University of Massachusetts and King Abdulaziz University
Louisiana State University and Agricultural and Mechanical College
Georgia State University
University of Arkansas, Fayetteville
University of Massachusetts Amherst
Validation Of Monitoring Septic Thymus Involution In Mice Using Ultrasound.,
2023
University of Kentucky
Validation Of Monitoring Septic Thymus Involution In Mice Using Ultrasound., Jianyao Xue, Xiang-An Li
Journal of Pharmacology & Nutritional Sciences
Sepsis is a dangerous condition commonly seen in the intensive care unit (ICU) of hospitals. It causes the thymus, a crucial immune organ, to shrink. This process is known as thymus involution. Although thymus involution is a natural process that occurs as we age, it is accelerated during sepsis. This process is associated with poor outcomes in septic patients, yet it had never been studied using ultrasonography in a septic mouse model. Researchers from the University of Kentucky have validated a non-invasive ultrasound imaging approach to monitor septic thymus involution in a cecum ligation and puncture (CLP) sepsis mouse model. …
The Last Of Us In Therapy: How Mind-Controlling Fungi And Gut Bacteria Affect Your Mental Health,
2023
University of Kentucky
The Last Of Us In Therapy: How Mind-Controlling Fungi And Gut Bacteria Affect Your Mental Health, Anastasia Lyon
Journal of Pharmacology & Nutritional Sciences
The "psilocybiome" represents the mutually beneficial relationship between ourselves, our bacteria, and psychedelic drugs. This short review briefly discusses the benefits and limitations surrounding the potential for psychedelic therapy to synergize with gut bacteria to help regulate and maintain proper balance in the immune system, diet, and stress levels. Psychedelic therapy is a novel treatment strategy that has the potential to improve patient mental health, and, by identifying the types of gut bacteria present in patients, it can aid in personalizing medicine by determining how well their "psilocybiome" may respond.
(Pro)Renin Receptor And Its Soluble Form In Metabolic Dysfunction: Friend Or Foe?,
2023
University of Kentucky
(Pro)Renin Receptor And Its Soluble Form In Metabolic Dysfunction: Friend Or Foe?, Gertrude Arthur
Journal of Pharmacology & Nutritional Sciences
(Pro)renin receptor is component of the renin angiotensin system which has been shown to be involved in several physiological and pathophysiological processes including blood pressure regulation and hypertension, water and electrolyte balance, kidney injury, obesity, and metabolic dysfunction. Enzymatic cleavage of prorenin receptor produces soluble prorenin receptor which can also activate the renin angiotensin system stimulate similar pathophysiological process like its full form receptor. This review explores findings on the role of prorenin receptor and soluble prorenin receptor in metabolic dysfunction and discusses the conflicting findings on soluble prorenin receptor in metabolic dysfunction.
