The Inconstancy Of Bodies: Yvonne Meier's Works, 1985 ' 2012,
2015
CUNY Graduate Center
The Inconstancy Of Bodies: Yvonne Meier's Works, 1985 ' 2012, Lindsey Ann Drury
Dissertations, Theses, and Capstone Projects
What is ability? And conversely, what is disability? This research on the dancer and choreographer Yvonne Meier theorizes that her more than 30-year career has challenged the oft perceived polarities between function and dysfunction, utility and futility through the physical actions of dance performances. As she developed as a dancer and choreographer, Meier engaged in forms of movement training that pledged to expand her ability by unearthing the hidden causes and effects of actions. And yet, she created works which foregrounded the very gaps in knowledge between acts, their intentions, and effects. The fundamental disability expressed through Meier's works is …
Elongation Factor-P At The Crossroads Of The Host-Endosymbiont Interface,
2015
The Ohio State University
Elongation Factor-P At The Crossroads Of The Host-Endosymbiont Interface, Andrei Rajkovic, Anne Witzky, William Navarre, Andrew J. Darwin, Michael Ibba
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Elongation factor P (EF-P) is an ancient bacterial translational factor that aids the ribosome in polymerizing oligo-prolines. EF-P structurally resembles tRNA and binds in-between the exit and peptidyl sites of the ribosome to accelerate the intrinsically slow reaction of peptidyl-prolyl bond formation. Recent studies have identified in separate organisms, two evolutionarily convergent EF-P post-translational modification systems (EPMS), split predominantly between gammaproteobacteria, and betaproteobacteria. In both cases EF-P receives a post-translational modification, critical for its function, on a highly conserved residue that protrudes into the peptidyl-transfer center of the ribosome. EPMSs are comprised of a gene(s) that synthesizes the precursor molecule …
Workforce Fitness: Description, Contextual Issues, And Implications For Public Health,
2015
HealthPartners
Workforce Fitness: Description, Contextual Issues, And Implications For Public Health, Nicolaas P. Pronk
Frontiers in Public Health Services and Systems Research
Workforce fitness matters for the prevention of premature death, chronic diseases, productivity loss, excess medical care costs, loss of income or family earnings, and other social and economic concerns. Yet fitness levels appear to be relatively low and declining. Over the past half century obesity has doubled, physical activity levels are below par, and cardiorespiratory fitness often does not meet minimally acceptable job standards. During this time, daily occupational energy expenditure has decreased by more than 100 calories. It is recommended for employers to consider best practices and design workplace wellness programs accordingly. Regulations that protect and promote worker health, …
Multi-Stress Proteomics: The Global Protein Response To Multiple Environmental Stressors In The Porcelain Crab Petrolisthes Cinctipes,
2015
California Polytechnic State University, San Luis Obispo
Multi-Stress Proteomics: The Global Protein Response To Multiple Environmental Stressors In The Porcelain Crab Petrolisthes Cinctipes, Michael A. Garland
Master's Theses
Global climate change is increasing the number of hot days along the California coast as well as increasing the incidence of off-shore upwelling events that lower the pH of intertidal seawater; thus, intertidal organisms are experiencing an increase in more than one stress simultaneously. This study seeks to characterize the global protein response of the eurythermal porcelain crab Petrolisthes cinctipes to changes in thermal, pH, and tidal regime treatments, either combined or individually. The first experiment examined temperature stress alone and sought to determine the effect of chronic temperature acclimation on the acute heat shock response. We compared the proteomic …
Endogenous Opioid-Masked Latent Pain Sensitization: Studies From Mouse To Human,
2015
Righospitalet, Denmark
