Epidemiology Commons^™

Studi Epidemiologi Deskriptif Talasemia, Dwi Sarwani Sri Rejeki, Nunung Nurhayati, Supriyanto Supriyanto, Elva Kartikasari

Kesmas

Talasemia adalah penyakit kelainan darah akibat kekurangan atau penurunan produksi hemoglobin. Jumlah penderita talasemia di Yayasan Talasemia Indonesia cabang Banyumas terus meningkat. Tujuan penelitian ini untuk mendeskripsikan karakteristik penderita talasemia di Yayasan Talasemia Indonesia cabang Banyumas tahun 2012. Penelitian kuantitatif dengan desain penelitian cross sectional ini dilakukan terhadap 64 sampel yang diambil dengan teknik proportionate stratified random sampling . Data dikumpulkan meliputi melalui wawancara terstruktur menggunakan kuesioner. Metode analisis yang digunakan adalah analisis deskriptif univariat. Hasil penelitian menunjukkan bahwa penderita talasemia rata-rata berusia 12,28 tahun, berjenis kelamin laki-laki (51,6%), sedang sekolah SD (40,6%), bukan angkatan kerja (92,2%), talasemia β-mayor (90,6%), …

Epidemiology Of Tuberculosis In Ohio, Usha Bala Vayuvegula

Master of Public Health Program Student Publications

Background: Tuberculosis (TB) is a global infectious disease often associated with HIV. Study of the distribution and epidemiologic trends may help target prevention and control measures towards high risk areas and groups.

Objective: To determine TB trends in four counties in Ohio, i.e. Franklin, Cuyahoga, Hamilton and Montgomery counties, and to explore differences in distribution of cases across gender, age groups and races.

Methods: TB surveillance data was collected from the Ohio Department of Health website for 12 years (1999-2011). Mean TB rates across gender were compared using the two sample t-test. One way ANOVA was used to compare means …

Effects Of Genetic Variants Previously Associated With Fasting Glucose And Insulin In The Diabetes Prevention Program, Jose C. Florez, Kathleen A. Jablonski, Jarred B. Mcateer, Paul W. Franks, Clinton C. Mason, Kieren J. Mather, Edward Horton, Ronald Goldberg, Dana Dabelea, Steven E. Kahn, Richard F. Arakaki, Alan R. Shuldiner, William C. Knowler

Epidemiology Faculty Publications

Common genetic variants have been recently associated with fasting glucose and insulin levels in white populations. Whether these associations replicate in pre-diabetes is not known. We extended these findings to the Diabetes Prevention Program, a clinical trial in which participants at high risk for diabetes were randomized to placebo, lifestyle modification or metformin for diabetes prevention. We genotyped previously reported polymorphisms (or their proxies) in/near G6PC2, MTNR1B, GCK, DGKB, GCKR, ADCY5, MADD, CRY2, ADRA2A,FADS1, PROX1, SLC2A2, GLIS3, C2CD4B, IGF1, and IRS1 in 3,548 Diabetes …

Measuring Infertility In Populations: Constructing A Standard Definition For Use With Demographic And Reproductive Health Surveys, Maya N. Mascarenhas, Hoiwan Cheung, Colin D. Mathers, Gretchen A. Stevens

Dartmouth Scholarship

Background: Infertility is a significant disability, yet there are no reliable estimates of its global prevalence. Studies on infertility prevalence define the condition inconsistently, rendering the comparison of studies or quantitative summaries of the literature difficult. This study analyzed key components of infertility to develop a definition that can be consistently applied to globally available household survey data.

Methods: We proposed a standard definition of infertility and used it to generate prevalence estimates using 53 Demographic and Health Surveys (DHS). The analysis was restricted to the subset of DHS that contained detailed fertility information collected through the reproductive health calendar. …

Genetic Modulation Of Lipid Profiles Following Lifestyle Modification Or Metformin Treatment: The Diabetes Prevention Program, Toni I. Pollin, Tamara Isakova, Kathleen A. Jablonski, Paul I.W. De Bakker, Andrew Taylor, Jarred B. Mcateer, Qing Pan, Edward Horton, Linda M. Delahanty, David Altshuler, Alan R. Shuldiner, Ronald Goldberg, Jose C. Florez, George A. Bray

