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Heart Rate, Mortality, And The Relation With Clinical And Subclinical Cardiovascular Diseases: Results From The Gutenberg Health Study, Thomas Munzel, Omar Hahad, Tommaso Gori, Sebastian Hollmann, Natalie Arnold, Jurgen H. Prochaska, Andreas Schulz, Manfred Beutel, Norbert Pfeiffer, Irene Schmidtmann, Karl J. Lackner, John F. Keaney Jr., Philipp S. Wild 2019 University Medical Center of the Johannes Gutenberg-University Mainz

Heart Rate, Mortality, And The Relation With Clinical And Subclinical Cardiovascular Diseases: Results From The Gutenberg Health Study, Thomas Munzel, Omar Hahad, Tommaso Gori, Sebastian Hollmann, Natalie Arnold, Jurgen H. Prochaska, Andreas Schulz, Manfred Beutel, Norbert Pfeiffer, Irene Schmidtmann, Karl J. Lackner, John F. Keaney Jr., Philipp S. Wild

Open Access Publications by UMMS Authors

BACKGROUND: Higher, but also lower resting heart rate (HR), has been associated with increased cardiovascular events and mortality. Little is known about the interplay between HR, cardiovascular risk factors, concomitant diseases, vascular (endothelial) function, neurohormonal biomarkers, and all-cause mortality in the general population. Thus, we aimed to investigate these relationships in a population-based cohort.

METHODS: 15,010 individuals (aged 35-74 at enrolment in 2007-2012) from the Gutenberg Health Study were analyzed. Multivariable regression modeling was used to assess the relation between the variables and conditional density plots were generated for cardiovascular risk factors, diseases, and mortality to show their dependence ...


Trends And Disparities In Self-Reported And Measured Osteoporosis Among Us Adults, 2007-2014., Qing Wu, Yingke Xu, Ge Lin 2019 University of Nevada, Las Vegas

Trends And Disparities In Self-Reported And Measured Osteoporosis Among Us Adults, 2007-2014., Qing Wu, Yingke Xu, Ge Lin

Environmental & Occupational Health Faculty Publications

(1) Background: Studies examining osteoporosis trends among US adults by different socioeconomic status (SES) are limited. The prevalence of self-reported osteoporosis in the US is rarely reported. (2) Methods: Data from the National Health and Nutritional Examination Survey (NHANES) between 2007–2008 and 2013–2014 cycles were analyzed. Age-adjusted prevalence of self-reported and that of measured osteoporosis were calculated overall and by sex, race/ethnicity, education attainment, and SES. (3) Results: The prevalence of self-reported osteoporosis was higher than that of measured osteoporosis in all three survey cycles for women, and in 2007–2008 and 2009–2010 for men. Participants ...


Bout Vs. Non-Bout Physical Activity Minutes As Predictors Of Waist Circumference In College Students, Valerie Olijar, Matt Scott, Brooke Ferraro, Elizabeth Edwards, Trent Hargens 2019 James Madison University

Bout Vs. Non-Bout Physical Activity Minutes As Predictors Of Waist Circumference In College Students, Valerie Olijar, Matt Scott, Brooke Ferraro, Elizabeth Edwards, Trent Hargens

Showcase of Graduate Research and Creative Activities

Physical activity recommendations to reduce all cause mortality consist of 10 minute bouts of a moderate-vigorous intensity, for a total of 150 min/week. This study investigates if those 10 minute bouts really matter. We found that step count was the best predictor of waist circumference. This finding supports many new technological devices that use step counts as a form of measuring activity. It provides support that the more steps you take, the likelier you will have a small waist.


Exploring The Hispanic Health Paradox In Mental Health Outcomes: Evidence From The Us-Mexico Border, Laryssa Mykyta, Suad Ghaddar, Leonel Vela 2019 The University of Texas Rio Grande Valley

Exploring The Hispanic Health Paradox In Mental Health Outcomes: Evidence From The Us-Mexico Border, Laryssa Mykyta, Suad Ghaddar, Leonel Vela

Health and Biomedical Sciences Faculty Publications and Presentations

Background: Research has established that Hispanic immigrants experience better health outcomes than their US-born counterparts. However, it is unclear whether the immigrant advantage holds for mental health. The purpose of this study is to examine mental health disparities by nativity status in an underserved Hispanic population along the southern border.

Methods: We collected data (N=713, weighted 733,644 adults) in four counties (90% Hispanic) along the Texas-Mexico border from March through August 2018 utilizing a dual-frame sampling design (random-digit dial telephone survey and field survey in randomly-selected colonias). We assessed several mental health outcomes (depression, anxiety, poor mental health ...


