Mastering Mycological Mysteries With Explorations Of Harpellales Associated With Culicidae And Other Dipterans In Idaho,
2018
Boise State University
Mastering Mycological Mysteries With Explorations Of Harpellales Associated With Culicidae And Other Dipterans In Idaho, Michael Mccormick
Boise State University Theses and Dissertations
Presented is the first field survey and laboratory-based study focused on Harpellales gut fungi found in Culicidae (mosquito) larvae collected from various parts of Idaho. Overall, 34 sites were sampled ranging from urban storm drains and irrigation puddles to pristine stream-side puddles. These sites yielded 17 different species of mosquitoes and three previously described species of gut fungi. Three species of mosquitoes were the first recorded observations as hosts of the following gut fungi: Culiseta alaskaensis was infested with Zancudomyces culisetae (from Renwyck Creek), Culex tarsalis with Smittium culicis (from Cottonwood Creek), and Ochleratus sp. with Smittium minutisporum (from Bear …
Modeling The Transmission Of Wolbachia In Mosquitoes For Controlling Mosquito-Borne Diseases,
2018
University of Texas at San Antonio
Modeling The Transmission Of Wolbachia In Mosquitoes For Controlling Mosquito-Borne Diseases, Zhuolin Qu
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Biomathematics And Social Justice: Reinventing Models Of Disease Spread To Study Efficacy Of Bystander Violence Prevention,
2018
University of Portland
Biomathematics And Social Justice: Reinventing Models Of Disease Spread To Study Efficacy Of Bystander Violence Prevention, Hannah Callender Highlander
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Proposed Interventions For The Containment Of Influenza In Boarding Schools And Small Colleges,
2018
Illinois State University
Proposed Interventions For The Containment Of Influenza In Boarding Schools And Small Colleges, Alexis Vittengl
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
The Rational Design, Synthesis, Characterization, And Biological Evaluation Of Cancer-Targeting Immunostimulatory Peptide-Protein Conjugates And Tripeptides,
2018
Seton Hall University
The Rational Design, Synthesis, Characterization, And Biological Evaluation Of Cancer-Targeting Immunostimulatory Peptide-Protein Conjugates And Tripeptides, Keith Smith
Seton Hall University Dissertations and Theses (ETDs)
With the advent of cancer immunotherapy and the rise in applications of synthetic biologics, there has been a steady decline in the incidence of cancer. Despite this trend, there is an anticipated 1.7 million new cancer cases with an estimated 610,000 deaths expected by the end of 2018.2 Therefore, the call for continued efforts in creating more effective treatment options are still in high demand. In this thesis, the rational design of a semi-synthetic cancer-targeting immunostimulatory peptide-protein bioconjugate—using N-succinimidyl carbamate chemistry is described. This bio-orthogonal chemistry approach was used to conjugate the synthetic Pep42, cancer-targeting peptide (CTP) and the immunostimulatory …
The Role Of Outcome Preferences In Optimizing Heterogenous Disease Control Strategies.,
2018
Arizona State University at the Tempe Campus
The Role Of Outcome Preferences In Optimizing Heterogenous Disease Control Strategies., Evan Milliken
Biology and Medicine Through Mathematics Conference
No abstract provided.
Changes In The Microbial Community Of Lubomirskia Baicalensis Affected By Red Sponge Disease,
2018
Stephen F Austin State University
Changes In The Microbial Community Of Lubomirskia Baicalensis Affected By Red Sponge Disease, Colin Rorex
Electronic Theses and Dissertations
Lake Baikal is the oldest known lake and a unique ecosystem, home to several species of fresh water sponge. A disease outbreak affecting the dominant species, Lubormirskia baialensis, was recently reported. The cause of the disease has not been determined but one of the current hypothesis is that the increase in methane concentration is correlated to the disease outbreak. This pilot study characterized the microbiomes of sick and healthy sponges through the use of 16S rRNA sequencing. Sick sponge microbiomes shared a conserved group of taxa while the healthy sponge microbiomes had greater diversity. Indicator species analysis identified two significant …
Enhanced Production Of Pro-Il-1Βeta Contributes To Immunopathology During The Coinfection Of Influenza A Virus And Streptococcus Pneumoniae,
2018
Missouri State University
Enhanced Production Of Pro-Il-1Βeta Contributes To Immunopathology During The Coinfection Of Influenza A Virus And Streptococcus Pneumoniae, Angeline E. Rodriguez
Graduate Theses/Dissertations
Viral bacterial coinfections are known to cause severe pneumonia, especially in the elderly and in pediatric patients. Antibiotics like β-Lactams kill the bacteria but fail to improve symptoms suggesting a faulty immune system may play an important role in the disease. Interleukin-1β (IL-1β) is an important immune signaling cytokine responsible for inflammation. It exists as an inactive precursor that can be activated by caspase-1 containing inflammasomes (multi-protein complex). Influenza A virus (IAV) and Streptococcus pneumoniae (S. pneumoniae) activate the inflammasome through the NOD-like receptor protein NLRP3 and/or AIM2. Previous reports in mice indicate that IL-1β levels are dramatically …
Autoimmune Disorders And Hypersensitivities In The Developed World,
2018
Northern Michigan University
Autoimmune Disorders And Hypersensitivities In The Developed World, Margaret S. Bohm
Conspectus Borealis
No abstract provided.
