Chemicals and Drugs Commons^™

Exploring The Intersection Of Sexual Identity And Route Of Administration In Relation To Cannabis Use Among Young Adult Females, Sarah J. Ehlke, Samantha A. Fitzer, Jennifer L. Shipley, Abby L. Braitman

Psychology Faculty Publications

Background and Objective: Rates of cannabis use continue to increase with sexual minority women (SMW) reporting greater use than heterosexual women. Along with these increasing trends, the routes of administration (ROA) for cannabis are evolving. The current study examined associations between cannabis ROA and frequency of use, as well as differences across sexual identity (heterosexual vs. SMW).

Methods: Participants were 949 young adult (18–25 years old) women (29.8% SMW) who reported past month cannabis use and were recruited through Amazon Mechanical Turk. Number of cannabis use days and each ROA used (joint, pipe, blunt, bong, vape, edible, and ointment) in …

Synergistic Interactions And Emulsion Preparation Of Antioxidant Potential Of Cannabidiol And Cold Brew Coffee, Karina Rosa

Theses, Dissertations and Culminating Projects

Antioxidants play an important role in mitigating the damage caused by oxidative stress in the human body. Over time, the oxidative stress can lead to diseases such cardiovascular disease, neurodegenerative disorders and even cancer. Notably, both cannabidiol and coffee antioxidants. Purpose: To investigate the interaction between the antioxidant potential observed from the combination of CBD and cold brew coffee and compare it to their individual effects. Additionally, develop a methodology for emulsion preparation for analysis of antioxidant potential of a beverage made of cold brew coffee infused with CBD. Materials and Methods: Two cold brew coffee and two CBD oil …

Young People's Alcohol Use In And Around Water: A Scoping Review Of The Literature, Renee N. Carey, Gemma Crawford, Jonine Jancey, Tina Lam, Lauren Nimmo, Gina Trapp, Christina Pollard, Paula Hooper, Justine E. Leavy

Research outputs 2022 to 2026

Issues: The surrounding social and commercial context, including alcohol advertising, heavily influences alcohol consumption. Alcohol use is a major risk factor for both fatal and non-fatal drowning, particularly for young people. Approach: We conducted a scoping review to explore the peer-reviewed literature on the use of alcohol by young people (aged 15–34 years) in the context of aquatic environments. Five electronic academic databases were searched for English-language studies conducted in high-income countries and published in the last 15 years (since 2008). The MetaQAT framework was used to assess methodological quality of included studies. Key Findings: The review included a total …

Insulin Signal Transduction Mediates Ethanol-Induced Feeding Dysfunction In A Fly Model Of Fetal Alcohol Spectrum Disorder, Manae Matsubara

McNair Research Journal SJSU

No abstract provided.

Selective Serotonin Reuptake Inhibitors And Pharmacological Resetting Of The Mind, Ion G. Motofei, David L. Rowland

Journal of Mind and Medical Sciences

Mental activity is capable of processing analytical data (mathematics, physics, socio-political science, philosophy, etc.) similar to computer software. At the same time, mental activity largely depends on the brain, which works like a hard component of a computer. While the computer stores data on a physical medium, mental activity and data are supported by physiological mechanisms that are constantly operating (both in wakefulness and sleep). For this reason, the lack of brain oxygenation even for short periods of time (5-10 minutes) causes the loss of all data, including the disappearance of the individual's existence as a mental entity. This means …

Sildenafil Versus Placebo For Early Pulmonary Vascular Disease In Scleroderma (Sepvadis): Protocol For A Randomized Controlled Trial, Matthew R. Lammi, Monica Mukherjee, Lesley Ann Saketkoo, Kyle Carey, Laura Hummers, Steven Hsu, Amita Krishnan, Marie Sandi, Ami A. Shah, Stefan L. Zimmerman, Paul M. Hassoun, Steven C. Mathai

