Pharmacy and Pharmaceutical Sciences Commons^™

Pediatric Vaccination Adherence: Enhancing Compliance Among First-Generation Asian American Parents, Katelyn Leong

Nursing | Senior Theses

Background: Vaccine adherence in the pediatric population refers to receiving vaccines as per the recommended schedule, which significantly reduces vaccine-preventable diseases and enhances community immunity. Vaccine hesitancy, driven by concerns such as safety, misinformation, or cultural beliefs can affect adherence. National coverage of state-mandated vaccines among kindergarteners declined from 95% to around 93% between 2019 and 2022, varying across different vaccines. Objective: This research proposal’s focus is to determine if an educational intervention targeting first-generation Asian Americans, who have adopted their immigrant parents' misinformation about vaccines, will effectively increase vaccination rates among their children. The study aims to assess the …

Increasing The Efficacy Of Actinomycin D With Resveratrol In Aerodigestive Tract Cancers, Lukmon Morenikeji Raji

Theses, Dissertations and Capstones

Chemotherapy poses a significant challenge for cancer patients due to drug-associated toxicity, which often results from their effects on both healthy (normal) and cancerous cells. While various options aim to reduce toxicity and optimize beneficial effects, a comprehensive solution remains elusive. Cyclotherapy is one such approach developed to protect normal cells from the toxic effects of chemotherapy drugs. The basic principle underlying cyclotherapy is p53- dependent cell cycle arrest of normal cells while killing cancer cells via a p53-independent mechanism using a second drug. In our research, we investigated the inhibitory effects of a combination of two low-dose anticancer drugs, …

Satisfaction And Absenteeism To Lectures:Cross-Sectionnel Study Of Dental Students, Manal El Hijazi, Soundouss Soulami, Ihsane Benyahya

Health Sciences

Introduction: Lectures are still the main pedagogical tool in universities. The aim of this study was to evaluate student satisfaction with lectures and to analyze the factors behind student absenteeism.

Methods: A descriptive cross-sectional study was carried out among dental student by a voluntary, anonymous self-administered questionnaire with open and closed question. Statistical analysis was performed by SPSS version 25 and the Chi2 test was used to compare percentages, with a significance level of p

Effective Risk-Based Decision Making In Quality Risk Management, Valerie Mulholland

Dissertations

Patients expect safe, effective, high-quality medicines that are available when needed. Meeting these expectations is increasingly challenging in a global pharmaceutical supply chain, as evidenced by persistent product quality and supply issues. A key contributory factor to these issues is disruptions in manufacturing operations, which in turn are often caused by a hesitancy to change and to continuously improve approved processes. Regulatory agencies repeatedly indicate that they will consider increased autonomy for post-approval changes, if pharmaceutical manufacturing operations can demonstrate the effectiveness of Quality Risk Management (QRM) within the Pharmaceutical Quality System (PQS). Thus, the question was posed by Dr …

Synthesis Of Leishmania Spp Antigens For The Development Of Vaccine Candidates, Dipesh Budhathoki

Theses and Dissertations

Leishmaniasis is a neglected tropical disease caused by the protozoan parasite of the genus Leishmania. Presently no vaccine against Leishmaniasis is available, so there is a need for new anti-leishmanial treatments, including an effective preventive vaccine. We focus on developing vaccine candidates based on leishmania’s cell surface carbohydrate antigens. Saccharides heavily envelop the cell surface of Leishmania, lipophosphoglycan (LPG) becoming a significant glycan in most leishmania species. Its intrinsic antigenicity makes this polysaccharide a useful target for developing conjugated vaccine candidates against all leishmaniasis variants. In this report, we present our progress towards the synthesis of the fragments of LPG …

Neuroprognostication In Patients With A Subarachnoid Hemorrhage: A Quasi-Review Of Anti-Inflammatory Agent Administration Versus Blood Pressure Management, Julia Gabalski, Marcie Mcmahon