Paclitaxel Enhances Oncolytic Potential Of Herpes Simplex Virus Type-1 In Cancer Cells,
2018
Louisiana State University and Agricultural and Mechanical College
Paclitaxel Enhances Oncolytic Potential Of Herpes Simplex Virus Type-1 In Cancer Cells, Misagh Naderi
LSU Master's Theses
Taxanes are spindle poisons that bind to and stabilize microtubules resulting in mitotic arrest. Herpes simplex Typ-1 (HSV-1) virions utilize the microtubular network for intracellular transport during both virus entry and virus egress from infected cells. It has been reported previously that taxanes may synergize with oncolytic herpes simplex viruses in the treatment of experimental prostate and breast tumors in mice. Other reports have indicated that taxanes may inhibit viral replication in infected cells. In this study the previously characterized Oncolytic Herpes Simplex Virus type 1 (OSVP), which was constructed in Kousoulas lab was used in conjugation with paclitaxel (taxol) …
Do Paraben Derivatives Alter T Cell Immunity?,
2018
Longwood University
Do Paraben Derivatives Alter T Cell Immunity?, Hailey Kintz
Spring Presentation of Undergraduate Research
T cells immunity is linked to a complex system of cytokines that determine differentiation of naïve T cells into Th1, Th2, Th17, and Treg cells. Estrogen production or periods of elevated production have been correlated with an anti-inflammatory state in which Th2 and Treg cells are up-regulated. Such responses in the immune system are capable of supporting pre-cancerous activity. We are investigating the tie between the xenoestrogen compounds found in cosmetics, parabens, and their ability to regulate T cell immunity. Testing parabens and paraben derivatives with weaker estrogen receptor association will allow for a better understanding of the interplay between …
Bone Marrow Derived Progenitor Cells And Their Contributions To The Thymic Stroma,
2018
CUNY City College
Bone Marrow Derived Progenitor Cells And Their Contributions To The Thymic Stroma, Mohammed Hoque
Dissertations and Theses
The thymus serves as the primary lymphoid organ responsible for the development and selection of a self-tolerant T cell repertoire. In paradox to its critical functions for the adaptive immune response, the thymus undergoes a profound age associated decline beginning in early adult life resulting in significant decline in T-cell function.Thymic epithelial cells (TECs) are the most critical component of the thymic microenvironment and undergo rapid turn-over, so understanding the cellular mechanisms responsible for the maintenance of TEC number and organization will be critical in counteracting age associated involution, particularly in cancer patients, due to enhanced degeneration in response to …
Establishing Relationships Among Environmental Stressors, Host Immune Status, And Wasting Disease Susceptibility In The Dominant Seagrass Species Thalassia Testudinum,
2018
University of North Florida
Establishing Relationships Among Environmental Stressors, Host Immune Status, And Wasting Disease Susceptibility In The Dominant Seagrass Species Thalassia Testudinum, Paige Joy Duffin
UNF Graduate Theses and Dissertations
A growing body of evidence supports the observation that marine disease outbreaks, especially those caused by opportunistic pathogens, are increasing in frequency and severity. One genus of such pathogens, Labyrinthula, has been identified as the causative agent of seagrass wasting disease, an epidemic that has historically plagued seagrass beds around the world. It is suspected that pathogenicity is intimately linked to the ability of the host to initiate defense responses, but a lack of compelling evidence prevents any meaningful application of preliminary observations. This body of work investigated the roles of host genotype, host immune status, and environmental stressors …
Prevention Of Childhood Obesity And Diabetes,
2017
The University of San Francisco
Prevention Of Childhood Obesity And Diabetes, Karen Carig
Master's Projects and Capstones
One of the public health concerns that have been on the rise is childhood obesity and diabetes. The National Health and Nutrition Examination Survey indicate that approximately one-third of children in the United States are overweight or obese with 17% meeting criteria for obesity (Pulgaron and Delamater, 2014). This crisis exists nationally and internationally which can effect children in the following ways: physically, socially, psychologically and mentally. Although, genetics also play a role in these diseases, environmental factors, lifestyle preferences and cultural environmental play have a major influence. My internship with the Food Education Project covers a better understanding to …
