Chemicals and Drugs Commons^™

Phytochemical And In-Vitro Cytotoxic Analyses Of Flavonoid Species Isolated From Chromolaena Leivensis, Luke A. Bryant

Electronic Theses and Dissertations

As a leading cause of death worldwide, cancer and its treatments remain a primary source of interest among researchers. Modern studies are looking into bioselective cytotoxicity to create new chemotherapies that do not have the same harsh side effects as those we use today. Natural product research has a promising future for the development of such treatments. Specifically, polar flavonoids may be the key to a bioselective treatment. Such flavonoid species are native to plants, often within flower petals or within the body. A natural antioxidant, they are designed not to harm healthy cells. This study focuses on the plant …

Exploring The Potential Benefits Of Combining Cannabidiol And Beta-Caryophyllene For Neuropathic And Inflammatory Pain: A Systematic Review, Khalid Benamar

School of Medicine Publications

Purpose: In this review, we examined the analgesic effect of the combination of cannabidiol (CBD) and beta-caryophyllene (BCP) in different pain conditions.

Methods: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Literature searches were performed across major academic databases (Google Scholar, Web of Science, and PubMed) from 2009 to 2026 to identify studies investigating the analgesic effect of the combination of CBD and BCP.

Results: The search identified 31 records. Ten reports were screened and assessed for eligibility, and five studies met the inclusion and exclusion criteria. Findings consistently demonstrate …

Release Of Bound Steroid From The Androgen And Estrogen Receptors Is Induced By Ddt And Its Analogs, Matthew D. Rosales, Tahyra Soto, Jacqueline I. Goodship, Ahyssa R. Cruz, Isaac A. Rodriguez, Ventura Cuba Flores, Amanda Chavez, Monica P. Solis, Esmeralda Lopez, Frank B. Dean, Evangelia Kotsikorou

School of Integrative Biological & Chemical Sciences Faculty Publications

The pesticide p,p'-DDT (DDT) and its analogs (p,p'-DDD, o,p'-DDD, and p,p'-DDE) inhibit the binding of dihydrotestosterone (DHT) to the androgen receptor (AR) and estradiol (E2) to the estrogen receptor (ERα) ligand-binding domains (LBDs), as previously reported. In this study, we introduce assays to measure the release of receptor-bound steroids. These compounds induced the release of DHT from the AR LBD and E2 from the ERα LBD. These findings suggest that DDT and its analogs may interact with a surface site on the LBD, thereby allosterically disrupting steroid binding. One potential site is binding function 3 (BF3). To explore this possibility, …

Contraception Or Complication: A Review Of Depo-Provera’S Pharmacology And Public Health Implication, Phylicia Carpenter

Best Integrated Writing

This review article explores the link between progestogens and meningioma risk and outlines the biological mechanisms that may contribute to tumorigenesis. Two progestogens are emphasized through the paper: cyproterone acetate and medroxyprogesterone acetate (Depo-Provera). An important French study examining the relationship between progestogens use and meningioma risk is discussed, along with the health risks associated with long-term use. Additionally, this review advocates for increased routine prescriber-patient consultations and stronger drug regulation to educate and protect patients, particularly those experiencing socioeconomic disadvantages. It is important to note that the FDA recently updated the label for injectable medroxyprogesterone acetate in December 2025 …

Best Integrated Writing Fall 2026 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Kristie Mckiernan

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University.

Innovative Development Of Synthetic Biology Industry From Perspective Of Deep Integration Of Four Chains, Qin Guo, Chao Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Future industries represent the development direction of technological innovation and emerging industries, and are the main path to accelerate the formation of new quality productivity. As an important subsector of the future industry, synthetic biology industry is becoming a new track and new format for new quality productivity, and various regions are making cutting-edge directions such as synthetic biology industry a hot topic for future industrial layout. Based on the analysis of typical cities such as Shenzhen, Beijing, Tianjin, Shanghai, Hangzhou, and Changzhou, the current integration of the Four Chains in the synthetic biology industry is facing a four-dimensional dilemma …