Soaring: A Journal of Undergraduate Research

A subarachnoid hemorrhage (SAH) is a type of stoke where a blood vessel bursts and causes the subarachnoid space to become filled with blood. Traditional nursing management of SAH includes close monitoring of blood pressure goals in order to prevent complications such as vasospasm. Vasospasm causes delayed cerebral ischemia and neurological deficits secondary to the initial injury. Recent research has expanded understanding of the underlying mechanisms behind the neuroinflammatory cascade that occurs after a SAH. In this study, a methodical search was conducted through the CINAHL and PubMed databases to form a quasi-review of current research. The comparison of traditional …

Evaluating Functional Inhibitors Of Acid Sphingomyelinase As Potential Negative Modulators Of Microvesicle Particle Release In Response To Skin Stressors, Taskin Sabit

Browse all Theses and Dissertations

Many diseases including lupus erythematosus, atopic eczema, and rosacea can be associated with photosensitivity, which is an abnormal response to sunlight. Recent studies by our group have implicated microvesicle particles (MVP) as playing an important role in causing inflammation and systemic immunosuppression. Previous studies show that functional inhibitors of acid sphingomyelinase (FIASMA) can block MVP release in response to ultraviolet B (UVB) radiation or Platelet-activating Factor (PAF) agonist, which are skin stressors. However, more research needs to be conducted to evaluate the role of PAF, UVB and FIASMA in MVP generation and to formulate a therapeutic medication to be potentially …

Research News, Publications, 2024, Volume 1, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of January 1 through March 31, 2024

In-Vitro Study On Cellular Damage Of Chemobrain, Zitao Ma

Selected Full-Text Master Theses 2021-

Chemotherapy-induced cognitive impairment (CICI), commonly referred to as "Chemobrain", represents a significant challenge for cancer survivors, affecting their quality of life by impairing memory, attention, and executive function. This study aims to elucidate the mechanisms behind CICI and evaluate the efficacy of potential neuroprotective agents in mitigating its effects. By focusing and developing in-vitro models, including differentiated SH-SY5Y neuron-like cells, undifferentiated SH- SY5Y neuroblastoma cells and co-culture systems with astrocytoma CCF-STTG1 and human microglia HMC3 cells, this study provides insights into the cellular and molecular alterations induced by chemotherapy and explores the protective capacities of selected compounds.

Chemotherapy drugs such …

Fentanyl And Methamphetamine Mixture Interactions On Drug Choice In Male And Female Sprague Dawley Rats, Voisava Bokciu, Nick Heslep, Allison Ortiz, Matthew L. Banks Phd

IRBEH/Spit for Science Publications and Presentations

No abstract provided.

Influence Of Human And Viral Il-6 On Kshv Infection In Human Tonsil Lymphocytes, Wajd Zakir

Pharmaceutical Sciences (MS) Theses

Infection of B cells by the lymphotropic gamma-herpesvirus Kaposi sarcoma-associated herpesvirus (KSHV) causes Multicentric Castleman Disease, Primary Effusion Lymphoma, and the newly-identified inflammatory syndrome designated KICS. Despite proven connections to lymphoproliferative disorders, little is known about how KSHV invades the human immune system or the early events governing infection in B lymphocytes. IL-6 signaling plays a critical role in KSHV-mediated disease, where elevated hIL-6 levels are positively associated with KSHV viral load and disease progression. This dynamic is even more complex due to the co-existence of human IL-6 (hIL6) and KSHV-encoded viral IL-6 (vIL6) in these diseases. Although the impact …

Molecular Study Of The Agr Gene In Multidrug-Resistant (Mdr) And Extensively Drug-Resistant (Xdr) In The S. Aureus, Mays Ali Salim, Estabraq Ali Maklef, Montaha Abdul-Karim Al-Saffar

