Physiology Commons^™

Stayin' Alive (Even Without Oxygen): Retinal Development In Austrofundulus Limnaeus, Carmen Zecilia Rodriguez

Dissertations and Theses

The vertebrate eye is one of the most metabolically active organs in the body and is particularly sensitive to environmental stressors such as oxygen deprivation. Understanding how eye development proceeds under such conditions can provide critical insights into mechanisms of cellular resilience, tissue organization, and developmental plasticity. The annual killifish Austrofundulus limnaeus represents a unique model for investigating these processes due to its remarkable tolerance to anoxia during embryogenesis. However, the wild-type form is heavily pigmented, limiting the effectiveness of traditional imaging techniques for studying eye development. This thesis characterizes eye development and anoxia resilience in both wild-type and melanin-deficient …

Performance Fatigability At Task Failure And Beyond: Distinct Patterns Of Recovery Following Constant Load Versus Intermittent Cycling Exercise, Zachary J. Mcclean, Keenan Macdougall, Matthew J. Jordan, Danilo Iannetta, Martin Macinnis, Saied J. Aboodarda

International Journal of Exercise Science

International Journal of Exercise Science 18(7): 971-983, 2025. The total work completed during an exercise session is often assumed to be the primary factor influencing the kinetics of post-exercise recovery. However, the duration of work and rest periods during high intensity interval training (HIIT) have been shown to impact the magnitude of physiological stress and could also impact post-exercise recovery. The aim of this study was to characterize the recovery time course of neuromuscular function following work-to-rest matched HIIT protocols with different work interval durations and conducted to task failure. Participants (n=12, n=6 females) completed a ramp incremental exercise test …

Positive Changes In Functional Capacity, Muscle Strength And Body Composition After Short Time Of Resistance Training Periodization In Older Women: A Quasi-Experimental Study, Ericles Vieira

International Journal of Exercise Science

International Journal of Exercise Science 18(7): 949-970, 2025. We investigated the effects of a new approach with mixed session periodization resistance training (MSP) on functional performance, muscular strength, and body composition in older women. Twenty-one participants were tested before and after the intervention (10 weeks) and were allocated for convenience into two groups according to their available time; our schedule made two classes available, one at 6 a.m. (MSP), and one at 7 a.m. (active group-control). Results were analyzed through a mixed-model analysis with repeated measures. There was a group vs. time interaction for timed up and go (p < 0.001, η_{p …}

Human Adipose Stem Cell-Derived Small Extracellular Vesicles Modulate Glial Cell Response In Aged And Young Tbi Mouse Models, Salma S. Abdelmaboud

USF Tampa Graduate Theses and Dissertations

Traumatic brain injury (TBI) is a leading cause of long-term neurological impairment, with aging significantly increasing vulnerability and worsening outcomes. Older individuals experience greater cognitive and motor deficits after TBI and often show diminished responses to therapeutic interventions. Both aging and TBI independently promote heightened neuroinflammation and cognitive dysfunction, increasing susceptibility to poor recovery. This study investigated the therapeutic potential of small extracellular vesicles (sEVs) derived from human adipose-derived stem cells (hASCs) to promote neurological recovery and modulate neuroinflammation in a mouse model of TBI. Male C57BL/6 mice aged 3, 15, and 20 months underwent controlled cortical impact (CCI) and …

Effects Of Acute Caffeine Ingestion On Physical Performance And Skill Execution In Volleyball Players: A Systematic Review And Meta-Analysis, Raoof Negaresh, Shihab Aldin A. Al-Riyami, Alireza Paahoo, Rastegar Hoseini, Juan Del Coso

International Journal of Exercise Science

International Journal of Exercise Science 18(6): 922-948, 2025. It is well established that oral caffeine administration (3-9 mg/kg) is ergogenic, enhancing numerous aspects of physical performance including strength and power. However, the extent to which these effects translate to volleyball-specific skills remains unclear. The purpose of this study was to systematically review the effects of acute caffeine ingestion on performance outcomes in volleyball-specific actions. A systematic review of published studies was conducted using scientific databases from their inception through December 2024 (registered in PROSPERO, CRD420251006314). We included studies with blinded crossover experimental designs that compared caffeine ingestion to a placebo …

Impact Of Varied Dietary Macronutrient Ratios On The Nutrition Status Of Swiss Albino Mice, Hellen Kinyi, Charles Kato, Gertrude Kiwanuka

Biomedical Sciences, East Africa

The nutrition status of an organism depends on the balance between nutrient intake and utilization. Malnutrition results not only from inadequate caloric intake but also from imbalanced macronutrient ratios, which can affect aging, metabolism, and health. While many studies focus on individual nutrients, this study used purified, isocaloric diets with varying macronutrient ratios to assess dietary effects on nutrition markers in Swiss albino mice.