Ai-Driven Drug Innovation Research: Trends, Challenges, And Countermeasures, Tian Miao, Qi Zhou, Lianzheng Zhou, Weijun Xu, Siyuan Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Artificial intelligence (AI) is profoundly transforming the innovation paradigm, industrial ecosystem, and business model of drug research and development. In recent years, the global AI-driven pharmaceutical market has grown rapidly. Major economies, multinational pharmaceutical enterprises, and technology giants are accelerating their strategic deployment. AI pharmaceutical industry has entered a critical stage of transitioning from proof-of-concept to commercial-application. China attaches great importance to the integrated development of AI and the biopharmaceutical industry, but it still faces challenges, including data scarcity, talent shortages, algorithmic black-boxes, regulatory lag, and weak foundations. This study proposes measures from the aspects of data supply, talent cultivation, …

Analysis And Study Of The Content Of Chloride Salts In Oil, Natalia Evgenievna Sheina, Muborak Akramovna Mirshomilova

Technical science and innovation

The article addresses the critical issue of crude oil quality control, specifically focusing on the determination of chloride salts (sodium, calcium, and magnesium), which exert a destructive impact on processing equipment. The paper provides a detailed analysis of the adverse effects of salts, which lead to severe equipment corrosion, scaling, and a reduced yield of valuable oil fractions. The chemical principles and specific applications of two standardized methods for analyzing aqueous extracts according to GOST 21534-2021 and ASTM D3230 are described: indicator (argentometric and mercurimetric) and potentiometric titration. The experimental section presents the results of a comparative analysis of crude …

October 2026, Swosu Rural Health Center

RURAL ROCKS

SWOSU Rural Health Center Highlights Innovation at Oklahoma Rural Health Conference

Rural Health. Community Strength

Adverse Events Linked to Injectable Glutathione Compounded with Dietary Supplement Grade Ingredient: Current Situation | HAIs | CDC

Epic shifts focus to cybersecurity while AI, interoperability agenda still on track, company says

UnitedHealthcare, Cigna, Centene sign on to CertifyOS' new provider credentialing model

Hospitals' use of AI coding tools cost BCBSA plans $942M more for similar care: analysis

Why Prime Therapeutics is betting on bridging the gaps between medical, pharmacy benefits

HRSA names 10 drugmakers for revised 340B rebate pilot ahead of 2027 launch

HRSA …

Making Indole-Based Drug Ingredients Faster With A Simple Iron Catalyst, Samuel Voell, Eike B. Bauer

Undergraduate Research Symposium

Substituted indoles have significant pharmaceutical relevance and are common building blocks in medicinal chemistry. They are part of many approved drugs across various areas and are also widely explored as leads for antiviral and antibacterial activity. This includes treatment of MRSA, a bacterium type that is resistant to common antibiotics and responsible for complicated infections. Many reactions in pharmaceutical production are slow and inefficient; catalysis facilitates the synthesis of pharmaceutically relevant products. Catalysis provides an efficient, lower-energy pathway to form a product, thereby saving time and energy. Ferrocenium tetrafluoroborate (FcBF4), is a catalyst we are currently investigating. FcBF4 is an …

Enantioselectivity Of The Photochemical Continuous-Flow Isomerization Of Humulones, Gregory M. Giovine, Trevor Smith, Bruce Hamper

Undergraduate Research Symposium

Humulones, the primary natural product present in the historically significant hop flower, represent a largely unexplored candidate for structure-based pharmaceutical design.  Showing promising biological activity as an anti-bacterial and anti-inflammatory agent, humulones are of interest both for their bioactive properties and for their long-established tolerability and natural abundance.  Humulones undergo a characteristic isomerization reaction, where the six-membered substituted phloroglucinol ring contracts to a five-membered ring isohumulone, under a variety of conditions, including those enabled by brewing conditions (thermal, metal-catalyzed) and by exposure to UV light.  Optimization of the photocatalyzed isomerization of n-humulone to n-isohumulone in flow conditions resulted in a …

Overview Of Glp-1ra Medications, Thomas A.F. Cordaro Pharmd, Sumaiya A. Difaa Pharmd, Amel J. Basil Pharmd

