Efficacy And Mechanism Of Â-Defensin2 Fused Antigen Protein Vaccines,
2010
University of Texas Graduate School of Biomedical Sciences at Houston
Efficacy And Mechanism Of Â-Defensin2 Fused Antigen Protein Vaccines, Hyun J. Park
Dissertations & Theses (Open Access)
Vaccines which use the strategy of fusing adjuvant murine â-defensin2 (mBD2) to an antigen in order to elicit stronger anti-antigen immune responses are referred to as murine â-defensin2 (mBD2) vaccines. Previous studies have validated the potential of mBD2 vaccines, thus in this study we focus on increasing vaccine efficacy as well as mechanism elucidation. Initially, we demonstrate superior IFN-ã release levels by antigen specific effector T cells when antigen is crosspresented by dendritic cells (DC) which absorbed mBD2 vaccine (mBD2 fused antigen protein) over antigen alone. We move unto an in vivo model and note significant increases in the expansion …
Identification Of Novel Antimalarials From Marine Natural Products For Lead Discovery,
2010
University of Central Florida
Identification Of Novel Antimalarials From Marine Natural Products For Lead Discovery, Stephenie M. Alvarado
Electronic Theses and Dissertations
An estimated 500 million cases of malaria occur each year. The increasing prevalence of drug resistant strains of Plasmodium in most malaria endemic areas has significantly reduced the efficacy of current antimalarial drugs for prophylaxis and treatment of this disease. Therefore, discovery of new, inexpensive, and effective drugs are urgently needed to combat this disease. Marine biodiversity is an enormous source of novel chemical entities and has been barely investigated for antimalarial drug discovery. In an effort to discover novel therapeutics for malaria, we studied the antimalarial activities of a unique marine-derived peak fraction library provided by Harbor Branch Oceanographic …