Endogenous Opioid-Masked Latent Pain Sensitization: Studies From Mouse To Human, Manuel P. Pereira, Renee R. Donahue, Jørgen B. Dahl, Marianne Werner, Bradley K. Taylor, Mads U. Werner
Physiology Faculty Publications
Following the resolution of a severe inflammatory injury in rodents, administration of mu-opioid receptor inverse agonists leads to reinstatement of pain hypersensitivity. The mechanisms underlying this form of latent pain sensitization (LS) likely contribute to the development of chronic pain, but LS has not yet been demonstrated in humans. Using a C57BL/6 mouse model of cutaneous mild heat injury (MHI) we demonstrated a dose-dependent reinstatement of pain sensitization, assessed as primary (P < 0.001) and secondary hyperalgesia (P < 0.001) by naloxone (0.3–10 mg/kg), 168 hrs after the induction of MHI. Forward-translating the dose data to a human MHI model (n = 12) we could show that LS does indeed occur after naloxone 2 mg/kg, 168 hrs after a MHI. Our previous unsuccessful efforts to demonstrate unmasking of LS in humans are thus likely explained by an insufficient naloxone dose (0.021 mg/kg). However, while LS was consistently demonstrated in 21/24 mice, LS was only seen in 4/12 subjects. This difference is likely due to selection bias since the C57BL/6 mouse strain exhibits markedly enhanced pain sensitivity in assays of acute thermal nociception. Future exploratory studies in humans should prioritize inclusion of “high-sensitizers” prone to develop LS and use post-surgical models to elucidate markers of vulnerability to chronic postsurgical pain.
The 133-Kda N-Terminal Domain Enables Myosin 15 To Maintain Mechanotransducing Stereocilia And Is Essential For Hearing,
2015
University of Michigan
The 133-Kda N-Terminal Domain Enables Myosin 15 To Maintain Mechanotransducing Stereocilia And Is Essential For Hearing, Qing Fang, Artur A. Indzhykulian, Mirna Mustapha, Gavin P. Riordan, David F. Dolan, Thomas B. Friedman, Inna A. Belyantseva, Gregory I. Frolenkov, Sally A. Camper, Jonathan E. Bird
Physiology Faculty Publications
The precise assembly of inner ear hair cell stereocilia into rows of increasing height is critical for mechanotransduction and the sense of hearing. Yet, how the lengths of actin-based stereocilia are regulated remains poorly understood. Mutations of the molecular motor myosin 15 stunt stereocilia growth and cause deafness. We found that hair cells express two isoforms of myosin 15 that differ by inclusion of an 133-kDa N-terminal domain, and that these isoforms can selectively traffic to different stereocilia rows. Using an isoform-specific knockout mouse, we show that hair cells expressing only the small isoform remarkably develop normal stereocilia bundles. However, …
Hippocalcin Response To Calcium: Do Conserved Tryptophans – W30 Or W103 – Matter?,
2015
Rowan University
Hippocalcin Response To Calcium: Do Conserved Tryptophans – W30 Or W103 – Matter?, Sunkesula K. Sagar
Graduate School of Biomedical Sciences Theses and Dissertations
Changes in intracellular calcium levels play a very important role in cell signaling, in turn, affecting neuronal functions such as memory, learning and cell death. A class of proteins called Neuronal Calcium Sensor (NCS) proteins serves to modulate the functioning of the neuronal cells in response to changes in calcium levels, and prevent neuronal apoptosis. Structurally, all NCS proteins have 4 calcium-binding EF hand motifs, although EF1 does not bind to calcium in many members. All NCS proteins have an acyl modification at the N- terminus – where a myristoyl group is added post-translationally. Hippocalcin (HPCA) is an NCS protein, …
Bioregulatory Systems Medicine: An Innovative Approach To Integrating The Science Of Molecular Networks, Inflammation, And Systems Biology With The Patient's Autoregulatory Capacity?,
2015
George Washington University
Bioregulatory Systems Medicine: An Innovative Approach To Integrating The Science Of Molecular Networks, Inflammation, And Systems Biology With The Patient's Autoregulatory Capacity?, Alyssa W Goldman, Yvonne Burmeister, Konstantin Cesnulevicius, Martha Herbert, Mary Kane, David Lescheid, Timothy Mccaffrey, Myron Schultz, Bernd Seilheimer, Alta Smit, Georges St Laurent, Brian Berman
