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With Love, ; An Interdisciplinary And Intersectional Look At Why Creativity Is Essential, Theo Starr Gardner 2024 Whittier College

With Love, ; An Interdisciplinary And Intersectional Look At Why Creativity Is Essential, Theo Starr Gardner

Whittier Scholars Program

My Whittier Scholars Program self-designed major, Teaching Creativity, is a mixture of Art, Literature, and Education classes. My research and praxis classes have been focused on the ‘how?’s and 'why?’s of creativity, so it felt only right that my project should be a constructivist, generative project. The project I have been working on throughout my time at Whittier, and that has just fully come to fruition on April 11th, 2024, was a solo art gallery/open mic event entitled ‘With Love,’. With Love, was conceptually inspired by the research I’ve conducted on creativity and creative arts education over the past few …


Characterizing The Role Of Pa5189 Of Pseudomonas Aeruginosa In Deletion And Overexpression Mutants, Seh Na Mellick 2024 University of Nebraska at Omaha

Characterizing The Role Of Pa5189 Of Pseudomonas Aeruginosa In Deletion And Overexpression Mutants, Seh Na Mellick

Theses/Capstones/Creative Projects

In the context of rising multidrug resistance in biofilm-forming pathogens like Pseudomonas aeruginosa, this study investigates the role of the understudied transcription factor PA5189 in antibiotic resistance and biofilm formation. PA5189 deletion and overexpression mutants were created in a parent P. aeruginosa strain using pEX18Tc-based recombinant suicide vectors, with genotypic verification of putative triparental conjugants achieved through restriction digestion and PCR. The study revealed that PA5189 overexpression significantly increases resistance to commonly used broad spectrum antibiotics such as ciprofloxacin and imipenem. Additionally, differential expression of PA5189 was found to notably affect biofilm formation, with variations contingent on the nutrient …


Towards Understanding The Function Of An Ets-Like Gene In Nematostella Vectensis: Generation Of A Knockout Mutant Line And A Transgenic Reporter Line, Emily Bullock 2024 University of Arkansas, Fayetteville

Towards Understanding The Function Of An Ets-Like Gene In Nematostella Vectensis: Generation Of A Knockout Mutant Line And A Transgenic Reporter Line, Emily Bullock

Biological Sciences Undergraduate Honors Theses

Due to their unique phylogenic position as sister to Bilateria, Cnidaria are often credited with the utility of allowing for reconstruction of ancestral biology based on characteristics shared with bilaterians and other animals. This factor makes investigation into the nervous systems of cnidarians critical in understanding early neural evolution. Wamides, a class of neuropeptides, have been shown to play a regulatory role in life cycle transitions across many different species. The cnidarian specific Wamide neuropeptide, GLWamide, has previously been identified to play an accelerator role in the metamorphic timing of a specific species of sea anemone, Nematostella vectensis. However, …


Annotation Of Hypothetical Genes In Lactococcus Lactis Ssp. Il403, Jennifer A. Tangires 2024 University of Lynchburg

Annotation Of Hypothetical Genes In Lactococcus Lactis Ssp. Il403, Jennifer A. Tangires

Student Scholar Showcase

The human gastrointestinal tract (GIT) harnesses various microbial organisms involved in almost all processes of physiological homeostasis, among these are lactic acid bacteria (LAB). These bacteria, almost all of which belong to the order Lactobacillales, are able to produce lactic acid, and play an important role in food preservation because they produce bacteriocins. Bacteriocins are antimicrobial proteins that are used to fight off related bacteria in their environment that are competing for the same resources. This study focuses on a specific LAB strain, Lactococcus lactis ssp. IL1403 where 21.9% of its predicted genes have not yet been assigned a function. …


Unravelling The Genetic Basis Of Schizophrenia, Clara Casey, John F. Fullard, Roy D. Sleator 2024 Department of Biological Sciences, Munster Technological University, Bishopstown, Cork, Ireland; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States;

