Optics Commons^™

Modeling Kinetics Of 5-Aminolevulinic Acid-Induced Protoporphyrin Ix Accumulation For Optimal Photodynamic Therapy, Priscilla Melebor

Graduate Masters Theses

Photodynamic therapy (PDT) is a minimally invasive treatment that uses light-activated photosensitizers to selectively destroy diseased tissue through the generation of reactive oxygen species. However, conventional in vitro models often fail to accurately reproduce the pharmacokinetics of photosensitizer accumulation and clearance observed in vivo. This study investigated protoporphyrin IX (PpIX) accumulation following 5-aminolevulinic acid (ALA) exposure under physiologically relevant conditions using two-dimensional (2D) monolayers and three-dimensional (3D) spheroids. By comparing continuous ALA exposure with transient exposure followed by ALA washout, this work provides a more biologically relevant framework for studying PpIX kinetics and optimizing photodynamic therapy.

Synthesizing Viscoelasticity: Living Polymers, Micro-Macro Relations, And Paths For Resolution, Adam M. Hasler

Graduate Masters Theses

This thesis investigates the relationship between macroscopic rheological signals and underlying microscopic dynamics in complex fluids, specifically focusing on ”living polymers” within the cetyltrimethylammonium bromide (CTAB) and sodium salicylate (NaSal) surfactant system. The research addresses the inverse parameterization problem, demonstrating how bulk measurements like zero-shear viscosity can mask fundamentally different physical topologies, such as purely cylindrical, reptating micelles versus highly branched networks. Through the successful synthesis of viscoelastically ”degenerate” samples, the study utilizes an array of characterization techniques including frequency sweeps, Large Amplitude Oscillatory Shear (LAOS) to resolve these unique underlying states. Furthermore, the work explores further avenues of study …

Fabrication Of Objectives For Imaging Ultracold Lithium, Danelle Akanova

Dartmouth College Master’s Theses

This thesis develops a documented, reproducible procedure for building diffraction-limited microscope objectives entirely from catalog singlets, for imaging ultracold 6Li atoms in a ring-trap experiment. The objectives must resolve micron-scale features through a 5 mm fused-silica vacuum window, operate at multiple wavelengths, fit inside a 48 mm magnet bore, and contain no conductive or magnetic material, because the surrounding coils switch 0.1 T fields on microsecond timescales. Commercial long-working-distance objectives are universally housed in metal, which the eddy-current constraint rules out, and custom fabrication of a suitable non-conductive matched pair is estimated at nearly $200k.

The procedure is developed and …

M.O.D.U.S. Modular Optical Design Using Specular Film, Mario Gutierrez, Robert Thibodeau, Emma Show, Desiree Robinson, Lingyuan Meng, Sean Martin, Conner Beeson

Discovery Day - Daytona Beach

High-quality parabolic mirrors, which are vital components in reflecting telescopes, are typically bulky, costly, and highly fragile. This experiment explores the feasibility of using specular Class B Mylar as an unconventional, lightweight, and cost-effective alternative. This approach could enable new telescope designs by greatly reducing weight and manufacturing expenses, while also opening options for potential adaptability.   This approach involves using Mylar, a flexible, reflective style of plastic. The mylar is formed into a concave mirror by stretching a sheet over a chamber and depressurizing one side to force the sheet into the necessary curved shape. Multiple designs are being created …

Visualizing The Invisible: Simulating Electromagnetic Field In 3d Space With Matlab, Aashman Gupta, Eliane Dean, Riley Esperanca, Hailey Grabinski, Jacob Summerhays, Ameya Sute

Discovery Day - Daytona Beach

Electromagnetic field behaviours in free space are defined by Maxwell’s Equations, which couple the temporal and spatial variations of electric and magnetic fields through partial derivatives. These derivatives quantify the rate of change of each field’s vector component with respect to position and time in a 3D lattice, forming the basis for numerical field analysis. This research will develop a mathematical and computational framework using multivariable calculus to model, simulate, and visualize electromagnetic wave propagation in free space using MATLAB. Gradient, divergence, and curl operations are implemented to compute local field variations and energy transfer. The resulting data are used …

