Open Access. Powered by Scholars. Published by Universities.®

Genetics Commons

Open Access. Powered by Scholars. Published by Universities.®

3,076 Full-Text Articles 7,108 Authors 1,068,127 Downloads 203 Institutions

All Articles in Genetics

Faceted Search

3,076 full-text articles. Page 1 of 118.

Knowledge And Attitudes Of Pharmacogenetics Among Canadian Nurses: Implications For Nursing Education, Noopur Swadas, Sarah Dewell, Sandra J. Davidson 2022 University of Calgary

Knowledge And Attitudes Of Pharmacogenetics Among Canadian Nurses: Implications For Nursing Education, Noopur Swadas, Sarah Dewell, Sandra J. Davidson

Quality Advancement in Nursing Education - Avancées en formation infirmière

Pharmacogenetic testing is used to tailor medication recommendations based on an individual's genetic makeup. Increased precision in prescribing medication through the use of genetics leads to a reduction in adverse drug reactions resulting in decreased morbidity and mortality. Due to the noted benefits to patient health outcomes and reduction in healthcare costs, a growing number of Canadian health centers and community pharmacies are beginning to offer pharmacogenetic testing. Previous studies indicate that Canadian nurses have minimal education in genomics; however, there has been an increase in attention to nursing roles in the implementation of genomic health practices in recent ...


Clearing The Air Between Methane And Commercial Beef Cattle In Ireland, Clodagh V. Ryan 2022 Department of Biological Sciences, Munster Technological University, Cork, Ireland

Clearing The Air Between Methane And Commercial Beef Cattle In Ireland, Clodagh V. Ryan

ORBioM (Open Research BioSciences Meeting)

Background

Rumen methanogenesis is the single most significant source of anthropogenic methane (CH4) emissions. This research aimed to analyse CH4 data recorded by GreenFeed systems by assessing the repeatability of such phenotypic measures, estimating the heritability of CH4, and generating CH4 estimated breeding values (EBVs) for inclusion in the national breeding index.

Methods

CH4 measurements were recorded on 979 cattle for 20 to 83 days using GreenFeed machines, resulting in 211,136 individual CH4 observations. The phenotypic repeatability of CH4 was estimated for six different averaging periods using a linear mixed model. Univariate ...


Mining Of Producer Recorded Data; Using Beef Calf And Cow Live-Weight Data As A Case Study, Shauna Walsh 2022 Department of Biological Sciences, Munster Technological University, Cork, Ireland; Teagasc, Moorepark, Cork, Ireland

Mining Of Producer Recorded Data; Using Beef Calf And Cow Live-Weight Data As A Case Study, Shauna Walsh

ORBioM (Open Research BioSciences Meeting)

Animal live-weight contributes to profitability in beef herds and is a key determinant of overall efficiency of the beef sector. The objective was to develop a novel editing criteria for anomaly detection of beef cow and calf live-weight data. Live-weight data from five sources (i.e., professionally-recorded, owned-scales, borrowed-scales, scales hired from a depot, other) were available from the Irish Cattle Breeding Federation.

A number of alternative methods were used for anomaly detection including: generation of within-herd regression estimates, partial correlations between cow and calf live-weight records and mahalanobis distance. Across each method a value was calculated for each herd ...


Genetic Trends For Carcass Traits Within Breeds In A Multi-Breed Evaluation, Shauna Mulhall 2022 Department of Biological Sciences, Munster Technological University, Cork, Ireland

Genetic Trends For Carcass Traits Within Breeds In A Multi-Breed Evaluation, Shauna Mulhall

ORBioM (Open Research BioSciences Meeting)

Most genetic evaluations and breeding objectives worldwide for beef traits tend to be on a within breed basis. Ireland is relatively unique in publishing national multi-breed genetic and genomic evaluation for carcass traits. The focus of this research is to determine genetic trends in carcass traits within each of the common sire breeds used in both dairy and beef populations. Estimated breeding values for carcass weight, carcass conformation, and carcass fat were available on 8,375,561 animals from the national carcass genetic evaluation. The mean of each animal’s sire EBV was estimated for each animal’s birth year ...


