, Yan Cheng

Markey Cancer Center Faculty Publications

Dysregulated eEF2K expression is implicated in the pathogenesis of many human cancers, including triple-negative breast cancer (TNBC), making it a plausible therapeutic target. However, specific eEF2K inhibitors with potent anti-cancer activity have not been available so far. Targeted protein degradation has emerged as a new strategy for drug discovery. In this study, a novel small molecule chemical is designed and synthesized, named as compound C1, which shows potent activity in degrading eEF2K. C1 selectively binds to F8, L10, R144, C146, E229, and Y236 of the eEF2K protein and promotes its proteasomal degradation by increasing the interaction between eEF2K and the …

Acoustically Levitated Whispering-Gallery Mode Microlasers, H. M. Reynoso-De La Cruz, E. D. Hernández-Campos, E. Ortiz-Ricardo, A. Martínez-Borquez, I. Rosas-Román, V. Contreras, G. Ramos-Ortiz, B. Mendoza-Santoyo, Cecilia Zurita-Lopez, R. Castro-Beltrán

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Acoustic levitation has become a crucial technique for contactless manipulation in several fields, particularly in biological applications. However, its application in the photonics field remains largely unexplored. In this study, we implement an affordable and innovative phased-array levitator that enables stable trapping in the air of micrometer dye-doped droplets, thereby enabling the creation of microlasers. For the first time, this paper presents a detailed performance of the levitated microlaser cavity, supported by theoretical analysis concerning the hybrid technology based on the combination of whispering-gallery modes and acoustic fields. The pressure field distribution inside the acoustic cavity is numerically solved and …

Perovskite Cspbbr3 Solar Cells With Novel Hole-Transporting Layer Of Metal Complexes, Liqiu Zheng, Evynn S. Jackson, Ny'kesha S. Warren, Robert Owor, Zhongrui Li

Georgia Journal of Science

For the first time, the novel application of Schiff-base copper complexes in all-inorganic perovskite CsBrBr₃ solar cells has been explored and turns out they could be utilized as effective hole-transporting materials. Schiff-base copper complexes with halogen ligands (R=Cl and Br) are synthesized with an ease approach at a low cost, both of which exhibit decent power conversion efficiency of 4.55% and 5.71%, respectively, when being constructed into solar devices as hole transport layers. Thanks to high thermal/chemical stability of those Schiff-base metal complexes, the strengthened stability was achieved which is comparable to that of carbon-based CsBrBr₃ solar cells. …

Digital Twins Of The Living Knee: From Measurements To Model, Thor Erik Andreassen

Electronic Theses and Dissertations

Modern medicine has dramatically improved the lives of many. In orthopaedics, robotic surgery has given clinicians superior accuracy when performing interventions over conventional methods. Nevertheless, while these and many other methods are available to ensure treatments are performed successfully, far fewer methods exist to predict the proper treatment option for a given person. Clinicians are forced to categorize individuals, choosing the best treatment on “average.” However, many individuals differ significantly from the “average” person, for which many of these treatments are designed. Going forward, a method of testing, evaluating, and predicting different treatment options' short- and long-term effects on an …

Time-Symmetry And Topology Of The Aharonov-Bohm Effect, Yakir Aharonov, Ismael L. Paiva, Zohar Schwartzman-Nowik, Avshalom C. Elitzur, Eliahu Cohen

Mathematics, Physics, and Computer Science Faculty Articles and Research

The Aharonov–Bohm (AB) effect has been highly influential in fundamental and applied physics. Its topological nature commonly implies that an electron encircling a magnetic flux source in a field-free region must close the loop in order to generate an observable effect. In this paper, we study a variant of the AB effect that apparently challenges this concept. The significance of weak values and nonlocal equations of motion is discussed as part of the analysis, shedding light on and connecting all these fundamental concepts.

Faster, Cheaper, And Better Cfd: A Case For Machine Learning To Augment Reynolds-Averaged Navier-Stokes, John Peter Romano Ii

Mechanical & Aerospace Engineering Theses & Dissertations

In recent years, the field of machine learning (ML) has made significant advances, particularly through applying deep learning (DL) algorithms and artificial intelligence (AI). The literature shows several ways that ML may enhance the power of computational fluid dynamics (CFD) to improve its solution accuracy, reduce the needed computational resources and reduce overall simulation cost. ML techniques have also expanded the understanding of underlying flow physics and improved data capture from experimental fluid dynamics.