Epidemiology Faculty Publications

Weight-loss interventions generally improve lipid profiles and reduce cardiovascular disease risk, but effects are variable and may depend on genetic factors. We performed a genetic association analysis of data from 2,993 participants in the Diabetes Prevention Program to test the hypotheses that a genetic risk score (GRS) based on deleterious alleles at 32 lipid-associated single-nucleotide polymorphisms modifies the effects of lifestyle and/or metformin interventions on lipid levels and nuclear magnetic resonance (NMR) lipoprotein subfraction size and number. Twenty-three loci previously associated with fasting LDL-C, HDL-C, or triglycerides replicated (P = 0.04–1×10−17). Except for total HDL particles (r = −0.03, …

Stubborn, Persistent, Dangerous C.Difficile Infections. Is Improvement Possible?, Sara Townsend

Master of Science in Healthcare Quality and Safety Capstone Presentations

C.difficile also known as C.diff or CDI has developed into a dangerous infection for the United States’ health care system. While much work has been done to improve C.diff rates, health care teams have not been successful in reducing C.difficile infections. Many studies have focused on the mode of transmission of C.difficle, yet there still is not consensus on understanding how this infection is spread. Bryn Mawr Hospital, a community hospital in the suburbs of Philadelphia, Pa, has struggled to improve their C.diff rates like their peers throughout the country. While their infection rates for C.diff are …

Epidemiology News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Variations in Birth Weight

Fall In C-Peptide During First 2 Years From Diagnosis: Evidence Of At Least Two Distinct Phases From Composite Type 1 Diabetes Trialnet Data., Carla J. Greenbaum, Craig A. Beam, David Boulware, Stephen E. Gitelman, Peter A. Gottlieb, Kevan C. Herold, John M. Lachin, Paula L. Mcgee, Jerry P. Palmer, Mark D. Pescovitz, Heidi Krause-Steinrauf, Jay S. Skyler, Jay M. Sosenko

Epidemiology Faculty Publications

Interpretation of clinical trials to alter the decline in β-cell function after diagnosis of type 1 diabetes depends on a robust understanding of the natural history of disease. Combining data from the Type 1 Diabetes TrialNet studies, we describe the natural history of β-cell function from shortly after diagnosis through 2 years post study randomization, assess the degree of variability between patients, and investigate factors that may be related to C-peptide preservation or loss. We found that 93% of individuals have detectable C-peptide 2 years from diagnosis. In 11% of subjects, there was no significant fall from baseline by 2 …

Refining The Global Spatial Limits Of Dengue Virus Transmission By Evidence-Based Consensus, Oliver J. Brady, Peter W. Gething, Samir Bhatt, Jane P. Messina, John S. Brownstein, Anne G. Hoen

Dartmouth Scholarship

Background: Dengue is a growing problem both in its geographical spread and in its intensity, and yet current global distribution remains highly uncertain. Challenges in diagnosis and diagnostic methods as well as highly variable national health systems mean no single data source can reliably estimate the distribution of this disease. As such, there is a lack of agreement on national dengue status among international health organisations. Here we bring together all available information on dengue occurrence using a novel approach to produce an evidence consensus map of the disease range that highlights nations with an uncertain dengue status.

Methods/Principle Findings: …

Genetic Predictors Of Clinical Outcomes In Non-Small Cell Lung Cancer Patients, Xia Pu

Dissertations and Theses (Open Access)

Lung cancer is the leading cause of cancer-related mortality in the US. Emerging evidence has shown that host genetic factors can interact with environmental exposures to influence patient susceptibility to the diseases as well as clinical outcomes, such as survival and recurrence. We aimed to identify genetic prognostic markers for non-small cell lung cancer (NSCLC), a major (85%) subtype of lung cancer, and also in other subgroups. With the fast evolution of genotyping technology, genetic association studies have went through candidate gene approach, to pathway-based approach, to the genome wide association study (GWAS). Even in the era of GWAS, pathway-based …

Missed Opportunities For Diagnosis And Treatment Of Diabetes, Hypertension, And Hypercholesterolemia In A Mexican American Population, Cameron County Hispanic Cohort, 2003-2008, Susan P. Fisher-Hoch, Kristina Vatcheva, Susan T. Laing, Monir Hossain, M Hossein Rahbar, Craig Hanis, H Shelton Brown, Anne R. Rentfro, Belinda M. Reininger, Joseph B. Mccormick

School of Mathematical & Statistical Sciences Faculty Publications

Introduction

Diabetes, hypertension, and hypercholesterolemia are common chronic diseases among Hispanics, a group projected to comprise 30% of the US population by 2050. Mexican Americans are the largest ethnically distinct subgroup among Hispanics. We assessed the prevalence of and risk factors for undiagnosed and untreated diabetes, hypertension, and hypercholesterolemia among Mexican Americans in Cameron County, Texas.