Is There Less Opioid Abuse In States Where Marijuana Has Been Decriminalized, Either For Medicinal Or Recreational Use? A Clin-Iq, Aaron M. Wendelboe, Richard Mathew, Tana Chongsuwat, Elizabeth Rainwater, Mark A. Wendelboe, Elizabeth Wickersham MD, Ann F. Chou 2019 University of Oklahoma Health Sciences Center

Is There Less Opioid Abuse In States Where Marijuana Has Been Decriminalized, Either For Medicinal Or Recreational Use? A Clin-Iq, Aaron M. Wendelboe, Richard Mathew, Tana Chongsuwat, Elizabeth Rainwater, Mark A. Wendelboe, Elizabeth Wickersham Md, Ann F. Chou

Journal of Patient-Centered Research and Reviews

Opioid use, abuse, and associated mortality have reached an epidemic level. In some states, cannabis is being used to treat chronic pain. To examine the hypothesis that medical marijuana legislation may reduce adverse opioid-related outcomes if patients substitute cannabis for opioids for pain management, we conducted a clinical inquiry (Clin-IQ). We searched Ovid MEDLINE, Ovid MEDLINE In-Process, and Embase for studies using the search terms marijuana, cannabis, legal, marijuana smoking, medical marijuana, opioid-related disorders, cannabis use, medical cannabis, legal aspect, and opiate addiction. We included population-based articles published from January 1, 2012, through December 5, 2018, that assessed the relationship ...


Choosing Clinical Variables For Risk Stratification Post-Acute Coronary Syndrome, Paul D. Myers, Wei Huang, Frederick A. Anderson Jr., Collin M. Stultz 2019 Massachusetts Institute of Technology

Choosing Clinical Variables For Risk Stratification Post-Acute Coronary Syndrome, Paul D. Myers, Wei Huang, Frederick A. Anderson Jr., Collin M. Stultz

Open Access Publications by UMMS Authors

Most risk stratification methods use expert opinion to identify a fixed number of clinical variables that have prognostic significance. In this study our goal was to develop improved metrics that utilize a variable number of input parameters. We first used Bootstrap Lasso Regression (BLR) - a Machine Learning method for selecting important variables - to identify a prognostic set of features that identify patients at high risk of death 6-months after presenting with an Acute Coronary Syndrome. Using data derived from the Global Registry of Acute Coronary Events (GRACE) we trained a logistic regression model using these features and evaluated its performance ...


Presumed Diffuse Unilateral Subacute Neuroretinitis: A Review Supported By A Unique Case, Kirsti K. Ramirez OD, Joseph Pizzimenti OD, Jeannette Wong-Powell OD, Jeffrey Rabin OD 2019 University of the Incarnate Word

Presumed Diffuse Unilateral Subacute Neuroretinitis: A Review Supported By A Unique Case, Kirsti K. Ramirez Od, Joseph Pizzimenti Od, Jeannette Wong-Powell Od, Jeffrey Rabin Od

Optometric Clinical Practice

Diffuse unilateral subacute neuroretinitis (DUSN) is a rare, sight-threatening inflammatory condition caused by a nematode. It typically affects healthy children and young adults. Various nematodes have been implicated, including those that originate from dogs and raccoons. Late stage findings include optic nerve atrophy, retinal arterial attenuation, “retinitis pigmentosa-like” retinal pigmentary changes, and central and peripheral vision loss. We present a case study of long-standing DUSN. The combination of optical coherence tomography (OCT) and visual electrophysiology testing proved invaluable in establishing a presumptive diagnosis of this rare condition.


Religious Practices And Long-Term Survival After Hospital Discharge For An Acute Coronary Syndrome, Hawa Ozien Abu, Kate L. Lapane, Molly E. Waring, Christine M. Ulbricht, Randolph S. Devereaux, David D. McManus, Jeroan J. Allison, Catarina I. Kiefe, Robert J. Goldberg 2019 University of Massachusetts Medical School

Religious Practices And Long-Term Survival After Hospital Discharge For An Acute Coronary Syndrome, Hawa Ozien Abu, Kate L. Lapane, Molly E. Waring, Christine M. Ulbricht, Randolph S. Devereaux, David D. Mcmanus, Jeroan J. Allison, Catarina I. Kiefe, Robert J. Goldberg

Open Access Publications by UMMS Authors

BACKGROUND: Prior studies of healthy populations have found religious practices to be associated with survival. However, no contemporary studies have examined whether religiosity influences survival among patients discharged from the hospital after an acute coronary syndrome (ACS). The present study examined the relationship between religious practices and 2-year all-cause mortality among hospital survivors of an ACS.

