Physiology Commons^™

Effects Of Winter And Summer Thermal Variability Regimes On Growth And Metabolism In Brook Trout (Salvelinus Fontinalis), Spenser Chicoine

All NMU Master's Theses

Brook trout (Salvelinus fontinalis) is a cold-water species with a narrow range of thermal tolerance. Climate change projections show that in addition to increases in average temperatures worldwide, daily thermal variability is increasing. Such conditions could prove challenging for brook trout and other ectotherms that are adapted to small temperature ranges. This research investigates how the growth and metabolic capacities of brook trout respond to long-term exposure to thermal variation. Groups of fish were reared under three thermal regimes: constant baily temperature, a 4°C daily range, and an 8°C daily range in a controlled lab setting. This was …

Nutrients, Infectious And Inflammatory Diseases, Helieh S. Oz

Physiology Faculty Publications

No abstract provided.

There’S More Than One Way To Climb A Tree: Limb Length And Microhabitat Use In Lizards With Toe Pads, Travis J. Hagey, Scott Hart, Matthew Vickers, Luke J. Harmon, Lin Schwarzkopf

Biology

Ecomorphology links microhabitat and morphology. By comparing ecomorphological associations across clades, we can investigate the extent to which evolution can produce similar solutions in response to similar challenges. While Anolis lizards represent a well-studied example of repeated convergent evolution, very few studies have investigated the ecomorphology of geckos. Similar to anoles, gekkonid lizards have independently evolved adhesive toe pads and many species are scansorial. We quantified gecko and anole limb length and microhabitat use, finding that geckos tend to have shorter limbs than anoles. Combining these measurements with microhabitat observations of geckos in Queensland, Australia, we observed geckos using similar …

Physiological Ecology Of Four Endemic Alabama Species And The Exotic Asiatic Weatherfish, Misgurnus Anguillicaudatus (Cantor, 1842), Lindsay M. White, Mark E. Meade, Benjamin A. Staton

Southeastern Fishes Council Proceedings

The occurrence of Asiatic Weatherfish, Misgurnus anguillicaudatus, in Alabama, a state known for its rich biodiversity, has generated concern among conservation managers. The current study used respirometry techniques to investigate the effects of increasing temperature on four native southeastern fishes (one cyprinid, two percids, and one elassomid) and the non-native M. anguillicaudatus. A minimum of five individuals of each species were used, and three experimental temperatures were chosen to represent spring and summer averages of northeast Alabama streams (15, 20, and 25°C). Overall, mean standard metabolic rates (SMRs) for M. anguillicaudatus were low (97.01, 127.75, and 158.50 mg …

Prevention Of Renal Apob Retention Is Protective Against Diabetic Nephropathy: Role Of Tgf-Β Inhibition, Patricia G. Wilson, Joel C. Thompson, Meghan S. Yoder, Richard Charnigo, Lisa R. Tannock

Internal Medicine Faculty Publications

Animal studies demonstrate that hyperlipidemia and renal lipid accumulation contribute to the pathogenesis of diabetic nephropathy (DN). We previously demonstrated that renal lipoproteins colocalize with biglycan, a renal proteoglycan. The purpose of this study was to determine whether prevention of renal lipid (apoB) accumulation attenuates DN. Biglycan-deficient and biglycan wild-type Ldlr^−/− mice were made diabetic via streptozotocin and fed a high cholesterol diet. As biglycan deficiency is associated with elevated transforming growth factor-β (TGF-β), in some experiments mice were injected with either the TGF-β-neutralizing antibody, 1D11, or with 13C4, an irrelevant control antibody. Biglycan deficiency had no significant effect …

The Relationship Between Athletic Identity And Academic Major Chosen By Student-Athletes, Sayvon Jl Foster, Matt R. Huml