Mice were randomized into 6 dietary groups, each containing 6 males and 6 females housed separately. Each group received an isocaloric diet with different carbohydrate, protein, and lipid ratios for 15 weeks. Animal weight, body mass …

Difference In Knee Joint Structure And Lower Extremity Functioning Among People With Varying Severity Of Knee Osteoarthritis: A Cross-Sectional Study, Shubham Tawade, Rajani Mullerpatan Dr., Bela Agarwal Dr.

International Journal of Exercise Science

International Journal of Exercise Science 18(5): 910-921, 2025. Osteoarthritis (OA) is a highly prevalent musculoskeletal condition. It is reported that knee OA progressively affects lower-extremity functioning. Evidence is lacking on when there is a substantial decline in function and whether this trend differs between males and females and disease severity. This study aimed to examine influence of gender and increasing grade of knee OA on lower-extremity function. Following Institutional Ethical Committee approval and signed-informed consent, 115 participants (57-males, 58-females), aged 40-65 years, with diagnosed knee OA (grade 1-4) were recruited. Lower-extremity function was studied using reliable and valid outcome …

Adults With Learning Disabilities Navigating The Transition From School To Work, Shatrece L. Jenkins

Doctoral Dissertations and Projects

The purpose of this qualitative case study was to explore the experiences of adults with learning disabilities when transitioning from academics to the workplace, with an emphasis on emotional intelligence. The two research questions asked how adults with learning disabilities described their lived experiences and experiences of emotions and emotional regulation in their transition from academic environments to the professional workplace. The theory guiding this study was the emotional intelligence theory developed by Salovey and Mayer, which was used as a determinant in building relationships and upholding social interactions. The sample consisted of 13 adults with learning disabilities working at …

Biddle Physical Ability Test (Bpat) Performance By Attempt In Southern California Structural Firefighter Candidates, Robert G. Lockie, Joseph Dulla, Jennifer Meloni, Kristina A. Ross, Robin (Rob) Marc Orr, J. Jay Dawes, Tomas J. Ruvalcaba

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 895-909, 2025. The Biddle Physical Ability Test (BPAT) is a job task simulation that must be completed in ≤9:34 min:s by structural firefighter candidates to be accepted to a fire training academy. This study investigated the influence of prior attempts on BPAT time. Retrospective analysis was conducted on 1435 male and 72 female candidates. All participants received equivalent instruction on how to complete the BPAT which incorporated: dry hose drag; charged hose drag; halyard raise; roof walk; attic crawl; roof ventilation; victim removal; ladder removal and carry; stair climb with hose bundle; crawling search; …

Nadph Oxidase Isoforms (Nox-2 And Nox-4) In Myocardial Ischemia/Reperfusion Injury: Platelet Rich Plasma (Prp) As A Therapeutic Agent, Barbara Y. Hargrave, Frank Lattanzio

Cardiovascular Research Symposium

Introduction: Blood flow restoration to ischemic cardiac tissue is a critical and necessary intervention that has an associated downside: reperfusion injury. Reperfusion injury is a complicated process mediated in part by a pathological increase in reactive oxygen species (ROS). Although extremely elevated levels of ROS can cause cell damage, a minimum level of ROS is necessary for activation of Hydroxylated-HIF-1a (HIF-1a) and inhibition of Peroxisome Proliferator-Activated Receptor-alpha (PPARa) during myocardial ischemic reperfusion injury (MIRI). MIRI clinical manifestations include arrhythmias, myocardial stunning, decreased ventricular contractility and no-reflow. Platelet rich plasma (PRP) has improved left ventricular (LV) function after MIRI in …

Rear Leg-Derived Moment Contributes To Resistance Against Hip Extension In Bulgarian Split Squats, Hiroshi Arakawa, Hikaru Nakashima, Xuanrui Li, Michiya Tanimoto

