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Il-21 Signaling Promotes The Establishment Of Kshv Infection In Human Tonsil Lymphocytes By Increasing Differentiation And Targeting Of Plasma Cells, Nedaa Alomari, Jennifer Totonchy 2022 Chapman University

Il-21 Signaling Promotes The Establishment Of Kshv Infection In Human Tonsil Lymphocytes By Increasing Differentiation And Targeting Of Plasma Cells, Nedaa Alomari, Jennifer Totonchy

Pharmacy Faculty Articles and Research

Introduction: Factors influencing Kaposi’s sarcoma-associated herpesvirus (KSHV) transmission and the early stages of KSHV infection in the human immune system remain poorly characterized. KSHV is known to extensively manipulate the host immune system and the cytokine milieu, and cytokines are known to influence the progression of KSHV-associated diseases. Our previous work identified the early targeting of plasma cells for KSHV infection. In this study, we examine whether IL-21, a cytokine known to profoundly influence plasma cell fate, influences the early stages of KSHV infection in B lymphocytes.

Methods: Using our unique model of ex vivo KSHV infection in tonsil lymphocytes, …


Comparison Of Cognitive Behavioral Therapy And Pharmacologic Intervention In Alcohol Use Disorder Treatment, AnaLily Wong, Collin Owen, Meghan Vatave 2022 Kennesaw State University

Comparison Of Cognitive Behavioral Therapy And Pharmacologic Intervention In Alcohol Use Disorder Treatment, Analily Wong, Collin Owen, Meghan Vatave

Symposium of Student Scholars

Background: Alcohol use disorder (AUD) is a condition that can result in chronic health conditions that negatively impact a person’s life. Methods to treat AUD involve cognitive behavioral therapy (CBT) and pharmacologic intervention, including disulfiram (DIS), naltrexone (NTX), and acamprosate (ACA).

Objectives: The purpose of this review is to determine the efficacy of CBT compared to pharmacologic intervention within one year of treatment in adult patients who have been diagnosed with AUD.

Methods: A reference search was conducted using various databases to locate literature. Combined keywords and Boolean operators were utilized to reveal desired articles. A total of 10 …


Designing And Synthesizing A Warhead-Fragment Inhibitory Ligand For Ivyp1 Through Fragment-Based Drug Discovery, Samuel Moore 2022 Kennesaw State University

Designing And Synthesizing A Warhead-Fragment Inhibitory Ligand For Ivyp1 Through Fragment-Based Drug Discovery, Samuel Moore

Symposium of Student Scholars

Fragment-based drug discovery (FBDD) is a powerful tool for developing anticancer and antimicrobial agents. Within this, magnetic resonance spectroscopy (NMR) provides a comprehensive qualitative and quantitative approach to screening and validating weak and robust binders with targeted proteins, making NMR among the most attractive strategies in FBDD. Inhibitor of vertebrate lysozyme (Ivyp1) of P. aeruginosa serves as an excellent target because of its active cellular location and implications in clinical prognosis for cystic fibrosis and immunocompromised patients. This study uses current NMR and biophysical techniques to develop a covalent, fragment-linked warhead inhibitor for Ivyp1 through synthetic methods, warhead linking, and …


Pregabalin May Reduce Neuropathic Pain In Burn Victims, Caroline Nikolaidis 2022 Wayne State University

Pregabalin May Reduce Neuropathic Pain In Burn Victims, Caroline Nikolaidis

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using:

Gray P, Kirby J, Smith MT, et al. Pregabalin in severe burn injury pain: a double-blind, randomized placebo-controlled trial. Pain. 2011;152(6):1279-1288. https://doi.org/10.1016/j.pain.2011.01.055

for a patient with burn injury pain.


Role Of Macrophages In Ocular Surface Fibrosis, Alyanna Corpuz 2022 Chapman University

Role Of Macrophages In Ocular Surface Fibrosis, Alyanna Corpuz

Pharmaceutical Sciences (MS) Theses

The present study is designed to investigate whether irradiation as used for conditioning regimen to ablate recipient’s diseased bone marrow prior to transplantation could trigger macrophage activation and polarization and whether macrophages could cause the transdifferentiation of ocular surface fibroblasts into myofibroblasts, thus contributing to oGVHD-associated fibrosis.

