Pharmacy and Pharmaceutical Sciences Commons^™

November / December 2023, Randy Curry, Cindy Brooks

RURAL ROCKS

This is the November & December 2023 issue of Rural Rocks from the SWOSU College of Pharmacy.

Crushability Analysis Of Immediate-Release Oral Tablets And Capsules Approved By Fda In 2020-2022, Kamaladdin Saei, Anne Schweighardt, Fang Zhao

Doctoral External Publications

Healthcare providers often need to explore dosage form options for patients who are unable to swallow whole tablets or capsules. Most newly approved immediate-release (IR) oral solid drugs carry a "do not crush" warning or similar language in their labeling due to the lack of supporting clinical data. A 2021 publication by Uttaro et al. presented a crushability analysis strategy for risk assessment and demonstrated its utility for the questionable drugs on the ISMP do-not-crush list. This study aimed to extend the crushability analysis to newly FDA-approved drugs.

Heading Towards Relief: An Evaluation Of Headache Management In A Community Hospital., Caleb Hoppe Pharmd, Sarah Meeks Pharmd, Bcccp, Heather Nichols Pharmd, Bcpps, Sarah Ferrell Pharmd, Bcpps

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. December 2023.

This study sought to examine the treatment of acute headache at a community hospital including prescribing habits, dosing practices, use of consultants, and analgesic effect of each medication.

A Review Of Guideline Directed Medication Therapy Adherence For Patients With Asthma., Jennifer Mccarthy Pharmd, Ms, Elizabeth Meisberger Pharmd, Bcps, Bccp, Sarah Pfaehler Pharmd, Mba, Bcps, Pacs, Bhavika Patel Pharmd

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. December 2023.

This project evaluated a health system’s prescribing adherence to the 2022 GINA guideline update for inhaled corticosteroid (ICS) in combination with a long-acting beta agonist (LABA) as preferred reliever/rescue therapy for asthma within the ambulatory setting.

Community Acquired Pneumonia Order Set Utilization Evaluation: A Retrospective Chart Review, Kristin Lytal Pharmd, Mspgx, Luke Keller Pharmd, Bcps, Bcccp, Blake Burton Pharmd, Bcps, Sarah Ferrell Pharmd, Bcpps

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. December 2023.

This poster evaluated adherence of antimicrobial regimen selection using a community acquired pneumonia (CAP) order set updated to Infectious Disease Society of America/American Thoracic Society guidelines.

An Economic And Regulatory Analysis Of Gene Therapy Products Authorized By The Us Food And Drug Administration And The European Medicines Agency, Buthainah Ghanem

Pharmaceutical Sciences (PhD) Dissertations

Background: Gene therapy has recently emerged as an alternative for preventing and treating disease. Concerns have been expressed about the clinical value and the high cost of gene therapies.

Objective: This study assessed the authorization process of gene therapy products by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA), evaluated the post-marketing safety signals reported to the FDA Adverse Event Reporting System (FAERS), and assessed the cost-effectiveness analysis of three gene therapies axicabtagene ciloleucel(axi-cel), lisocabtagene maraleucel (liso-cel), and tisagenlecleucel (tisa-cel).

Research Design: For aim 1; data was collected using regulatory information from the FDA and the …

Medication Use Evaluation Of Neonatal Starter Total Parenteral Nutrition, Allexa Buckingham Pharmd, Heather Kistler Rd, Csp, Ldn, Ophira Silbert Md, Nisha Vyas Rph, Sharyn Jones Rph, Laura Hayn Pharmd

Department of Pharmacy

No abstract provided.

Exploratory Analysis Of Medication Adherence And Social Determinants Ofhealth Among Older Adults With Diabetes, M. L. Blakely, F. Sherbeny, T. J. Hastings, L. Boyd, Omolola A. Adeoye-Olatunde

Department of Pharmacy Practice Faculty Publications

Background

Diabetes is the fifth leading cause of death in the United States (US), affecting approximately 27%, or 15.9 million adults 65 years of age and older. Diabetes is the most expensive chronic condition in the US and accounts for the second largest avoidable healthcare cost. Adherence to long-term medication treatment plans is crucial among patients with diabetes because it decreases risk of developing comorbid conditions and improves quality of life. Greater exposure to adverse social determinants of health (SDOH) over an individual's lifespan can result in worse health outcomes. Hence, it is important to obtain a better understanding of …