Medicine Faculty Publications
Bioregulatory systems medicine (BrSM) is a paradigm that aims to advance current medical practices. The basic scientific and clinical tenets of this approach embrace an interconnected picture of human health, supported largely by recent advances in systems biology and genomics, and focus on the implications of multi-scale interconnectivity for improving therapeutic approaches to disease. This article introduces the formal incorporation of these scientific and clinical elements into a cohesive theoretical model of the BrSM approach. The authors review this integrated body of knowledge and discuss how the emergent conceptual model offers the medical field a new avenue for extending the …
The Effect Of Yoga On Growth Hormone Secretion In Young Men And Women,
2015
Northern Michigan University
The Effect Of Yoga On Growth Hormone Secretion In Young Men And Women, Aaron Eastham
All NMU Master's Theses
PURPOSE The purpose of this study was to examine the effects of an acute bout of yoga exercise on the secretion of growth hormone (GH) in healthy, young males and females. METHODS Seventeen participants (mean age 23.9 ± 3.9) were volunteered and completed the university IRB approved study. Participants completed a 60-min, certified instructor led yoga session. Blood (5ml) was collected at rest, 10-min prior (PRE), at the 35-min point during (MID), and immediately post (POST) the yoga session. Serum GH was measured using immunochemiluminometric assay. Resting GH levels were statistically compared to mid- and post-yoga GH levels using a …
Gating Mechanisms Of The Canonical Trp Channel Isoform Trpc4,
2015
The University of Texas Graduate School of Biomedical Sciences at Houston
Gating Mechanisms Of The Canonical Trp Channel Isoform Trpc4, Dhananjay P. Thakur
Dissertations and Theses (Open Access)
Non-selective cation channels formed by Transient Receptor Potential Canonical (TRPC) proteins play important roles in regulatory and pathophysiological processes. These channels are known to be activated downstream from phospholipase C (PLC) signaling. However, the mechanism by which the PLC pathway activates TRPC4/C5 remains unclear. Uniquely, TRPC4 is maximally activated only when two separate G protein pathways, Gq/11 and Gi/o, are co-stimulated, making it a coincidence detector of Gq/11- and Gi/o -coupled receptor activation. Using HEK293 cells co-expressing mouse TRPC4β and selected G protein-coupled receptors, I observed that coincident stimulation of Gi/o proteins and …
Salivary Vip Concentrations Are Elevated In Humans After Acute Stress,
2015
Seton Hall University
Salivary Vip Concentrations Are Elevated In Humans After Acute Stress, Giovanni Ventre
Seton Hall University Dissertations and Theses (ETDs)
The purpose of this research was to evaluate two salivary neuropeptides in the context of the stress response. The research was focused first and foremost on evaluating the usefulness of salivary Neuropeptide Y (NPY) and salivary vasoactive intestinal peptide (VIP) as stress indicators. Secondly, we questioned whether these markers help us in distinguishing between physical and psychological stress. Psychological stress can be experienced in a situation such as that in anticipation of an important exam or mental task. Physical stress can be experienced usually by strenuous exercise. Salivary NPY and salivary VIP are two neuropeptides that are released as a …
Combination Treatment With Conjugated Linoleic Acid And Nitrite Protects Against Myocaridal Infarction.,
2015
University of Louisville
Combination Treatment With Conjugated Linoleic Acid And Nitrite Protects Against Myocaridal Infarction., Natia Qipshidze Kelm
Electronic Theses and Dissertations
According to the CDC, the most common type of heart disease is coronary artery disease, which frequently leads to myocardial infarction (MI). Therapeutic approaches to lessen the resulting cardiovascular injury associated with MI are limited. Recently, the management paradigm for cardiac injury has entered the molecular era and microRNAs (miRNAs) have been shown to act as negative regulators of gene expression by inhibiting mRNA translation and/or stimulating mRNA degradation. A single miRNA can modulate physiological or disease phenotypes by regulating whole functional systems. Importantly, miRNAs can regulate cardiac function, thereby modulating heart muscle contraction, heart growth and morphogenesis. MicroRNA-499 (miRNA-499) …