School of Medicine Faculty Publications

BACKGROUND: Pulmonary hypertension (PH) is a leading cause of death in patients with systemic sclerosis (SSc). An important component of SSc patient management is early detection and treatment of PH. Recently the threshold for the diagnosis of PH has been lowered to a mean pulmonary artery pressure (mPAP) threshold of > 20 mmHg on right heart catheterization (RHC). However, it is unknown if PH-specific therapy is beneficial in SSc patients with mildly elevated pressure (SSc-MEP, mPAP 21-24 mmHg). METHODS: The SEPVADIS trial is a randomized, double-blind, placebo-controlled phase 2 trial of sildenafil in SSc-MEP patients with a target enrollment of 30 …

Design A Friendly Nanoscale Chemical Sensor Based On Gold Nanoclusters For Detecting Thiocyanate Ions In Food Industry Applications, Reham Ali, Sayed M Saleh

Faculty, Staff and Student Publications

The surfactant cetyltrimethylammonium bromide (CTAB) induces the aggregation of gold nanoclusters (GNCs), leading to the development of a proposed fluorometric technique for detecting thiocyanate (SCN-) ions based on an anti-aggregation mechanism. This approach is straightforward to execute, highly sensitive, and selective. A significant quenching effect occurs in fluorescence upon using the aggregation agent CTAB in GNCs synthesis, resulting in a transition from intense red fluorescence to dim red. The decrease in fluorescence intensity of GNCs in the presence of CTAB is caused by the mechanism of fluorescence quenching mediated by aggregation. As the levels of SCN- rise, the fluorescence of …

Affect Variability And Cortisol In Context: The Moderating Roles Of Mean Affect And Stress, Brooke N. Jenkins, Logan T. Martin, Hee Youn (Helen) Lee, John F. Hunter, Amanda M. Acevedo, Sarah D. Pressman

Psychology Faculty Articles and Research

Positive and negative affect have been shown to have implications for hormones like cortisol but how moment to moment changes in affect (i.e., affect variability) influence cortisol secretion is less well understood. Additionally, context characteristics such as mean affect and stress may influence the association between affect variability and cortisol output. In the current study, we examined affect, stress, and cortisol data from 113 participants (age range = 25–63, M = 35.63, SD = 11.34; 29 % male; 42 % White/Caucasian, 37 % Asian or Pacific Islander, 13 % Hispanic/Latino, 4 % Black/African American, 1 % Native American, Eskimo, or …

Education Of The Effects Of Obesity Medications And A Stepwise Approach To Mitigate Prevalence And Encourage Lifestyle Medicine For Primary Care Physicians, Kiely M. Curran

Department of Nutrition Student Projects

My Capstone project is an Educational Manual that emphasizes a healthcare team approach to the treatment and management of obesity. The Educational Manual consists of a standardized protocol in management of obesity in patients and a document with summarized references for primary care providers; and a simplified document for patient education. There is a growing interest in the usage of obesity medications. The purpose of my Capstone project is to provide a simplified manual for the primary care provider to reference to make knowledgeable and patient-centered decisions in the prescription of obesity medications and decisions in weight-management. My methodology included …

The Purification And Thermal Stability Of The Peroxidase Enzyme In Cucurbita Moschata, Garen Hamner

Senior Honors Theses

Peroxidases are enzymes that catalyze the reduction of hydrogen peroxide to water while oxidizing organic substrates and are valuable in spheres like industrial and medical applications and histochemistry. Limitations still exist in the use of the well-studied horseradish peroxidase for certain activities due to limitations like poor thermal stability, thus the search for novel peroxidases that can overcome these limitations is an active area of research. Butternut squash peroxidase (Cucurbita moschata) (BSP) shows promise due to significant activity being found in the skin and apparent enhanced thermal stability, but an efficient purification scheme for it is lacking, as well as …

Psychedelic-Assisted Therapy: An Emerging Best Practice For Trauma Care?, Amelie Neubert '24

Social Work Student Scholarship

Amelie Neubert ’24, Social Work major
Faculty Mentor: Dr. Katherine Kranz, Social Work