Resolving The Repression Pathway Of Virulence Gene Hila In Salmonella, Alexandra King, Lon Chubiz PhD, Brenda Pratte, Lauren Daugherty 2022 University of Missouri-St. Louis

Resolving The Repression Pathway Of Virulence Gene Hila In Salmonella, Alexandra King, Lon Chubiz Phd, Brenda Pratte, Lauren Daugherty

Undergraduate Research Symposium

Salmonella is a relatively abundant, virulent species of bacteria that is most known for spreading gastrointestinal diseases through food. These illnesses result in approximately 1.35 million infections, including over 25,000 hospitalizations each year, in the U.S. alone (CDC.gov). As antibiotic resistance becomes an increasingly urgent public health problem, the importance of developing alternative treatment methods is only becoming more crucial. One of the genes responsible for this virulence is known as hilA. HilA is the main transcriptional regulator of Salmonella Pathogenicity Island-1 gene (UniProt). SPI-1 plays an important role in the invasion of Salmonella into epithelial ...


Genetic Impacts Of Deforestation On Mouse Lemurs, Darice Westphal 2022 The Graduate Center, City University of New York

Genetic Impacts Of Deforestation On Mouse Lemurs, Darice Westphal

Dissertations, Theses, and Capstone Projects

The impact of deforestation on the genetic structure of mouse lemurs is poorly understood. In this project, I assess deforestation of Madagascar’s terrestrial protected regions, quantify genomic wide genetic variation in two sympatric mouse lemurs, and evaluate the role of landscape structure in genetic relatedness patterns within two sympatric mouse lemur species. Overall deforestation rates across the 98 terrestrial protected areas in Madagascar are increasing, resulting in an average annual deforestation rate of 0.68% per year, with approximately 10,600 km2 lost between 2000 and 2019. In a comparison of relatedness patterns between the sympatric gray mouse ...


The Effect Of Media And Filtration In Inducing The Oxidative Stress Response In Escherichia Coli, Suzanne Hollingsworth 2022 Portland State University

The Effect Of Media And Filtration In Inducing The Oxidative Stress Response In Escherichia Coli, Suzanne Hollingsworth

University Honors Theses

Escherichia coli grown in complex medium (LB), but not defined medium (DGC), arrest DNA replication when collected on membrane filters and resuspended in fresh media. The arrest is similar to that observed when cells are challenged with hydrogen peroxide. Yet, the reason behind this arrest is unknown.

I hypothesized that the arrest in replication in complex medium after filtering might be due to oxidative shock, and therefore cells grown in complex medium and filtered should induce an oxidative stress response similar to cells treated with hydrogen peroxide. Utilizing the indicator dye H2DCFDA, which fluoresces in response to reactive ...


Gene Drives And The Consequences Of Over-Suppression, Cole Butler 2022 Virginia Commonwealth University

Gene Drives And The Consequences Of Over-Suppression, Cole Butler

Biology and Medicine Through Mathematics Conference

No abstract provided.


Elevated Substitution Rates Among Wolbachia-Infected Mosquito Species Results In Apparent Phylogenetic Discordance., James E. Russell, Michael Saum, Rebekah Williams 2022 Georgia Gwinnett College

Elevated Substitution Rates Among Wolbachia-Infected Mosquito Species Results In Apparent Phylogenetic Discordance., James E. Russell, Michael Saum, Rebekah Williams

Georgia Journal of Science

As one of the most widely distributed bacterial cytoplasmic symbionts on earth, Wolbachia pipientis Hertig serves as a model organism for the understanding of host-symbiont interactions. Many mosquito species are infected with Wolbachia strains that induce a form of reproductive manipulation called cytoplasmic incompatibility, in which infected females gain a reproductive advantage over uninfected females in mixed infection populations. The selective advantage of cytoplasmic incompatibility often results in a population sweep of Wolbachia and co-transmitted mitochondrial genomes. Mitochondrial evolution and phylogenetic inferences drawn from mitochondrial gene sequences are thus potentially compromised by reproductive manipulating symbionts, like Wolbachia. Our initial analyses ...