Determining The Effects Of Maternal Adiposity On Preterm Neonatal Microbiome And Short Chain Fatty Acid Profiles,
2023
East Tennessee State University
Determining The Effects Of Maternal Adiposity On Preterm Neonatal Microbiome And Short Chain Fatty Acid Profiles, Dalton James, William A. Clark Phd, Kristy L. Thomas
Undergraduate Honors Theses
The gut microbiota and its metabolites have vast impacts on the human digestive system, immune system, and health outcomes. Short chain volatile fatty acids (SCVFAs) present in feces can be representative of the interactions of the microbiota present in the gut. Low microbiota diversity in the human gut is highly associated with obesity and adverse health outcomes. Furthermore, the maternal microbiome has a direct impact on neonatal microbiota through various pathways such as environment, skin flora, breast milk composition, and vaginal secretions. This study is aimed to further understand the associations between various factors (maternal adiposity, gestational time, length of …
Bifidobacterial Metabolism Of Fucosylated Human Milk Oligosaccharides Influences Structure And Function Of The Infant Gut Microbiome,
2023
University of Massachusetts Amherst
Bifidobacterial Metabolism Of Fucosylated Human Milk Oligosaccharides Influences Structure And Function Of The Infant Gut Microbiome
Doctoral Dissertations
Human milk contains human milk oligosaccharides (HMOs) that are indigestible and pass intact through the infant gastrointestinal tract where they are available for microbial metabolism. HMOs incorporate the same monosaccharide building blocks but vary structurally in primary sequence of monomeric components. Primary sequences are further diversified by degree of polymerization, branching, and secondary modifications such as fucosylation. Fucosylated HMOs (fHMOs) are highly abundant and can account for over 30% of total HMOs. Infant-colonizing Bifidobacterium longum subsp. infantis (B. infantis) possesses a specialized gene cluster conveying the ability to metabolize fHMOs. This study presents an in-depth analysis of B. …
Evaluation Of Some Toxic Trace Elements In Crocus Sativus L. And Soil Using Neutron Activation Analysis Technique,
2023
University of Torbat Heydarieh
Evaluation Of Some Toxic Trace Elements In Crocus Sativus L. And Soil Using Neutron Activation Analysis Technique, Ehsan Taghizadeh Tousi
The Philippine Agricultural Scientist
Neutron activation analysis was used in this research to measure the concentrations of aluminum (Al), bromine (Br), chlorine (Cl), mercury (Hg), arsenic (As), and thorium (Th) in soil and saffron plants as well as their contamination, enrichment, and translocation rates. The edible part of the saffron showed a higher Hg concentration than the WHO/FAO-permitted level in the urban area. The soil was not intoxicated and contaminated by Al, As, and Th except in the urban areas, which were slightly polluted by As. The calculated contamination degree and pollution load index indicated that the soil was almost uncontaminated. The enrichment factors …
Utilizing The Rpe‑Clamp Model To Examine Interactions Among Factors Associated With Perceived Fatigability And Performance Fatigability In Women And Men,
2023
University of Nebraska-Lincoln
Utilizing The Rpe‑Clamp Model To Examine Interactions Among Factors Associated With Perceived Fatigability And Performance Fatigability In Women And Men, Robert W. Smith, Terry J. Housh, Jocelyn E. Arnett, John Paul V. Anders, Tyler J. Neltner, Dolores G. Ortega, Richard J. Schmidt, Glen O. Johnson
Nutrition and Health Sciences -- Faculty Publications
Purpose The purpose of the present study was to examine the interactions between perceived fatigability and performance fatigability in women and men by utilizing the RPE-Clamp model to assess the fatigue-induced effects of a sustained, isometric forearm flexion task anchored to RPE = 8 on time to task failure (TTF), torque, and neuromuscular responses.
Methods Twenty adults (10 men and 10 women) performed two, 3 s forearm flexion maximal voluntary isometric contractions (MVICs) followed by a sustained, isometric forearm flexion task anchored to RPE = 8 using the OMNI-RES (0–10) scale at an elbow joint angle of 100°. Electromyographic amplitude …
Vitamin C Contributes To Epigenetic Regulation Of Genes Related To Diabetic Retinopathy In Retinal Endothelial Cells,
2023
Noorda College of Osteopathic Medicine
Vitamin C Contributes To Epigenetic Regulation Of Genes Related To Diabetic Retinopathy In Retinal Endothelial Cells, Elizabeth L. Turner, Jonathon Reynolds, Walker Kay, Marianne Becnel, Matthew Conway, Alexander Kim, John A. Kriak, Kyle B. Bills, David W. Sant
Annual Research Symposium
No abstract provided.
A Composition Of Phytonutrients For Glycemic And Weight Management,
2023
Roseman University of Health Sciences
A Composition Of Phytonutrients For Glycemic And Weight Management, Yasuyo Urasaki
Annual Research Symposium
No abstract provided.
