Physiology Commons^™

Hypothyroidism, Kelly Cruz '23, Riman Doodin '23, Venus Obazuaye '23

Human Diseases Graphic Novels

No abstract provided.

Med13 Degradation Defines A New Receptor-Mediated Autophagy Pathway Activated By Nutrient Deprivation, Sara E. Hanley

Graduate School of Biomedical Sciences Theses and Dissertations

Cells are exposed to an enormous amount of diverse extracellular cues but have a limited arsenal of weapons for protecting and maintaining homeostasis. To overcome these restrictions, nature has engineered proteins that have multiple functions. The pleiotropy of using one protein to carry out a variety of functions allows cells to rapidly execute tailored responses to a diverse set of signals. The Cdk8 kinase module (CKM) is a conserved detachable unit of the Mediator complex predominantly known for its role in transcriptional regulation. The CKM is composed of four proteins, the scaffolding proteins Med13 and Med12, as well as the …

Neurofibromatosis, Sanjana Nekkanti '23, Divya Choudhary '23

Human Diseases Graphic Novels

No abstract provided.

Endometriosis, Illinois Mathematics And Science Academy

Human Diseases Graphic Novels

No abstract provided.

Does Stress Physiology Mediate Disease Resistance In The Arizona Tiger Salamander (Ambystoma Mavortium Nebulosum)?, Megan Zerger

2023 Midwest Ecology & Evolution Conference

Amphibian biodiversity has greatly diminished in recent years due to disease. Panzootic pathogenic fungi Batrachochytrium dendrobatidis (Bd) causes the deadly disease chytridiomycosis (chytrid), a primary driver of catastrophic global amphibian declines and extinctions. The pathogenesis of chytrid is still unclear, as certain species and individuals within a species are differentially affected. Susceptibility and mortality of Bd are influenced by prolonged chronic stress. Prolonged glucocorticoid activity deleteriously affects many of the same physiological processes as Bd infections, and corticosterone is the primary glucocorticoid released by amphibians in response to stress. Thus, the objective of our study is to assess …

Effect Of Functional Trait Variation On Bee Body Temperature, Gabriella A. Muller

2023 Midwest Ecology & Evolution Conference

Bees are both ecologically and economically important pollinators for maintaining agricultural production and the health of many diverse ecosystems. As our world continues to change, bee diversity and population numbers are declining due to increasing temperatures. Functional traits such as body size and coloration can mediate the effects of such harsh thermal conditions on insect performance. Specifically, bee body size can significantly impact thermal parameters, with larger bees gaining and losing heat more slowly than smaller bees due to higher surface area to volume ratios. To obtain a better understanding of these relationships, we studied the variation in body temperature …

Effect Of Temperature Variation On Endurance Swimming Capacity Of Juvenile White Sturgeon (Acipenser Transmontanus), Alex M. Stolberg

2023 Midwest Ecology & Evolution Conference

White sturgeon (Acipenser transmontanus), a species within one of the most globally threatened taxa, are highly susceptible to changes in their environments due to unique life history traits. Specifically, juvenile white sturgeon are impacted by altered watershed dynamics caused by water diversion structures such as dams, weirs, irrigation ditches, or levees. One location of great concern is the Sacramento-San Joaquin (S-SJ) watershed where decades of water diversion has brought on changes to the temperature, flow, and management of the area. This study looks to primarily identify the impact of water temperature on the endurance swimming capacity of juvenile white sturgeon, …

The Miracle Doctor Vs. Pcos, Ellen Nguyen '24, Sindhu Chalasani '24, Iris Amit '24, Karina Byers '24

Human Diseases Graphic Novels

No abstract provided.