Effective Visibility In The Infrared Bands, Peter L. Dean-Erlander, Steven T. Fiorino, Ronald G. Driggers

Faculty Publications

Visibility is an atmospheric metric for the comparison of terrestrial imaging conditions and locations. A limitation of visibility is that it is defined for the visible spectrum only, and there is no simple infrared equivalent. This study compares three reflective infrared wavebands: near-IR (NIR), shortwave IR (SWIR), and extended shortwave IR (eSWIR), to the visible band across a global set of cities to develop three rule-of-thumb functions for IR effective visibility. To accomplish this, a radiometric sensor model is combined with the Laser Environmental Effects Definition and Reference (LEEDR) software package to calculate the visibility of a black-and-white contrast target …

Measuring Cosmic Expansion From Early To Late Times Using Quasars, Galaxies, & Local Supernovae, Rajeev Vaisakh

Physics Theses and Dissertations

This dissertation investigates the evolution of cosmic expansion across a wide redshift ($z$) range by combining measurements from quasars \& galaxies in the distant universe $(z > 0.8)$ with those obtained from stripped-core collapse supernovae observations from the nearby universe $(z < 0.1)$. Using the DESI spectroscopic survey, we analyze large-scale clustering from quasars over $0.8 < z < 2.1$ and emission line galaxies over $0.8 < z < 1.6$, contributing to DESI DR2 BAO and full-shape measurements of cosmic expansion and structure growth. Combined with BBN in flat $\Lambda$CDM, DESI DR2 BAO gives $H_0 = 68.51 \pm 0.58$ km s$^{-1}$ Mpc$^{-1}$, while combinations of DESI BAO with CMB and supernova data show a preference for evolving dark energy, with representative constraints such as $w_0 = -0.752 \pm 0.057$ and $w_a = -0.86^{+0.23}_{-0.20}$ for DESI+CMB+DESY5. Using the ROTSE-III Supernova Survey and the expanding photosphere method (EPM), we measure distances to a sample of six supernovae for which the thermal phase can be clearly identified. This analysis focuses on testing whether reliable EPM distances can be obtained for this population. The resulting distances will eventually be compared with independent estimates from the literature. Establishing consistency with these external measurements represents an important step toward applying this methodology to larger samples, with the eventual goal of using ROTSE supernova distances to provide an independent measurement of the local Hubble constant.

Single Fluorogens And Orientation-Localization Microscopy For Quantifying Chemical And Biomolecular Dynamics At The Nanoscale, Yiyang Chen, Yuanxin Qiu, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

Many chemical systems look uniform only because ensemble measurements average over their most interesting molecules. Electron-transfer rates vary across electrode surfaces; lipid membranes contain nanodomains with distinct packing and fluidity; peptide aggregates exhibit local polymorphism; and biomolecular condensates contain transient networks of interactions that are blurred in ensemble images. A central challenge in chemical imaging is not simply to see smaller structures, but to measure chemical variables such as polarity, redox potential, and molecular confinement at the single-molecule level. In this Account, we describe how fluorogens, molecules whose brightness, blinking, spectral shifts, orientation, rotational mobility, and motion are directly shaped …

Synthesis And Characterization Of Carbon Quantum Dots And Gold Nanoparticles For Norovirus Biosensing Applications In Water Systems, Breanne Evans

Master's Theses

Rapid, reliable detection of viral pathogens remains a significant challenge across water-treatment and environmental monitoring systems, including drinking-water, wastewater, water reuse, and environmental surveillance applications. Waterborne viral contamination can pose substantial public-health risks, making early detection essential for protecting water quality and responding quickly to treatment failures or contamination events. Direct potable reuse (DPR) is one particularly demanding example because it requires continuous verification of treatment performance and the broader need for rapid virus monitoring extends across many water-treatment and environmental surveillance applications. Norovirus is a priority target because of its widespread occurrence in wastewater, environmental persistence, and exceptionally low …

Generation Of Khz-Rate Complex-Structured Liquid Targets For Relativistic Laser–Plasma Interactions, Michael L. Dexter, Stephen J. Hageman, Gregory Ngirmang, Kyle D. Frische, Joseph Snyder, John T. Morrison, Enam A. Chowdury, Anil K. Patnaik