METHODS: Patients hospitalized for an ACS were recruited from 6 medical centers in Massachusetts and Georgia between 2011 and 2013. Study participants self-reported three items assessing religiosity: strength/comfort from religion, petition prayers for health, and awareness of intercessory prayers by others. All cause-mortality ...


Assessment And Improvement Of Data Collection Errors Through Inter-Departmental Collaboration, Charlott Williams, Kelli L. Behr, Mary Moffatt, Rangaraj Selvarangan 2019 Children's Mercy Hospital

Assessment And Improvement Of Data Collection Errors Through Inter-Departmental Collaboration, Charlott Williams, Kelli L. Behr, Mary Moffatt, Rangaraj Selvarangan

Posters

Specific Aims:

  1. To maintain the ED team's high rate of accuracy in data collection
  2. To begin team participation in corrective action planning
  3. To improve interdepartmental problem solving

Conclusion

Open communication about errors among all collaborating departments, combing with a shared approach to solving them:

  • improved morale and perception of error tracking by the team
  • led to a decrease in errors overall, and
  • increased interdepartmental collaboration

When all members of the interdepartmental team work together with a positive approach to corrective action, improvement in error rates is a natural outcome of the solutions derived.


Comparison Of On-Site Versus Remote Mobile Device Support In The Framingham Heart Study Using The Health Eheart Study For Digital Follow-Up: Randomized Pilot Study Set Within An Observational Study Design, Nicole L. Spartano, Honghuang Lin, Fangui Sun, Kathryn L. Lunetta, Ludovic Trinquart, Maureen Valentino, Emily S. Manders, Mark J. Pletcher, Gregory M. Marcus, David D. McManus, Emelia J. Benjamin, Caroline S. Fox, Jeffrey E. Olgin, Joanne M. Murabito 2019 Boston University

Comparison Of On-Site Versus Remote Mobile Device Support In The Framingham Heart Study Using The Health Eheart Study For Digital Follow-Up: Randomized Pilot Study Set Within An Observational Study Design, Nicole L. Spartano, Honghuang Lin, Fangui Sun, Kathryn L. Lunetta, Ludovic Trinquart, Maureen Valentino, Emily S. Manders, Mark J. Pletcher, Gregory M. Marcus, David D. Mcmanus, Emelia J. Benjamin, Caroline S. Fox, Jeffrey E. Olgin, Joanne M. Murabito

Open Access Publications by UMMS Authors

BACKGROUND: New electronic cohort (e-Cohort) study designs provide resource-effective methods for collecting participant data. It is unclear if implementing an e-Cohort study without direct, in-person participant contact can achieve successful participation rates.

OBJECTIVE: The objective of this study was to compare 2 distinct enrollment methods for setting up mobile health (mHealth) devices and to assess the ongoing adherence to device use in an e-Cohort pilot study.

METHODS: We coenrolled participants from the Framingham Heart Study (FHS) into the FHS-Health eHeart (HeH) pilot study, a digital cohort with infrastructure for collecting mHealth data. FHS participants who had an email address and ...


Estimated Stroke Risk, Yield, And Number Needed To Screen For Atrial Fibrillation Detected Through Single Time Screening: A Multicountry Patient-Level Meta-Analysis Of 141,220 Screened Individuals, Nicole Lowres, David D. McManus, Apurv Soni 2019 University of Sydney

Estimated Stroke Risk, Yield, And Number Needed To Screen For Atrial Fibrillation Detected Through Single Time Screening: A Multicountry Patient-Level Meta-Analysis Of 141,220 Screened Individuals, Nicole Lowres, David D. Mcmanus, Apurv Soni

Open Access Publications by UMMS Authors

BACKGROUND: The precise age distribution and calculated stroke risk of screen-detected atrial fibrillation (AF) is not known. Therefore, it is not possible to determine the number needed to screen (NNS) to identify one treatable new AF case (NNS-Rx) (i.e., Class-1 oral anticoagulation [OAC] treatment recommendation) in each age stratum. If the NNS-Rx is known for each age stratum, precise cost-effectiveness and sensitivity simulations can be performed based on the age distribution of the population/region to be screened. Such calculations are required by national authorities and organisations responsible for health system budgets to determine the best age cutoffs for ...