Methods

We analyzed cross-sectional baseline data collected from 2003 to 2008 in the Cameron County Hispanic Cohort, a randomly selected, community-recruited cohort of 2,000 Mexican American adults aged 18 or older, to assess prevalence of diabetes, hypertension, and hypercholesterolemia; to assess the extent to …

A Geographical Analysis Of Hiv/Aids Infection In Nigeria, 1991-2001, Chinekwu Azuka Obidoa, Robert G. Cromley

Journal of Social, Behavioral, and Health Sciences

Abstract

Objectives: Within the gradually accumulating literature on the Acquired Immune Deficiency Syndrome (AIDS) in Nigeria, investigations concerning the spatial dimensions of the infection are virtually non-existent. An understanding of the spatial dimensions of the epidemic is central in the development and implementation of appropriate intervention strategies. This study is a geographic analysis of HIV/AIDS infection in Nigeria from 1991 – 2001. The three objectives of this study were: 1) to examine the geographic pattern of the epidemic, 2) to examine the spatial-temporal trend and diffusion pattern of the epidemic, and 3) to explore the factors associated with the spatial …

Surveillance Of Mosquitoes For Arthropod-Borne Viruses In El Paso, Tx., Stephanie Coronado, Douglas Watts

COURI Symposium Abstracts, Summer 2012

West Nile encephalitis is the only arthropod-borne virus that causes annual cases of human illness in El Paso, Texas. Cases more commonly affect the young and elderly and the illness may range from a mild febrile disease to fatal encephalitis. The primary vector(s) of West Nile virus are Culex species mosquitoes, including Culex tarsalis and Culex quinquefaciatus. Further, surveillance is needed to determine the relative importance of these and possibly other mosquito species. More recently, cases of dengue fever and fatal hemorrhagic fever have been occurring in communities along the USA-Mexico border. Dengue has been endemic in Mexico since the …

Disparities In Cause-Specific Cancer Survival By Census Tract Poverty Level In Idaho, U.S., Christopher J. Johnson, Aliza K. Fink, Robert R. German

Journal of Health Disparities Research and Practice

Objective. This population-based study compared cause-specific cancer survival by socioeconomic status using methods to more accurately assign cancer deaths to primary site. Methods. The current study analyzed Idaho data used in the Accuracy of Cancer Mortality Statistics Based on Death Certificates (ACM) study supplemented with additional information to measure cause-specific cancer survival by census tract poverty level. Results. The distribution of cases by primary site group differed significantly by poverty level (chi-square = 265.3, 100 df, p In the life table analyses, for 8 of 24 primary site groups investigated, and all sites combined, there was a significant gradient relating …

Multilevel Analysis Of Physical Activity Among Us Adults Across Us Census Regions: The Role Of Environmental Contexts, Sariyamon Tiraphat

Health Services Research Dissertations

This study uses nationally representative data to explain the variation in physical activity among U.S. adults across four geographic regions of Northeast, Midwest, South, and West. The purpose of the study is to investigate whether environmental conditions inclusive of natural amenity, built environment, urbanization, crime, and social economic neighborhood are associated with physical activity and whether these associations are modified by geographic region. The study also investigates whether the influences of environmental contexts vary by subgroup and whether they are modified by geographic region. Determining regional factors that influence physical activity is essential to planning appropriate physical activity interventions.

The …

Associations Between Toenail Arsenic Concentration And Dietary Factors In A New Hampshire Ppopulation, Joann F. Gruber, Margaret R. Karagas, Diane Gilbert-Diamond, Pamela J. Bagley, M Scot Zens, Vicki Sayarath, Tracy Punshon, J Steven Morris, Kathryn L. Cottingham

Dartmouth Scholarship

Background: Dietary factors such as folate, vitamin B12, protein, and methionine are important for the excretion of arsenic via one-carbon metabolism in undernourished populations exposed to high levels of arsenic via drinking water. However, the effects of dietary factors on toenail arsenic concentrations in well-nourished populations exposed to relatively low levels of water arsenic are unknown.