Unravelling The Genetic Basis Of Schizophrenia, Clara Casey, John F. Fullard, Roy D. Sleator

Department of Biological Sciences Publications

Neuronal development is a highly regulated mechanism that is central to organismal function in animals. In humans, disruptions to this process can lead to a range of neurodevelopmental phenotypes, including Schizophrenia (SCZ). SCZ has a significant genetic component, whereby an individual with an SCZ affected family member is eight times more likely to develop the disease than someone with no family history of SCZ. By examining a combination of genomic, transcriptomic and epigenomic datasets, large-scale ‘omics’ studies aim to delineate the relationship between genetic variation and abnormal cellular activity in the SCZ brain. Herein, we provide a brief overview of …


Comparative Genomics Of Selected Lactobacillus Helveticus Strains, Cain Petty 2024 Mississippi University for Women

Comparative Genomics Of Selected Lactobacillus Helveticus Strains, Cain Petty

Undergraduate Research Conference

My research is to compare two strains (D76 and H10) of Lactobacillus helveticus and a shared gene between them. I would want to experiment with overexpression to test for any difference in the regulatory function of genes associated with CggR - the central glycolytic genes regulator. The poster I am presenting would outline this and provide a clearer understanding of genes and potential overexpression.


"The Relevant History And Medical And Ethical Future Viability Of Xenotransplantation", Morgan Janes 2024 Augustana College, Rock Island Illinois

"The Relevant History And Medical And Ethical Future Viability Of Xenotransplantation", Morgan Janes

Augustana Center for the Study of Ethics Essay Contest

Xenotransplantation, the transplantation of organs or tissues from one species to another, presents a complex nexus of medical, ethical, and cultural considerations. In this article, we delve into the multifaceted landscape of xenotransplantation, beginning with a thorough examination of its relevant historical trajectory. From early experiments to recent advancements, we chart the evolution of this field, setting the stage for a nuanced discussion. We then confront the central issue: the true medical viability of xenotransplantation and the looming specter of operative risk. By scrutinizing the ethical dilemmas inherent in xenotransplantation through a multicultural lens, we illuminate the diverse perspectives that …


Pedigree Analysis Of Congenital Stationary Night Blindness And Surveillance Of Related Problems In The Area Of Depalpur, Okara-Pakistan, Muhammad Abdullah, Muhammad Sajjad Sarwar, Muhammad Rizwan, Muhammad Iqbal Usama, Hamza Zulfiqar, Muhammad Wajid, Saira Ashfaq 2024 Department of Zoology University of Okara, Pakistan

Pedigree Analysis Of Congenital Stationary Night Blindness And Surveillance Of Related Problems In The Area Of Depalpur, Okara-Pakistan, Muhammad Abdullah, Muhammad Sajjad Sarwar, Muhammad Rizwan, Muhammad Iqbal Usama, Hamza Zulfiqar, Muhammad Wajid, Saira Ashfaq

Journal of Bioresource Management

Congenital stationary night blindness (CSNB) is described as a set of inherited, non-progressive retinal conditions in which the rod pathway is primarily affected, resulting in difficulty adapting to low-light situations due to impaired photoreceptor transmission. Objectives of study was to identify patients with CSNB and explore their lifestyle and the impact of CSNB on their daily routines in selected areas. Total seven families having CSNB, belonging to five villages (Abadi Haji Ismaeel, Sunari wala, Tibba, Shamdin, and Chorasta Mian Khan) of Depalpur, district Okara, were investigated in March 2023. The CSNB prevalence was calculated as 2.528 % in all selected …


The Genome Of Huauzontle (Chenopodium Berlandieri), A North American Relative Of Quinoa, Ashley K. Marcheschi, Jeff Maughan, Peter J. Maughan, David E. Jarvis, Kate E. Jaggi, Eric N. Jellen 2024 Brigham Young University - Provo