Transformative Medicine

GLP-1 is an incretin hormone that is naturally produced in the body that regulates blood glucose and appetite. The first GLP-1RA that was FDA approved, exenatide, in 2005, originated from the Gila monster and beaded lizard, via the discovery of the exendin-4 peptide. GLP-1RAs function by mimicking endogenous GLP-1 incretin hormone, leading to an increase in glucose-dependent insulin release from beta-cells of the pancreas, decrease in glucagon release, delayed gastric emptying, and satiety. Due to the benefits seen from initiating GLP-1RAs in the market, it sparked interest in numerous studies which proved that certain GLP-1RAs can provide cardiorenal protection. The …

Glp-1 Receptor Agonists And Wound Healing In Diabetic Foot Ulcers: A Scoping Review, Merlin Sajeev, Amanda L. Killeen

School of Podiatric Medicine - Student Research

Level of Evidence: Level 5

Poster Category: Non-sponsored

Introduction: Diabetic foot ulcers (DFUs) are a major complication of diabetes and are associated with delayed wound healing, infection, amputation, and substantial morbidity. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) improve glycemic control and may influence inflammation, vascular function, and tissue repair. However, clinical evidence evaluating their relationship with DFU healing remains limited.

Aim: To characterize available clinical evidence examining the association between GLP-1 RA use and wound-healing outcomes in patients with diabetic foot ulcers.

Methods: PubMed and Google Scholar were searched for English-language studies published from 2021–2026 using terms combining “GLP-1 receptor …

Journal Ida 2023 102 4

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Prenatal Cannabis Exposure Is Associated With Occipitotemporal Brain Surface Area In Neonates, Alexander J. Dufford, Sun Hyung Kim, Martin Styner, Xinyi Shen, Erika Iisa, Marilyn A. Huestis, Peter Fried, Christine Conageski, Jocelyn E. Phipers, Cristina Sempio, Jost Klawitter, Pilyoung Kim, Tessa L. Crume

Institute of Emerging Health Professions Faculty Papers

IMPORTANCE: Prenatal cannabis use has been associated with neurodevelopmental consequences for the offspring beginning in childhood; however, it is unclear if neonatal brain structural morphometry is impacted shortly after birth.

OBJECTIVE: We examined differences in regional surface morphometry among neonates exposed to chronic in utero cannabis compared to unexposed neonates.

DESIGN: The Moms Helping Moms study is a prospective pre-birth cohort selected based on chronic prenatal cannabis use and an unexposed control group. Exclusion criteria included alcohol, tobacco, or other substance use. Participants included in this analysis included 18 mother-neonate pairs with prenatal cannabis exposure and 21 unexposed pairs. Chronic …

Studying Peripheral Neuropathy And Associated Neuropathic Pain In Hiv-1 Transgenic Rats: Evaluation Of The Therapeutic Effect Of Cannabidiol And Beta-Caryophyllene, Mohammed Alnoud, Jose Rios, Salique Hassan Shaham, Manish K. Tripathi, Khalid Benamar

School of Medicine Publications

Background/Objectives: Peripheral neuropathy affects up to 50% of people living with HIV (PLWH). Currently, no small translational rodent model accurately replicates the peripheral neuropathy observed in PLWH. The primary objectives of this study are to assess whether HIV transgenic (HIV-tg) rats develop peripheral neuropathy with pathological and pain-like behaviors similar to those observed in PLWH and to evaluate the analgesic effects of the non-psychoactive cannabis compounds cannabidiol (CBD) and β-caryophyllene (BCP) in HIV-related neuropathic pain. Methods: We used a comprehensive set of behavioral, pharmacological, molecular, biochemical, and proteomic approaches. Results: Tissue analyses showed that HIV-tg rats had significantly reduced intra-epidermal …

Antigen 85b Of Mycobacterium Tuberculosis: From Immunodominant Antigen To Vaccine Candidate, Vivek Chauhan, Gaytri Mahajan, Rakesh Kumar, Shrikanth S. Gadad, Subhash Chauhan, Chinnaswamy Jagannath, Subramanian Dhandayuthapani