Methods: As part of a population-based case-control study of skin and bladder cancer from the USA, we evaluated relationships between consumption of dietary factors and arsenic concentrations in toenail clippings. Consumption of each dietary factor was determined from a validated food frequency questionnaire. We …

Peran Juru Pantau Jentik Dalam Sistem Kewaspadaan Dini Demam Berdarah Dengue Di Indonesia, Diana Andriyani Pratamawati

Kesmas

Program pencegahan dan pemberantasan demam berdarah dengue (DBD) telah berlangsung sekitar 43 tahun dan berhasil menurunkan angka kematian dari 41,3% pada tahun 1968 menjadi 0,87% pada tahun 2010, tetapi belum berhasil menurunkan angka kesakitan. Bahkan, Indonesia menduduki urutan tertinggi kasus DBD di Association of Southeast Asian Nations (ASEAN) pada tahun 2010. Salah satu faktor belum efektifnya pencegahan DBD di Indonesia adalah masih lemahnya sistem kewaspadaan dini. Peran juru pantau jentik (jumantik) sangat penting dalam sistem kewaspadaan dini mewabahnya DBD karena berfungsi untuk memantau keberadaan dan menghambat perkembangan awal dari vektor penular DBD. Seiring masih tingginya angka kasus DBD di Indonesia, …

Konfirmasi Pemeriksaan Mikroskopik Terhadap Diagnosis Klinis Malaria, A. Arsunan Arsin, Heri Paerunan, Sri Syatriani

Kesmas

Penyakit malaria masih menjadi salah satu masalah kesehatan masyarakat yang penting di dunia. Di Indonesia, terutama di luar daerah Jawa dan Bali, sampai kini angka kesakitan malaria masih tergolong tinggi. Di Puskesmas Bunta Kabupaten Banggai, pada tahun 2008 Annual Malaria Incidence (AMI) dilaporkan mencapai 109,9‰. Penelitian ini bertujuan untuk membandingkan serta mengetahui hubungan gejala, tanda klinis, dan hasil pemeriksaan mikroskopik malaria. Desain studi yang digunakan adalah cross sectional. Pengumpulan data wawancara dan mengambil sediaan darah dilakukan pada 150 penderita suspect malaria di puskesmas dan rumah penduduk. Penderita malaria klinis dengan pemeriksaan mikroskopik malaria positif ditemukan sekitar 52%. Gejala dan tanda …

Faktor Risiko Kematian Neonatal Dini Di Rumah Sakit Bersalin, Andi Zulkifli Abdullah, M. Furqaan Naiem, Nurul Ulmy Mahmud

Kesmas

Angka kematian bayi di Indonesia masih tergolong tinggi, kematian neonatal 50% terjadi pada bayi berat lahir rendah (BBLR) dan lebih dari 50% kematian bayi adalah kematian neonatal dini. Penelitian ini bertujuan untuk mengetahui faktor-faktor antenatal care (ANC), status imunisasi Tetanus Toxoid (TT) ibu hamil, anemia pada saat hamil, berat lahir, status paritas, dan status hipotermia terhadap kematian neonatal dini. Penelitian meng- gunakan desain penelitian case control di Rumah Sakit Bersalin Kota Makassar dengan sampel 40 kasus dan 120 kontrol. Data diperoleh melalui wawancara langsung dengan responden. Hasil penelitian menunjukkan bahwa faktor risiko kejadian kematian neonatal dini meliputi ANC (nilai p …

Two Boundaries Separate Borrelia Burgdorferi Populations In North America, Gabriele Margos, Jean I. Tsao, Santiago Castillo-Ramirez, Yvette A. Girard, Anne G. Hoen

Dartmouth Scholarship

Understanding the spread of infectious diseases is crucial for implementing effective control measures. For this, it is important to obtain information on the contemporary population structure of a disease agent and to infer the evolutionary processes that may have shaped it. Here, we investigate on a continental scale the population structure of Borrelia burgdorferi, the causative agent of Lyme borreliosis (LB), a tick-borne disease, in North America. We test the hypothesis that the observed d population structure is congruent with recent population expansions and that these were preceded by bottlenecks mostly likely caused by the near extirpation in the 1900s …