Religious Practices And Changes In Health-Related Quality Of Life After Hospital Discharge For An Acute Coronary Syndrome, Hawa Ozien Abu, David D. McManus, Darleen M. Lessard, Catarina I. Kiefe, Robert J. Goldberg 2019 University of Massachusetts Medical School

Religious Practices And Changes In Health-Related Quality Of Life After Hospital Discharge For An Acute Coronary Syndrome, Hawa Ozien Abu, David D. Mcmanus, Darleen M. Lessard, Catarina I. Kiefe, Robert J. Goldberg

Open Access Publications by UMMS Authors

BACKGROUND: Religious beliefs and practices influence coping mechanisms and quality of life in patients with various chronic illnesses. However, little is known about the influence of religious practices on changes in health-related quality of life (HRQOL) among hospital survivors of an acute coronary syndrome (ACS). The present study examined the association between several items assessing religiosity and clinically meaningful changes in HRQOL between 1 and 6 months after hospital discharge for an ACS.

METHODS: We recruited patients hospitalized for an ACS at six medical centers in Central Massachusetts and Georgia (2011-2013). Participants reported making petition prayers for their health, awareness ...


Prevalence, Trends, Outcomes, And Disparities In Hospitalizations For Nonalcoholic Fatty Liver Disease In The United States, Adeyinka Adejumo, Gbeminiyi Olanrewaju Samuel, Oluwole Muyiwa Adegbala, Kelechi Lauretta. Adejumo, Ogooluwa Ojelabi, Olalekan Akanbi, Olumuyiwa Akinbolaji Ogundipe, Lydie Pani 2019 University of Massachusetts Medical School

Prevalence, Trends, Outcomes, And Disparities In Hospitalizations For Nonalcoholic Fatty Liver Disease In The United States, Adeyinka Adejumo, Gbeminiyi Olanrewaju Samuel, Oluwole Muyiwa Adegbala, Kelechi Lauretta. Adejumo, Ogooluwa Ojelabi, Olalekan Akanbi, Olumuyiwa Akinbolaji Ogundipe, Lydie Pani

Open Access Publications by UMMS Authors

Background: As the frequency of nonalcoholic fatty liver disease (NAFLD) continues to rise in the United States (US) community, more patients are hospitalized with NAFLD. However, data on the prevalence and outcomes of hospitalizations with NAFLD are lacking. We investigated the prevalence, trends and outcomes of NAFLD hospitalizations in the US.

Methods: Hospitalizations with NAFLD were identified in the National Inpatient Sample (2007-2014) by their ICD-9-CM codes, and the prevalence and trends over an 8-year period were calculated among different demographic groups. After excluding other causes of liver disease among the NAFLD cohorts (n=210,660), the impact of sex ...


First Responders' Narratives Of Drowning: Perceptions Of Family And Community Impacts And Policy Implications, John Wells PhD, Michael Bergin PhD, John Connolly B.Ed., MA in Ed., Suzanne Denieffe PhD 2019 Waterford Institute of Technology

First Responders' Narratives Of Drowning: Perceptions Of Family And Community Impacts And Policy Implications, John Wells Phd, Michael Bergin Phd, John Connolly B.Ed., Ma In Ed., Suzanne Denieffe Phd

International Journal of Aquatic Research and Education

This is an exploratory study of the impacts of drowning death on local communities and families in the Republic of Ireland as perceived by first responders. The impact of a death may be particularly stressful. The identified population of interest were members of the Garda and first responders from Community Rescue Boats Ireland. The principal data collection method was one-to-one narrative interviews followed by a focus group. Questioning involved asking interviewees to talk about specific events rather than providing general opinions. Community identity was a source of impact, an urban or rural setting was a significant factor, social media was ...


Lab Values In Research: An Introduction, Steven C. Hatch 2019 University of Massachusetts Medical School

Lab Values In Research: An Introduction, Steven C. Hatch

PEER Liberia Project

This presentation provides an overview of lab values in research from a clinical research perspective. Presentation goals include: Discuss sensitivity and specificity; Discuss predictive value; Reviews Type I and Type II error; Consider reliability and validity.


Trace-Core Dataset On Religious Practices And Long-Term Survival After Hospital Discharge For An Acute Coronary Syndrome, Hawa O. Abu, Kate L. Lapane, Molly E. Waring, Christine M. Ulbricht, Randolph S. Devereaux, David D. McManus, Jeroan J. Allison, Catarina I. Kiefe, Robert J. Goldberg 2019 University of Massachusetts Medical School

Trace-Core Dataset On Religious Practices And Long-Term Survival After Hospital Discharge For An Acute Coronary Syndrome, Hawa O. Abu, Kate L. Lapane, Molly E. Waring, Christine M. Ulbricht, Randolph S. Devereaux, David D. Mcmanus, Jeroan J. Allison, Catarina I. Kiefe, Robert J. Goldberg

University of Massachusetts Medical School Publications

Manuscript abstract:

Background: Prior studies of healthy populations have found religious practices to be associated with survival. However, no contemporary studies have examined whether religiosity influences survival among patients discharged from the hospital after an acute coronary syndrome (ACS). The present study examined the relationship between religious practices and 2-year all-cause mortality among hospital survivors of an ACS.