Appearance Of Two Distinct Clusters Of Glucose Dysregulation In Chronic Intractable Migraine,
2023
Noorda College of Osteopathic Medicine
Appearance Of Two Distinct Clusters Of Glucose Dysregulation In Chronic Intractable Migraine, Roshni Jogin, Kaitlyn Mcfarland, Aparna Naik, Tanner Williford, Matthew Conway, Amar Paul, John A. Kriak, David W. Sant, Kyle B. Bills
Annual Research Symposium
No abstract provided.
Type Ii Taste Cells Participate In Mucosal Immune Surveillance,
2023
Zhejiang Gongshang University
Type Ii Taste Cells Participate In Mucosal Immune Surveillance, Yumei Qin, Salin Raj Palayyan, Xin Zheng, Shiyi Tian, Robert F. Margolskee, Sunil Kumar Sukumaran
Nutrition and Health Sciences -- Faculty Publications
The oral microbiome is second only to its intestinal counterpart in diversity and abundance but its effects on taste cells remains largely unexplored. Using single-cell RNASeq, we found that mouse taste cells, in particular, sweet and umami receptor cells that express taste 1 receptor member 3 (Tas1r3), have a gene expression signature reminiscent of Microfold (M) cells, a central player in immune surveillance in the mucosa-associated lymphoid tissue (MALT) such as those in the Peyer’s patch and tonsils. Administration of tumor necrosis factor ligand superfamily member 11 (TNFSF11; also known as RANKL), a growth factor required for differentiation …
Something Smells Fishy: How Lipid Mediators Impact The
Maternal–Fetal Interface And Neonatal Development,
2023
University of Nebraska Medical Center
Something Smells Fishy: How Lipid Mediators Impact The Maternal–Fetal Interface And Neonatal Development, Maranda Thompson, Arzu Ulu, Maheswari Mukherjee, Ana G. Yuil-Valdes, Melissa Thoene, Matthew Van Ormer, Rebecca Slotkowski, Teri Mauch, Ann Anderson-Berry, Corrine K. Hanson, Tara M. Nordgren, Sathish Kumar Natarajan
Nutrition and Health Sciences -- Faculty Publications
Normal pregnancy relies on inflammation for implantation, placentation, and parturition, but uncontrolled inflammation can lead to poor maternal and infant outcomes. Maternal diet is one modifiable factor that can impact inflammation. Omega-3 and -6 fatty acids obtained through the diet are metabolized into bioactive compounds that effect inflammation. Recent evidence has shown that the downstream products of omega-3 and -6 fatty acids may influence physiology during pregnancy. In this review, the current knowledge relating to omega-3 and omega-6 metabolites during pregnancy will be summarized.
Something Smells Fishy: How Lipid Mediators Impact The
Maternal–Fetal Interface And Neonatal Development,
2023
University of Nebraska Medical Center
Something Smells Fishy: How Lipid Mediators Impact The Maternal–Fetal Interface And Neonatal Development, Maranda Thompson, Arzu Ulu, Maheswari Mukherjee, Ana G. Yuil-Valdes, Melissa K. Thoene, Matthew Van Ormer, Rebecca Slotkowski, Teri Mauch, Ann Anderson-Berry, Corrine K. Hanson, Tara M. Nordgren, Sathish Kumar Natarajan
Nutrition and Health Sciences -- Faculty Publications
Normal pregnancy relies on inflammation for implantation, placentation, and parturition, but uncontrolled inflammation can lead to poor maternal and infant outcomes. Maternal diet is one modifiable factor that can impact inflammation. Omega-3 and -6 fatty acids obtained through the diet are metabolized into bioactive compounds that effect inflammation. Recent evidence has shown that the downstream products of omega-3 and -6 fatty acids may influence physiology during pregnancy. In this review, the current knowledge relating to omega-3 and omega-6 metabolites during pregnancy will be summarized.