Al-Esraa University College Journal for Medical Sciences

Staphylococcus aureus a gram-positive coccus and one of the most important opportunistic bacteria that can lead to nosocomial infections. The purpose of this study is to explore the distribution and prevalence of the Agr gene in multidrug-resistance (MDR) and extensively drug-resistant (XDR) S. aureus. 62 isolates performed antibiotic sensitivity test. The isolates showed 66.12% resistance to clindamycin with MIC at range≥4, erythromycin 77.41% with MIC at range≥8, ciprofloxacin 19.35% with MIC at range≥4, oxacillin 75.80% with MIC at range≥4, cefoxitin 45.16% with MIC at range≥8, gentamycin 29.03% with MIC at range≥16, nitrofurantoin 14.51% and MIC at range≥128, and tetracycline …

Nanoscale Characterization Of Interaction Of Nucleosomes With H1 Linker Histone, Ahmed Yesvi Rafa, Shaun Filliaux, Yuri L. Lyubchenko

Journal Articles: Pharmaceutical Sciences

In eukaryotic nuclei, DNA is wrapped around an octamer of core histones to form nucleosomes. H1 binds to the linker DNA of nucleosome to form the chromatosome, the next structural unit of chromatin. Structural features on individual chromatosomes contribute to chromatin structure, but not fully characterized. In addition to canonical nucleosomes composed of two copies each of histones H2A, H2B, H3, and H4 (H3 nucleosomes), centromeres chromatin contain nucleosomes in which H3 is replaced with its analog CENP-A, changing structural properties of CENP-A nucleosomes. Nothing is known about the interaction of H1 with CENP-A nucleosomes. Here we filled this gap …

Neuroimmune Response And Neurodegeneration In Adolescent Rats Following Binge Alcohol Exposure, Catherine Van Doorn

Theses and Dissertations--Pharmacy

Studies of adolescent drinking show a distinct prevalence of binge drinking, including at extreme levels, and this type of drinking has been identified as increasing risk of developing an Alcohol Use Disorder (AUD). Additionally, females suffer greater levels of harm from binge drinking and AUD and in an abbreviated timeline compared to males. Neuroimmune reactivity, specifically with microglial reactivity following binge drinking, may influence the sex differences seen in negative alcohol-related health disparities.

The first set of experiments sought to examine a marker of microglial reactivity, TSPO, in adolescent females and males and found the sexes displayed different temporal and …

Distribution Of Epidemiological Characteristics Of Low Back Pain Patients Attending To Baghdad Teaching Hospital, Khadija Kamil Salman, Ali Hussein. Al-Hafid, Shatha Ahmed Mohammed Ali

Al-Esraa University College Journal for Medical Sciences

Background: Low back pain (LBP) is a very common health problem worldwide especially in the low and middle-income countries. The LBP may be acute or chronic in nature caused by several medical conditions. The majority of acute low back pain is mechanical in nature due to sprains and strains. Chronic LBP, on the other hand, is most commonly attributed to sciatica, which a radiculopathy condition caused by compression, inflammation and/or injury to the spinal nerve roots. Aims of study: To study epidemiological features of low back pain. Patients and Methods: A cross-sectional study of 440 individuals diagnosed with …

Comparison Between Crp Level And Some Biochemical Parameters In Hashimoto And Hypothyroidism Iraqi Patients, Shahad Muthanna Abdulsattar, Ahmed Salem Mohammed, Susan Ahmed Zwyea

Al-Esraa University College Journal for Medical Sciences

Background: Hypothyroidism is a common medical condition that occurs due to a lack of the hormone thyroxine. Hashimoto's thyroiditis (HT) is the most prevalent thyroid disorder, also known as autoimmune thyroid disease (AITD). Approximately 20-30% of people develop hypothyroidism due to ongoing inflammation of the thyroid tissue it triggers. Aims: To investigate the difference between inflammatory and biochemical test in Hashimoto autoimmune thyroiditis (AITD) and hypothyroidism patients (non-autoimmune) Methods: The study was done on 50 Hashimotos patients, 50 Hypothyroidism patients from the Endocrinology Unit at Baghdad Teaching Hospital and Educational Laboratories / Baghdad City, Iraq, and 50 control healthy …