International Journal of Exercise Science

International Journal of Exercise Science 10(6): 915-925, 2017. This study examines the correlation between athletic identity and academic major selection among intercollegiate student-athletes. A thorough review of literature focusing on academic clustering, athletic identity, and academic development leads to the development of two hypotheses – 1) student-athletes with stronger athletic identity will have a declared major of decreased academic rigor; and 2) student-athletes with stronger athletic identity will be more likely to be undecided on their major. Data were collected through a survey administered to Division I, II, and III student-athletes recording academic major and their Athletic Identity Measurement Scale …

Corporate Social Responsibility: Considerations For Sport Management In The Age Of Neoliberalism, Anthony J. Weems, Justin R. Garner, Kristi Oshiro, John N. Singer

International Journal of Exercise Science

International Journal of Exercise Science 10(6): 900-914, 2017. For financial reasons, in efforts to maintain legitimacy, and in response to social pressures, sport organizations increasingly engage with corporate social responsibility (CSR). However, with the rise of global neoliberalism, the logic of CSR can be problematic. In this essay, we provide a brief overview, critique, and reconstruction of CSR in the sport industry. Specifically, we call into question three popularized forms of CSR: (1) diversity, inclusion, and diversity management, (2) environmental responsibility, and (3) health and physical activity-based initiatives. In a neoliberal context, CSR in sport provides, at best, a limited …

From Crisis To De-Escalation: An Examination Of Politics In A U.S. High School Steroid Testing Program, Brennan K. Berg, Kathryn Winsley, Rhema D. Fuller, Michael Hutchinson

International Journal of Exercise Science

International Journal of Exercise Science 10(6): 890-899, 2017. Preventing the use of performance enhancing drugs in sport has long been a concern for policymakers. In the United States, amidst national attention the state of Texas constructed the country’s largest steroid testing program for high school athletes. However, resource allocation steadily declined until the program was defunded in 2015. Using escalation of commitment theory as a framework, this conceptual paper examines the critical, but less studied, role of politics and de-escalation behavior that directed this distinct sport situation. By combining policy and media documents with the academic literature, this paper allows …

Coaches’ Perception Of Organizational Socialization Process Of International Student-Athletes And The Effect Of Cultural Distance: An Exploratory Study., Evelyn S. Jara-Pazmino, Bob Heere, Tom H. Regan, Christine E. Blake, Richard Southall

International Journal of Exercise Science

International Journal of Exercise Science 10(6): 875-889, 2017. This study focuses on the coaches’ perspective of the organizational socialization process of new international student-athletes. After analyzing the information of 10 in-depth interviews with experienced NCAA Division I coaches, this exploratory study aided the researchers to identify socialization tactics being used to successfully integrate international student-athletes entering USA college teams. ISAs come from different cultures, and pending on their home nation culture they might be challenged in their ability to socialize within their new surroundings. Results indicate that the cultural distance between team culture and ISA’s culture affects the effectiveness of …

Cultural Values And Gender Equity On National Olympic Committee Boards, Na Young Ahn, George B. Cunningham

International Journal of Exercise Science

International Journal of Exercise Science 10(6): 857-874, 2017. Women are under-represented in leadership positions throughout sport, and researchers have largely explored organizational, group, and individual antecedents of this phenomenon. The purpose of the current study was to expand on this understanding by investigating the influence of a country’s cultural values on the representation of women on National Olympic Committees. Drawing from Hofstede’s cultural dimensions theory, the authors included five cultural values: power distance, uncertainty avoidance, individualism-collectivism, masculinity-femininity, and long-term orientation. Results indicate that women constituted only 19.7 percent of the positions on the boards. Regression analysis, controlling for size of …

“I Will Change The World”: The Intersection Of Social Change And Male College Athletes’ Leadership Perspectives, Rhema D. Fuller, C. Keith Harrison, S. Malia Lawrence, Jeff Eyanson, Danielle Mccardle