Scavenger Receptor B1 Facilitates
The Endocytosis Of Escherichia Coli Via Tlr4
Signaling In Mammary Gland Infection,
2023
Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, University of Kashmir
Scavenger Receptor B1 Facilitates The Endocytosis Of Escherichia Coli Via Tlr4 Signaling In Mammary Gland Infection, Qamar Taban, Syed Mudasir Ahmad, Peerzada Tajamul Mumtaz, Basharat Bhat, Ehtishamul Haq, Suhail Magray, Sahar Saleem, Nadeem Shabir, Amatul Muhee, Zahid Amin Kashoo, Mahrukh Hameed Zargar6, Abrar A. Malik, Nazir A. Ganai, Riaz A. Shah
Nutrition and Health Sciences -- Faculty Publications
SCARB1 belongs to class B of Scavenger receptors (SRs) that are known to be involved in binding and endocytosis of various pathogens. SRs have emerging role in regulating innate immunity and host–pathogen interactions by acting in co-ordination with Toll-like receptors.Query Little is known about the function of SCARB1 in milk-derived mammary epithelial cells (MECs). This study reports the role of SCARB1 in infection and its potential association in TLR4 signaling on bacterial challenge in Goat mammary epithelial cells (GMECs). The novelty in the establishment of MEC culture lies in the method that aims to enhance the viability of the cells …
Alzheimer’S Disease Genetics And Short-Chain Fatty Acid Treatment In Studies Of The Murine Gut Microbiome,
2023
University of Kentucky
Alzheimer’S Disease Genetics And Short-Chain Fatty Acid Treatment In Studies Of The Murine Gut Microbiome, Diana Zajac
Theses and Dissertations--Physiology
Elucidating the relationship of the gut microbiome in Alzheimer's Disease (AD) risk and pathogenesis is an area of intense interest. Since 60 to 80% of AD risk is related to genetics and APOE alleles represent the most impactful genetic risk factors for AD, their mechanism(s) of action are under intense scrutiny.
First, I conducted a study on APOE targeted replacement mice to investigate the impact of APOE alleles on the murine gut microbiome. The relative abundance of bacteria from the family Ruminococacceae and related genera increased with APOE2 status. The relative abundance of the class Erysipelotrichia increased with APOE4 status, …
Novel Therapeutic Nutrients Molecules That Protect Against
Zika Virus Infection With A Special Note On Palmitoleate,
2022
University of Nebraska-Lincoln
Novel Therapeutic Nutrients Molecules That Protect Against Zika Virus Infection With A Special Note On Palmitoleate, Philma Glora Muthuraj, Chandan Krishnamoorthy, Ann Anderson-Berry, Corrine K. Hanson, Sathish Kumar Natarajan
Nutrition and Health Sciences -- Faculty Publications
Zika virus (ZIKV) is a Flavivirus from the Flaviviridae family and a positive-sense single strand RNA virus. ZIKV infection can cause a mild infection to the mother but can be vertically transmitted to the developing fetus, causing congenital anomalies. The prevalence of ZIKV infections was relatively insignificant with sporadic outbreaks in the Asian and African continents until 2006. However, recent epidemic in the Caribbean showed significant increased incidence of Congenital Zika Syndrome. ZIKV infection results in placental pathology which plays a crucial role in disease transmission from mother to fetus. Currently, there is no Food and Drug Administration (FDA) approved …
Extracellular Vesicle Characteristics And Micro Rna Content In Cerebral Palsy And Typically Developed Individuals At Rest And In Response To Aerobic Exercise.,
2022
University of Nebraska-Lincoln
Extracellular Vesicle Characteristics And Micro Rna Content In Cerebral Palsy And Typically Developed Individuals At Rest And In Response To Aerobic Exercise., Ivan Jose Vechetti Jr, Jessica Norrbom, Björn Alkner, Emma Hjalmarsson, Alexandra Palmcrantz, Eva Pontén, Jessica Pingel, Ferdinand Von Walden, Rodrigo Fernandez-Gonzalo
Nutrition and Health Sciences -- Faculty Publications
