Doxazosin Immediate Release As A Novel Treatment For Nightmares In Posttraumatic Stress Disorder.,
2024
Rowan University
Doxazosin Immediate Release As A Novel Treatment For Nightmares In Posttraumatic Stress Disorder., Danyaal Khan, Christie Richardson, Martin Forsberg
Rowan-Virtua School of Osteopathic Medicine Departmental Research
Nightmares and flashbacks are common debilitating symptoms of posttraumatic stress disorder (PTSD) that can disrupt daily functioning. Prazosin, an alpha-1 adrenergic antagonist, has been commonly used off-label for the treatment of these intrusion symptoms, although its short half-life makes it so that often multiple doses are needed. Doxazosin, another alpha-1 antagonist, is starting to be investigated in the treatment of PTSD-related nightmares due to its lesser side effect profile and longer half-life. In our case series, we present three cases of patients with PTSD-related nightmares who were successfully treated with doxazosin following a relapse of symptoms after discontinuation of prazosin …
Exploring The Metabolic And Mitogenic Potential Of A Hyper-Stable Variant Of Fgf1,
2024
University of Arkansas, Fayetteville
Exploring The Metabolic And Mitogenic Potential Of A Hyper-Stable Variant Of Fgf1, Emma Starr, Oshadi Edirisinghe, Thallapuranam Krishnaswamy Suresh Kumar
Inquiry: The University of Arkansas Undergraduate Research Journal
Fibroblast growth factors (FGFs) are a family of 22 human cytokines involved in critical cellular processes, such as proliferation, differentiation, metabolism, angiogenesis, tumor metastasis, and wound healing. Among these, fibroblast growth factor 1 (FGF1) possesses a powerful mitogenic potential as it can nonspecifically bind to all four FGF receptors. However, the therapeutic applications of FGF1 are hindered by its inherent thermal and proteolytic instability, especially at physiological temperatures. This is believed to be attributed to the heparin-binding pocket at the C-terminus, which contains numerous positively charged residues that repel each other. To combat this instability, FGF1 binds to a negatively …
A Retrospective Study Of Procalcitonin Utilization In Clinical Practice,
2024
HCA Healthcare
A Retrospective Study Of Procalcitonin Utilization In Clinical Practice, Tanner Norris, Matthew Yurkewicz, Patrick Jenkins, Beth Hicks, Dmitriy Scherbak
Continental, MidAmerica, & Mountain Divisions GME Research Day 2024
No abstract provided.
Pharmacoepidemiology Of Glp-1 Receptor Agonists,
2024
HCA Healthcare
Pharmacoepidemiology Of Glp-1 Receptor Agonists, Nicholas E. Woessner
Continental, MidAmerica, & Mountain Divisions GME Research Day 2024
No abstract provided.
Fentanyl And Methamphetamine Mixture Interactions On Drug Choice In Male And Female Sprague Dawley Rats,
2024
Virginia Commonwealth University
Fentanyl And Methamphetamine Mixture Interactions On Drug Choice In Male And Female Sprague Dawley Rats, Voisava Bokciu, Nick Heslep, Allison Ortiz, Matthew L. Banks Phd
IRBEH/Spit for Science Publications and Presentations
No abstract provided.
Improving Medication-Enhanced Psychotherapy Options For Ptsd: The Potential Of Oxytocin As A Treatment For Hypervigilance In Women With A History Of Childhood Sexual Abuse And Related Ptsd,
2024
Virginia Commonwealth University
Improving Medication-Enhanced Psychotherapy Options For Ptsd: The Potential Of Oxytocin As A Treatment For Hypervigilance In Women With A History Of Childhood Sexual Abuse And Related Ptsd, Elianna Bavuso
AUCTUS: The Journal of Undergraduate Research and Creative Scholarship
Childhood sexual abuse (CSA) is a notable public health concern, affecting a significant proportion of girls in high-income countries. A considerable number of CSA survivors develop Post-Traumatic Stress Disorder (PTSD) by adolescence, which is often considered to be a lifelong disorder with severe emotional and social consequences. Women with CSA-related PTSD display hypervigilance, which is characterized by significantly increased fear network activity and poor top-down control over the amygdala. This meta-analysis examines the potential of intranasal oxytocin (OT) as a treatment for hypervigilance symptoms in women with CSA-related PTSD. The evidence reviewed suggests that intranasal oxytocin can help normalize the …
Managing Stress: A Study Of Stress Response Mechanisms In Mycobacteria,
2024
University of Texas at Arlington
Managing Stress: A Study Of Stress Response Mechanisms In Mycobacteria, Augusto C. Hunt Serracin
Biology Dissertations - Archive
Mycobacteria encompass many pathogenic species known to cause severe disease in humans. A well-known example is Mycobacterium tuberculosis (Mtb), the causative agent of the lung disease tuberculosis, which kills millions of humans worldwide yearly. Pathogenic mycobacteria like Mtb are challenging to treat because of their innate ability to adapt to environmental stress. Their unique cell physiology and conserved stress responses allow them to combat biological insults, regulate growth, and regulate genes involved in stress; all these responses increase tolerance to antibiotics. The current therapies to treat mycobacterial infections are lengthy and, at times, unsuccessful, partly due to antibiotic tolerance. A …
