Data Science Commons^™

Identifying Missing Is-A Relations In Orphanet Rare Disease Ontology

Faculty, Staff and Student Publications

The Orphanet Rare Disease Ontology (ORDO) provides a structured vocabulary encapsulating rare diseases. Downstream applications of ORDO depend on its accuracy to effectively perform their tasks. In this paper, we implement an automated quality assurance pipeline to identify missing is-a relations in ORDO. We first obtain lexical features from concept names. Then we generate related and unrelated feature sharing concept-pairs, where a feature sharing concept-pair can further generate derived term-pairs. If an unrelated and related feature sharing concept-pair generate the same derived term-pair, then we suggest a potential missing is-a relation between the unrelated feature sharing concept-pair. Applying this approach …

A Systematic Approach To Configuring Metamap For Optimal Performance, Yang Gong, James J Cimino, Dean F Sittig, Lior Rennert, David Robinson, Paul Biondich, Adam Wright, Christian Nøhr, Timothy Law, Arild Faxvaag, Ronald Gimbel

Faculty, Staff and Student Publications

BACKGROUND: MetaMap is a valuable tool for processing biomedical texts to identify concepts. Although MetaMap is highly configurative, configuration decisions are not straightforward.

OBJECTIVE: To develop a systematic, data-driven methodology for configuring MetaMap for optimal performance.

METHODS: MetaMap, the word2vec model, and the phrase model were used to build a pipeline. For unsupervised training, the phrase and word2vec models used abstracts related to clinical decision support as input. During testing, MetaMap was configured with the default option, one behavior option, and two behavior options. For each configuration, cosine and soft cosine similarity scores between identified entities and gold-standard terms were …

Identity Term Sampling For Measuring Gender Bias In Training Data, Nasim Sobhani, Sarah Jane Delany

Conference Papers

Predictions from machine learning models can reflect biases in the data on which they are trained. Gender bias has been identified in natural language processing systems such as those used for recruitment. The development of approaches to mitigate gender bias in training data typically need to be able to isolate the effect of gender on the output to see the impact of gender. While it is possible to isolate and identify gender for some types of training data, e.g. CVs in recruitment, for most textual corpora there is no obvious gender label. This paper proposes a general approach to measure …

From Computer Curriculum That Works For The Use Of Computer Intellignece Computer Science, Malachi B. Bacchus

Publications and Research

Computer interconnection can link different networks by using electrical artificial flow ways that can travel through different connections. these are called data network which travels through different sectors of the network simulation of service computer network using artificial intelligence to enhanced further understanding the computations, I've also demonstrated knowing by using the network to get better understanding of how ethical computing can be learned through universities and collegiate that can help established knowledge and healthy computer information. The main tools for the research are using data networking, ethical learning and translation towards different computer systems.

Natural Language Processing For Disaster Tweets, Akinyemi D. Apampa, Nan Li

Publications and Research

Our goal is to establish an automatic model that identifies which tweets are about natural disasters based on the content of the tweets. Our method is to construct a decision tree based on keyword searching. We will construct the model using 7,645 tweets and test our model on 3,465 tweets as an assessment of the performance.

Intraoperative Localization And Preservation Of Reading In Ventral Occipitotemporal Cortex, Samden D Lhatoo, Nitin Tandon

Faculty, Staff and Student Publications

OBJECTIVE: Resective surgery in language-dominant ventral occipitotemporal cortex (vOTC) carries the risk of causing impairment to reading. Because it is not on the lateral surface, it is not easily accessible for intraoperative mapping, and extensive stimulation mapping can be time-consuming. Here the authors assess the feasibility of using task-based electrocorticography (ECoG) recordings intraoperatively to help guide stimulation mapping of reading in vOTC.