Comprehensive, Evidence-Based, Consensus Guidelines For Prescription Of Opioids For Chronic Non-Cancer Pain From The American Society Of Interventional Pain Physicians (Asipp)., Laxmaiah Manchikanti, Adam M. Kaye, Nebojsa Nick Knezevic, James Giordano, Megan K. Applewhite, Alexander Bautista, Amol Soin, Susan K. Blank, Mahendra R. Sanapati, Jay Karri, Paul J. Christo, Alaa Abd-Elsayed, Alan D. Kaye, Aaron Calodney, Annu Navani, Christopher G. Gharibo, Michael Harned, Mayank Gupta, Mustafa Broachwala, Nalini Sehgal, Andrew Kaufman, Bradley Wargo, Daneshvari R. Solanki, Eric S. Hsu, Gerard Limerick, Allen Dennis, John R. Swicegood, Konstantin Slavin, Lee Snook, Ramarao Pasupuleti, Radomir Kosanovic, Rafael Justiz, Robert Barkin, Sairam Atluri, Shalini Shah, Vidyasagar Pampati, Standiford Helm Ii, Vahid Grami, Vicki Myckowiak, Vincent Galan, Vijay Singh, Vivek Manocha, Joshua A. Hirsch

School of Pharmacy Faculty Articles

BACKGROUND: Opioid prescribing in the United States is decreasing, however, the opioid epidemic is continuing at an uncontrollable rate. Available data show a significant number of opioid deaths, primarily associated with illicit fentanyl use. It is interesting to also note that the data show no clear correlation between opioid prescribing (either number of prescriptions or morphine milligram equivalent [MME] per capita), opioid hospitalizations, and deaths. Furthermore, the data suggest that the 2016 guidelines from the Centers for Disease Control and Prevention (CDC) have resulted in notable problems including increased hospitalizations and mental health disorders due to the lack of appropriate …

Assessment Of A Pharmacist-Led Antibiotic Time-Out For Transition Of Iv Vancomycin To Oral Linezolid, Mary S. Vogel, Jefferson Cua, Erika Dittmar, Timothy Gauthier, Kelsey N. Williams

Nursing & Health Sciences Research Journal

Introduction: Intravenous (IV) vancomycin requires therapeutic drug monitoring and line placement and may prolong hospital stay. Linezolid requires less monitoring, is orally bioavailable, and may expedite transitions of care. This study assessed the impact of a pharmacist-led antibiotic timeout for the transition from IV vancomycin to oral linezolid. Methods: This single-center, quasi-experimental study included admitted adult patients receiving IV vancomycin for over 48 hours. Patients receiving vasopressors, of immunocompromised status, or with specific antibiotic indications were excluded. The primary outcome was the pharmacist intervention acceptance rate. Secondary outcomes included median hospital length of stay, median antibiotic treatment days, and incidence …

Evaluation Of Intravenous Iron In The Inpatient Setting At A Large Health System., Abby Miller Pharmd Candidate, Robert D. Beckett Pharmd, Bcps, Cole Luty Pharmd, Jamie Gaul Pharmd, Bcps

Parkview Pharmacy Department

Presented at the ASHP Midyear Clinical Meeting. December 2023.

This project evaluated the appropriateness of interleukin (IL)-17 and IL-23 inhibitor usage within Parkview Health, in both inpatient and outpatient settings. This project set out to determine whether the inpatient use of intravenous (IV) iron replacement was justified and followed evidence-based guidelines.

Medication Use Evaluation Of Il-17 And Il-23 Inhibitors At A Large Health System., Corey Uetrecht Pharmd Candidate, Robert D. Beckett , Pharmd, Bcps, Kevin Baumgartner Pharmd, Jennifer Sposito Pharmd

Parkview Pharmacy Department

Presented at the ASHP Midyear Clinical Meeting. December 2023.

This project evaluated the appropriateness of interleukin (IL)-17 and IL-23 inhibitor usage within Parkview Health, in both inpatient and outpatient settings.

J Mich Dent Assoc December 2023

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following:

• A cover story on “New Dentists’ Most Asked Legal Questions”
• A case report on “Endodontic Therapy, Crown Amputation, and Soft Tissue Advancement to Treat a Hopeless Tooth”
• A feature “Be a Leader in Your Practice: What’s Your Style?”
• 2023 Author/Title Index to the Journal of the Michigan Dental Association
• News you need, a Guest Editorial and regular …

Geospatial Distribution Of Pharmacist Diabetes Management Within A Patient Centered Medical Home Model In Omaha, Nebraska, Anthony Donovan

Capstone Experience: Master of Public Health

Patients with uncontrolled diabetes, defined as a hemoglobin A1c value greater than 9%, are at an increased risk of diabetes progression. Primary care is often the first point of contact where patients with uncontrolled diabetes are identified and treated. Pharmacists are utilized in diabetes medication management of patients with uncontrolled diabetes as one component of primary care multidisciplinary models of care. This descriptive project describes the geospatial distribution of patients with uncontrolled diabetes from a single institution in the Omaha, Nebraska area who were exposed to pharmacists within a Patient Centered Medical Home (PCMH) model of care compared to those …

Discovery Of Novel Hit Molecules Targeting Parp1 Using Structure-Based Design, Shahrazad Polk

Dissertations (2016-Present)