The Genome Of Huauzontle (Chenopodium Berlandieri), A North American Relative Of Quinoa, Ashley K. Marcheschi, Jeff Maughan, Peter J. Maughan, David E. Jarvis, Kate E. Jaggi, Eric N. Jellen

Library/Life Sciences Undergraduate Poster Competition 2024

Quinoa (Chenopodium quinoa) is a popular Andean seed crop that has a reduced ability to thrive outside of its native range. A related member of the Allotetraploid Goosefoot Complex (ATGC), pitseed goosefoot (Chenopodium berlandieri), is a minimally invasive North American weed that is able to survive in climates and environments that are restrictive to quinoa growth. C. berlandieri has been independently domesticated at least three times, including in Mesoamerica as the immature panicle vegetable ‘huauzontle.’ To assess the capacity of C. berlandieri as a genetic resource for improvement of C. quinoa, we sequenced the whole genome of a huauzontle accession …


Solving The Hiv Enigma: Investigating Mutant Long-Term Non-Progressor Vpr Strands, Megan Knight, Bradford Berges 2024 Brigham Young University - Provo

Solving The Hiv Enigma: Investigating Mutant Long-Term Non-Progressor Vpr Strands, Megan Knight, Bradford Berges

Library/Life Sciences Undergraduate Poster Competition 2024

Different variants of HIV:

➢ Rapid Progressor: aggressive symptoms, quick progression into AIDs

➢ Wild-Type: regular symptoms, regular progression into AIDs

➢ Long-Term Non-Progressor: little-


Leucine Lock: A Diagnostic Tool To Revolutionize Rapid Antigen Testing, Kaitlyn Robinson, Jonathon Hill, Benjamin Johnson, Matt Goff 2024 Brigham Young University - Provo

Leucine Lock: A Diagnostic Tool To Revolutionize Rapid Antigen Testing, Kaitlyn Robinson, Jonathon Hill, Benjamin Johnson, Matt Goff

Library/Life Sciences Undergraduate Poster Competition 2024

• The current field of rapid testing uses antigen tests that are ELISA-based.

• ELISA tests are expensive and can only provide results for high-antigen loads. (asymptomatic patients and/or low-antigen samples generate inaccurate results).1

• We aim to provide a cheaper rapid test that produces both quantitative and qualitative results.


Chasing The Rainbow: Systematics Of New Guinean Rainbow Skinks, Taylor Probst, Alison Whiting 2024 Brigham Young University - Provo

Chasing The Rainbow: Systematics Of New Guinean Rainbow Skinks, Taylor Probst, Alison Whiting

Library/Life Sciences Undergraduate Poster Competition 2024

Oral Presentation Honorable Mention

• Carlia are known as the “Rainbow skinks” due to their iridescent scales (see Figure 1).

• Carlia are found across Oceania (see figure 2), however only relationships among the Australian species are known.

• New Guinean Carlia are divided into three species groups based on size, distribution, and morphology.

• Species within the Carlia fusca complex have primarily been delineated based on regional color patterns (see Figure 4).

• New Guinea is known for extreme lizard diversity, specifically within skinks.

• Research has shown that many lizard groups underwent a rapid diversification within New Guinea, …


Examining Cetp Gene Associated With Ad-Related Diseases Of The Hispanic Population In The Rio Grande Valley., Erika Guajardo, Luis Aguillon, Daniela Ollervides-Charles, KeSheng Wang, Gladys E. Maestre, J. Garza, Chun Xu 2024 The University of Texas Rio Grande Valley

Examining Cetp Gene Associated With Ad-Related Diseases Of The Hispanic Population In The Rio Grande Valley., Erika Guajardo, Luis Aguillon, Daniela Ollervides-Charles, Kesheng Wang, Gladys E. Maestre, J. Garza, Chun Xu

Research Symposium

Background: There are currently about 6 million people in the United States that suffer from Alzheimer’s Disease (AD) and Alzheimer’s Disease related dementia (ADRD). It is a progressive disease beginning with mild memory loss and possibly leading to loss of the ability to carry on a conversation and respond to the environment. Over time, these conditions can cause many different health issues that decrease the quality of life. In addition, Hispanic people are twice as likely to develop AD or AD related dementia than non-Hispanic White people. In our study, we are investigating a known gene, CETP, that directly corresponds …


