Physiology Commons^™

Primary Upper Urinary Tract Small Cell Carcinoma: A Case Series And Literature Review, Patrick J. Hensley, Amul A. Bhalodi, Shubham Gupta

Urology Faculty Publications

Background: Primary upper urinary tract small cell carcinoma (SCC) is exceedingly rare with < 30 cases reported in the literature. Little is known about the incidence, diagnosis, treatment, and outcomes in these patients. We present a series of three patients with primary upper tract SCC.

Case Presentation: Patient 1 is an 89-year-old Caucasian male who presented with hydroureteronephrosis and a mass in the proximal right ureter. Biopsy revealed SCC. Without further intervention, the patient died 2 months after his diagnosis. Patient 2 is a 67-year-old Caucasian female who underwent left laparoscopic nephroureterectomy for primary distal ureteral SCC, pT4N1M0. She developed lymphadenopathy and completed external beam radiation to the pelvis and four courses of cisplatin-based chemotherapy. She died from metastatic disease 7 months after diagnosis. Patient 3 is a 45-year-old female who underwent …

Abnormal Contractility In Human Heart Myofibrils From Patients With Dilated Cardiomyopathy Due To Mutations In Ttn And Contractile Protein Genes, Petr G. Vikhorev, Natalia Smoktunowicz, Alex B. Munster, O'Neal Copeland, Sawa Kostin, Cecile Montgiraud, Andrew E. Messer, Mohammad R. Toliat, Amy Li, Cristobal G. Dos Remedios, Sean Lal, Cheavar A. Blair, Kenneth S. Campbell, Maya E. Guglin, Ralph Knoll, Steven B. Marston

Physiology Faculty Publications

Dilated cardiomyopathy (DCM) is an important cause of heart failure. Single gene mutations in at least 50 genes have been proposed to account for 25–50% of DCM cases and up to 25% of inherited DCM has been attributed to truncating mutations in the sarcomeric structural protein titin (TTNtv). Whilst the primary molecular mechanism of some DCM-associated mutations in the contractile apparatus has been studied in vitro and in transgenic mice, the contractile defect in human heart muscle has not been studied. In this study we isolated cardiac myofibrils from 3 TTNtv mutants, and 3 with contractile protein mutations (TNNI3 …

Pharmaceutical And Natural (Exercise) Mechanisms To Mitigate The Negative Impact Of Ptsd And Chronic Stress On Synaptic Plasticity And Memory, Roxanne M. Miller

Theses and Dissertations

Synapses can be altered due to experiences in a process called synaptic plasticity, which causes memory formations. Synapses can be strengthened through methods known as long-term potentiation (LTP) or weakened through long-term depression (LTD). Stresses can cause changes by altering synapses through either LTP or LTD. Rats were used to study the effects of post-traumatic stress disorder (PTSD)-like symptoms and a prophylactic treatment using pharmaceuticals. The first model used was the single prolonged stress (SPS) with two weeks of chronic light, which was not as effective for causing changes in synaptic plasticity. The second model, seven days of social defeat …

Calpain Inhibition Attenuates Adipose Tissue Inflammation And Fibrosis In Diet-Induced Obese Mice, Latha Muniappan, Aida Javidan, Weihua Jiang, Shayan Mohammadmoradi, Jessica J. Moorleghen, Wendy S. Katz, Anju Balakrishnan, Deborah A. Howatt, Venkateswaran Subramanian

Saha Cardiovascular Research Center Faculty Publications

Adipose tissue macrophages have been proposed as a link between obesity and insulin resistance. However, the mechanisms underlying these processes are not completely defined. Calpains are calcium-dependent neutral cysteine proteases that modulate cellular function and have been implicated in various inflammatory diseases. To define whether activated calpains influence diet-induced obesity and adipose tissue macrophage accumulation, mice that were either wild type (WT) or overexpressing calpastatin (CAST Tg), the endogenous inhibitor of calpains were fed with high (60% kcal) fat diet for 16 weeks. CAST overexpression did not influence high fat diet-induced body weight and fat mass gain throughout the study. …

Identifying New Treatment Options And Risk Factors For Type 2 Diabetes: The Potential Role Of Thymoquinone And Persistent Organic Pollutants, Shpetim Karandrea

