Data Science Commons^™

Ghcu, A Molecular Chaperone, Regulates Leaf Curling By Modulating The Distribution Of Kngh1 In Cotton, Yihao Zang, Chenyu Xu, Lishan Yu, Longen Ma, Lisha Xuan, Sunyi Yan, Yayao Zhang, Yiwen Cao, Xiaoran Li, Zhanfeng Si, Jieqiong Deng, Tianzhen Zhang, Yan Hu

Faculty, Staff and Student Publications

Leaf shape is considered to be one of the most significant agronomic traits in crop breeding. However, the molecular basis underlying leaf morphogenesis in cotton is still largely unknown. In this study, through genetic mapping and molecular investigation using a natural cotton mutant cu with leaves curling upward, the causal gene GHCU is successfully identified as the key regulator of leaf flattening. Knockout of GHCU or its homolog in cotton and tobacco using CRISPR results in abnormal leaf shape. It is further discovered that GHCU facilitates the transport of the HD protein KNOTTED1-like (KNGH1) from the adaxial to the abaxial …

Genetic Analysis Of Seven Patients With Inherited Ichthyosis And Nagashima-Type Palmoplantar Keratoderma, Jing Zhang, Yue Yao, Ya Tan, Hua-Ying Hu, Lin-Xi Zeng, Guo-Qiang Zhang

Faculty, Staff and Student Publications

Inherited ichthyosis comprises a series of heterogeneous dermal conditions; it mainly manifests as widespread hyperkeratosis, xerosis and scaling of the skin. At times, overlapping symptoms require differential diagnosis between ichthyosis and several other similar disorders. The present study reports seven patients with confirmed or suspected to be associated with ichthyosis by conducting a thorough clinical and genetic investigation. Genetic testing was conducted using whole-exome sequencing, with Sanger sequencing as the validation method. The MEGA7 program was used to analyze the conservation of amino acid residues affected by the detected missense variants. The enrolled patients exhibited ichthyosis-like but distinct clinical manifestations. …

An Integrated Space Test Lexicon: A Taxonomy For The Integrated Test And Evaluation Of Space Systems, Stephen K. Tullino, Andrew S. Keys, Robert A. Bettinger, Amy M. Cox, David R. Jacques

Faculty Publications

The proposed Integrated Space Test Lexicon is intended to amalgamate the numerous definitions of integrated (IT or IT&E), development test (DT or DT&E), and operational test (OT or OT&E) into unified, service-wide definitions, aligned with the Space Test Enterprise Vision. Refining such definitions will help distill the core characteristics of these fundamental test types to first identify space system activities composing what is traditionally known as DT and OT, then to provide a means of how these activities fit into the IT paradigm and support space system development. In forging a common understanding of how DT and OT support space …

Streaminghub - A Realtime Biosignal Processing Framework For Lab Scale Experimentation, Yasith Jayawardana

Computer Science Theses & Dissertations

In human subjects research, biosignals such as eye movements, heart rate, and brain activity, are often collected and analyzed to find patterns with tangible real-world implications. Modern advancements in technology have sparked interest towards analyzing biosignals in realtime. When developing such algorithms, one may expect to find free, open-source tools that provide easy access to live, recorded, and simulated data streams. Yet, biosignal interfaces are often vendor-specific, making cross-vendor biosignal streaming non-trivial. Likewise, reading biosignal datasets is also non-trivial, as their content may be arranged quite differently.

To combat this divide, we provide the scientific community with a realtime biosignal …

Development Of The Roadway Pothole Management Program, Dingxin Cheng

Mineta Transportation Institute

Addressing the issue of potholes is a primary concern for maintaining urban infrastructure. The research team has developed a prototype pothole management program. The program includes a mobile application and two machine learning models. The mobile app enables users to upload images of potholes, report relevant information, and provide driving directions to the pothole location. With the help of this application, the user can seamlessly capture images of the potholes, record pertinent information, and submit the data for necessary action. The mobile application is an essential tool in the Pothole Management Program (PMP), as it enhances the program's efficiency, effectiveness, …

Metabolomics Analysis Reveals Metabolite Diversity Of The Rare Cliff Plant Oresitrophe Rupifraga Unge, Hao Wang, Jinjun Cao, Sheng Chang, Caifeng Yan, Guangming Zhang

Faculty, Staff and Student Publications

Oresitrophe is monotypic, with the only species, Oresitrophe rupifraga Bunge, which is exclusive to China, having special growth and developmental traits due to its habitat. Furthermore, it has bright flowers and medicinal benefits. This study investigated the metabolites present in various tissues of Oresitrophe rupifraga Bunge. Using a widely targeted metabolomics approach, 1965 different metabolites were identified in Oresitrophe rupifraga Bunge. Based on principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA), the aboveground and underground metabolites of Oresitrophe rupifraga differed significantly. The comparison between bulblets and leaves revealed the differential expression of 461 metabolites, whereas the …

Considerations For Quality Control Monitoring Of Machine Learning Models In Clinical Practice, Louis Faust, Patrick Wilson, Shusaku Asai, Sunyang Fu, Hongfang Liu, Xiaoyang Ruan, Curt Storlie