Exercise Mitigates The Effects Of Hyperhomocysteinemia On Adverse Skeletal Muscle Remodeling.,
2015
University of Louisville
Exercise Mitigates The Effects Of Hyperhomocysteinemia On Adverse Skeletal Muscle Remodeling., Lee Winchester
Electronic Theses and Dissertations
Background: Hyperhomocysteinemia (HHcy) is heavily implicated in diabetes and cardiovascular disease. HHcy is known for causing inflammation and vascular remodeling, particularly through production of reactive oxygen species (ROS) and matrix metalloproteinase-9 (MMP-9). Although its impact on skeletal muscle is rather unclear, HHcy is known to cause skeletal muscle weakness and functional impairment. The impact of HHcy on inflammation makes it seem likely that HHcy causes skeletal muscle fibrosis through induction of inflammatory factors and destructive macrophages. Exercise has been shown to reduce homocysteine levels and therefore, could serve as a promising intervention for HHcy. The purpose of this study was …
Use And Misuse Of The Likert Item Responses And Other Ordinal Measures,
2015
Univ of Alabama
Use And Misuse Of The Likert Item Responses And Other Ordinal Measures, Phillip A. Bishop, Robert L. Herron
International Journal of Exercise Science
International Journal of Exercise Science 8(3): 297-302, 2015. Likert, Likert-type, and ordinal-scale responses are very popular psychometric item scoring schemes for attempting to quantify people’s opinions, interests, or perceived efficacy of an intervention and are used extensively in Physical Education and Exercise Science research. However, these numbered measures are generally considered ordinal and violate some statistical assumptions needed to evaluate them as normally distributed, parametric data. This is an issue because parametric statistics are generally perceived as being more statistically powerful than non-parametric statistics. To avoid possible misinterpretation, care must be taken in analyzing these types of data. The use …
Evaluation Of A New Automated Pulmonary Gas Analysis System,
2015
Department of Surgical and Perioperative Sciences, Sport medicine Unit, Umeå University, Umeå, Sweden
Evaluation Of A New Automated Pulmonary Gas Analysis System, Tove Hallenstål, Ida Sundqvist, Michael Svensson, Ji-Guo Yu Dr.
International Journal of Exercise Science
International Journal of Exercise Science 8(3): 287-296, 2015. The study aimed to evaluate the validity and reliability of a new automated pulmonary gas analysis system - Exercise Physiology System (EPS). The Oxycon Pro, a well-established automated pulmonary gas analysis system was used as a reference system. Six well-trained cyclists were recruited and performed two identical submaximal exercises on a cycle ergometer over one week interval. During the exercises, pulmonary gas exchange: ventilation (VE), oxygen consumption (VO2), elimination of carbon dioxide (VCO2), and ratio between carbon dioxide and oxygen (RER) was measured using both systems in randomized …
Effect Of Beetroot Juice On Self-Regulated, Moderate-Intensity Exercise,
2015
University of Colorado Colorado Springs
Effect Of Beetroot Juice On Self-Regulated, Moderate-Intensity Exercise, Jordyn N. Rienks, Andrea A. Vanderwoude, Elizabeth Maas, Zachary M. Blea, Andrew W. Subudhi
International Journal of Exercise Science
International Journal of Exercise Science 8(3): 277-286, 2015. Dietary nitrate supplementation has been shown to reduce oxygen consumption at a fixed work rate. We questioned whether a similar effect would be observed during variable work rate exercise at a specific rating of perceived exertion (RPE), as is commonly prescribed for aerobic training sessions. Using a double-blind, placebo controlled, crossover design, ten females (25 ± 3 years; VO2peak 37.1 ± 5.3 ml/kg/min) performed two 20-min cycle ergometer trials at a constant RPE of 13 (somewhat hard) 2.5 hours following ingestion of 140 ml of concentrated beetroot juice (12.9 mmol …
