Epidemiology Commons^™

Do You Know The Pathophysiology Of Cytokine Storm During Covid-19?, Shameera Shaik Masthan, Deekshitha Turaka, Ahmed Abdelhaleem, Mounica Vorla, Steven B. Lippmann

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Patterns And Determinants Of Hiv Postexposure Prophylaxis In A Tertiary Health Facility In Nigeria, Onyinye H. Chime, Edmund O Ndibuagu, Wilfred O. Okenwa

International Journal of Health and Allied Sciences

Background: One of the targets of HIV prevention strategy is to ensure that 95% of the population access prevention services by 2030 with the aspiration of ending the AIDS epidemic by 2030. Methods: This is a record-based cross-sectional review. Data was extracted from the PEP registers and treatment folders from January 2017 to December 2021. Results: Non-occupational exposure (82.5%) was reported more than occupational (17.5%). Majority of cases (442) resulted from rape. Only 9.1% of the clients returned for follow-up and all were negative. Conclusion: Behavioral interventions designed to promote HIV risk reduction and protective behaviors should ...

Anxiety And Depression Prevalence In Chinese Patients With Gastroesophageal Reflux Disease：A Meta-Analysis, Jinchi Zhou Co-First Authors, Weijia Dou Co-First Authors, Yan Wei, Shuguang Zhao, Wei Han, Hao Cheng, Zhenxiong Liu

General Practice in China

Background　Gastroesophageal reflux disease（GERD）is a common digestive disease with high global incidence trend，which may cause serious psychological burden on patients，and is closely related to anxiety and depression prevalence in them.Therefore，accurate understanding of the mental state of GERD will contribute to better diagnosis and treatment of GERD.However，there is no systematic analysis of mental status and GERD in Chinese population. Objective　To perform a Meta-analysis of studies regarding anxiety and depression prevalence in Chinese GERD patients.Methods Investigative studies on anxiety and depression in Chinese GERD patients published from January 2000 to May 2020 ...

The Prevalence Of Cerebral Palsy In Children Aged 0-6 Years In China：A Meta-Analysis, Yuxia Feng, Wei Peng, Xin Li, Shunbo Yang, Shiyu Liu, Shuqing Lu

General Practice in China

BackgroundAs one of the main causes of children's disability, cerebral palsy (hereinafter referred to as CP) affects the improvement of our population quality. At present, the results of researches on the prevalence of children suffering from CP in our country are quite different, and there is a lack of epidemiological studies based on larger sample sizes and the current prevalence of CP. ObjectiveTo learn about the prevalence of CP in children aged 0~6 years in China. MethodsLiteratures on the prevalence of CP in children aged 0~6 years in China were retrievaled through computer in PubMed, Web of ...

Analysis Of Prevalence Characteristics Of Post-Stroke Complications And Recommendations For Optimization Of Primary Management, Bin Jing

General Practice in China

Stroke is the leading cause of death among Chinese residents，with the improvement of hospital treatment level，the number of stroke survivors returning to the community is also increasing.This has greatly increased the demand for primary community health services，but also brought great challenges to the grassroots community health services.This article discusses the risk factors of stroke survivors in the community and the epidemiological characteristics of post-stroke complications，the grass-roots management plan after stroke recommended based on evidence or expert consensus，and how to establish and optimize the grass-roots management system after stroke，which aims to improve existing ...

Prevalence Survey Of Overweight, Obesity And Central Obesity Among Community-Living Residents In Beijing's Pinggu District, Zihou Zhao, Xiangshuang Kong, Lianying Wang, Guangxia Guo, Yufeng Li

General Practice in China

Background Overweight and obesity have been proved to be important risk factors of chronic diseases such as diabetes，hypertension，arteriosclerotic cardiovascular disease and tumor. According to the latest data，the total number of overweight and obesity population in China is close to 1/4 of the total population. Timely knowing the prevalence of overweight and obesity in different regions may provide theoretical basis for formulating prevention and control strategies of obesity and other chronic diseases.Objective To investigate the prevalence of overweight，obesity and central obesity in communityliving residents in Pinggu District of Beijing，to provide a science-based strategy for ...