Bone marrow cells were cultured in M-CSF to obtain M0 macrophages, which were subsequently polarized into M1 and M2 phenotypes using IFN-g + LPS and IL-4, respectively.

The macrophages were exposed to 7 Gy radiation. The effect of irradiation on macrophage activation markers, phagocytosis, and apoptosis was assessed using real-time PCR, confocal microscopy, …


Medication Use Evaluation Of Angiotensin Ii, Kevin Baumgartner PharmD, Dustin D Linn PharmD, BCCCP, Michael Todt PharmD 2022 Parkview Health

Medication Use Evaluation Of Angiotensin Ii, Kevin Baumgartner Pharmd, Dustin D Linn Pharmd, Bcccp, Michael Todt Pharmd

Pharmacy

Poster presentation completed at ASHP Midyear Clinical Conference & Exhibition

Background: Angiotensin II is a vasopressor agent used for septic shock and has been found to effectively raise the blood pressure in patients who did not respond to other conventional high dose vasopressors. Angiotensin II’s wholesale acquisition cost (WAC) of $1800 per vial creates a significant financial burden for health care institutions. A limited warranty manufacturer program replaces angiotensin II vials in patients not achieving an increase in mean arterial pressure (MAP) of at least 10 mmHg or to >65mmHg within the first 3 hours of initiation.

Objective: Evaluate compliance …


Characterizing Appropriate Use Of Octreotide Continuous Infusions For Gastroesophageal Bleeding, Austin Harris PharmD, Curtis Stump PharmD, Luke Keller PharmD, BCPS, BCCCP 2022 Parkview Health

Characterizing Appropriate Use Of Octreotide Continuous Infusions For Gastroesophageal Bleeding, Austin Harris Pharmd, Curtis Stump Pharmd, Luke Keller Pharmd, Bcps, Bcccp

Pharmacy

Poster Presentation completed at ASHP Midyear Clinical Conference & Exhibition.

Objective: To characterize the appropriate use of octreotide infusions for gastroesophageal bleeding at a community hospital system to pursue guideline-driven standardization of care.


Evaluation Of Intravenous Loop Diuretic Use In Acute Decompensated Heart Failure In A Community Hospital, Catherine Eichler PharmD, Cole Luty PharmD, Kris Howard PharmD, AACC 2022 Parkview Health

Evaluation Of Intravenous Loop Diuretic Use In Acute Decompensated Heart Failure In A Community Hospital, Catherine Eichler Pharmd, Cole Luty Pharmd, Kris Howard Pharmd, Aacc

Pharmacy

Poster presentation completed at ASHP Midyear Clinical Conference & Exhibition

Objective: To characterize the use of intravenous loop diuretics in patients hospitalized with fluid overload secondary to acute decompensated heart failure (ADHF) within the heart failure service of a community hospital


Comparison Of Clinical Pharmacist Versus Nurse Led Medicare Annual Wellness Visits In The Primary Care Clinic Setting, Payton Waltz PharmD, Erin Copi PharmD, BCACP, Rachel Steele PharmD, BCACP 2022 Parkview Health

Comparison Of Clinical Pharmacist Versus Nurse Led Medicare Annual Wellness Visits In The Primary Care Clinic Setting, Payton Waltz Pharmd, Erin Copi Pharmd, Bcacp, Rachel Steele Pharmd, Bcacp

Pharmacy

Poster presentation completed at ASHP Midyear Clinical Conference & Exhibition.

Objective: To characterize the impact of a primary care pharmacist completing Medicare Annual Wellness Visits by determining:

• Primary: The rate of overall care gap closure by pharmacist-led versus nurse-led visits.

• Secondary: The percentage of recommended care gap opportunities during pharmacist-led versus nurse-led visits and the number of pharmacist made medication interventions during AWVs.


Evaluation Of Therapies For Treatment Of Hyponatremia, Laura Fischer PharmD Candidate, Jennifer Sposito PharmD, Blake Burton PharmD, BCPS, Jamie Gaul PharmD, BCPS 2022 Parkview Health

Evaluation Of Therapies For Treatment Of Hyponatremia, Laura Fischer Pharmd Candidate, Jennifer Sposito Pharmd, Blake Burton Pharmd, Bcps, Jamie Gaul Pharmd, Bcps

Pharmacy

Poster presentation completed at ASHP Midyear Clinical Conference & Exhibition.