Predicting Ffar4 Agonists Using Structure-Based Machine Learning Approach Based On Molecular Fingerprints, Zaid Anis Sherwani, Syeda Sumayya Tariq, Mamona Mushtaq, Ali Raza Siddiqui, Mohammad Nur-E-Alam, Aftab Ahmed, Zaheer Ul-Haq

Pharmacy Faculty Articles and Research

Free Fatty Acid Receptor 4 (FFAR4), a G-protein-coupled receptor, is responsible for triggering intracellular signaling pathways that regulate various physiological processes. FFAR4 agonists are associated with enhancing insulin release and mitigating the atherogenic, obesogenic, pro-carcinogenic, and pro-diabetogenic effects, normally associated with the free fatty acids bound to FFAR4. In this research, molecular structure-based machine-learning techniques were employed to evaluate compounds as potential agonists for FFAR4. Molecular structures were encoded into bit arrays, serving as molecular fingerprints, which were subsequently analyzed using the Bayesian network algorithm to identify patterns for screening the data. The shortlisted hits obtained via machine learning protocols …

Two Green Uv-Spectrophotometric Techniques Applying Successive And Progressive Resolution With New Concepts For Simultaneous Determination Of Completely Overlapping Ternary Mixture, Ekram Hany Mohamed, Menna Hesham, Ehab Elkady, Sally Mohkles

Pharmacy

A spectrophotometric platform based on two smart techniques namely Double Divisor ratio difference spectra spectrophotometry (DDRD) and Derivative ratio amplitude difference method (DR-AD) was applied and validated. These techniques were used for determining and resolving the overlapped spectra of the 3 drugs paracetamol (PAR), pseudoephedrine (PSE) and pholcodine (PHO) in their ternary mixture. DDRD is a successive technique while DR-AD is a progressive one. In DDRD, the mixtures’ spectrum underwent division by a double divisor, and then the ratio difference method was applied. For DR-AD, consequent steps were performed to resolve each drug stepwise. DR-AD technique included division using a …

Broad-Spectrum Activity Of Membranolytic Cationic Macrocyclic Peptides Against Multi-Drug Resistant Bacteria And Fungi, Sandeep Lohan, Anastasia G. Konshina, Rakesh K. Tiwari, Roman G. Efremov, Innokentiy Maslennikov, Keykavous Parang

Pharmacy Faculty Articles and Research

The emergence of multidrug-resistant (MDR) strains causes severe problems in the treatment of microbial infections owing to limited treatment options. Antimicrobial peptides (AMPs) are drawing considerable attention as promising antibiotic alternative candidates to combat MDR bacterial and fungal infections. Herein, we present a series of small amphiphilic membrane-active cyclic peptides composed, in part, of various nongenetically encoded hydrophilic and hydrophobic amino acids. Notably, lead cyclic peptides 3b and 4b showed broad-spectrum activity against drug-resistant Gram-positive (MIC = 1.5–6.2 µg/mL) and Gram-negative (MIC = 12.5–25 µg/mL) bacteria, and fungi (MIC = 3.1–12.5 µg/mL). Furthermore, lead peptides displayed substantial antibiofilm action comparable …

Short-Term Effects Of Caffeine Supplementation On Cardiac Dynamics And Anaerobic Strength Output In Collegiate Male Athletes, Tyler Clum, Katelyn Messner, Alyssa Jagger, Caeden Gurganus, Kylie Miller, Rema Suniga

ONU Student Research Colloquium

ABSTRACT. Caffeine, a widely consumed drug, has been shown to significantly increase heart rate (HR) and blood pressure (Geethavani et al., 2014), but had only insignificant changes in these cardiovascular measurements (Alhabeeb et al., 2022); while Matsumara and his colleagues (2023) reported that caffeine decreased 100-meter sprint times indicating that caffeine may improve anaerobic performance. The current study investigated the short-term effects of caffeine on heart rate (HR, beats per minute), blood pressure (mmHg), and 20-yard sprint performance time (seconds; Dashr Sprint Timing System). These parameters were measured in triplicate before and at 45-minutes after caffeine supplementation at a dose …

