Comprehensive Analysis Of Bulk And Single-Cell Transcriptomic Data Reveals A Novel Signature Associated With Endoplasmic Reticulum Stress, Lipid Metabolism, And Liver Metastasis In Pancreatic Cancer, Xiaohong Liu, Bo Ren, Yuan Fang, Jie Ren, Xing Wang, Minzhi Gu, Feihan Zhou, Ruiling Xiao, Xiyuan Luo, Lei You, Yupei Zhao

Faculty, Staff and Student Publications

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with high probability of recurrence and distant metastasis. Liver metastasis is the predominant metastatic mode developed in most pancreatic cancer cases, which seriously affects the overall survival rate of patients. Abnormally activated endoplasmic reticulum stress and lipid metabolism reprogramming are closely related to tumor growth and metastasis. This study aims to construct a prognostic model based on endoplasmic reticulum stress and lipid metabolism for pancreatic cancer, and further explore its correlation with tumor immunity and the possibility of immunotherapy.

METHODS: Transcriptomic and clinical data are acquired from TCGA, ICGC, and GEO …

An Investigation Into The Causes Of Home Field Advantage In Professional Soccer, Paige E. Tomer

Mathematics, Statistics, and Computer Science Honors Projects

Home-field advantage is the sporting phenomenon in which the home team outperforms the away team. Despite its widespread occurrence across sports, the underlying reasons for home-field advantage remain uncertain. In this paper, we employ a range of statistical methods to explore the causal relationships of potential determinants of home-field advantage. We measure home-field advantage using match outcomes and differential metrics (e.g., differences in yellow cards received). In an attempt to narrow the research disparity between men’s and women’s sports, we utilize data from the National Women’s Soccer League (NWSL) and the English Premier League (EPL) to investigate potential causes of …

Develop An Interactive Python Dashboard For Analyzing Ezproxy Logs, Andy Huff, Matthew Roth, Weiling Liu

Faculty and Staff Scholarship

This paper describes the development of an interactive dashboard in Python with EZproxy log data. Hopefully, this dashboard will help improve the evidence-based decision-making process in electronic resources management and explore the impact of library use.

Cradle Explorer: Casfer Interactive Platform For Data And Model Visualization, Olatunde D. Akanbi, Vibha S. Mandayam, Haiping Ai, Arafath Nihar, Erika I. Barcelos, Laura S. Bruckman, Jeffrey Yarus, Yinghui Wu, Huichun (Judy) Zhang, Roger H. French

Student Scholarship

No abstract provided.

The Impact Of Family Functioning Factors On Smartphone Addiction And Phubbing Among Muslim Adolescents In Thailand, Yejin Kim, Wanchai Dhammasaccakarn, Kasetchai Laeheem, Idsaratt Rinthaisong

Faculty, Staff and Student Publications

BACKGROUND: While there is research on protective factors against smartphone addiction (SA) and phubbing, which impact adolescents' physical, psychological, interpersonal, and academic well-being, focused studies on these issues among Thai Muslim students in Southern Thailand remain scarce.

OBJECTIVES: To bridge this gap, this research aimed to explore the influence of five family functioning factors-discipline, communication and problem-solving (CPS), relationship, emotional status, and family support-guided by family systems theory and the McMaster Model, on SA and phubbing.

METHODS: Data from 825 Thai Muslim adolescent secondary school students (Female N = 459 (55.7%), M

RESULTS: Significant connections were identified between family functioning …

Uconn Baseball Reliever Lane Optimization Tool, Jason Bartholomew

Honors Scholar Theses

The building of a tool to be utilized by UConn’s Division I baseball team that will generate a game plan for when different relievers should be used against different parts of the opponent’s lineup to achieve the lowest total expected value of runs allowed for the remainder of the game based on game situations and matchup probabilities. The tool will also examine and determine situations that may be vital enough to the outcome of the game to bring in a better reliever normally saved for later in the game.

Virtual Reality As An Adjunct To Behavior Therapy: A Systematic Literature Review, Alya Alharrasi

Honors Theses

The World Health Organization (WHO) projects that by 2030, mental disorders will become the primary source of global disease burden [1]. Anxiety-related disorders, including specific phobias, post-traumatic stress disorder (PTSD), and various forms of general or specific anxiety, are the most rapidly growing mental health disorders worldwide [2]. In the United States (US), over 1 in 10 American youths are experiencing depression, resulting in a severe impact on their personal, academic, or professional encounters and social engagements [3]. Similarly, anxiety disorders affect up to one-third of the US population during their lifetime [4].