The Importance Of Translationally Evaluating Steroid Hormone Contributions To Substance Use, Erin E. Maher, Ashley Strzelecki, Jessica J. Weafer, Cassandra D. Gipson

Markey Cancer Center Faculty Publications

Clinically, women appear to be more susceptible to certain aspects of substance use disorders (SUDs). The steroid hormones 17β-estradiol (E2) and progesterone (Pg) have been linked to women-specific drug behaviors. Here, we review clinical and preclinical studies investigating how cycling ovarian hormones affect nicotine-, cocaine-, and opioid-related behaviors. We also highlight gaps in the literature regarding how synthetic steroid hormone use may influence drug-related behaviors. In addition, we explore how E2 and Pg are known to interact in brain reward pathways and provide evidence of how these interactions may influence drug-related behaviors. The synthesis of this review demonstrates the critical …

Effect Of Resistance Training On White Blood Cell Count And Chemotherapy Efficacy In Triple-Negative Breast Cancer Patients During Adriamycin-Cyclophosphamide Chemotherapy Treatment, Mimi Wassef

The Larrie and Bobbi Weil Undergraduate Research Award

Triple-negative breast cancer (TNBC) is one of the most difficult subtypes of breast cancer to treat due to a lack of molecular targets. While chemotherapy (CT) has become the standard form of treatment, the administration of CT depends on adequate white blood cell (WBC) count. When WBC becomes too low, patients risk becoming ineligible for treatment. In the general population, WBC count has been shown to increase as a result of exercise, but little research has been done on the effects of exercise and WBC count in the TNBC population. The purpose of this study is to determine if 12 …

Life Line Spring 2023, Otterbein Biology And Earth Science Department

Life Line - The Biology Department Newsletter

In this Issue:

Feathered Friends Living on Campus; The Hidden Mussels of the Olentangy River; Early Assurance Program Students Graduate from HCOM; Students Present at American Society for Microbiology Microbe 2022 Meeting; Environmental Science Upgrades Its Remote Monitoring Capabilities; Speed!; UK Students Visit Local Attractions; That's a Lottl Axolotls.

Introduction To Human Biology, Sharon S. Ellerton, Christopher Roblodowski

Open Educational Resources

This OER is intended as a textbook for a one semester introductory course in Human Anatomy and Physiology for non-science majors. It covers the major topics typically covered in A&P, but in a simplified, easier to understand manner. This textbook aims to educate students interested in lower-level health careers and non-science majors without the intimidating detail found in current textbooks. Text and images were created to be more accessible for these student populations.

The Possible Role For Basigin Receptor Function In The Induction Of Matrix Metalloproteinase Expression In Human Endometrial Stromal Cells, Amy Abel

All NMU Master's Theses

10-15% of couples worldwide are affected by infertility. The leading cause of infertility is implantation failure. Molecular communication in precise time and space between an implanting embryo and a receptive uterus is essential for successful implantation. Basigin has been shown to have vital functions within the implantation process. Basigin is best known for inducing the expression of matrix metalloproteinases. Basigin has been shown to induce MMP expression in vitro in human endometrial stromal cell lines (HESC). Understanding how basigin induces matrix metalloproteinases within normal cellular conditions will help researchers understand how these signaling cascades flow in the framework of implantation. …

Flexible Materials And Applications For Wearable Sensors, Brock Ferrari

Senior Honors Theses

This literature review aimed to address the limitations of rigid wearable sensors in the medical community by investigating the development of flexible materials for remote health monitoring. A keyword search was conducted on Google Scholar, PubMed, and the Jerry Falwell Library, which yielded 9,102 articles. After applying filtering techniques, the results were narrowed down to 21 articles, which were categorized into "Present Market Conditions," "Flexible Materials for Medical Use," "Applications for Wearable Sensors," and "Potential Use Cases." Discussions were held on prominent materials such as substrate, nanocomposite, and liquid metal materials, exploring their potential applications for chemical and physical sensing, …

A Look Into The Physiological Impacts Of Childhood Cancers And Modeling Of Tumor Growth Rate, Erica Steiner, Kimberly Hansen, Marissa Stanton

Honors Program: Senior Projects (Public)

Cancer is one of the deadliest diseases present in the world. Children have different reactions to diseases and treatments; thus, it is important to study those reactions specifically in children. Knowing how children are impacted by these factors can be helpful in diagnosis and treatment of cancer. I performed this study by researching the different types of cancer I was interested in and using MATLAB to code for and simulate a growth curve of a brain tumor. I found that there are many different physiological impacts of different cancers in children. As for the modeling, I was able to get …

A Comparison Of Continuous And Interval Exercise On Cognition In Young Adults, Emily C. Tagesen, Lawrence W. Judge, David M. Bellar