Smart Indigenous Youth, Jamin Patel

Undergraduate Student Research Internships Conference

There is evidence that indicates the immense benefits of physical activity for the physical and mental health of youth. To respond to the youth mental health crisis in Indigenous communities in Canada, a culturally appropriate, land-based active living program called Smart Indigenous Youth (SIY) was developed by the Digital Epidemiology and Population Health Laboratory (DEPtH Lab). SIY is a longitudinal digital health community trial that applies the concept of citizen science to assess land-based active living’s impact on Indigenous youth mental health. My project examined the challenges to mental health faced by youth living in Indigenous Rural Communities during ...

Comparing Outcomes For Community-Acquired Pneumonia Between Females And Males: Results From The University Of Louisville Pneumonia Study, Pavani Nathala, Simrat Sarai, Vidyulata Salunkhe, Mahder A. Tella, Stephen P. Furmanek, Forest W. Arnold

The University of Louisville Journal of Respiratory Infections

Introduction: Male sex is currently considered to be a risk factor for worsened community-acquired pneumonia (CAP) outcomes compared to female sex; hence, female sex equates to a lower score on the Pneumonia Severity Index. There is no recent update on sex-based outcomes of patients with CAP. The objective of this study was to compare the outcomes of CAP between females and males.

Methods: This was a secondary analysis of the University of Louisville Pneumonia Study database. It was a prospective population-based cohort study of all hospitalized adults with CAP who were residents of Jefferson County in the city of Louisville ...

The Quality Of Life Of Patients With Eye Diseases, Brian Edward Yu

Electronic Thesis and Dissertation Repository

Background: Health-related Quality of Life (HRQoL) values determined using direct elicitation methods and generic preference-based measures are important for economic evaluations of healthcare interventions. The ophthalmology clientele is vulnerable to psychological stressors in the context of the coronavirus disease 2019 (COVID-19) pandemic.

Objectives: To systematically identify and summarize the quality of life (QoL) of eye disease patients in general in North America and seniors with eye diseases during the COVID-19 pandemic.

Methods: A systematic review identified North American studies that quantified HRQoL of eye disease patients. A cross-sectional study was conducted among seniors with eye diseases and backwards stepwise regression ...

Patient And Provider Experiences With Virtual Care During The Covid-19 Pandemic: A Mixed Methods Study, Mars Zhao, Hisham Elshoni, Jennifer O'Brien, Erin Barbour-Tuck, Mary Ellen Walker, Heather Dyck, Andrea Vasquez, Eric Sy, Angela Baerwald, Clara Michaels, Rejina Kamrul, Olivia Reis, Brenda Schuster, Barb Beaurivage, Adam Clay, Mark Lees, Jonathan Gamble

Patient Experience Journal

The COVID-19 pandemic prompted the rapid uptake of Virtual Care (VC). Positive patient outcomes with VC are previously reported but little is known about the experiences of patients and providers using VC during the pandemic. We aimed to describe patient and primary care provider experiences, satisfaction, perceptions, and attitudes to VC during the COVID-19 pandemic that might explain adoption of VC across the continuum of care and inform sustained uptake. We conducted a sequential explanatory mixed methods study using online surveys and virtual interviews with a convenience sample of primary care providers and patients in a Canadian province (July – December ...

Examining Mental Health Disparities In A Rural County: A Community Health Needs Assessment Analysis, Dustin M. Schulz

Capstone Experience

Over 20% of adults in the United States experience some form of mental illness each year. Those residing in rural areas can see increased prevalence of mental illness, and typically face disparities in access and availability of services for mental health. The goal of this project was to examine the impact of mental health in Woodford County, Illinois using data collected through the 2022 Community Health Needs Assessment (CHNA) process, with the intent of identifying areas of improvement that could be implemented at the local level. Analysis of the CHNA data was conducted using frequency analysis in SAS 9.4 ...