Objective: Characterize the use and assess the efficacy of tolvaptan and urea in the treatment of patients who were admitted to the hospital with chronic hyponatremia.


Characterization Of Vancomycin Use At A Community Hospital, Caleb Hoppe PharmD Candidate, Jamie Gaul PharmD, BCPS, Christina Ford Pharm, BCPSD 2022 Parkview Health

Characterization Of Vancomycin Use At A Community Hospital, Caleb Hoppe Pharmd Candidate, Jamie Gaul Pharmd, Bcps, Christina Ford Pharm, Bcpsd

Pharmacy

Poster presentation completed at ASHP Midyear Clinical Conference & Exhibition.

Objective: To characterize the use of vancomycin medication therapy at a non-profit community hospital (Parkview Regional Medical Center) in preparation for a potential change to AUC:MIC dosing and monitoring.


Safety Of 10,000 Unit Unfractionated Heparin Boluses For Acute Myocardial Infarction In The Emergency Department, Emma Pastula PharmD, Sarah Meeks PharmD, Amber Ooley PharmD, BCPS, BCCCP, Sarah Ferrell PharmD 2022 Parkview Health

Safety Of 10,000 Unit Unfractionated Heparin Boluses For Acute Myocardial Infarction In The Emergency Department, Emma Pastula Pharmd, Sarah Meeks Pharmd, Amber Ooley Pharmd, Bcps, Bcccp, Sarah Ferrell Pharmd

Pharmacy

Poster presentation completed at ASHP Midyear Clinical Conference & Exhibition.

The purpose of this retrospective chart-review study is to evaluate the safety and efficacy of a 10,000 unit unfractionated heparin bolus in the emergency department prior to PCI. • The primary objective was percentage of ACT values within goal range of 250-300 seconds. • Secondary objectives included major bleeding rate, weight-based UFH bolus dose in comparison to guideline recommended bolus dose, percentage of initial ACT values within goal range, protamine use, and need for additional UFH boluses.


Evaluation Of Piperacillin/Tazobactam Utilization In Suspected Urinary Tract Infections At A Community Hospital, Adam P. Yagodinski, Jamie Gaul PharmD, BCPS, Dana Lorber PharmD, BCPS, Alissa Keillor PharmD 2022 Parkview Health

Evaluation Of Piperacillin/Tazobactam Utilization In Suspected Urinary Tract Infections At A Community Hospital, Adam P. Yagodinski, Jamie Gaul Pharmd, Bcps, Dana Lorber Pharmd, Bcps, Alissa Keillor Pharmd

Pharmacy

Poster presentation completed at ASHP Midyear Clinical Conference & Exhibition.

Objective: Evaluate and characterize the utilization of piperacillin/tazobactam in patients with a suspected urinary tract infection (UTI) at a community hospital in Fort Wayne, Indiana.


Continued Use Of Proton Pump Inhibitors And Risk For Recurrence Of Clostridium Difficile Infection-A Retrospective Study, Cecilia Schowe PharmD Candidate, Breia Leavell PharmD Candidate, Cole Luty PharmD 2022 Parkview Health

Continued Use Of Proton Pump Inhibitors And Risk For Recurrence Of Clostridium Difficile Infection-A Retrospective Study, Cecilia Schowe Pharmd Candidate, Breia Leavell Pharmd Candidate, Cole Luty Pharmd

Pharmacy

Poster presentation completed at ASHP Midyear Clinical Conference & Exhibition.

Objective: To determine if the continued use of proton pump inhibitors leads to an increased risk of recurrent Clostridium difficile infections.


Impact Of Pharmacist-Led Direct Oral Anticoagulant Monitoring On Appropriate Medication Use, Bhavika Patel PharmD, Kenneth Wiley PharmD, BCACP, Alicia Sawmiller PharmD, BCACP 2022 Parkview Health

Impact Of Pharmacist-Led Direct Oral Anticoagulant Monitoring On Appropriate Medication Use, Bhavika Patel Pharmd, Kenneth Wiley Pharmd, Bcacp, Alicia Sawmiller Pharmd, Bcacp

Pharmacy

Poster presentation completed at ASHP Midyear Clinical Conference & Exhibition.