Faculty Publications

With the rise of high repetition rate ultra-intense laser systems, there is a need for solid density targets to study relativistic laser–plasma interactions that can operate at the same repetition rate. Flowing liquid targets are attractive because they are self-replenished, debris free, cost effective and easy to use. Liquid targets have been used for high-repetition rate (up to kHz rate) generation of electrons, protons, x rays, and neutrons by our group and elsewhere. In this Letter, we demonstrate a kHz-rate generation of a variety of dynamically shaped complex-structured targets from the interaction of a 10¹⁶ W/cm² focused laser …

Rapid-Prototyping Nanofabrication: Lcd-Based Projection Lithography And Physical Vapor Deposition, Sabeel Saleem Mohammmed

University Honors Theses

The semiconductor industry's continued growth, driven in large part by demand for artificial intelligence hardware, has highlighted the need for greater workforce development in regions adjacent to major fabrication centers like Oregon's Silicon Forest. This capstone project lays the groundwork for a small scale and student led semiconductor fabrication lab at Portland State University by demonstrating two of the core steps in chip manufacturing: photolithography and thin film deposition. Rather than relying on conventional fixed reticles, this work explores a unique, low cost approach to patterning that uses an ultraviolet-compatible liquid crystal display (LCD) as a programmable reticle, allowing arbitrary …

Phase-Resolved Measurement And Arbitrary Mode Conversion Of Structured Light, Somayeh Ghazanfarpour

Electronic Theses and Dissertations

This dissertation presents a single-shot phase and amplitude retrieval technique based on spatial light modulator (SLM)-based digital holography. The proposed method enables accurate reconstruction of complex optical fields from a single interferogram, reducing sensitivity to environmental fluctuations and improving experimental stability compared to conventional multi-shot approaches. In addition, a programmable arbitrary mode converter is developed using SLM-based wavefront shaping. By introducing controlled astigmatism and engineering the differential Gouy phase between orthogonal components, the system enables flexible transformation between structured light modes, including Hermite–Gaussian and Laguerre–Gaussian beams. Numerical results demonstrate reliable phase recovery and efficient mode conversion, validating the performance of …

The Method Of Periodic Averaging Applied To Reduced Coupled Mode Theory Models For Fiber Laser Amplifiers, Rebecca Nicole Bryant

Dissertations and Theses

Fiber laser amplifier (FLA) models are often implemented without rigorous mathematical justification or thorough numerical validation. Without a proper theoretical basis for assumptions and approximations, or a technical analysis of model performance, there is significant uncertainty about the limitations of any given reduced model and its suitability for an application. This research aims to address the lack of comprehensive assessment of FLA models by directly comparing distinct models and recommending a mathematical alternative to replace heuristic model-reduction techniques. The work in this dissertation is divided into two projects: a comparative study that uses existing FLA models to assess the validity …

Matching Two Long Interferometric Pathlengths Using Low Temporal Coherence Light For Finding Hong–Ou–Mandel Dip, Keith A. Wyman, Noah S. Everett, Anil K. Patnaik

Faculty Publications

Hong–Ou–Mandel (HOM) dip from a biphoton source in a two-photon interferometer provides a myriad of quantum tools for quantum communication and sensing. But the stringent requirements for spatial coherence between the photon pair makes it prohibitively difficult to observe high-fidelity HOM dip in long-distance free-space implementations, e.g., for the photon pairs involved in quantum communication need to match the two path lengths within a few 10 s of micron because of the short coherence width of the two-photon wave-packet. While many techniques for the pathlength balancing of two interferometric arms have been studied and applied extensively, such balancing is further …

Winddensity-Mbir: Model-Based Iterative Reconstruction For Wind Tunnel 3d Density Estimation, Karl J. Weisenburger, Gregery T. Buzzard, Charles A. Bouman, Matthew R. Kemnetz