Methods: Patients hospitalized for an ACS were recruited from 6 medical centers in Massachusetts and Georgia between 2011 and 2013. Study participants self-reported three items assessing religiosity: strength/comfort from religion, petition prayers for health, and awareness of intercessory prayers by others ...


Factors Associated With Full Immunization Coverage Among Children Up To 12 Months, Kakuma Mission Hospital, Turkana County, Kenya, Kevin Lomuria, Naomi Nyakio, Elvis Oyugi, James A. Ransom 2019 Moi University

Factors Associated With Full Immunization Coverage Among Children Up To 12 Months, Kakuma Mission Hospital, Turkana County, Kenya, Kevin Lomuria, Naomi Nyakio, Elvis Oyugi, James A. Ransom

Journal of Refugee & Global Health

The 2014 Kenya Demographic Health Survey showed that only 56.7% of children in Turkana County had received all recommended vaccines by 12 months of age, which is 12% below national and 24% below World Health Organization global coverage rates. This study aimed to identify factors that influence full immunization coverage (FIC) by 12 months of age in Kakuma Mission Hospital (KMH), Turkana County, in 2015. Kakuma is the site of a UNHCR refugee camp, established in 1969. Administration of vitamin A by 6 months of age and administration of measles-containing vaccine by 9 months of age were predictive of ...


Planning And Conducting A Research Survey, Ann M. Moormann 2019 University of Massachusetts Medical School

Planning And Conducting A Research Survey, Ann M. Moormann

PEER Liberia Project

This presentation provides an introduction to using surveys in clinical research, including the benefits and limitations of various types of observational and experimental surveys.


Segmental Distribution Of Hepatocellular Carcinoma Correlates With Microvascular Invasion In Liver Explants Undergoing Transplantation, Yasir Al-Azzawai, Eva Rouanet, Ryan J. Hendrix, Lidia Spaho, Hesham Malik, Deepika Devuni, Gyongyi Szabo, Graham Barnard 2019 University of Massachusetts Medical School

Segmental Distribution Of Hepatocellular Carcinoma Correlates With Microvascular Invasion In Liver Explants Undergoing Transplantation, Yasir Al-Azzawai, Eva Rouanet, Ryan J. Hendrix, Lidia Spaho, Hesham Malik, Deepika Devuni, Gyongyi Szabo, Graham Barnard

Gyongyi Szabo

Introduction: Microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients is a poor prognostic factor after liver transplantation and/or resection. Any correlation between MVI and segmental location of HCC has yet to be studied. Our aim is to evaluate the segmental location of HCC and any correlation with the presence of MVI, portal vein thrombosis (PVT) in explanted livers, and the recurrence of HCC after transplantation. Another objective of the study is to assess the treatment history (ablation or transarterial chemoembolization (TACE)) and size of the tumor with respect to the risk of MVI.

Methods: A single center, retrospective chart ...


Changes In Anticoagulant Utilization Among United States Nursing Home Residents With Atrial Fibrillation From 2011 To 2016, Matthew Alcusky, David D. McManus, Anne L. Hume, Marc Fisher, Jennifer Tjia, Kate L. Lapane 2019 University of Massachusetts Medical School

Changes In Anticoagulant Utilization Among United States Nursing Home Residents With Atrial Fibrillation From 2011 To 2016, Matthew Alcusky, David D. Mcmanus, Anne L. Hume, Marc Fisher, Jennifer Tjia, Kate L. Lapane

Jennifer Tjia

Background: Nursing home residents with atrial fibrillation are at high risk for ischemic stroke and bleeding events. The most recent national estimate (2004) indicated less than one third of this high-risk population was anticoagulated. Whether direct-acting oral anticoagulant ( DOAC ) use has disseminated into nursing homes and increased anticoagulant use is unknown.

Methods and Results: A repeated cross-sectional design was used to estimate the point prevalence of oral anticoagulant use on July 1 and December 31 of calendar years 2011 to 2016 among Medicare fee-for-service beneficiaries with atrial fibrillation residing in long-stay nursing homes. Nursing home residence was determined using Minimum ...


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