Background: Direct oral anticoagulants (DOACs) are the preferred treatment for patients with venous thromboembolism and atrial fibrillation and are an attractive alternative to vitamin K antagonists in multiple indications for long-term anticoagulation. Although DOACs require less frequent clinical monitoring than vitamin K antagonists and their standardized dosing is often more convenient for patients, these medications still require monitoring. Medication adherence, monitoring renal function, hepatic function and drug interactions are important safety concerns for managing patients on DOAC therapy. Previous studies have shown pharmacist can impact monitoring, dosing and adherence to …


Impact Of Specialty Pharmacy Services On Pneumococcal Vaccination Rates In A Large Inflammatory Bowel Disease Population, Jessica Offerle PharmD, Tara Jellison PharmD, MBA,FASHP, Michele Walters PharmD, BCPS, BCIDP, Toni Zahorian PharmD, BCACP 2022 Parkview Health

Impact Of Specialty Pharmacy Services On Pneumococcal Vaccination Rates In A Large Inflammatory Bowel Disease Population, Jessica Offerle Pharmd, Tara Jellison Pharmd, Mba,Fashp, Michele Walters Pharmd, Bcps, Bcidp, Toni Zahorian Pharmd, Bcacp

Pharmacy

Poster presentation completed at ASHP Midyear Clinical Conference & Exhibition.

Objective: The purpose of this study is to assess the impact of clinical specialty pharmacy services and education on compliance with vaccine recommendations in subjects with IBD.


Evaluation Of Rituximab Use At Parkview Health, Sarah Stopczynski PharmD Candidate, Jesse Christman PharmD, BCOP, Kristen Christman PharmD, BCPS, Jamie Gaul PharmD, BCPS 2022 Parkview Health

Evaluation Of Rituximab Use At Parkview Health, Sarah Stopczynski Pharmd Candidate, Jesse Christman Pharmd, Bcop, Kristen Christman Pharmd, Bcps, Jamie Gaul Pharmd, Bcps

Pharmacy

Poster Presentation completed at ASHP Midyear Clinical Conference & Exhibition.

Objective: Characterize the use of rituximab at Parkview Health by differentiating between inpatient and outpatient use as well as evaluate indications for use, incidence of documented infusion reactions, and biosimilar use.


Computer-Aided Drug Discovery For Helicobacter Pylori, Nicole Ann Vita 2022 University of Tennessee Health Science Center

Computer-Aided Drug Discovery For Helicobacter Pylori, Nicole Ann Vita

Theses and Dissertations (ETD)

Helicobacter pylori is a high-priority drug-resistant pathogen and is currently the only bacteria considered to be a class I carcinogen and there is a critical need to identify novel chemical matter to treat H. pylori infections. Hp is responsible for greater than 60% of gastric cancer related deaths and 89% of all gastric cancer morbidities. In a previous study, our lab identified novel Hp thienopyrmidine inhibitors that target respiratory complex I, an essential enzyme in respiration. Respiratory complex I is a large asymmetric multidomain and membrane bound enzyme and due to these innate features, it is not practical for biophysical …


November / December 2022, Randy Curry, Cindy Brooks 2022 Southwestern Oklahoma State University

November / December 2022, Randy Curry, Cindy Brooks

RURAL ROCKS

This is the November & December 2022 issue of Rural Rocks from the SWOSU College of Pharmacy.


Biomarkers In The Development Of Individualized Treatment Regimens For Colorectal Cancer, Madison Crutcher, Scott A Waldman 2022 Thomas Jefferson University

Biomarkers In The Development Of Individualized Treatment Regimens For Colorectal Cancer, Madison Crutcher, Scott A Waldman

Department of Surgery Faculty Papers

Introduction: Colorectal cancer (CRC) is the third most common and second most deadly malignancy in the world with an estimated 1. 9 million cases and 0.9 million deaths in 2020. The 5-year overall survival for stage I disease is 92% compared to a dismal 11% in stage IV disease. At initial presentation, up to 35% of patients have metastatic colorectal cancer (mCRC), and 20-50% of stage II and III patients eventually progress to mCRC. These statistics imply both that there is a proportion of early stage patients who are not receiving adequate treatment and that we are not adequately treating …


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