Faculty Publications

Experimentalists often use wind tunnels to study aerodynamic turbulence, but most wind tunnel imaging techniques are limited in their ability to take non-invasive three-dimensional (3D) density measurements of turbulence. Wavefront tomography is a technique that uses multiple wavefront measurements from various viewing angles to non-invasively measure the 3D density field of a turbulent medium. Existing methods make strong assumptions, such as a spline basis representation, to address the ill-conditioned nature of this problem. We formulate this problem as a Bayesian, sparse-view tomographic reconstruction problem and develop a model-based iterative reconstruction algorithm for measuring the volumetric 3D density field inside a …

30 Db On-Chip Ultra-High Inverse Weak Value Amplification, Yuhan Mei, Meiting Song, Andrew N. Jordan, Jaime Cardenas

Mathematics, Physics, and Computer Science Faculty Articles and Research

Weak value amplification (WVA) has emerged as a powerful technique that enhances measurement precision. However, traditional table-top WVA setups and on-chip demonstrations have not achieved an amplification over 20 dB. The practical limit of the amplification is the fidelity of photon post-selection. To address this limit, we design a weak value device with an over 30 dB interferometer extinction ratio, where the stray light in the dark port is minimized with thermally tunable phase shifters. As a result, the device successfully shows 30 dB WVA, termed ultra-high WVA. This WVA optimization strategy by improving interferometer extinction is extensible to a …

Improving The Reliability And Performance Of A Supersonic Indraft Tube Wind Tunnel, Christian J. Kaml

Master's Theses

Access to supersonic testing is increasing in demand, and wind tunnels remain one of the safest and most cost-effective methods for gathering high-speed flow data. Despite being more economical than alternative options, supersonic wind tunnel facilities often require substantial investment to construct, operate, and maintain.

The novel indraft tube tunnel architecture was conceived as a high-speed flow testbed that incorporates features of both Ludwieg tubes and indraft wind tunnels to maintain costs low enough to be accessible even to small universities. This design was first developed and tested in 2018 at California Polytechnic State University, featuring a cost per test …

Developing A High-Resolution Off-Axis Common-Mode Digital Holographic Microscope, Lucy Cook

University Honors Theses

Off-axis digital holographic microscopy (DHM) is a powerful tool for 3D, non-invasive live-cell tracking without moving parts. However, traditional setups face an inherent dilemma: split-path interferometers offer high spatial resolution but poor temporal stability, while more stable common-mode configurations are historically limited to lower numerical aperture (NA) regimes. This thesis bridges that gap by scaling a common-mode DHM architecture into a high-resolution benchtop instrument featuring NA = 0.65 objectives, paired with a high-power 520 nm laser source to combat transmission losses and sustain imaging frame rates across an expanded optical footprint. We map the multi-variable design space required to satisfy …

Polarimetric Terahertz Imaging For The Measurement Of Birefringence In Plastic, Rachel Cohen

Theses

Birefringence offers a promising way to observe stress concentration in materials such as glass and plastic, and thereby to identify weaknesses. Polarimetric imaging can be used to measure the birefringence of material, so long as the material is transparent to the light being used for the imaging. In this research, 2D Terahertz imaging was investigated as a means of measuring the birefringence of plastics that are opaque to visible light but transparent to THz radiation, for the eventual purpose of analyzing the residual stress present. In order to do so, two separate terahertz cameras were characterized for potential use in …

Characterizing Stiffness Dynamics Of Normal And Malignant Breast Spheroids Using Brillouin Microscopy, Razanne Rafat Zaghloul, Karlin Hilai, Chenjun Shi, Jitao Zhang

Medical Student Research Symposium

Background: Breast cancer progression and metastasis are closely linked to alterations in the mechanical properties of tumor cells and their microenvironment. Softer, more deformable cells are often associated with higher metastatic potential. While atomic force microscopy (AFM) is the current gold standard for mechanical characterization, it is limited to surface measurements and can damage 3D cultures. It remains unclear how the mechanical properties evolve over time in normal versus malignant spheroids. This study utilizes Brillouin light-scattering microscopy, a non-contact and label-free optical technique, to assess stiffness changes in normal and malignant breast epithelial spheroids over time. Understanding these mechanical signatures …