USF Tampa Graduate Theses and Dissertations

Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia, which develops as a consequence of peripheral insulin resistance and defective insulin secretion from pancreatic β-cells. A high calorie diet coupled with physical inactivity are known risk factors for the development of T2DM; however, these alone fail to account for the rapid rise of the disease. Recent attention has turned to the role of environmental pollutants in the development of metabolic diseases. PBDEs (polybrominated diphenyl ethers) are environmental pollutants that have been linked to the development of type 2 diabetes (T2D), however, the precise mechanisms are not …

Effects Of Heat Exposure On Body Water Assessed Using Single-Frequency Bioelectrical Impedance Analysis And Bioimpedance Spectroscopy, Brett S. Nickerson, Michael R. Esco, Phillip A. Bishop, Brian M. Kliszczewicz, Henry N. Williford, Kyung-Shin Park, Bailey A. Welborn, Ronald L. Snarr, Danilo V. Tolusso

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1085-1093, 2017. The purpose of this study was to determine if heat exposure alters the measures of total body water (TBW), extracellular water (ECW), and intracellular water (ICW) in both single-frequency bioelectrical impedance analysis (BIA) and bioimpedance spectroscopy (BIS). Additionally, we sought to determine if any differences exist between the BIA and BIS techniques before and after brief exposure to heat. Body water was evaluated for twenty men (age=24±4 years) in a thermoneutral environment (22°C) before (PRE) and immediately after (POST) 15 min of passive heating (35°C) in an environmental chamber. The mean difference …

Repeated Plyometric Exercise Attenuates Blood Glucose In Healthy Adults, Saldiam R. Barillas, Casey M. Watkins, Megan A. Wong, Ian J. Dobbs, David C. Archer, Cameron N. Munger, Andrew J. Galpin, Jared W. Coburn, Lee E. Brown

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1076-1084, 2017. Plyometric exercise is popular in commercial exercise programs aiming to maximize energy expenditure for weight loss. However, the effect of plyometric exercise on blood glucose is unknown. The purpose of this study was to investigate the effect of relatively high intensity plyometric exercise on blood glucose. Thirteen subjects (6 females age= 21.8 ± 1.0 yrs.; height= 163.7 ± 7.8 cm; mass= 60.8 ± 6.7 kg and 7 males age= 22.0 ± 2.6 yrs.; height= 182.3 ± 3.6 cm; mass= 87.4 ± 12.5 kg) volunteered to participate. Subjects completed two random conditions on …

Is The Relationship Between Stride Length, Frequency, And Velocity Influenced By Running On A Treadmill Or Overground?, Joshua Paul Bailey, Tiffany Mata, John Mercer Dr.

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1067-1075, 2017. The purpose of the study was to compare the relationship between stride length (SL), stride frequency (SF), and velocity while running on a treadmill and overground. Participants (n=10; 22.3±2.6 yrs; 1.71±.08 m; 71.4±15.5 kg) completed a total of 14 runs (7 treadmill, 7 overground) with each run at a different velocity. SL, SF, and velocity data were recorded using wearable technology (Garmin, Fenix2). The outdoor trials occurred first. The treadmill velocities were selected to match the range of velocities used overgroud. SL vs. velocity plots were generated for treadmill and overground data …

The Effects Of Resistance Training Volume On Skeletal Muscle Proteome, Ramires A. Tibana, Octávio L. Franco, Gabriel V. Cunha, Nuno M. F Sousa, Ivo V. Sousa Neto, Márcia M. Carvalho, Jeeser Alves De Almeida, James W. Navalta, Mariana O. Lobo, Fabricio A. Voltarelli, Rita C. Marqueti, João L.Q Durigan, Jonato Prestes

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1051-1066, 2017. Studies are conflicting to whether low volume resistance training (RT) is as effective as high-volume RT protocols with respect to promoting morphological and molecular adaptations. Thus, the aim of the present study was to compare, using a climbing a vertical ladder, the effects of 8 weeks, 3 times per week, resistance training with 4 sets (RT4), resistance training with 8 sets (RT8) and without resistance training control (CON) on gastrocnemius muscle proteome using liquid chromatography mass spectrometry (LC-MS/MS) and cross sectional area (CSA) of rats. Fifty-two proteins were identified by LC-MS/MS, …

Energy Cost Of Active And Sedentary Music Video Games: Handheld Gaming Vs. Walking And Sitting, Edwin Miranda, Brittany S. Overstreet, William A. Fountain, Vincent Gutierrez, Michael Kolankowski, Matthew L. Overstreet, Ryan M. Sapp, Christopher A. Wolff, Scott A. Mazzetti Ph.D.