School of Medicine Publications

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), continues to pose a significant global health challenge despite the existence of effective treatments. The only licensed TB vaccine, Bacillus Calmette–Guérin (BCG), offers inconsistent and generally limited protection against adult pulmonary TB. As a result, the pursuit of more effective TB vaccines has intensified over the past two decades, prompting the evaluation of several immunodominant Mtb antigens as vaccines. Among these, antigen 85B (Ag85B) has emerged as a promising candidate due to its critical roles in mycobacterial cell wall biosynthesis, host cell adhesion, and the induction of immune responses. Ag85B has been incorporated …

Charge Modulation Of Peptide/Nucleic Acid Complexes: An Anionic Additive Enhances Gene Silencing And Crispr/Cas9 Editing By Promoting Intracellular Nucleic Acid Release, Abdulelah Alhazza, Sorour Khayyatnejad Shoushtari, Hasan Uludag, Keykavous Parang, Hamidreza Montazeri Aliabadi

Pharmacy Faculty Articles and Research

Introduction: Small interfering RNA (siRNA) and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated Protein 9 (Cas9) complexes are effective approaches to temporarily downregulate protein expression via post-transcription RNA interference or permanently altering protein expression via editing genomic DNA, respectively. However, the efficient delivery of these mediators to targeted cells has been challenging, largely due to their anionic and hydrophilic nature, which hinders their interaction with the cell membrane and cellular internalization. Cell-penetrating peptides (CPPs) exhibit dual characteristics as a carrier for nucleic acid delivery, where positively charged components bind to the negatively charged nucleic acid, and the hydrophobic components …

An Observational Study Of The Effect Of Concomitant Levetiracetam On Apixaban Concentrations In A Hospital Cohort, Chazmyn Riley, Kevin Lam, Cristina Micale, Lynda Thomson, Douglas F. Stickle, Walter K. Kraft

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Despite the lack of evidence of a mechanism-based drug interaction, some professional organizations have advised caution coadministering apixaban and levetiracetam. Eligible patients taking apixaban with or without levetiracetam for any indication for at least 72 h were screened from the electronic medical records. Plasma samples from 77 patients were retrieved from salvaged clinical blood collections. Apixaban minimum and maximum concentrations (Cmin and Cmax) were compared using descriptive statistics in R. While the median Cmin and Cmax appear to be marginally elevated, there were no apparent differences relative to apixaban alone. These findings suggest no apparent interaction of levetiracetam and support …

Timing Of Isotretinoin Exposure And Early Postoperative Complications After Anterior Cruciate Ligament Reconstruction, Areeb Ahmad, Ronald J. Shamus, Kassem Ghayyad, Daryl C. Osbahr, Adam J. Money, Michael G. Ciccotti, George J. Richard

Rothman Institute Papers

INTRODUCTION: Isotretinoin (ITN) is widely prescribed for severe acne in adolescents and young adults, a population where anterior cruciate ligament reconstruction (ACLR) is commonly performed. Long-standing concerns about impaired wound healing have prompted many surgeons to delay procedures, despite limited orthopaedic-specific evidence. This retrospective case series evaluates early postoperative clinical complications in patients with documented ITN exposure undergoing ACLR.

METHODS: We retrospectively reviewed primary ACLR cases from 2015 to 2025 at a multisite orthopaedic practice with documented ITN exposure within 12 months of surgery and at least 3 months of follow-up. ITN exposure was categorized as perioperative (≤10 days), recent …

September 2026, Swosu Rural Health Center

RURAL ROCKS

Introducing Hilltop Health: Connecting Campus, Community & Care

This fall marks an exciting new chapter for SWOSU Hilltop Health as services and partnerships continue to grow within the Jerry & Margaret Hodge College of Pharmacy and Rural Health Center. Designed to create a more connected approach to health and wellness, Hilltop Health brings together healthcare access, prevention, education, and community resources while creating new opportunities for collaboration across SWOSU and western Oklahoma.