An Analysis Of Demographics And Risk Factors Associated With Increasing Syphilis Cases In Iowa, Eleanore H. Nelson

Capstone Experience

Background:

Syphilis is easily detectable and treatable with the appropriate medical attention, yet national incidence rates have been on the rise since reaching an all-time low in 2000 (Shockman et al, 2014). Similar to HIV, men who have sex with other men (MSM), represent most syphilis transmission, yet in recent years, syphilis rates have concerningly increased among both genders and among all racial/ethnic groups (CDC, 2019).

Methods:

Surveillance data was collected on all syphilis cases reported to the Iowa Department of Public Health (IDPH) regarding demographics and risk factors of cases. Variables were analyzed using chi-square and Fisher’s ...

Quantile Differences In The Age-Related Decline In Cardiorespiratory Fitness Between Sexes In Adults Without Type 2 Diabetes Mellitus In The United States, Andrew Ortaglia, Melissa Stansbury, Michael David Wirth, Xuemei Sui, Matteo Bottai

Faculty Publications

Objective: To comprehensively assess the extent to which the decline in cardiorespiratory fitness (CRF) with age differs between sexes. Participants and Methods: This study used data from the Aerobics Center Longitudinal Study, conducted between September 1974 and August 2006, consisting primarily of White adults from middle-to-upper socioeconomic strata restricted to adults without type 2 diabetes mellitus (33,742 men and 9,415 women). Quantile regression models were used to estimate the differences in age-associated changes in CRF between the sexes, estimated using a maximal treadmill test. Results: For adults aged up to 45 years, significant differences in slopes relating to ...

Effectiveness Of Machine Learning Classifiers For Cataract Screening, Ronald Cheung

Electronic Thesis and Dissertation Repository

Cataract is the leading cause of blindness and vision loss globally. The implementation of artificial intelligence (AI) in the healthcare industry has been on the rise in the past few decades and machine learning (ML) classifiers have shown to be able to diagnose patients with cataracts. A systematic review and meta-analysis were conducted to assess the diagnostic accuracy of these ML classifiers for cataracts currently published in the literature. Retrieved from nine articles, the pooled sensitivity was 94.8% and the specificity was 96.0% for adult cataracts. Additionally, an economic analysis was conducted to explore the cost-effectiveness of implementing ...

Sars-Cov-2 (Covid-19) Vaccine Intentions In Kentucky, Kevin A. Pearce Md, Mph, Emily Messerli Dnp, Aprn, Mary E. Lacy, Brittany L. Smalls, Diane B. Francis, Sukruthi Yerramreddy, Marc Kiviniemi

Journal of Appalachian Health

Background: At the time of our writing, the COVID-19 pandemic continues to cause significant disruption to daily lives. In Kentucky, the burdens from this disease are higher, and vaccination rates for COVID-19 are lower, in comparison to the U.S. as a whole. Understanding vaccine intentions across key subpopulations is critical to increasing vaccination rates.

Purpose: This study explores COVID-19 vaccine intentions in Kentucky across demographic subpopulations and also investigates the influences on vaccine intention of attitudes and beliefs about COVID-19.

Methods: A population-based survey of 1,459 Kentucky adults was conducted between January 26 and March 20, 2021, with ...

Mental Health, Chronic Disease, And Substance Use: Findings From Rural Texas, Subi Gandhi, Ryan Glaman, Elizabeth Wachira, Muna Bashir, Sushma Sharma, Chelsea Mowles, Jasmine Luttrell

Journal of Social, Behavioral, and Health Sciences

There are vital links among mental health conditions, chronic diseases, and substance use disorders. Simultaneous examination of the relationship among these three conditions is essential for providing well-integrated care to rural residents who have limited resources and for representing medically underserved areas. We aimed to assess the burden of behavioral health conditions and chronic diseases from a rural Texas community to garner context-specific insights and inform effective health promotion strategies in similar communities. We conducted a cross-sectional study among 181 residents from various zip codes in a rural Texas county. A self-administered, 18-item health-needs questionnaire was used to collect data ...