METHODS: In 11 patients undergoing extraoperative, intracranial seizure mapping, the authors recorded induced broadband gamma activation (70-150 Hz) during a visual category localizer. In 2 additional patients, whose pathologies necessitated resections in language-dominant vOTC, task-based functional mapping was …

Appley: Approximate Shapley Values For Model Explainability In Linear Time, Md Shafiul Alam

Doctor of Data Science and Analytics Dissertations

We have seen complex deep learning models outperforming human benchmarks in many areas (e.g. computer vision, natural language processing). Clever architectures and higher model complexity are two of the major drivers of such outstanding performances. Higher model complexity generally makes the decision-making process of a model opaque to human perception. But understanding the decision-making process is very important for many reasons including enhancing trust in the model's prediction, improving model robustness, gaining actionable insight from why a model made a particular prediction, and discovering new knowledge about a problem. Model explainability has been an active area of research for some …

Privacy-Aware Estimation Of Relatedness In Admixed Populations, Han Chen, Arif Harmanci

Faculty, Staff and Student Publications

BACKGROUND: Estimation of genetic relatedness, or kinship, is used occasionally for recreational purposes and in forensic applications. While numerous methods were developed to estimate kinship, they suffer from high computational requirements and often make an untenable assumption of homogeneous population ancestry of the samples. Moreover, genetic privacy is generally overlooked in the usage of kinship estimation methods. There can be ethical concerns about finding unknown familial relationships in third-party databases. Similar ethical concerns may arise while estimating and reporting sensitive population-level statistics such as inbreeding coefficients for the concerns around marginalization and stigmatization.

RESULTS: Here, we present SIGFRIED, which makes …

Extracellular Dnases Facilitate Antagonism And Coexistence In Bacterial Competitor-Sensing Interference Competition, Aoi Ogawa, Christophe Golé, Maria Bermudez, Odrine Habarugira, Gabrielle Joslin, Taylor Mccain, Autumn Mineo, Jennifer Wise, Julie Xiong, Katherine Yan, Jan A.C. Vriezen

Biological Sciences: Faculty Publications

Over the last 4 decades, the rate of discovery of novel antibiotics has decreased drastically, ending the era of fortuitous antibiotic discovery. A better understanding of the biology of bacteriogenic toxins potentially helps to prospect for new antibiotics. To initiate this line of research, we quantified antagonists from two different sites at two different depths of soil and found the relative number of antagonists to correlate with the bacterial load and carbon-to-nitrogen (C/N) ratio of the soil. Consecutive studies show the importance of antagonist interactions between soil isolates and the lack of a predicted role for nutrient availability and, therefore, …

The Evolving Privacy And Security Concerns For Genomic Data Analysis And Sharing As Observed From The Idash Competition, Arif Harmanci, Miran Kim, Kai Post, Diyue Bu, Tyler Bath, Jihoon Kim, Weijie Liu, Hongbo Chen, Lucila Ohno-Machado

Faculty, Staff and Student Publications

Concerns regarding inappropriate leakage of sensitive personal information as well as unauthorized data use are increasing with the growth of genomic data repositories. Therefore, privacy and security of genomic data have become increasingly important and need to be studied. With many proposed protection techniques, their applicability in support of biomedical research should be well understood. For this purpose, we have organized a community effort in the past 8 years through the integrating data for analysis, anonymization and sharing consortium to address this practical challenge. In this article, we summarize our experience from these competitions, report lessons learned from the events …

I-Climate: A “Clinical Climate Informatics” Action Framework To Reduce Environmental Pollution From Healthcare, Hardeep Singh

Faculty, Staff and Student Publications

Addressing environmental pollution and climate change is one of the biggest sociotechnical challenges of our time. While information technology has led to improvements in healthcare, it has also contributed to increased energy usage, destructive natural resource extraction, piles of e-waste, and increased greenhouse gases. We introduce a framework "Information technology-enabled Clinical cLimate InforMAtics acTions for the Environment" (i-CLIMATE) to illustrate how clinical informatics can help reduce healthcare's environmental pollution and climate-related impacts using 5 actionable components: (1) create a circular economy for health IT, (2) reduce energy consumption through smarter use of health IT, (3) support more environmentally friendly decision-making …

Sentiment Analysis In Application To Behavior Prediction, Anna Singley

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Ischaemic Hepatitis (Ih): Modeling Outcome Based On Ih Patients' Attributes, Madison Utterback, Christiana Beard

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

A Comprehensive Artificial Intelligence Framework For Dental Diagnosis And Charting, Shayan Shams

Faculty, Staff and Student Publications

BACKGROUND: The aim of this study was to develop artificial intelligence (AI) guided framework to recognize tooth numbers in panoramic and intraoral radiographs (periapical and bitewing) without prior domain knowledge and arrange the intraoral radiographs into a full mouth series (FMS) arrangement template. This model can be integrated with different diseases diagnosis models, such as periodontitis or caries, to facilitate clinical examinations and diagnoses.