This dissertation presents an in-depth literature review and discusses ways the field of fluid dynamics has leveraged ML modeling to date. The author selects and describes …

Superoscillations And Fock Spaces, Daniel Alpay, Fabrizio Colombo, Kamal Diki, Irene Sabadini, Daniele C. Struppa

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this paper we use techniques in Fock spaces theory and compute how the Segal-Bargmann transform acts on special wave functions obtained by multiplying superoscillating sequences with normalized Hermite functions. It turns out that these special wave functions can be constructed also by computing the approximating sequence of the normalized Hermite functions. First, we start by treating the case when a superoscillating sequence is multiplied by the Gaussian function. Then, we extend these calculations to the case of normalized Hermite functions leading to interesting relations with Weyl operators. In particular, we show that the Segal-Bargmann transform maps superoscillating sequences onto …

Trumpet Directivity From A Rotating Semicircular Array, Samuel D. Bellows, Joseph E. Avila, Timothy W. Leishman

Directivity

The directivity function of a played musical instrument describes the angular dependence of its acoustic radiation and diffraction about the instrument, musician, and musician’s chair. Directivity influences sound in rehearsal, performance, and recording environments and signals in audio systems. Because high-resolution, spherically comprehensive measurements of played musical instruments have been unavailable in the past, the authors have undertaken research to produce and share such data for studies of musical instruments, simulations of acoustical environments, optimizations of microphone placements, and other applications. The authors acquired the data from repeated chromatic scales produced by a trumpet played at mezzo-forte in an anechoic …

Ferroelectric Hafnia Surface In Action, Xia Hong

Nebraska Center for Materials and Nanoscience: Faculty Publications

Piezoresponse microscopy and spectroscopy reveal the inextricable role of surface electrochemistry in stabilizing and controlling ferroelectricity in doped hafnia.

Doped hafnia (HfO₂), a relatively new member of the ferroelectric family, has challenged in many ways our conventional perception of ferroelectric oxides. It possesses extremely localized electric dipoles that are independently switchable,¹ making it immune to finite size effects — the loss of long-range dipole order in ferroic materials due to size scaling. While polycrystalline grains and microstructures can yield lower polarization and poorer cycling behavior in canonical ferroelectrics such as Pb(Zr,Ti)O₃ and BaTiO₃, in …

Molecular Mechanisms Of Amyloid-Like Fibril Formation, Sharareh Jalali

Dissertations

Proteins play a critical role in living systems by performing most of the functions inside cells. The latter is determined by the protein's three-dimensional structure when it is folded in its native state. However, under pathological conditions, proteins can misfold and aggregate, accounting for the formation of highly ordered insoluble assemblies known as amyloid fibrils. These assemblies are associated with diseases like Parkinson's and Alzheimer's. Strong evidence suggests that three mechanisms are critical for forming amyloid fibrils. These mechanisms are the nucleation of amyloid fibrils in solution (primary nucleation) as well as on the surface of existing fibrils (secondary nucleation) …

Exploring Topological Phonons In Different Length Scales: Microtubules And Acoustic Metamaterials, Ssu-Ying Chen

Dissertations

The topological concepts of electronic states have been extended to phononic systems, leading to the prediction of topological phonons in a variety of materials. These phonons play a crucial role in determining material properties such as thermal conductivity, thermoelectricity, superconductivity, and specific heat. The objective of this dissertation is to investigate the role of topological phonons at different length scales.

Firstly, the acoustic resonator properties of tubulin proteins, which form microtubules, will be explored The microtubule has been proposed as an analog of a topological phononic insulator due to its unique properties. One key characteristic of topological materials is the …

Optimization Of A Ball's Launch In Sports, Andrew C. Smith, Javier E. Hasbun

Georgia Journal of Science

Newton's laws are used to study the effects of air resistance on an object's motion. In ball-related sports such as baseball, soccer, etc., understanding the effects of air resistance is essential to optimize ball launch performance. This performance optimization can be studied by identifying the minimal time it takes for a ball with speed to travel a certain distance. We work with two models that apply to an object's motion. One of the models assumes a linear air drag while a second model makes use of a quadratic air drag. We do investigate known differential equations for when the Magnus …

Strong Ultrafast Demagnetization Due To The Intraband Transitions, G. P. Zhang, Mitsuko Murakami

Symposium Projects

Demagnetization in ferromagnetic transition metals driven by a femtosecond laser pulse is a fundamental problem in solid state physics, and its understanding is essential to the development of spintronic devices. Ab initio calculation of time-dependent magnetic moment in the velocity gauge so far has not been successful in reproducing the large amount of demagnetization observed in experiments. In this work, we propose a method to incorporate intraband transitions within the velocity gauge through a convective derivative in the crystal momentum space. Our results for transition-element bulk crystals (bcc Fe, hcp Co and fcc Ni) based on the time-dependent quantum Liouville …

Depression, Anxiety, And Estimated Cardiorespiratory Fitness In College Students, Christian Ison