Due to the growth of mental health …

Data Engineering: Building Software Efficiency In Medium To Large Organizations, Alessandro De La Torre

Whittier Scholars Program

The introduction of PoetHQ, a mobile application, offers an economical strategy for colleges, potentially ushering in significant cost savings. These savings could be redirected towards enhancing academic programs and services, enriching the educational landscape for students. PoetHQ aims to democratize access to crucial software, effectively removing financial barriers and facilitating a richer educational experience. By providing an efficient software solution that reduces organizational overhead while maximizing accessibility for students, the project highlights the essential role of equitable education and resource optimization within academic institutions.

An Assessment On The Influence Of Aridity And Vegetation Cover On Land Surface Temperatures: Case Of Dodoma Urban District, Tanzania, Carolyne Vincent Mbirika

Research, Papers & Creative Work

This study examines the influence of aridity and vegetation cover on land surface temperature (LST) in Dodoma Urban District, Tanzania, a semi-arid environment experiencing rapid urban growth. Using Landsat 9 satellite imagery (30 m resolution) for October 2023, key environmental variables including the Normalized Difference Vegetation Index (NDVI), Normalized Difference Moisture Index (NDMI), and LST were derived and analyzed using ArcGIS Pro. The study applies remote sensing techniques and spatial analysis to examine the relationships between vegetation, moisture availability, and surface temperature patterns. The results reveal substantial spatial variation across the study area, with NDVI values ranging from -0.17 to …

Subject Analysis Ex Machina: Developing A Subject Heading Recommendation Service For Jmu Libraries, Steven W. Holloway

Libraries

Results of a 2022 evaluation of ANNIF, open-source software designed to generate controlled vocabulary subject headings, using James Madison University Libraries resources.

Nurse Anesthetists’ Perceptions And Experiences Of Managing Emergence Delirium: A Qualitative Study, Yi Xin, Fu-Cai Lin, Chen Huang, Bin He, Ya-Ling Yan, Shuo Wang, Guang-Ming Zhang, Rui Li

Faculty, Staff and Student Publications

BACKGROUND: This study employs a descriptive phenomenological approach to investigate the challenges anesthesia nurses face in managing emergence delirium (ED), a common and complex postoperative complication in the post-anesthesia care unit. The role of nurses in managing ED is critical, yet research on their understanding and management strategies for ED is lacking.

AIM: To investigate anesthetic nurses' cognition and management experiences of ED in hopes of developing a standardized management protocol.

METHODS: This study employed a descriptive phenomenological approach from qualitative research methodologies. Purposeful sampling was utilized to select 12 anesthetic nurses from a tertiary hospital in Shanghai as research …

Visualizing Nfl Player Metrics, Jayson Rhea

Campus Research Month

This project is dedicated to reshaping the exploration of NFL player data. Tailored for sports analysts and fantasy football managers, the goal is to deliver convenience through seamless data navigation and precise filtering through an interactive dashboard. In contrast to the static formats found on the NFL website and ESPN, this dynamic interface offers interactive visualizations, empowering users to effortlessly compare data. These comparisons can be used draw quick conclusions about player performance.

Dashboard To Quickly Estimate The Cost And Duration Of An Nyc Green Taxi Trip, Isaac Braun

Campus Research Month

Before hailing a New York City (NYC) taxi, residents and tourists do not easily know how much the trip will cost them or how long it may take. Taxis are still heavily used, even with the increase of ride-hailing services like Uber, and a new system has yet to be built to provide customers with these two metrics before taking a trip. This project aims to give riders a quick way to estimate a ride’s cost and duration through an interactive dashboard that allows filtering by pickup and drop-off neighborhoods. This is accomplished by analyzing three years of public data …

Binder, Tyler A. Peaster, Lindsey M. Davenport, Madelyn Little, Alex Bales

ATU Scholars Symposium

Binder is a mobile application that aims to introduce readers to a book recommendation service that appeals to devoted and casual readers. The main goal of Binder is to enrich book selection and reading experience. This project was created in response to deficiencies in the mobile space for book suggestions, library management, and reading personalization. The tools we used to create the project include Visual Studio, .Net Maui Framework, C#, XAML, CSS, MongoDB, NoSQL, Git, GitHub, and Figma. The project’s selection of books were sourced from the Google Books repository. Binder aims to provide an intuitive interface that allows users …

Techniques To Detect Fake Profiles On Social Media Using The New Age Algorithms – A Survey, A K M Rubaiyat Reza Habib, Edidiong Elijah Akpan