In this study, the properties of circulating extracellular vesicles (EVs) were examined in cerebral palsy (CP) and typically developed (TD) individuals at rest and after aerobic exercise, focusing on the size, concentration, and microRNA cargo of EVs. Nine adult individuals with CP performed a single exercise bout consisting of 45 min of Frame Running, and TD participants completed either 45 min of cycling (n = 10; TD EX) or were enrolled as controls with no exercise (n = 10; TD CON). Blood was drawn before and 30 min after exercise and analyzed for EV concentration, size, and microRNA …
A Prophylactic Subcutaneous Dose Of The
Anticoagulant Tinzaparin Does Not Influence
Qpcr-Based Assessment Of Circulating Levels
Of Mirna In Humans,
2022
Linköping University
A Prophylactic Subcutaneous Dose Of The Anticoagulant Tinzaparin Does Not Influence Qpcr-Based Assessment Of Circulating Levels Of Mirna In Humans, Abraham Nilsson, Anna Maria Nerhall, Ivan Jose Vechetti Jr, Lotta Fornander, Simon Wiklund, Björn Alkner, Jörg Schilcher, Ferdinand Von Walden
Nutrition and Health Sciences -- Faculty Publications
Circulating microRNAs (miRNAs) have become increasingly popular biomarker candidates in various diseases. However, heparin-based anticoagulants might affect the detection of target miRNAs in blood samples during quantitative polymerase chain reaction (qPCR)- based analysis of miRNAs involving RNA extraction, cDNA synthesis and the polymerase catalyzed reaction. Because low-molecular-weight heparins (LMWH) are widely used in routine healthcare, we aimed to investigate whether a prophylactic dose of the LMWH tinzaparin influences qPCR-based quantification of circulating miRNAs. A total of 30 subjects were included: 16 fracture patients with tinzaparin treatment and 14 non-fracture controls without anticoagulation therapy. To control for the effect of tinzaparin …
The Effects Of Surface Composition On 6-Weeks Of Plyometric Training,
2022
Middle Tennessee State University
The Effects Of Surface Composition On 6-Weeks Of Plyometric Training, Cameron D. Addie, Richard S. Farley, Sandra L. Stevens, Halle J. Brandt3, Jocelyn E. Arnett, Jennifer L. Caputo
Nutrition and Health Sciences -- Faculty Publications
Background: Plyometric training programs may be performed on a hard surface or a soft surface to target specific training adaptations and enhance jump performance. However, it is unknown how surface compliance impacts jump performance. Objective: To compare changes in horizontal lower body power following a 6-week plyometric training program performed on a soft surface (n = 9) and a hard surface (n = 11). Methods: This was a quasi-experimental study. University students (N = 20; males = 11, females = 9; age: 20.4 ± 3.7 yr; body mass: 68.4 ± 12.5 kg; height 1.7 …
Plum Supplementation And Lipid Profile: A Systematic Review And
Meta-Analysis Of Randomised Controlled Trials,
2022
Shiraz University of Medical Sciences
Plum Supplementation And Lipid Profile: A Systematic Review And Meta-Analysis Of Randomised Controlled Trials, Moein Askarpour, Hamid Ghalandari, Leila Setayesh, Ehsan Ghaedi
Nutrition and Health Sciences -- Faculty Publications
Plums are abundant in bioactive compounds which have been associated with numerous health benefits. In the present study, we aimed at examining the impact of plum supplementation on lipid profile of individuals. Electronic bibliographical databases were searched for relevant randomised clinical trials. Articles meeting our eligibility criteria were included for data extraction and final analysis. Weighted mean difference (WMD) was estimated using a random-effect model. Of the total articles retrieved in the initial search, nine articles were found to be eligible to be included in the analysis. Our results show that plum supplementation significantly improves total cholesterols levels in the …