Defining The Role Of Rare Genetic Variants That Drive Risk And Pathogenesis Of Alzheimer’S Disease, Matthew James Rosene 2022 Washington University in St. Louis

Defining The Role Of Rare Genetic Variants That Drive Risk And Pathogenesis Of Alzheimer’S Disease, Matthew James Rosene

Arts & Sciences Electronic Theses and Dissertations

Alzheimer’s disease (AD) is the leading cause of dementia and is pathologically defined by the aggregation of extracellular amyloid plaques and intracellular neurofibrillary tangles. Rare heritable mutations within the genes for amyloid precursor protein (APP) and presenilin 1 (PSEN1), and presenilin 2 (PSEN2) cause early onset AD and account for approximately 1% of AD cases. While the majority of AD cases are late-onset (LOAD), which is defined by a markedly more complex genetic architecture that is comprised of many genetic risk factors that influence AD through multiple cellular pathways. The advent of deep sequencing analyses have allowed for the ...


Understanding The Role Of Involucrin In Skin Inflammation, Alina Schmidt 2022 Washington University in St. Louis

Understanding The Role Of Involucrin In Skin Inflammation, Alina Schmidt

Arts & Sciences Electronic Theses and Dissertations

Terminally differentiated keratinocytes are essential for skin barrier function and are surrounded by an involucrin (IVL)-rich cornified envelope. Increased IVL expression in the epidermis is associated with recent positive selection in European populations, yet the functional significance of this finding is unclear. An upstream enhancer of IVL, the 923 enhancer, regulates IVL expression, and the impact of IVL enhancer variants on involucrin expression in modifying the penetrance of filaggrin (FLG) loss-of-function variants associated with atopic dermatitis (AD) has not been explored. I hypothesize involucrin to modulate the environmentally sensitive Vitamin D receptor (Vdr) activity in the epidermis and involucrin ...


Investigation Of Dna Variability And Phylogenetic Relationships Of Perlesta (Plecoptera: Perlidae) In Mississippi, James C. Valentine, Mac H. Alford 2022 University of Southern Mississippi

Investigation Of Dna Variability And Phylogenetic Relationships Of Perlesta (Plecoptera: Perlidae) In Mississippi, James C. Valentine, Mac H. Alford

Master's Theses

The genus Perlesta Banks, 1906 (Plecoptera: Perlidae) consists of 35 species, 33 native to the United States and Canada and two native to China. For over a century these small, brown stonefly adults and freckled yellow nymphs have gone by the name of the type species of the genus, Perlesta placida, but taxonomic work in the genus since 1989 has resulted in the recognition of additional species. These species were mostly recognized and described using morphological characteristics, but two areas that are lacking include (1) linking nymphs to adults and (2) phylogenetic analysis of all species occurring in Mississippi using ...


Developing A Novel Place Preference Assay To Compare Drosophila Species Over Time, Martha M. Brinson 2022 University of Mississippi

Developing A Novel Place Preference Assay To Compare Drosophila Species Over Time, Martha M. Brinson

Honors Theses

Across phylogeny, integration of external factors, memory, and internal states of the organism dictate organismal behavior and mechanisms. The underlying genetic components can affect these behaviors such as in genomic changes arising from speciation. In this thesis, a new place preference assay was evaluated in the analysis and investigation of two species of Drosophila flies (D. melanogaster and D. simulans) to measure similarities and differences and their attraction to two different food substrates. Sleep and circadian measurements were also recorded during experimentation. The Drosophila Activity Monitor 5M (DAM5M) System and Sleep Circadian Analysis MATLAB Program (SCAMP) analysis were used in ...