ATU Scholars Symposium

This research explores the growing issue of fake accounts in Online Social Networks [OSNs]. While platforms like Twitter, Instagram, and Facebook foster connections, their lax authentication measures have attracted many scammers and cybercriminals. Fake profiles conduct malicious activities, such as phishing, spreading misinformation, and inciting social discord. The consequences range from cyberbullying to deceptive commercial practices. Detecting fake profiles manually is often challenging and causes considerable stress and trust issues for the users. Typically, a social media user scrutinizes various elements like the profile picture, bio, and shared posts to identify fake profiles. These evaluations sometimes lead users to conclude …

Advanced Nano-Drug Delivery Systems In The Treatment Of Ischemic Stroke, Jiajie Zhang, Zhong Chen, Qi Chen

Faculty, Staff and Student Publications

In recent years, the frequency of strokes has been on the rise year by year and has become the second leading cause of death around the world, which is characterized by a high mortality rate, high recurrence rate, and high disability rate. Ischemic strokes account for a large percentage of strokes. A reperfusion injury in ischemic strokes is a complex cascade of oxidative stress, neuroinflammation, immune infiltration, and mitochondrial damage. Conventional treatments are ineffective, and the presence of the blood-brain barrier (BBB) leads to inefficient drug delivery utilization, so researchers are turning their attention to nano-drug delivery systems. Functionalized nano-drug …

Determining Reading Complexity Using Regression Models, Joshua Talamayan

Seton Hall University Dissertations and Theses (ETDs)

Reading is an essential skill when pursuing academic success. In order to assist students in developing their critical reading skills, it is essential to offer texts that are both within their capability, yet challenging enough to push them beyond their boundaries. At the moment, the majority of excerpts are matched to readability scores utilizing tools such as the Flesch-Kincaid Grade Level scoring in order to determine reader level. The core issue with reading scores structured around the Flesch-Kincaid Grade Level scoring is that the scoring process is not readily available to the public while also lacking validation studies. In this …

Accessing Advanced National Supercomputing And Storage Resources For Computational Research, Ramazan Aygun

All Things Open

This presentation will cover ACCESS (Advanced Cyberinfrastructure Coordination Ecosystem: Services & Support), and Kennesaw State University's involvement in Open Science Data Federation program as a data origin to help researchers and educators with or without supporting grants to utilize the nation’s advanced computing systems and services. ACCESS, a program established and funded by the National Science Foundation, is an ecosystem with capabilities for new modes of research and further democratizing participation. The presentation covers how to apply for allocations on ACCESS. The last part of the presentation will briefly explain Open Science Data Federation and Kennesaw State University's involvement as …

Ml241 Antagonizes Erk 1/2 Activation And Inhibits Rotavirus Proliferation, Jinlan Wang, Xiaoqing Hu, Jinyuan Wu, Xiaochen Lin, Rong Chen, Chenxing Lu, Xiaopeng Song, Qingmei Leng, Yan Li, Xiangjing Kuang, Jinmei Li, Lida Yao, Xianqiong Tang, Jun Ye, Guangming Zhang, Maosheng Sun, Yan Zhou, Hongjun Li

Faculty, Staff and Student Publications

Rotavirus (RV) is the main pathogen that causes severe diarrhea in infants and children under 5 years of age. No specific antiviral therapies or licensed anti-rotavirus drugs are available. It is crucial to develop effective and low-toxicity anti-rotavirus small-molecule drugs that act on novel host targets. In this study, a new anti-rotavirus compound was selected by ELISA, and cell activity was detected from 453 small-molecule compounds. The anti-RV effects and underlying mechanisms of the screened compounds were explored. In vitro experimental results showed that the small-molecule compound ML241 has a good effect on inhibiting rotavirus proliferation and has low cytotoxicity …

Tissue-Specific Atlas Of Trans-Models For Gene Regulation Elucidates Complex Regulation Patterns, Robert Dagostino, Assaf Gottlieb

Faculty, Staff and Student Publications

BACKGROUND: Deciphering gene regulation is essential for understanding the underlying mechanisms of healthy and disease states. While the regulatory networks formed by transcription factors (TFs) and their target genes has been mostly studied with relation to cis effects such as in TF binding sites, we focused on trans effects of TFs on the expression of their transcribed genes and their potential mechanisms.

RESULTS: We provide a comprehensive tissue-specific atlas, spanning 49 tissues of TF variations affecting gene expression through computational models considering two potential mechanisms, including combinatorial regulation by the expression of the TFs, and by genetic variants within the …