International Journal of Exercise Science

International Journal of Exercise Science 10(6): 845-856, 2017. Historically, men have been characterized as task-oriented leaders who are motivated by desires for autonomy, wealth, and power (17, 33). However, these “masculine” views of leadership might not accurately capture the leadership motivations of Millennial males as the views were developed in previous generations (4). Given the commitment of many Millennials towards socially responsible attitudes and behaviors (18, 25), we utilized a qualitative research design to examine the influence of social change on the leadership motivations of Millennial male intercollegiate athletes. In doing so, we found participants were motivated to lead in …

Are You Welcomed? A Racial And Ethnic Comparison Of Perceived Welcomeness In Sport Participation, Trevor Bopp, Robert Turick, Joshua D. Vadeboncoeur, Thomas J. Aicher

International Journal of Exercise Science

International Journal of Exercise Science 10(6): 833-844, 2017. Sport has become racialized such that minority youth accrue limited health and academic benefits from participation, compared to their White counterparts. Understanding the welcomeness that minorities feel in sport, leisure and physical activities plays an important role in breaking down barriers to participation. Thus, the overall aim of this study is to further examine the determinants of sport participation, particularly as it relates to race, socialization and perceived welcomeness. College students (N = 451) scored their perceived level of welcomeness for Whites, African Americans and Hispanic/Latinos in 14 sports. Results reveal significant …

Does Time Heal All Wounds? A Case Study On Rival Perceptions Before And After Conference Realignment, Cody T. Havard, Daniel L. Wann, Timothy D. Ryan, Norman O'Neal

International Journal of Exercise Science

International Journal of Exercise Science 10(6): 823-832, 2017. The current longitudinal case study investigated how conference realignment and beginning new annual competitions impacted fan rival perceptions for fans of the Texas A&M Aggies, Missouri Tigers, and Texas Christian University Horned Frogs. In particular, fan rival perceptions before and after conference realignment were compared to determine if significant differences were present. Findings indicate that history plays an important role in rivalry as fans of teams sharing long-standing rivalries with schools in their previous conference (i.e., Texas A&M/Texas and Missouri/Kansas) did not differ in their rival perceptions before or after conference realignment. …

The Musicality Of The Water Lilies/La Musicalité Des Nymphéas (Library Resources), Holy Cross Libraries

Library Resources for Campus Events

A bibliography of resources available through the Holy Cross Libraries which provide additional information related to the Iris and B. Gerald Cantor Art Gallery exhibition “Gabrielle Thierry: The Musicality of the Water Lilies/La Musicalité des Nymphéas” from Aug. 30 through Oct. 7.

Thierry’s series of eight large-scale paintings were inspired by her rediscovery of the “Water Lilies” landscapes by Claude Monet on view at the the Musée de l’Orangerie in Paris. With special permission from the museum, Thierry painted in front of Monet’s originals over a period of 18 months from 2010 to 2012, where she explored the inner musical …

Energy Balance During A Self-Sufficient, Multistage Ultramarathon, Paul A. Hough, James Earle

Journal of Human Performance in Extreme Environments

Endurance athletes are recommended to maintain energy balance and ensure adequate energy availability (EA) so that endurance performance is not compromised. Purpose: Describe and evaluate the energy balance of an athlete competing in a self-sufficient, multistage ultramarathon (MSU). Methods: A male endurance athlete (age 35 years; height 183.0 cm; body mass 78.4 kg; VO_2max 66 ml/kg/min) volunteered to take part in this observational case study prior to competing in the Marathon des Sables (MdS) 2016. The subject self-reported energy intake (EI) by reviewing his dietary plan following each stage. Basal metabolic rate (BMR) was estimated prior to the MdS …

Intrathecal Administration Of Ayx2 Dna Decoy Produces A Long-Term Pain Treatment In Rat Models Of Chronic Pain By Inhibiting The Klf6, Klf9, And Klf15 Transcription Factors, Julien Mamet, Michael Klukinov, Scott Harris, Donald C. Manning, Simon Xie, Conrado Pascual, Bradley K. Taylor, Renee R. Donahue, David C. Yeomans