Faculty, Staff and Student Publications

Integrating machine learning (ML) models into clinical practice presents a challenge of maintaining their efficacy over time. While existing literature offers valuable strategies for detecting declining model performance, there is a need to document the broader challenges and solutions associated with the real-world development and integration of model monitoring solutions. This work details the development and use of a platform for monitoring the performance of a production-level ML model operating in Mayo Clinic. In this paper, we aimed to provide a series of considerations and guidelines necessary for integrating such a platform into a team's technical infrastructure and workflow. We …

Discovery Of Runs-Of-Homozygosity Diplotype Clusters And Their Associations With Diseases In Uk Biobank, Ardalan Naseri, Degui Zhi, Shaojie Zhang

Faculty, Staff and Student Publications

Runs-of-homozygosity (ROH) segments, contiguous homozygous regions in a genome were traditionally linked to families and inbred populations. However, a growing literature suggests that ROHs are ubiquitous in outbred populations. Still, most existing genetic studies of ROH in populations are limited to aggregated ROH content across the genome, which does not offer the resolution for mapping causal loci. This limitation is mainly due to a lack of methods for the efficient identification of shared ROH diplotypes. Here, we present a new method, ROH-DICE (runs-of-homozygous diplotype cluster enumerator), to find large ROH diplotype clusters, sufficiently long ROHs shared by a sufficient number …

Study Of Prognostic Splicing Factors In Cancer Using Machine Learning Approaches, Mengyuan Yang, Jiajia Liu, Pora Kim, Xiaobo Zhou

Faculty, Staff and Student Publications

Splicing factors (SFs) are the major RNA-binding proteins (RBPs) and key molecules that regulate the splicing of mRNA molecules through binding to mRNAs. The expression of splicing factors is frequently deregulated in different cancer types, causing the generation of oncogenic proteins involved in cancer hallmarks. In this study, we investigated the genes that encode RNA-binding proteins and identified potential splicing factors that contribute to the aberrant splicing applying a random forest classification model. The result suggested 56 splicing factors were related to the prognosis of 13 cancers, two SF complexes in liver hepatocellular carcinoma, and one SF complex in esophageal …

Successful Management Of Chromoblastomycosis Utilizing Conventional Antifungal Agents And Imiquimod Therapy, Jinjin Zheng, Shougang Liu, Zhenmou Xie, Yangxia Chen, Liyan Xi, Hongfang Liu, Yinghui Liu

Faculty, Staff and Student Publications

Chromoblastomycosis (CBM), a chronic fungal infection affecting the skin and subcutaneous tissues, is predominantly caused by dematiaceous fungi in tropical and subtropical areas. Characteristically, CBM presents as plaques and nodules, often leading to scarring post-healing. Besides traditional diagnostic methods such as fungal microscopy, culture, and histopathology, dermatoscopy and reflectance confocal microscopy can aid in diagnosis. The treatment of CBM is an extended and protracted process. Imiquimod, acting as an immune response modifier, boosts the host's immune response against CBM, and controls scar hyperplasia, thereby reducing the treatment duration. We present a case of CBM in Guangdong with characteristic reflectance confocal …

Extreme Value Statistics Analysis Of Process Defects In Additive Manufacturing Materials, Ayorinde E. Olatunde, Kristen Hernandez, Austin Ngo, Arafath Nihar, Thomas G. Ciardi, Rachel Yamamoto, Pawan K. Tripathi, Roger H. French, John J. Lewandowski, Anirban Mondal

Faculty Scholarship

Fatigue and fracture studies focused on process defects that occur in Additive Manufacturing (AM) materials have shown that defect populations possess features which are better measured with extreme value statistics (EVS). In AM alloys, defect occurrences increase with material volume. This situation facilitates the need to model process defects in the path of fatigue crack growth with suitable statistical tools, such as EVS, which is more cost-effective when compared to destructive experiments. The application of EVS on defect space features helps determine the difference in defects present on fracture surfaces. As the fatigue quality of any material depends on its …

Diverse Mentoring Connections Across Institutional Boundaries In The Biomedical Sciences: Innovative Graph Database Analysis, Toufeeq Ahmed Syed, Erika L Thompson, Zainab Latif, Jay Johnson, Damaris Javier, Katie Stinson, Gabrielle Saleh, Jamboor K Vishwanatha

Faculty, Staff and Student Publications

BACKGROUND: With an overarching goal of increasing diversity and inclusion in biomedical sciences, the National Research Mentoring Network (NRMN) developed a web-based national mentoring platform (MyNRMN) that seeks to connect mentors and mentees to support the persistence of underrepresented minorities in the biomedical sciences. As of May 15, 2024, the MyNRMN platform, which provides mentoring, networking, and professional development tools, has facilitated more than 12,100 unique mentoring connections between faculty, students, and researchers in the biomedical domain.