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1038-1050, 2017. To compare energy expenditure during and after active and handheld video game drumming compared to walking and sitting. Ten experienced, college-aged men performed four protocols (one per week): no-exercise seated control (CTRL), virtual drumming on a handheld gaming device (HANDHELD), active drumming on drum pads (DRUM), and walking on a treadmill at ~30% of VO_2max (WALK). Protocols were performed after an overnight fast, and expired air was collected continuously during (30min) and after (30min) exercise. DRUM and HANDHELD song lists, day of the week, and time of day were identical for …

A Pre-Exercise Dose Of Melatonin Can Alter Substrate Use During Exercise, Cardyl P. Trionfante, Greggory R. Davis, Tyler M. Farney, Ryan W. Miskowiec, Arnold G. Nelson

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1029-1037, 2017. Notwithstanding the lack of exercise research, several reviews have championed the use of melatonin to combat metabolic syndrome. Therefore, this study compared substrate utilization during a 30-minute (min) graded exercise protocol following the ingestion of either 6 mg melatonin (M) or a placebo (P). Participants (12 women, 12 men) performed stages 1-5 of the Naughton graded exercise protocol (6 min per stage). The protocol was repeated 4 times (2x M, 2x P) at the same time of day with one week separating each session. Expired gases were monitored, VO₂ and respiratory …

Nutrient Intake Of Elite Canadian And American Athletes With Spinal Cord Injury, Heather R. Gerrish, Elizabeth Broad, Melissa Lacroix, Dana Ogan, Robert C. Pritchett, Kelly Pritchett

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1018-1028, 2017. The nutrient needs of athletes with Spinal Cord Injury (SCI) are dependent on their physiological alterations and training status. Limited research is available regarding dietary intake of elite athletes with SCI and possible nutrient deficiencies. Therefore, the purpose of this study was to examine dietary intake of elite athletes with SCI, and determine dietary intake inadequacies based on the Estimated Average Requirement (EAR) comparisons. Additionally, the average energy and macronutrient (carbohydrate, protein, and fat) intake was compared based on level of injury (C level, T1-T6, T7-T12, Lumbar). A total of 39 athletes …

College Student Work Habits Are Related To Physical Activity And Fitness, Jesse Calestine, Melissa Bopp, Christopher M. Bopp, Zack Papalia

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1009-1017, 2017. Despite the known benefits of regular physical activity, research shows a significant decline in physical activity participation and an increase in sedentary behavior during young adulthood during the college years. Studies examining the relationship between academic outcomes and fitness/physical activity have not extensively examined this among college students. Therefore, the purpose of this study was to examine the relationship between fitness measures (cardiovascular endurance, muscular endurance, flexibility and body composition), physical activity, and academic outcomes in college students. This cross-sectional study had college students complete a one-time fitness assessment and survey examining …

A Pre-Exercise Dose Of Muscle Sentry® Has No Effect On Performing Repeated Leg Press Sets To Failure, Trezlyn M. Bartschi, David C. Sanders, Tyler M. Farney, Joke Kokkonen, Arnold G. Nelson

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 1000-1008, 2017. This study compared the number of bilateral leg presses done at 150% of body mass while on either Muscle Sentry^® (MS) or placebo (PL). Participants (16 women, 14 men, college students 19-26 years) performed 2 sets of leg press to failure using 150% of their body mass with 5 min rest separating the 2 sets. Each exercise was performed twice (1x MS, 1x PL) at the same time of day with 48 h separating each exercise. Both MS and PL were ingested 30 min prior to performing the exercise. Just prior …

The Effect Of A Single Bout Of Surfing On Exercise Induced Affect, Ryan Pittsinger, Jeff Kress, Jill Crussemeyer