Unique Pharmaceutical Laboratories (A Div. of J. B. Chemicals & Pharmaceuticals Ltd.) Issues Voluntary Nationwide Recall of Cetirizine Hydrochloride Tablets USP 5 mg Due to Potential Cross Contamination …

Development Of Ultrafast Protein Digestion And Standards Free Quantitation Methods For Mass Spectrometric Analysis, Praneeth Ivan Joel Fnu

Dissertations

A wide variety of biologically important molecules, such as enzymes, antibodies, hormones, transporters and receptors are proteins by composition and they play key roles in biological functions such as cellular regulation, communication, metabolism and physiological function. Protein dysfunctions and abnormalities are associated with numerous diseases, making proteins critical targets for understanding disease mechanisms and developing therapeutic interventions. Protein-based therapeutics such as monoclonal antibodies, hormones and vaccines gained popularity due to their high specificity, efficacy, and ability to treat complex diseases that are often difficult to address with small-molecule drugs.

Given the important role of proteins in a variety of biological …

Isolation, Structural Characterization, And In Vitro Bioactivity Assessment Of Extracellular Vesicles Derived From Lacticaseibacillus Paracasei, Dwi Liza Ramadiani, Ratika Rahmasari, Tri Wahyuni, Kusmiati Kusmiati, Herman Irawan, Khatarina Meldawati Pasaribu

Pharmaceutical Sciences and Research

The field of study on extracellular vesicles (EVs) has recently focused on probiotic bacteria, due to their ability to exhibit a wide variety of biological activity. Therefore, this study aims to evaluate the effect of nutrient modulation during Lacticaseibacillus paracasei cultivation on EVs production and bioactivity. EVs were isolated by ultrafiltration method and were characterized using NTA and cryo-TEM. An in vitro evaluation was used to assess the bioactivities, antioxidant properties, anti-inflammatory potential, and ability to inhibit α-glucosidase activity. The results showed that the 2 LPEV exhibited the characteristics of vesicles with size of 96.04–100.29 nm. Cultivation in 50% MRS …

Metabolomic And Biochemometric Profiling Of Tecoma Stans With Mechanistic Insights Of Its In Vitro Cytotoxic Activity, Ahmed Sekkien, Noha Swilam, Dalia Adel Al-Mahdy, Meselhy Ragab Meselhy, Mohamed Mohey Elmazar, Maha Abdollah, Muhammad Alsherbiny

Pharmacy

Tecoma stans is an ornamental plant recognized for its diverse biological activities, including notable cytotoxic effects. This study integrates LC–MS/MS-guided biochemometric analysis with mechanistic cytotoxicity evaluation to prioritize metabolites potentially associated with the cytotoxic activity of T. stans leaves. The hydroalcoholic extract and its solvent fractions n-hexane (HEX), dichloromethane (DCM), and ethyl acetate (EAC) were assessed for in vitro cytotoxicity against human lung adenocarcinoma (A549) and ovarian carcinoma (SKOV-3) cell lines using the MTT assay. Comprehensive LC–MS/MS-based metabolomic profiling and biochemometric correlation analysis were performed on the DCM fraction. The major correlated compound, chrysoeriol (CRY), was isolated and, along …

Norman H. Cromwell, Unl Chemistry; Nu System Dean; Eppley Cancer Center Director, Norman H. Cromwell, Pete Boughn, Mark A. Griep

UNL ORCA Interview Series

This 1980 interview of Normal Cromwell was done by Pete Boughn at the University of Nebraska Medical Center in Omaha. He asked about Cromwell’s history but mostly about his time as director of the Eppley Cancer Center. The interview is reproduced with permission from the UNMC McGoogan Library.