International Journal of Exercise Science

International Journal of Exercise Science 18(7): 881-894, 2025. The Bulgarian split squat (BSS) is a unilateral exercise that emphasizes hip extension more than knee extension, compared to other squat variations. This study aimed to (1) empirically verify the existence of the rear leg-derived moment (M_RL)—a theoretically plausible but previously untested external resistive hip moment acting against the net hip extension moment (M_HE) of the front leg—and (2) examine how stance width and forward trunk-leaning angles affect M_RL during the BSS. Nine trained male participants performed bodyweight BSS under two stance conditions (wide and narrow) and …

Idmatch Bike Fitting Enhances Power Output In Recreational Cyclists: A Pilot Study, Evan T. Hoyt, Gregory N. Ruegsegger

International Journal of Exercise Science

International Journal of Exercise Science 18(2): 864-880, 2025. Optimizing bike position is essential for enhancing cycling performance, improving comfort, and reducing injury risk. This study examined the acute effects of a bike fit using the idmatch^® system on power output, rate of perceived exertion (RPE), and discomfort in recreational cyclists. Twelve participants (10 males, 2 females; 37.0 ± 9.4 years) underwent an idmatch system bike fit, which employs three-dimensional motion capture to optimize rider position. Cyclists completed a six-second peak power test (PPT6) and a 20-minute functional threshold power (FTP) test before and after the fit. Performance metrics (power, …

The Effects Of Exercise Training In A Novel Full-Body Compression Garment On Anaerobic Performance In Healthy Men, Benjamin W. Cunningham, Mikayla M. Reese, Jesse M. Jansen, Benjamin S. Minier, Curtis A. Cornell, Faith C. Benedict, Joshua T. Mayne, Justin A. O'Dell, Gabriel M. Lysak, James R. Sackett

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 836-851, 2025. Although acutely donning compression garments improves several markers of athletic performance, the effects of training in compression garments remains largely unexplored. Thus, this study aimed to determine the effects of exercise training while donning a novel full-body compression garment on multiple measures of anaerobic performance. Sixteen sedentary males (age: 21±3 y; BMI: 25±3 kg/m²) completed 4 weeks of training with (CG; n=8) or without (CON; n=8) a novel full-body compression garment. Subjects performed a 40m sprint (time and velocity), a 5-repetition maximum barbell back squat (barbell weight and serratus anterior …

Change In Free-Living Daily Steps Does Not Affect Vo2max Adaptation In Response To A Supervised Aerobic Walking Program In Females Ages 18-45, Catherine L. Jarrett, Brandon J. Sawyer, Wesley Tucker, Dharini M. Bhammar, Justin R. Ryder, Siddhartha Angadi, Glenn A. Gaesser

International Journal of Exercise Science

International Journal of Exercise Science 18(5): 852-863, 2025. We hypothesized that an increase in nonexercise physical activity (NEPA), assessed by daily steps outside of steps accrued during supervised exercise training sessions, would be positively correlated with the change in VO_2max. Females ages 18-45 yr (n = 44; 30 ± 7 yr; 67.7 ± 18.3 kg; 24.9 ± 6.4 kg/m²) completed 36 supervised training sessions on a motorized treadmill (3 sessions/week, 30 min/session) over 12 weeks, at 70% VO_2max (80% max heart rate). VO_2max was assessed at baseline, 4, 8, and 12 weeks, and …

Enhancing Cataract Surgery Outcomes: Optimal Use Of Pre- And Post-Operative Eye Drops, Keith Skolnick M.D., Anu Valiaveedu

Mako: NSU Undergraduate Student Journal

Many preoperative and postoperative cataract patients struggle with comprehending the use of prescription medication as directed. Language barriers and low health literacy levels are major factors contributing to improper use of prescriptions. To increase patients comprehension, the Fort Lauderdale Eye Institute employed an educational intervention consisting of a live presentation and an instructional video. Results found that 44% of patients were hesitant to ask questions to clinical staff, 32% felt overwhelmed, and nearly 70% lacked confidence in using their prescribed eye drops. Following the intervention, 91% of patients reported increased confidence in their medications, and most indicated that the video …

Biophysical Effects Of Altered Myosin Binding Protein Stoichiometry In Atrial Myofilaments, Kelly N. Araujo