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 989-999, 2017. Exercise-induced affect (EIA) has been well documented and is often composed of positive affect, negative affect, tranquility, and fatigue. Research on EIA has focused on mainstream sports such as running, walking, or cycling; however, no research has evaluated the influence of action sports participation in activities such surfing on EIA. The current study examined the effect of a single 30-min surfing bout on EIA in 107 adult volunteers. An additional purpose was if change in affect was similar based on surfing history, surfing frequency, and surfing skill level. To assess EIA, each …

Validity Of Arm-To-Arm Bia Devices Compared To Dxa For Estimating %Fat In College Men And Women, Rebecca A. Rockamann, Emily K. Dalton, Jana L. Arabas, Liz Jorn, Jerry L. Mayhew

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 977-988, 2017. Bioelectric impedance analysis (BIA) devices are commonly used to estimate percent body fat (%fat), although validation of their accuracy varies widely. The purpose of this study was to assess the validity of four commonly used BIA devices compared to dual-energy X-ray absorptiometry (DXA). College-aged men (n = 29, age = 19.7 ± 1.2 y, weight = 76.9 ± 12.5 kg) and women (n = 31, age = 20.5 ± 0.8 y, weight = 61.5 ± 9.2 kg) were evaluated for %fat using four single-frequency (50 mHz) BIA devices and DXA. A gender …

Effects Of The Boy Scouts Of America Personal Fitness Merit Badge On Cardio-Metabolic Risk, Health Related Fitness And Physical Activity In Adolescents Boys, Justin Maxwell, Ryan D. Burns, Timothy A. Brusseau

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 964-976, 2017. A growing number of adolescents are more sedentary and have fewer formal opportunities to participate in physical activity. With the mounting evidence that sedentary time has a negative impact on cardio-metabolic profiles, health related fitness and physical activity, there is a pressing need to find an affordable adolescent physical activity intervention. One possible intervention that has been overlooked in the past is Boy Scouts of America. There are nearly 900,000 adolescent boys who participate in Boy Scouts in the United States. The purpose of this research study was to evaluate the effect …

Effects Of Flexibility And Balance On Driving Distance And Club Head Speed In Collegiate Golfers, Kelsey J. Marshall

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 954-963, 2017. Good balance, flexibility, and strength are all required to maintain a steady stance during the kinematic chain to produce successful golf shots. When the body can produce more power, more club head speed is generated. This formation of power translates into greater distance and accuracy. Athletes today are seeking exercise programs to enhance these qualities of their golf swing. The purpose of this study is to investigate the correlations between flexibility and balance with club head speed and driving distance in the golf swing of male and female collegiate golfers. Five male …

Speed- And Circuit-Based High-Intensity Interval Training On Recovery Oxygen Consumption, Lindsay N. Schleppenbach, Andreas B. Ezer, Sarah A. Gronemus, Katelyn R. Widenski, Saori Braun, Jeffery Janot

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 942-953, 2017. Due to the current obesity epidemic in the United States, there is growing interest in efficient, effective ways to increase energy expenditure and weight loss. Research has shown that high-intensity exercise elicits a higher Excess Post-Exercise Oxygen Consumption (EPOC) throughout the day compared to steady-state exercise. Currently, there is no single research study that examines the differences in Recovery Oxygen Consumption (ROC) resulting from high-intensity interval training (HIIT) modalities. The purpose of this study is to review the impact of circuit training (CT) and speed interval training (SIT), on ROC in both …

Students’ Perceptions Of An Applied Research Experience In An Undergraduate Exercise Science Course, Regis C. Pearson, K. Jason Crandall, Kathryn Dispennette, Jill M. Maples

International Journal of Exercise Science

International Journal of Exercise Science 10(7): 926-941, 2017. Applied research experiences can provide numerous benefits to undergraduate students, however few studies have assessed the perceptions of Exercise Science (EXS) students to an applied research experience. The purpose of this study was two-fold: 1) to describe the rationale and implementation of an applied research experience into an EXS curriculum and 2) to evaluate EXS undergraduate students’ perceptions of an applied research experience. An EXS measurement course was chosen for implementation of an applied research experience. The applied research experience required groups of students to design, implement, and evaluate a student-led research …