A Closer Look At The Humanistic Aspects Of The Opioid Epidemic And Its Implications For Pharmaceutical Ethics And Law, Eriel Burns

Gaines Fellow Senior Theses

This paper elucidates the humanistic elements of this crisis, that is, the ethical challenges it poses and the role of culture in it. The opioid crisis disturbs several bioethics principles as indicated by the fact that it burgeoned out of the health care system as opposed to the illicit environments of the underground market. The book Dreamland by investigative journalist and storyteller, Sam Quinones encapsulates the complexity of the opioid epidemic through research and interviews with important figures related to the crisis such as physicians, people with opioid use disorder, and pharmaceutical sales representatives, among others. Quinones details that the …

Nanoscale Interaction Of Endonuclease Ape1 With Dna, Sridhar Vemulapalli, Mohtadin Hashemi, Yingling Chen, Suravi Pramanik, Kishor Bhakat, Yuri L. Lyubchenko

Journal Articles: Pharmaceutical Sciences

Apurinic/apyrimidinic endonuclease 1 (APE1) is involved in DNA repair and transcriptional regulation mechanisms. This multifunctional activity of APE1 should be supported by specific structural properties of APE1 that have not yet been elucidated. Herein, we applied atomic force microscopy (AFM) to characterize the interactions of APE1 with DNA containing two well-separated G-rich segments. Complexes of APE1 with DNA containing G-rich segments were visualized, and analysis of the complexes revealed the affinity of APE1 to G-rich DNA sequences, and their yield was as high as 53%. Furthermore, APE1 is capable of binding two DNA segments leading to the formation of loops …

Coumarin-Based Aldo-Keto Reductase Family 1c (Akr1c) 2 And 3 Inhibitors, Sravan Jonnalagadda, Ling Duan, Louise F. Dow, Geetha P. Boligala, Elizabeth A. Kosmacek, Kristyn Mccoy, Rebecca E. Oberley-Deegan, Yashpal Singh Chhonker, Darryl J. Murry, C. Patrick Reynolds, Barry J. Maurer, Trevor M. Penning, Paul C. Trippier

Journal Articles: Pharmaceutical Sciences

A series of 7-substituted coumarin derivatives have been characterized as pan-aldo-keto reductase family 1C (AKR1C) inhibitors. The AKR1C family of enzymes are overexpressed in numerous cancers where they are involved in drug resistance development. 7-hydroxy coumarin ethyl esters and their corresponding amides have high potency for AKR1C3 and AKR1C2 inhibition. Coumarin amide 3 a possessed IC50 values of 50 nM and 90 nM for AKR1C3 and AKR1C2, respectively, and exhibits 'drug-like' metabolic stability and half-life in human and mouse liver microsomes and plasma. Compound 3 a was employed as a chemical tool to determine pan-AKR1C2/3 inhibition effects both as a …

Discovery Of An Aldo-Keto Reductase 1c3 (Akr1c3) Degrader, Angelica V. Carmona, Shirisha Jonnalagadda, Alfie M. Case, Krishnaiah Maddeboina, Sravan K. Jonnalagadda, Louise F. Dow, Ling Duan, Trevor M. Penning, Paul C. Trippier

Journal Articles: Pharmaceutical Sciences

Aldo-keto reductase 1C3 (AKR1C3) is a protein upregulated in prostate cancer, hematological malignancies, and other cancers where it contributes to proliferation and chemotherapeutic resistance. Androgen receptor splice variant 7 (ARv7) is the most common mutation of the AR receptor that confers resistance to clinical androgen receptor signalling inhibitors in castration-resistant prostate cancer. AKR1C3 interacts with ARv7 promoting stabilization. Herein we report the discovery of the first-in-class AKR1C3 Proteolysis-Targeting Chimera (PROTAC) degrader. This first-generation degrader potently reduced AKR1C3 expression in 22Rv1 prostate cancer cells with a half-maximal degradation concentration (DC₅₀) of 52 nM. Gratifyingly, concomitant degradation of ARv7 was …