OBJECTIVE: This study aimed to examine the large-scale mentoring connections facilitated by our web-based platform between students (mentees) and faculty (mentors) across institutional …

Sre-Yolov8: : An Improved Uav Object Detection Model Utilizing Swin Transformer And Re-Fpn, Jun Li, Jiajie Zhang, Yanhua Shao, Feng Liu

Faculty, Staff and Student Publications

To tackle the intricate challenges associated with the low detection accuracy of images taken by unmanned aerial vehicles (UAVs), arising from the diverse sizes and types of objects coupled with limited feature information, we present the SRE-YOLOv8 as an advanced method. Our method enhances the YOLOv8 object detection algorithm by leveraging the Swin Transformer and a lightweight residual feature pyramid network (RE-FPN) structure. Firstly, we introduce an optimized Swin Transformer module into the backbone network to preserve ample global contextual information during feature extraction and to extract a broader spectrum of features using self-attention mechanisms. Subsequently, we integrate a Residual …

Prevalence And Relevant Factors Of Nocturia And Its Impact On Sleep Quality In Chinese University Students, Yakai Liu, Zhenwei Zhang, Huijie Hu, Xiangfei He, Pengchao Xu, Qifeng Dou, Cuiping Song, Huiqing Zhang, Israel Franco, Konstantinos Kamperis, Søren Rittig, Jianguo Wen

Faculty, Staff and Student Publications

The purpose of this study was to investigate the prevalence and relevant factors of nocturia and its impact on sleep quality in university students in Mainland China. A large-scale survey was conducted on 14,000 university students from 3 universities in Henan province, China by using an anonymous questionnaire. The questionnaire collected the information from the past six months. The relationships between the prevalence of nocturia and its relevant factors were evaluated. A total of 13,874 questionnaires were collected and 13,104 qualified for statistical analysis. A total of 659 students suffered from clinically relevant nocturia (CRN) (4.56% in male and 5.34% …

Examining The Interaction Between Calcium Supplement Use, Demographics, And Lifestyle Factors On Bone Health In Women, Vix Talbot

University Honors Theses

Osteoporosis is a condition which poses a significant health threat, particularly among women during the menopause transition, where accelerated bone loss increases fracture risk. Calcium supplementation has been shown to be an important intervention to mitigate bone mineral density (BMD) decline during this and other periods of life. However, the efficacy of calcium supplementation is influenced by various individual factors, including demographics and lifestyle habits. This study investigates the interaction between calcium supplement use, and several interaction terms on bone health in women. Multiple linear regression analysis is employed to assess the impact of these factors on BMD. Data from …

Gis-Based Dashboard For Data Analysis And Visualization At The Water Hub In Franschhoek, South Africa, Liliana Rosa Simon

Geography and the Environment: Graduate Student Capstones

This capstone project analyzes the land use change in the Franschhoek Valley, South Africa, and implements this information into an ArcGIS Experience Builder Dashboard. The development of an ArcGIS Experience Builder is utilized as a tool for improved spatial data communication at The Water Hub. An increase in urban development in the informal settlement upstream of the Stiebeuel River in the catchment basin north of the Water Hub research institute is found. The capstone uses geographic information systems, remote sensing, and ArcGIS Experience Builder to integrate spatial data into the Water Hub’s standard operating procedures. It highlights the importance of …

Information Technology In The Christian Sphere, Kaylen Frazee

NEXUS: The Liberty Journal of Interdisciplinary Studies

No abstract provided.

The Institutional Challenges Of A Quantified Self Study: An Attempt To Ascertain How Data Collected From A Mobile Device Can Be An Indicator Of Personal Mental Health Over Time, Julian Lazaras

University Honors Theses

The adoption of an application of new technology always comes with a bias, this is never more true for the case of human behavioral analytics within higher education. While movements such as the quantified self movement make strides to reinterpret the realm of data analytics, psychology, and computer science, there are inevitably limitations to the adoption and application of such approaches within the standard realm of research. Herein is presented a case where an effort to evaluate the prospect of use of mobile phone data as secondary indicators of personal mental health through the lens of data analysis was put …

A Machine Learning Framework For Predicting Fabrication Hours For Industrial Steel Structure Projects, Dalia Ibrahim

Theses and Dissertations

Construction projects are considered high risk projects especially due to their required large capital making them require extreme attention in estimation as overestimating a project will lead to losing bids and underestimating them will lead to incurring more costs than budgeted resulting in losses. However, estimators are often faced with very tight timelines to finish their estimates leading them to primarily rely on their experience disregarding some crucial factors resulting in inaccurate estimates. In the steel structures industry, the steel fabrication phase accounts for 30 to 40% of the overall project cost; in addition, the steel industry is labor driven; …

The Budget Proposal As A Constructive Collections Engagement Tool And Practice, Evan Rusch, Pat Lienemann, Heidi J. Southworth, Nat Gustafson-Sundell

Library Services Publications

At Minnesota State University Mankato (MNSU), our story might sound familiar. After more than a decade of flat or decreased budgets, we have cancelled hundreds of journal subscriptions and numerous journal packages. We do occasionally add journals, but only by cancelling others. We often say we are “managing library decline,” and our primary objective is to cut cleanly and accurately, so that we can continue to support accreditation and an evolving curriculum. Over the years, we have developed various tools to guide our cuts and we have demonstrated these at NASIG and elsewhere. These tools have also served for collection …