Analysis Of The Population Structure And Migrationhabits Of The Northern Leopard Frog (Lithobates Pipiens) At Midewin National Tallgrass Prairie, Gretchen A. Brinkman 2024 Olivet Nazarene University

Analysis Of The Population Structure And Migrationhabits Of The Northern Leopard Frog (Lithobates Pipiens) At Midewin National Tallgrass Prairie, Gretchen A. Brinkman

ELAIA

Massive amphibian declines of recent years have pushed researchers to pursue population genetics surveys and assess the status of these essential components of many ecosystems. The Northern Leopard Frog (Lithobates pipiens) has continuously experienced population declines across the continental United States due to a combination of habitat losses and environmental changes. Midewin National Tallgrass Prairie houses a considerable portion of L. pipiens in Illinois, and the two creek watersheds studied within this location provide ideal conditions to support these animals. Because this prairie restoration project is a relatively recent development, further assessments regarding the population structure and degree of migration …


A Machine Learning Model Of Perturb-Seq Data For Use In Space Flight Gene Expression Profile Analysis, Liam F. Johnson, James Casaletto, Lauren Sanders, Sylvain Costes 2024 Purdue University

A Machine Learning Model Of Perturb-Seq Data For Use In Space Flight Gene Expression Profile Analysis, Liam F. Johnson, James Casaletto, Lauren Sanders, Sylvain Costes

Graduate Industrial Research Symposium

The genetic perturbations caused by spaceflight on biological systems tend to have a system-wide effect which is often difficult to deconvolute it into individual signals with specific points of origin. Single cell multi-omic data can provide a profile of the perturbational effects, but does not necessarily indicate the initial point of interference within the network. The objective of this project is to take advantage of large scale and genome-wide perturbational datasets by using them to train a tuned machine learning model that is capable of predicting the effects of unseen perturbations in new data. Perturb-Seq datasets are large libraries of …


Applicability Of Fibrous Cellulose –D In Extracting Double-Stranded Rna (Dsrna) Of Tobrfv, Raed Alkow, Reem Hijaz, Beesan Jamoos, Najah Khandaqji, We’am Daraghmeh, Saja Salah, Alaa Bari, Rahaf Ben Ali, Osama Alabdalla 2024 Biology & Biotechnology Department; Faculty of Science, An-Najah National University, Nablus, Palestine National Agricultural Research Center (NARC), Jenin, Palestine

Applicability Of Fibrous Cellulose –D In Extracting Double-Stranded Rna (Dsrna) Of Tobrfv, Raed Alkow, Reem Hijaz, Beesan Jamoos, Najah Khandaqji, We’Am Daraghmeh, Saja Salah, Alaa Bari, Rahaf Ben Ali, Osama Alabdalla

Jerash for Research and Studies Journal مجلة جرش للبحوث والدراسات

The viral replicative form double strand RNA (dsRNA) is a unique feature to the plant RNA viruses that used for non-specific detection of plant viruses. For decades; fibrous cellulose -11 (CF11) was used for dsRNA purification, but recently was no-more produced. Other fibrous celluloses (CF-A; -B; -C; -D; and –E) were suggested as alternatives to CF11. This study was to evaluate the applicability and reproducibility of using CF-D with two different dsRNA extracting methods: micro-spin column and modified Dodds extraction methods. The best results were recorded on Dodds extraction method over micro-spin one. This results also confirmed the applicability of …


Species Delimitation Of Slimy Salamanders, Plethodon Kisatchie And Plethodon Mississippi, Across The Lower Mississippi River, Brock Hunter Stevenson 2024 Louisiana Tech University

Species Delimitation Of Slimy Salamanders, Plethodon Kisatchie And Plethodon Mississippi, Across The Lower Mississippi River, Brock Hunter Stevenson