Beyond Mitragynine: Composition Survey And Stability Assessment Of Kratom Tea Ordered Via Food Delivery Platforms In Bangkok, Thailand, Yuta Tokuda, Apinya Tubtimrattana, Nat Tansrisawad, Kornvalee Meesilpavikkai, Parath Thirati

Chulalongkorn Medical Journal

Background: Kratom is a native tree to Southeast Asia. Kratom leaves have long been used medicinally and recreationally due to their stimulative and opioid-like effects attributed to high endogenous levels of mitragynine and related alkaloids. Kratom is widely consumed as tea and is now publicly sold, including on food delivery platforms, after recent decriminalization despite selling of kratom products being still considered illegal by other acts.

Objectives: To assess the formulas of kratom teas sold on Thai food delivery platform together with their consistency and the stability of refrigerated teas.

Methods: Kratom alkaloids, mitragynine and 7-hydroxymitragynine, and additive contents of …

Aspects Of Pharmaceutical Networks, Hannah Rita Joseph, Afia L. Rahaman, Kaya Wilson

ENGL 1102 Showcase

The theme of our anthology is different drugs and processes of drug usage in the result how the various aspects of the pharmaceutical companies. We analyze the quality of health that Americans receive from certain parts of the health care industry. We have focused on informing and analyzing the increase of insulin prices, and how that affects Americans everyday lives. The delivery methods of medical cannabis, how each method is effective, and how they are administered. As well as pharmaceutical scams and how it affects elderly people, who rely on medication.

Investigation Of The Anticancer Activity Of Phenylbismuthbis(4-Carboxychalcone), Megan Baker

Undergraduate Theses

Cancer is currently the second leading cause of death in the US. While much progress has been made, there is still a significant need for novel therapies. Chalcones are privileged, natural products that have shown cytotoxic activity and potential as chemotherapeutics in multiple cancerous cell lines. Additionally, bismuth complexes of small organic molecules have been shown to have anti-tumor activity. The anti-proliferative activity of phenylbismuthbis(4-carboxychalcone), a bismuth-coordinated chalcone was assessed in multiple cancer cell lines using MTS assays. The compound demonstrated micromolecular inhibition. Additionally, mechanism of action studies were performed to assess if the anti-proliferative activity seen is due to …

Identification And Characterization Of Novel, Small Molecule Inhibitors Of Spermine Oxidase, Amelia Bryn Furbish

MUSC Theses and Dissertations

The major intracellular polyamines spermine and spermidine are abundant endogenous compounds that are essential for cellular growth and development. Dysregulation of polyamine metabolism has been implicated as a key mechanism of injury across multiple forms of clinically challenging pathologies. Of the enzymes within the polyamine pathway, the catabolic enzyme spermine oxidase (SMOX) is of particular interest as it is subject to induction in response to infection, neuronal excitotoxicity, ischemia, and oxidative stress. In addition to the loss of radical scavenging capabilities associated with spermine depletion, catabolism of spermine by SMOX results in the production of toxic byproducts, including H_{2 …}

Tabletized Nanomedicine: From The Current Scenario To Developing Future Medicine, Rahul Tiwari, Meghana Kolli, Sumeet S. Chauhan, Murali Yallapu

School of Medicine Publications

The limitations of conventional therapeutic treatments prevailed in the development of nanotechnology-based medical formulations, termed nanomedicine. Nanomedicine is an advanced medicine that often consists of therapeutic agent(s) embedded in biodegradable or biocompatible nanomaterial-based formulations. Among nanomedicine approaches, tablet (oral) nanomedicine is still under development. In tabletized nanomedicine, the dynamic interplay between nanoformulations and the intricate milieu of the gastrointestinal tract simulates a pivotal role, particularly accentuating the influence exerted upon the luminal, mucosal, and epithelial cells. In this work, we document the perspectives and opportunities of nanoformulations toward the development of tabletized nanomedicine. This review also unveils the notion of …