In the United States of America alone, cancer is the second highest cause of death. While there have been many remarkable breakthroughs in cancer research, there is still a need for the development of new therapies that target the different mechanisms of cancer cells. Therefore, the focus of our research is identifying novel hit molecules targeting Poly (ADP-ribose) polymerase 1. Poly (ADP-ribose) polymerase 1 (PARP1) is an enzyme that has many distinct functions in the body. PARP1 has four domains: zinc fingers also known as the DNA binding domain, BRCT domain, WGR domain, and the ART catalytic domain. Its most …

Efficacy And Safety Of Ciltacabtagene Autoleucel And Idecabtagene Vicleucel In Multiple Myeloma Patients, Buthainah Ghanem, Marc L. Fleming, Lawrence M. Brown, Rosa Rodriguez-Monguio, Enrique Seoane-Vazquez

Student Scholar Symposium Abstracts and Posters

Background: Ciltacabtagene autoleucel (cilta-cel) and idecabtagene vicleucel (ide-cel) are chimeric antigen receptor (CAR) T-cell therapies used to treat adult patients with relapsed or refractory multiple myeloma (rrMM) after at least four lines of therapy. However, no head-to-head clinical trials to compare them have been conducted.

Objective: To compare between CARTITUDE-1 and KarMMa clinical trials in terms of efficacy, safety, and patient characteristics.

Method: Overall response rate (ORR) and safety signals were compared using reporting odds ratios (RORs) with 95% confidence intervals (CIs) at p < 0.05. Overall survival (OS) and progression-free survival (PFS) were compared using the Kaplan–Meier method with a log-rank test. Patient characteristics were compared using the chi-square test. Statistical analyses were conducted using Microsoft Excel and R version 4.0.5.

Results: Statistically significant differences were observed between cilta-cel and ide-cel in terms of ORR, complete response …

Promoting Mammography Screenings In African American Women: Media, Church, And Health Providers, Lasonya Little, Debra C. Wallace, K.Jay Poole

Journal of Health Disparities Research and Practice

Due to the underutilization of screening mammography, African American women (AAW) are more likely to experience negative health outcomes after receiving a late-stage breast cancer diagnosis than White Women (WW). The purpose of this article is to examine the roles of the media, health community and the African American church and pastor and their potential impact in AAW screening decisions. Fifteen AAW, ages 45 and older, were invited to participate in a semi-structured interview. Most women agreed the African American pastor and church as well as the health community, and media are an integral part of their lives. Therefore, specific …

Effect Of Pharmacoprophylaxis On Postoperative Outcomes In Adult Elective Colorectal Surgery: A Multi-Center Retrospective Cohort Study Within An Enhanced Recovery After Surgery Framework., William Olin Blair, Mary Allison Ellis, Maria Fada, Austin Allen Wiggins, Rachel C Wolfe, Gourang P Patel, Kara K Brockhaus, Molly Droege, Laura M Ebbitt, Brian Kramer, Eric Likar, Kerilyn Petrucci, Sapna Shah, Jerusha Taylor, Paula Bingham, Samuel Krabacher, Jin Hyung Moon, Monica Rogoz, Edson Jean-Jacques, Robert K Cleary, Ransome Eke, Rachelle Findley, Richard H Parrish

Pharmacy Articles

BACKGROUND: The application of enhanced recovery after surgery principles decreases postoperative complications (POCs), length of stay (LOS), and readmissions. Pharmacoprophylaxis decreases morbidity, but the effect of specific regimens on clinical outcomes is unclear.

METHODS AND MATERIALS: Records of 476 randomly selected adult patients who underwent elective colorectal surgeries (ECRS) at 10 US hospitals were abstracted. Primary outcomes were surgical site infection (SSI), venous thromboembolism (VTE), postoperative nausea and vomiting (PONV), pain, and ileus rates. Secondary outcomes included LOS and 7- and 30-day readmission rates.

RESULTS: POC rates were SSI (3.4%), VTE (1.5%), PONV (47.9%), pain (58.1%), and ileus (16.1%). Cefazolin …

Ozgene: To Advance Humanity – Inspire Curiosity, Maarit Patrick, Mike Dixon

Huntsman School of Business Teaching Scholarship Series

The case introduces the students to Ozgene, an Australian firm that experienced a dramatic reduction in lead time of their products because of implementation of Lean principles. The case can be used in undergraduate or graduate courses in operations management or supply chain management as an introduction to Lean principles. The case also encourages students to consider the challenges that make-to-order differ from those of make-to-stock and explore production design principles.

Conference Proceedings: Select Abstracts Presented At 2023 Advocate Aurora Scientific Day

Journal of Patient-Centered Research and Reviews

This abstract supplement includes findings presented at the 49th annual Advocate Aurora Scientific Day on May 24, 2023. The Scientific Day symposium provides a virtual forum for the sharing of preliminary results from research and case studies conducted by faculty, fellows, residents, and other health professionals associated with Illinois-based Advocate Health Care and Wisconsin-based Aurora Health Care.