Relation Of Income And Education Level With Cardiorespiratory Fitness,
2015
University of Kansas Medical Center
Relation Of Income And Education Level With Cardiorespiratory Fitness, Erik A. Willis, Dave White, Alex Shafer, Kristofer Wisniewski, Fredric L. Goss, Laurel B. Chiapetta, Vincent C. Arena, Robert J. Robertson, Elizabeth F. Nagle
International Journal of Exercise Science
International Journal of Exercise Science 8(3): 265-276, 2015. While there is strong evidence measuring the association between leisure time physical activity (LTPA) and socioeconomic status (SES) there are limited data on the relationship between cardiorespiratory fitness (CRF) and SES. The purpose of this cross-sectional study was to examine differences in CRF and LTPA between household income and individual education in young adults. A sample of 171 (males n=98, female n=73) young adults participated in the University of Pittsburgh-Physical Activity Study. Participants completed CRF testing. Demographic characteristics were assessed via interviewer administered standardized survey and LTPA was assessed using the interviewer …
Risk Of Disordered Eating Among Division I Female College Athletes,
2015
Campbell University
Risk Of Disordered Eating Among Division I Female College Athletes, Elizabeth Wells, Alexandra Chin, Jennifer Tacke, Jennifer Bunn
International Journal of Exercise Science
International Journal of Exercise Science 8(3): 256-264, 2015. The purpose of this study was to assess the risk of disordered eating (DE) among female athletes in lean and non-lean sports using the ATHLETE survey. The ATHLETE survey is divided into six different constructs, and a high score indicates a high risk for DE. Eighty-three varsity female athletes from eight Campbell University sports teams completed the survey and a medical history form anonymously. The sports were divided into sports that traditionally have a high risk for DE (lean sports) and those with a low risk (non-lean sports). The lean sports included: …
Effects Of Caffeine On Repeated Upper/Lower Body Wingates And Handgrip Performance,
2015
Baylor University
Effects Of Caffeine On Repeated Upper/Lower Body Wingates And Handgrip Performance, Thomas Andre, Matt Green, Joshua Gann, Eric O'Neal, Tom Coates
International Journal of Exercise Science
International Journal of Exercise Science 8(3): 243-255, 2015. Caffeine enhances aerobic performance, but research is equivocal regarding anaerobic performance. This study examined effects of caffeine (7 mg/kg) on anaerobic performance in anaerobically active males (n = 10). Participants completed counterbalanced, double blind caffeine (Caf) and placebo (Pl) trials including a) 6 x 15 s upper body Wingates (UWant), b) 6 x 15 s lower body Wingates (LWant) and c) 6 x15 s maximal effort static hand grip test (HG) with 3 min recovery between bouts, 30 min between exercises. Peak power (Ppeak), mean power …
The Relationship Of Gender And Self-Efficacy On Social Physique Anxiety Among College Students,
2015
Georgia Southern University
The Relationship Of Gender And Self-Efficacy On Social Physique Anxiety Among College Students, Sara M. Rothberger, Brandonn Harris, Daniel Czech, Bridget F. Melton
International Journal of Exercise Science
International Journal of Exercise Science 8(3): 234-242, 2015. The anxiety or fear associated with physique evaluation is defined as Social Physique Anxiety (SPA). Numerous studies have examined this construct, yet a gap exists exploring this phenomenon among current college students with SPA, self-efficacy, and gender concurrently. Therefore, the purposes of this study included quantitatively analyzing the association between SPA, gender, and self-efficacy. Participants included 237 students at a Southeastern university participating in jogging, body conditioning, or weight training courses. Analysis of Variance yielded a significant main effect for self-efficacy as well, as those with lower self-efficacy displayed higher levels of …