Cromwell was born in 1913 in Terre Haute, Indiana. In 1935, he earned a bachelor’s degree in chemical engineering from the Rose-Hulman Institute of Technology in his hometown. In 1939, three things happened: he earned a doctorate in organic chemistry from the University of Minnesota, he got married, and he was hired …

Exploring Red Palm Oil As A Sustainable Plasticizer For Carbon Black-Filled Ssbr/Br Tire Tread Compounds: A Comparative Evaluation Of Commercial Alternatives, Norma Arisanti Kinasih, Mohamad Irfan Fathurrohman, Santi Puspitasari, Dewi Kusuma Arti, Abdulhakim Masa

Journal of Materials Exploration and Findings

This study investigates the application of red palm oil (RPO) as an alternative vegetable oil resource to substitute petroleum-based plasticizers, which have environmental and health concerns, in carbon black (CB)-filled SSBR/BR tire tread compounds. The plasticizing effects of RPO were thoroughly evaluated by comparing them with a commercial bio-based plasticizer, Epoxidized Soybean Oil (ESBO), and two safer petroleum-based oils, Naphthenic Oil (NYNAS) and Treated Distillate Aromatic Extract (TDAE). The initial investigation shows that fatty acid composition is imposing regarding the plasticizing effect. The higher unsaturated fatty acid content in RPO than in ESBO improved tensile strength and degraded rolling resistance …

Metallurgical Investigation Of A Modified Eye Bolt Failure Caused By Improper Weld Extension, Specification Deviation, And Crevice Corrosion, Dimas Muhammad Fawwaz, Reza Miftahul Ulum, Johny Wahyuadi Soedarsono, Yudha Pratesa

Journal of Materials Exploration and Findings

A modified eye bolt from the David Arm Manhole Storage Tank underwent thorough metallurgical study due to the consequences of the bolt's malfunction during operation. Safety issues arose when the manhole door detached during operation. The mechanical testing and chemical composition analysis of the bolts indicated they were manufactured from an ASTM A193 Grade B7 material used for high-temperature bolting. This material did not conform to the engineering drawing, which mentioned SA 563A, which is about nuts, not bolts. This contradiction clearly shows that the eye bolt which was installed does not conform to the intended design. Welded connections of …

Rejection Of Fe (Iron) And Kmno4 (Organic Substance) Parameters In Peat Water Using Organic Membranes, Muhamad Rafli Sakti Mulia Gonera, Siti Umi Kalsum, Sarah Fiebrina Heraningsih

Journal of Materials Exploration and Findings

Peat water is a surface water source widely used by people in swampy and lowland areas, but it has poor quality characteristics such as high organic matter content, low pH, and dissolved metal levels such as iron that exceed the threshold. These conditions can cause health problems and reduce the quality of clean water so that effective treatment technology is needed. This study aims to analyze the effectiveness of ultrafiltration membranes made from chitosan from shrimp shell waste in rejecting iron (Fe) and organic substances in peat water, and to determine the effect of pressure on separation performance. This study …

The Efficacy Of Transversus Abdominis Plane Block As An Adjunct To Spinal Anesthesia For Cesarean Delivery: An Evidence Synthesis And Implementation Toolkit, Alyssa Hebert, Alex Potts, Gabriela Robertson

Graduate Theses, Dissertations, and Capstones

Postoperative pain hinders cesarean delivery recovery and overall patient experience. Although spinal anesthesia with intrathecal opioids remains the standard of practice, associated side effects and concerns regarding opioid exposure highlight the need for effective opioid-sparing strategies. Anesthesia providers play a critical role in advancing postoperative pain management through evidence-based protocol development, provider education, and interdisciplinary collaboration to optimize maternal outcomes. The transversus abdominis plane (TAP) block provides somatic analgesia to the anterior abdominal wall by targeting the thoracolumbar nerves (T6–L1) and has increasingly been incorporated into multimodal postoperative pain management strategies for abdominal surgery. Nevertheless, a gap remains in obstetric …

Towards The Synthesis Of Dragonamide E And Analogs Thereof, Dante Glover

Chemistry Theses

Leishmaniasis is a disease caused by a parasite spread through the female sand fly. It is categorized as a Neglected Tropical Disease and can cause very severe symptoms, even death, if left untreated. Symptoms include skin lesions that can cause permanent scarring, and mucosal membrane infections that can cause facial deformities. More aggressive forms of leishmaniasis can lead to infections of internal organs like the liver and/or spleen and can lead to death. Drug resistance of these parasites has rendered treatment limited and the side effects of which can be harmful as well.

Scientists looking towards new treatments for tropical …