Improving Hpv Vaccination Series Initiation Rates And Compliance Among Indigent Women In South Texas, Ages 19-26, Through Provider Recommendation And Additional Clinic Funding: A Quality Improvement Project,
2017
University of the Incarnate Word
Improving Hpv Vaccination Series Initiation Rates And Compliance Among Indigent Women In South Texas, Ages 19-26, Through Provider Recommendation And Additional Clinic Funding: A Quality Improvement Project, Lacey Cudd
Doctor of Nursing Practice
The purpose of this quality improvement project was to increase human papillomavirus vaccination series initiation rates among indigent women, ages 19-26, at a clinic in South Texas. The human papillomavirus is a sexually transmitted infection that has been associated with multiple types of cancers. Each year, approximately 6.2 million cases of the human papillomavirus infection are diagnosed; as many as 75% of all new infections occur among females 18-26 years of age. The human papillomavirus vaccination has a high efficacy in regards to cancer prevention, preventing as many as 76% of cancers with only one dose. The project included educating …
A License To Kill: Understanding Natural Killer Cell Licensing To Fight Cancer,
2017
The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences
A License To Kill: Understanding Natural Killer Cell Licensing To Fight Cancer, Jolie Schafer
Dissertations and Theses (Open Access)
Natural killer (NK) cell education is an essential developmental process for NK cell effector function, that renders some NK cells “licensed” and others “unlicensed” (with heightened or lowered effector function potential, respectively) against tumor and targets lacking self-molecules. However, the underlying mechanisms responsible for the heightened effector responses of licensed cells remain unknown. Using NK cells derived from humans and expanded ex vivo we performed high-throughput protein expression analysis, and identified multiple proteins that are differentially regulated in licensed and unlicensed human NK cells before and after inhibition by killer-cell immunoglobulin-like receptors (KIRs) and activation by the NKp46 natural cytotoxicity …
Age-Structured And Vaccination Models Of Devil Facial Tumor Disease,
2017
University of St. Francis
Age-Structured And Vaccination Models Of Devil Facial Tumor Disease, Christopher D. Bruno, Timothy Comar, Megan O. Powell, Adjo Tameklo
Spora: A Journal of Biomathematics
Tasmanian devil populations have been devastated by devil facial tumor disease (DFTD) since its first appearance in 1996. The average lifespan of a devil has decreased from six years to three years. We present an age-structured model to represent how the disease has affected the age and breeding structures of the population. We show that with the recent increase in the breeding of juvenile devils, the overall devil population will increase but not nearly to pre-DFTD levels. The basic reproductive number may be increased with the influx of young breeding devils. In addition, our model shows that the release of …
Cd80 Expressed By Cd8+ T Cells Contributes To Pd-L1-Induced Apoptosis Of Activated Cd8+ T Cells,
2017
University of Minnesota - Morris and Mayo Clinic
Cd80 Expressed By Cd8+ T Cells Contributes To Pd-L1-Induced Apoptosis Of Activated Cd8+ T Cells, Meagan R. Rollins, Rachel M. Gibbons Johnson
Biology Publications
Tumor cells are capable of limiting antitumor CD8+ T cell responses through their cell surface expression of PD-L1. In addition to PD-1 expressed by CD8+ T cells, PD-L1 also binds to CD80 expressed by CD8+ T cells. The influence of the PD-L1/CD80 interaction on CD8+ T cell function has not been fully characterized, so we sought to investigate the impact of the PD-L1/CD80 interaction on PD-L1-induced apoptosis of activated CD8+ T cells. We found that CD8+ T cells that lacked CD80 expression got activated to the same extent as wild-type CD8+ T cells, but when cultured with anti-CD3 and PD-L1/Fc …
Modeling Vaccination Strategies To Control White-Nose Syndrome In Little Brown Bat Colonies,
2017
St. Olaf College
Modeling Vaccination Strategies To Control White-Nose Syndrome In Little Brown Bat Colonies, Eva Cornwell, David Elzinga, Shelby Stowe, Alex Capaldi
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
A Model Of Dengue Transmission With Wolbachia-Free And Wolbachia-Infected Mosquitoes,
2017
Illinois State University
A Model Of Dengue Transmission With Wolbachia-Free And Wolbachia-Infected Mosquitoes, Iftikhar Ahmed
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