A Closer Look At The Humanistic Aspects Of The Opioid Epidemic And Its Implications For Pharmaceutical Ethics And Law,
2024
University of Kentucky
A Closer Look At The Humanistic Aspects Of The Opioid Epidemic And Its Implications For Pharmaceutical Ethics And Law, Eriel Burns
Gaines Fellow Senior Theses
This paper elucidates the humanistic elements of this crisis, that is, the ethical challenges it poses and the role of culture in it. The opioid crisis disturbs several bioethics principles as indicated by the fact that it burgeoned out of the health care system as opposed to the illicit environments of the underground market. The book Dreamland by investigative journalist and storyteller, Sam Quinones encapsulates the complexity of the opioid epidemic through research and interviews with important figures related to the crisis such as physicians, people with opioid use disorder, and pharmaceutical sales representatives, among others. Quinones details that the …
Beer,
2024
University of Kentucky
Beer, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
The Complex Protein Analysis Of Purified Extracellular Vesicles In The Study Of Colorectal Cancer,
2024
Belmont University
The Complex Protein Analysis Of Purified Extracellular Vesicles In The Study Of Colorectal Cancer, Renee Boone, Cecilia Osthoff
Science University Research Symposium (SURS)
Proteomics, the study of complex protein mixtures in which liquid chromatography-mass spectrometry (LC-MS) is used to analyze peptide sequences, is commonly utilized to study the double membrane, cell-derived vesicles known as exosomes. Exosomes are double membrane, cell-derived vesicles that contain cell components such as DNA, lipids, and proteins. They function to transport proteins and cellular materials between cells and are involved in the progression and metastasis of cancer. The impact of these extracellular vesicles on cancer spread can be analyzed using proteomics, through the purification of the proteins isolated from the vesicles. The purpose of our research is to analyze …
Fxr Agonism With Bile Acid Mimetic Reduces Pre-Clinical Triple-Negative Breast Cancer Burden,
2024
University of Mary Washington
Fxr Agonism With Bile Acid Mimetic Reduces Pre-Clinical Triple-Negative Breast Cancer Burden, Sydney Joseph, Samson Eugin Simon, Margaret S. Bohm, Minjeong Kim, Madeline E. Pye, Boston W. Simmons, Dillon G. Graves, Stacey M. Thomas-Gooch, Ubaid A. Tanveer, Jeremiah R. Holt, Suriyan Ponnusamy, Laura M. Sipe, Et Al.
Biological Sciences Research
Bariatric surgery is associated with improved outcomes for several cancers, including breast cancer (BC), although the mechanisms mediating this protection are unknown. We hypothesized that elevated bile acid pools detected after bariatric surgery may be factors that contribute to improved BC outcomes. Patients with greater expression of the bile acid receptor FXR displayed improved survival in specific aggressive BC subtypes. FXR is a nuclear hormone receptor activated by primary bile acids. Therefore, we posited that activating FXR using an established FDA-approved agonist would induce anticancer effects. Using in vivo and in vitro approaches, we determined the anti-tumor potential of bile …
Effectiveness Of Harm Reduction And Narcan Education For Young Adults,
2024
Dominican University of California
Effectiveness Of Harm Reduction And Narcan Education For Young Adults, Jason Bolfango
Nursing | Student Research Posters
Education on the Harm Reduction Model is an upstream preventative approach to addressing the opioid crisis and a strategic method to promote safety among young adults.
Wine, Sparkling,
2024
University of Kentucky
Wine, Sparkling, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Wine, Other,
2024
University of Kentucky
Wine, Other, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Table B: Generally Recognized As Safe (Gras) Food Additives Containing Aluminum,
2024
University of Kentucky
Table B: Generally Recognized As Safe (Gras) Food Additives Containing Aluminum, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Mineral, Spring, Table, And Bottled Water,
2024
University of Kentucky
Mineral, Spring, Table, And Bottled Water, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Liquors And Spirits,
2024
University of Kentucky
Liquors And Spirits, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Wine, Red,
2024
University of Kentucky
Wine, Red, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Wine, White,
2024
University of Kentucky
Wine, White, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
Table D: Aluminum-Containing Additives Allowed By The Eu And Fao/Who,
2024
University of Kentucky
Table D: Aluminum-Containing Additives Allowed By The Eu And Fao/Who, Robert Yokel
Aluminum in Beverages and Foods: A Compilation
No abstract provided.