Integrating Conformational Dynamics And Perturbation-Based Network Modeling For Mutational Profiling Of Binding And Allostery In The Sars-Cov-2 Spike Variant Complexes With Antibodies: Balancing Local And Global Determinants Of Mutational Escape Mechanisms, Gennady M. Verkhivker, Steve Agajanian, Ryan Kassab, Keerthi Krishnan

Mathematics, Physics, and Computer Science Faculty Articles and Research

n this study, we combined all-atom MD simulations, the ensemble-based mutational scanning of protein stability and binding, and perturbation-based network profiling of allosteric interactions in the SARS-CoV-2 spike complexes with a panel of cross-reactive and ultra-potent single antibodies (B1-182.1 and A23-58.1) as well as antibody combinations (A19-61.1/B1-182.1 and A19-46.1/B1-182.1). Using this approach, we quantify the local and global effects of mutations in the complexes, identify protein stability centers, characterize binding energy hotspots, and predict the allosteric control points of long-range interactions and communications. Conformational dynamics and distance fluctuation analysis revealed the antibody-specific ...

What About Anosmia From Covid-19 ?, Sharanya S E Santhi, Sara Elnour, Steven B Lippmann

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Genomic Epidemiology Of Salmonella Typhi In Central Division, Fiji, 2012 To 2016, Mark R. Davies, Sebastian Duchene, Mary Valcanis, Aaron P. Jenkins, Adam Jenney, Varanisese Rosa, Andrew J. Hayes, Aneley Getahun Strobel, Liam Mcintyre, Jake A. Lacey, Elizabeth J. Klemm, Vanessa K. Wong, Aalisha Sahukhan, Helen Thomson, Andrew Page, Dianna Hocking, Nancy Wang, Litia Tudravu, Eric Rafai, Gordon Dougan, Benjamin P. Howden, John A. Crump, Kim Mulholland, Richard A. Strugnell

Research outputs 2022 to 2026

Background: Typhoid fever is endemic in some Pacific Island Countries including Fiji and Samoa yet genomic surveillance is not routine in such settings. Previous studies suggested imports of the global H58 clade of Salmonella enterica var Typhi (Salmonella Typhi) contribute to disease in these countries which, given the MDR potential of H58, does not auger well for treatment. The objective of the study was to define the genomic epidemiology of Salmonella Typhi in Fiji. Methods: Genomic sequencing approaches were implemented to study the distribution of 255 Salmonella Typhi isolates from the Central Division of Fiji. We augmented epidemiological surveillance and ...

Assessing Covid-19 Booster Hesitancy And Its Correlates: An Early Evidence From India, Geetanjali C. Achrekar, Kavita Batra, Yashashri Urankar, Ravi Batra, Naved Iqbal, Sabiha A. Choudhury, Deepti Hooda, Roohi Khan, Suraj Arora, Aditi Singh, Francesco Chirico, Manoj Sharma

School of Medicine Faculty Publications

The emergence of SARS-CoV-2 mutants, waning immunity, and breakthrough infections prompted the use of booster doses of the COVID-19 vaccine to fight against the pandemic. India started booster doses in January 2022 and it is critical to determine the intention of booster dose uptake and its correlates. Therefore, the current cross-sectional study aimed to investigate booster dose acceptability and associated predictors among the Indian population. A convenience sampling technique was utilized to recruit a sample of 687 Indian residents. A 55-item psychometric validated survey tool was used to assess booster dose acceptability, vaccine literacy and vaccine confidence. Univariate, bivariate, and ...