Physiology Faculty Publications

Background: Nociception is maintained by genome-wide regulation of transcription in the dorsal root ganglia—spinal cord network. Hence, transcription factors constitute a promising class of targets for breakthrough pharmacological interventions to treat chronic pain. DNA decoys are oligonucleotides and specific inhibitors of transcription factor activities. A methodological series of in vivo–in vitro screening cycles was performed with decoy/transcription factor couples to identify targets capable of producing a robust and long-lasting inhibition of established chronic pain. Decoys were injected intrathecally and their efficacy was tested in the spared nerve injury and chronic constriction injury models of chronic pain in rats using repetitive …

Temporal Changes In Cortical And Hippocampal Expression Of Genes Important For Brain Glucose Metabolism Following Controlled Cortical Impact Injury In Mice, June Zhou, Mark Burns, Linda Huynh, Sonia Villapol, Daniel D. Taub, Juan M. Saavedra, Marc R. Blackman

Pharmacology and Physiology Faculty Publications

Traumatic brain injury (TBI) causes transient increases and subsequent decreases in brain glucose utilization. The underlying molecular pathways are orchestrated processes and poorly understood. In the current study, we determined temporal changes in cortical and hippocampal expression of genes important for brain glucose/lactate metabolism and the effect of a known neuroprotective drug telmisartan on the expression of these genes after experimental TBI. Adult male C57BL/6J mice (n = 6/group) underwent sham or unilateral controlled cortical impact (CCI) injury. Their ipsilateral and contralateral cortex and hippocampus were collected 6 h, 1, 3, 7, 14, 21, and 28 days after injury. …

Brain Injury-Induced Synaptic Reorganization In Hilar Inhibitory Neurons Is Differentially Suppressed By Rapamycin, Corwin R. Butler, Jeffery A. Boychuk, Bret N. Smith

Physiology Faculty Publications

Following traumatic brain injury (TBI), treatment with rapamycin suppresses mammalian (mechanistic) target of rapamycin (mTOR) activity and specific components of hippocampal synaptic reorganization associated with altered cortical excitability and seizure susceptibility. Reemergence of seizures after cessation of rapamycin treatment suggests, however, an incomplete suppression of epileptogenesis. Hilar inhibitory interneurons regulate dentate granule cell (DGC) activity, and de novo synaptic input from both DGCs and CA3 pyramidal cells after TBI increases their excitability but effects of rapamycin treatment on the injury-induced plasticity of interneurons is only partially described. Using transgenic mice in which enhanced green fluorescent protein (eGFP) is expressed in …

Behavioral Responses To Pulses Of Light In The Longfin Inshore Squid, Doryteuthis Pealeii (Lesueur, 1821), Stavros P. Hadjisolomou

Dissertations, Theses, and Capstone Projects

The coleoid cephalopods (octopus, squid, and cuttlefish) are masters of rapid, adaptive camouflage. Unlike the slower hormonal chromatophore control of flatfish and chameleons, coleoid mollusks can change body patterns in milliseconds. Visual camouflage in coleoids is driven by a sensorimotor system consisting of visual input of their surroundings, a sophisticated central nervous system for information processing, and a neuromuscular control for body patterning. Motor neurons selectively activate millions of muscles, alternately expanding and reducing the pigmented chromatophores to generate visible brown, red, orange and yellow patterns on the skin. Below the chromatophore-layered skin are two types of reflecting cells, iridophores …

The Role Of T-Box Proteins In Vertebrate Germ Layer Formation And Patterning, Sushma Teegala

Dissertations, Theses, and Capstone Projects

All of the tissues in triploblastic organisms, with the exception of the germ cells, arise from the three germ layers, ectoderm, mesoderm and the endoderm. The identification of the genes that underlie the differentiation of these layers is crucial to our understanding of development. T-box family proteins are DNA-binding transcriptional regulators that play important roles during germ layer formation in the early vertebrate embryo. Well-characterized members of this family, including the transcriptional activators Brachyury and VegT, are essential for the proper formation of mesoderm and endoderm, respectively. To date, T-box proteins have not been shown to play a role in …