Dissertations

Cardiomyopathies, such as hypertrophic and dilated subtypes, are leading causes of heart failure and are often driven by genetic mutations that disrupt the structure and function of the cardiac sarcomere. While much of the research has focused on ventricular involvement, the role of atrial sarcomere dysfunction remains unexplored. The regulation of contractile function by sarcomeric proteins in the atria remains poorly understood, especially the impact of protein stoichiometry among myosin binding proteins. Cardiac myosin binding protein-C (cMyBP-C) and its atrial paralog, myosin binding protein H-like (MyBP-HL), have been shown to have a stoichiometric relationship within the atrial sarcomere. These two …

Comprehensive Fitness Assessment In A Professional Military Education Cohort: A Cross-Sectional Study, Daniel J. Lawson, Russell K. Lowell, C. Brooks Mobley, Katherine Frick, Nicholas C. Bordonie, Kaitlyn G. Clouse, Cameron D. Ott, Harrison C. Dimick, Nicholas R. Mauldin, Joellen M. Sefton

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 811-835, 2025. Military personnel face rigorous physical and cognitive demands critical for operational readiness and long-term health. This study evaluated body composition, cognitive performance, and physical fitness metrics in non-entry-level service members to inform tailored fitness interventions. This cross-sectional study analyzed data from Air Command Staff College personnel (N = 307; 89 females, 218 males; age: 37 ± 5 years) at Air University, Maxwell Air Force Base. Participants completed assessments for body composition (body mass index [BMI], body fat percentage [%BF], fat mass index [FMI], fat-free mass index [FFMI]), flexibility (sit-and-reach test, functional reach …

Validity And Reliability Of The 'Feelfit®' Accelerometer In Evaluating Physical Activity And Sedentary Time In Children: A Comparative Study With Two Different Accelerometers, Songdhasn Chinapong, Korntawat Klinchan, Hanif Abdul Rahman, Michael Chia, Waris Wongpipit, Jetsada Arnin, Areekul Amornsriwatanakul

International Journal of Exercise Science

International Journal of Exercise Science 18(2): 794-810, 2025. Accurate physical activity (PA) measurement is crucial for public health surveillance. While self-report questionnaires are commonly used, they have limitations, especially in young children. An affordable and user-friendly device like Feelfit® offers a promising alternative particularly for countries with limited research resources. This study aimed to evaluate Feelfit®’s performance against the widely used ActiGraph® accelerometer in measuring PA among children. A quasi-experimental design was applied. Thirty-nine children (19 boys; 20 girls; aged 11.4 ± 0.5 years) wore both Feelfit® and ActiGraph® during sequentially specified activities of varying intensity ranging from sedentary to …

Asymmetric Fgf Receptor Dimerization: Implications For Fgf23 Biology And Drug Discovery, Mohammed S. Razzaque, Moosa Mohammadi

School of Medicine Publications

Fibroblast growth factor 23 (FGF23) requires both αKlotho and heparan sulfate proteoglycans (HSPGs) as obligatory coreceptors to bind, dimerize, and activate its FGF receptors (FGFRs) in the kidney, thereby regulating mineral ion and vitamin D homeostasis. Cryogenic electron microscopy studies reveal that FGF23 signaling proceeds through an asymmetric 1:2:1:1 FGF23–FGFR–αKlotho–HS assembly. According to this structural model, αKlotho simultaneously anchors FGF23 and one FGFR chain, referred to as the primary receptor (FGFRP), to form a 1:1:1 FGF23-FGFRP-αKlotho triplex, which boosts FGF23-FGFRP interaction. Subsequently, the HS coreceptor aids the triplex in recruiting a second FGFR chain, or secondary receptor (FGFRS), leading to …

Differences In Fitness Between Cadet And General Population Firefighter Academy Recruits, Scott D. Brau, David Cornell, Benjamin J. Mendelson, Rudi A. Marciniak, Kyle Ebersole

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 774-793, 2025. This longitudinal study explored entry route- and age-related fitness differences between cadet (CR) and general population (GR) firefighter recruits. Fitness data were collected from eight separate firefighter recruit academy cohorts (N = 317; 122 CR, 195 GR; 27.17 ± 7.58 yrs, 177.30 ± 8.72 cm, 88.65 ± 17.78 kg). In the first week of the academy, recruits completed an assessment battery including: body composition via skinfold measures to estimate body fat (BF, %) and fat-free mass (FFM, kg); aerobic fitness (VO_2peak, mL· kg^-1· min^-1) and …