Master's Theses

Species are fundamental units of biodiversity yet delimiting species can be challenging. Slimy Salamanders of the Plethodon glutinosus species complex are a classic example of cryptic species for which species boundaries and relationships have proved difficult to determine. Once thought to be a single species ranging across the eastern United States, protein analysis revealed high genetic divergences among geographically distinct groups of populations, leading to 16 species being recognized within the group. Two of these species, the Louisiana Slimy Salamander (Plethodon kisatchie) and the Mississippi Slimy Salamander (Plethodon mississippi), are closely related but occur on opposite sides of the Mississippi …


Investigating The Mechanisms Of Surface Sensing Using Motility Appendages By Pseudomonas Aeruginosa Pa14, Christopher James Geiger 2024 Dartmouth College

Investigating The Mechanisms Of Surface Sensing Using Motility Appendages By Pseudomonas Aeruginosa Pa14, Christopher James Geiger

Dartmouth College Ph.D Dissertations

Biofilms are surfaced attached communities of cells encased in an extracellular matrix. The transition from free-swimming planktonic cells to a surface attached biofilm begins with cellular changes that occur after surface contact. This process is known as "surface sensing" and the opportunistic pathogen Pseudomonas aeruginosa PA14 uses its two motility appendages, type IV pili (T4P) and a single, polar flagellum to sense and traverse surfaces. The first cellular changes to occur within this organism upon surface contact is an increase in the second messengers cAMP and cdi- GMP. While the genes involved in surface sensing by P. aeruginosa are known, …


Diagnostic Yield Of Exome Sequencing In Prenatal Agenesis Of Corpus Callosum: Systematic Review And Meta-Analysis, H. J. Mustafa, J. P. Barbera, E. V. Sambatur, G. Pagani, Y. Yaron, C. D. Baptiste, R. J. Wapner, C. J. Brewer, A. Khalil 2024 Thomas Jefferson University

Diagnostic Yield Of Exome Sequencing In Prenatal Agenesis Of Corpus Callosum: Systematic Review And Meta-Analysis, H. J. Mustafa, J. P. Barbera, E. V. Sambatur, G. Pagani, Y. Yaron, C. D. Baptiste, R. J. Wapner, C. J. Brewer, A. Khalil

Department of Medicine Faculty Papers

OBJECTIVES: To determine the incremental diagnostic yield of exome sequencing (ES) after negative chromosomal microarray analysis (CMA) in cases of prenatally diagnosed agenesis of the corpus callosum (ACC) and to identify the associated genes and variants.

METHODS: A systematic search was performed to identify relevant studies published up until June 2022 using four databases: PubMed, SCOPUS, Web of Science and The Cochrane Library. Studies in English reporting on the diagnostic yield of ES following negative CMA in prenatally diagnosed partial or complete ACC were included. Authors of cohort studies were contacted for individual participant data and extended cohorts were provided …


Current Strategies For Increasing Knock-In Efficiency In Crispr/Cas9-Based Approaches, Andrés Felipe Leal, Angelica María Herreno-Pachón, Eliana Benincore-Flórez, Amali Karunathilaka, Shunji Tomatsu 2024 Thomas Jefferson University

Current Strategies For Increasing Knock-In Efficiency In Crispr/Cas9-Based Approaches, Andrés Felipe Leal, Angelica María Herreno-Pachón, Eliana Benincore-Flórez, Amali Karunathilaka, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Since its discovery in 2012, the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (Cas9) system has supposed a promising panorama for developing novel and highly precise genome editing-based gene therapy (GT) alternatives, leading to overcoming the challenges associated with classical GT. Classical GT aims to deliver transgenes to the cells via their random integration in the genome or episomal persistence into the nucleus through lentivirus (LV) or adeno-associated virus (AAV), respectively. Although high transgene expression efficiency is achieved by using either LV or AAV, their nature can result in severe side effects in humans. For instance, …


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