METHODS: The framework utilized image segmentation models to generate the masks of bone area, tooth, and cementoenamel junction (CEJ) lines from intraoral radiographs. These masks were used to detect and extract teeth bounding boxes utilizing several …

Atomistic Measurement And Modeling Of Intrinsic Fracture Toughness Of Two-Dimensional Materials, Jianguo Wen, Horacio D Espinosa

Faculty, Staff and Student Publications

Quantifying the intrinsic mechanical properties of two-dimensional (2D) materials is essential to predict the long-term reliability of materials and systems in emerging applications ranging from energy to health to next-generation sensors and electronics. Currently, measurements of fracture toughness and identification of associated atomistic mechanisms remain challenging. Herein, we report an integrated experimental-computational framework in which in-situ high-resolution transmission electron microscopy (HRTEM) measurements of the intrinsic fracture energy of monolayer MoS

A New Kind Of Data Science: The Need For Ethical Analytics, Jonathan Boardman

Published and Grey Literature from PhD Candidates

Ethics can no longer be regarded as an add-on in data science and analytics. This paper argues for the necessity of formalizing a new, practically-oriented sub-discipline of AI ethics by outlining the needs, highlighting shortcomings in current approaches, and providing a framework for ethical analytics, which is concerned with the study of the ethical issues surrounding the development, deployment, and/or dissemination of ML/AI systems and data science research, as well as the development of tools and procedures to mitigate ethical harms. While data science and machine learning are primarily concerned with data from start to finish, ethical analytics is concerned …

Ethical Analytics: A Framework For A Practically-Oriented Sub-Discipline Of Ai Ethics, Jonathan Boardman

Doctor of Data Science and Analytics Dissertations

Ethics can no longer be regarded as an add-on in data science and analytics. This dissertation argues for the necessity of formalizing a new, practically-oriented sub-discipline of AI Ethics by outlining needs, highlighting shortcomings in current approaches, and providing a framework for Ethical Analytics, a field concerned with the study of the ethical issues surrounding the development, deployment, and/or dissemination of ML/AI systems and data science research, as well as the development of tools and procedures to mitigate ethical harms. While data science and machine learning are primarily concerned with data from start to finish, ethical analytics is concerned primarily …

The Benefits And Challenges Of Virtual Education For Interprofessional Teams In A Post-Covid Environment

Faculty, Staff and Student Publications

There have been a series of disruptions in the healthcare environment since 2019, starting with the global pandemic [...].

Polarimetric Radar And Vhf Lightning Observations In A Significantly Tornadic Supercell, Jacob Bruss

The Journal of Purdue Undergraduate Research

No abstract provided.

Supporting The Protect Initiative, Josh Lefton, Jackson Murray, Ahmed Thabet, Sriram Baireddy, Prakash Shukla, Mridul Gupta, Reagan Becker, Julie Ertle, Tony Doan, Aerin Yang

Purdue Journal of Service-Learning and International Engagement

Recently, medication dosage errors have received more political and media attention. Dosage errors are the most common medical errors, affecting about 1.5 million people annually.

Furthermore, U.S. poison-control centers reported more than 200,000 cases per year of medication errors. These cases result in medical costs of around $3.5 billion, and children under 6 years old constitute approximately 30% of these cases.

The PROTECT Initiative (Preventing Overdoses and Treatment Errors in Children Taskforce) was launched in 2008 as a collaborative effort between public health agencies and patient advocates to minimize dosage errors.

In alignment with the PROTECT Initiative effort, this project …