UNLV Theses, Dissertations, Professional Papers, and Capstones

Depression and anxiety disorders are two common mental health conditions worldwide. College students are considered a high-risk population for the development of these conditions. Improved cardiorespiratory fitness (CRF) has been shown to decrease depression and anxiety risk, symptoms, and severity but this relationship and the extent to which improved CRF can reduce these risks has yet to be examined in the college student population. Validated and reliable non-exercise estimated cardiorespiratory fitness (eCRF) algorithms could be used to identify relationships and associations with depression and anxiety severity levels among college students. The purpose of this study was to assess eCRF and …

Entanglement In The Hawking Effect: From Astrophysical To Optical Black Holes, Dimitrios Kranas

LSU Doctoral Dissertations

The Hawking effect is an exciting physical prediction lying at the intersection of the two most successful theories of the past century, namely, Einstein’s theory of relativity and quantum mechanics. In this dissertation, we put special emphasis on the quantum aspects of the Hawking process encoded in the entanglement shared by the emitted fluxes of created quanta. In particular, we employ sharp tools from quantum information theory to quantify the entanglement produced by the Hawking effect throughout the black hole evaporation process. Our framework allows us to extend previous calculations of entanglement to a larger set of cases, for instance, …

Adaptive Plasmonic Metasurfaces For Radiative Cooling And Passive Thermoregulation, Azadeh Didari-Bader, Nooshin M. Estakhri, Nasim Mohammadi Estrakhri

Engineering Faculty Articles and Research

In this work, we investigate a class of planar photonic structures operating as passive thermoregulators. The radiative cooling process is adjusted through the incorporation of a phase change material (Vanadium Dioxide, VO₂) in conjunction with a layer of transparent conductive oxide (Aluminum-doped Zinc Oxide, AZO). VO₂ is known to undergo a phase transition from the “dielectric” phase to the “plasmonic” or “metallic” phase at a critical temperature close to 68°C. In addition, AZO shows plasmonic properties at the long-wave infrared spectrum, which, combined with VO₂, provides a rich platform to achieve low reflections across the …

Dyonic Taub-Nut-Ads Space Phase Structure, Mohamed Tharwat

Theses and Dissertations

The Taub-NUT spacetime remains to hold many mysteries more than half a century after its discovery. The metric's controversy owes largely to the nut charge and the existence of Misner strings. Traditionally the metric is treated in the euclidean signature, this treatment hides the Misner strings. We treat the Taub-NUT spacetime with the Misner strings visible, not enforcing the time periodicity condition. We examine the phase structure belonging to three different horizon geometries. We deal with the hyperbolic, flat and spherical cases. We consider the stable phases, the phase transitions that exist between them, and find the preferable phases in …

Optimizing Solid Thermal Storage In Insulated Solar Electric Cookers, Stefan Avramov

Physics

Insulated Solar Electric Cookers, more commonly known by their acronym ISECookers, are an alternative to biomass cooking. The ISECooker in its simplest form is a solar panel connected to a heating element, in contact with a cooking pot in an insulated chamber. An aluminum puck can be heated as solid thermal storage (STS) for increased power and night time cooking. Power was limited to about 500 W by the interface between the STS and cookpot. Powdered graphite and silver were separately applied to increase thermal flow. However, the powdered graphite decreased the thermal flow, while powdered silver decreased the temperature …

Characterization Of Boreal-Arctic Vegetation Growth Phases And Active Soil Layer Dynamics In The High-Latitudes Of North America: A Study Combining Multi-Year In Situ And Satellite-Based Observations, Michael G. Brown

Dissertations, Theses, and Capstone Projects

This dissertation examined the seasonal freeze/thaw activity in boreal-Arctic soils and vegetation physiology in Alaska, USA and Alberta, Canada, using in situ environmental measurements and passive microwave satellite observations. The boreal-Arctic high-latitudes have been experiencing ecosystem changes more rapidly in comparison to the rest of Earth due to the presently warming climatic conditions having a magnified effect over Polar Regions. Currently, the boreal-Arctic is a carbon sink; however, recent studies indicate a shift over the next century to become a carbon source. High-latitude vegetation and cold soil dynamics are influenced by climatic shifts and are largely responsible for the regions …

Large-Scale And Meso-Scale Ion Dynamics Of The Near-Earth Space Environment, Matthew Cooper

Dissertations

The mechanisms whereby low energy (order of lOs to 100s of eV) solar wind and ionosphere sourced particles are accelerated to high energy (order of 10s to 100s keV) in the Earth's magnetosphere are a trending research topic due to impacts on radiation belt populations, coupling to the high-latitude ionosphere, and energy budgets for collision-less plasma in dipole fields. Ultra-low frequency (ULF, order of 1-100 mHz) Alfven waves observed in the nightside inner magnetosphere during geomagnetic activity are one such acceleration mechanism. Several source processes for these waves, including the micro-scale drift-mirror mode, have been previously suggested but observational evidence …