International Journal of Exercise Science

International Journal of Exercise Science 16(5): 458-468, 2023. Exercise stimulates the production and secretion of testosterone, cortisol, and brain-derived neurotrophic factor (BDNF) and affects cognitive performance. However, the interaction of these variables is unknown. To investigate these interactions, 21 college-aged men completed two work-matched exercise protocols: continuous (CONT) exercise and an interval protocol (INT). Blood and saliva samples were collected before and after exercise to quantify BDNF, cortisol, and testosterone. Participants completed a battery of cognitive assessments after exercise. A MANOVA analysis of condition demonstrated that no domains were significantly different after CONT and INT (p > 0.05). A repeated …

Blood Flow Restriction Attenuates Muscle Damage In Resistance Exercise Performed Until Concentric Muscle Failure., Victor Magalhães Curty, Paulo Vinicios Camuzi Zovico, Rafael Barrera Salgueiro, Leonardo Carvalho Caldas, Richard Diego Leite, Nuno Manuel Frade Souza, Lucas Guimaraes-Ferreira, Valério Garrone Barauna

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 469-481, 2023. The present study aimed to evaluate whether blood flow restriction (BFR) can prevent exercise-induced muscle damage in resistance exercise (RE) performed until concentric muscle failure (CMF). Twenty healthy volunteers (25 ± 4 years, 80.4 ± 11.8 kg, 175 ± 8 cm) performed three sets of unilateral biceps curl exercise (40% of 1RM) with (RE + BFR) and without (RE) BFR until CMF. A third condition was to perform the same number of repetitions as RE + BFR without using BFR (matched). Performing fewer repetitions, RE + BFR caused muscle fatigue post-exercise as …

The Mindful Athlete Program, Joanne Bullard, Sojung Kim

Rita & Larry Salva School of Nursing and Health Professions Departmental Research

According to the spring 2020 NCAA Well-Being Study, collegiate student-athletes reported experiencing mental health concerns due to the impact of the COVID-19 pandemic. The data indicated that student-athletes were experiencing mental health concerns 150%-250% higher than historically reported (NCAA, 2020). These concerns were prevalent among all divisions. For Division III student-athletes, mental health concerns experienced during the COVID-19 pandemic included “feeling overwhelmed by all they had to do, sleep difficulties, feeling mentally exhausted, feeling very lonely, feeling a sense of loss, and feeling very lonely and sad” (NCAA, 2020). This study indicated desired resources of Division III student-athletes included elements …

Effects Of Equine Interaction On Mutual Autonomic Nervous System Responses And Interoception In A Learning Program For Older Adults, Ann L. Baldwin, Lisa Walters, Barbara K. Rector, Ann C. Alden

People and Animals: The International Journal of Research and Practice

Equine-assisted learning (EAL) may improve the health of older adults, but scientific data are sparse. This study investigated whether people aged 55 and older show increased heart rate variability (HRV) during EAL and awareness of bodily sensations that are overall pleasant. Subjects (n = 24) participated in mindful grooming during which they slowed their breathing and brushed a horse while noticing sensations in their body and watching the horse’s reactions. The subject’s and horse’s HRV were recorded simultaneously before, during, and after mindful grooming. For control, the same subjects performed mindful grooming with a plush simulation horse. During exit …

Ijes Self-Study On Participants’ Sex In Exercise Science: Sex-Data Gap And Corresponding Author Survey, Matthew J. Garver, James W. Navalta, Michel J.H. Heijnen, Dustin W. Davis, Joel D. Reece, Whitley J. Stone, Shannon R. Siegel, T. Scott Lyons

International Journal of Exercise Science

International Journal of Exercise Science 16(6): 364-376, 2023. A sex-data gap exists between females and males within the sport and exercise science literature, and implications are far-reaching. The purpose of this work was to (a) heed recent calls and scrutinize data from within IJES to address the gap and (b) gain insight on self-identified sex of IJES corresponding authors. The present self-study included all published manuscripts from 2008 through 2021. A total of 851 publications were included, and 806 (94.7%) reported data on participant sex. There was a difference between publications that included only females (n = 132) versus …