Isolation Of Arabidopsis Thaliana Plants Homozygous For An Insertional Inactivation Mutation Within Atprp4., Sydney Raitz, Timothy D. Trott 2022 Southern Adventist University

Isolation Of Arabidopsis Thaliana Plants Homozygous For An Insertional Inactivation Mutation Within Atprp4., Sydney Raitz, Timothy D. Trott

Faculty Works

The AtPRP4 gene in Arabidopsis thaliana has been shown to function in several specific parts of the plant’s cell wall. It is shown to be expressed in the seeds, radicles, roots, leaves, inflorescences, and embryos of Arabidopsis thaliana. These patterns have suggested unique functions for ATPRP4 in determining cell-type-specific wall structure during the development of a plant as well as contributing to defense reactions against physical damage to the plant and pathogen infection within the plant. In this study, a simple DNA prep was performed on the true leaves of Arabidopsis thaliana. Subsequent PCR reactions were performed using AtPRP4F ...


A Genetic Evaluation Of The Impacts Of Dams On Sauger Movement Patterns In The Arkansas River, Emily R. Jonagan 2022 Arkansas Tech University

A Genetic Evaluation Of The Impacts Of Dams On Sauger Movement Patterns In The Arkansas River, Emily R. Jonagan

ATU Theses and Dissertations

Decreased habitat connectivity as a result of damming can lead to genetic isolation in fish communities, especially in highly migratory species. Sauger Sander canadensis is a migratory freshwater species native to the Arkansas River. Sauger are highly sought after by anglers during their annual spawning migration in late winter. In order to investigate the impacts Arkansas River dams on Sauger populations, fin clips were collected in the winters of 2019, 2020, and 2021 below eight dams in the McClellan-Kerr Arkansas River Navigational System (MKARNS). Fin clips were also collected from two reservoirs in Kansas to serve as distinct reference populations ...


Effects Of Sunrise/Sunset Lighting On Corticosterone Levels In Coturnix Quail (Coturnix Coturnix), Hannah Feuerborn 2022 University of Arkansas, Fayetteville

Effects Of Sunrise/Sunset Lighting On Corticosterone Levels In Coturnix Quail (Coturnix Coturnix), Hannah Feuerborn

Poultry Science Undergraduate Honors Theses

Both genetics and environment play an important role in the growth, performance and overall welfare of poultry species. Current commercial production practices typically do not mimic the natural environmental conditions of ancestral poultry species, specifically lighting requirements. In nature, poultry species are subjected to natural day length and the slow rising and setting of the sun. This is compared to commercial conditions in which lights are sudden on/off, not mimicking the natural trajectory of the sun in terms of light intensity and exposure. The current study aimed to evaluate the impact of genetics and the effect of sunrise/sunset ...


Characterizing The Expression Pattern And Function Of Tartan During Drosophila Development, Alaina Baggett 2022 University of Arkansas, Fayetteville

Characterizing The Expression Pattern And Function Of Tartan During Drosophila Development, Alaina Baggett

Biomedical Engineering Undergraduate Honors Theses

The development of complex structures and organs by multicellular organisms relies on the ability of epithelial cells to self-organize. Epithelia are sheets of connected cells, and compartment boundaries are formed between certain epithelial cells to create distinct tissue compartments. Compartment boundaries are specialized cell-cell interfaces that are enriched for the cytoskeletal proteins actin and myosin, leading to straight cell edges under relatively high tension that act as fences keep cells from moving between compartments. In the model organism Drosophila melanogaster (fruit fly), compartment boundaries in the early embryo are established in response to the non-uniform striped expression of the cell-surface ...


Root Phenotyping Of Peptide-Treated Glycine Max, Salem Jackson 2022 University of Arkansas, Fayetteville

Root Phenotyping Of Peptide-Treated Glycine Max, Salem Jackson

Biological Sciences Undergraduate Honors Theses

Plant elicitor peptides (Peps) – endogenous chains of amino acids involved in natural plant defense – have been shown to decrease damage from herbivores and pathogens by inducing an immune response, increasing the emission of volatile organic compounds (VOCS), transcripts, and metabolites. Exogenous treatment of soybean seeds with plant elicitor peptide GmPep3 has been shown to induce these broad-spectrum defenses and offers a new method for increasing crop yield. However, the effects of GmPep3 on indicators of soybean health – root characteristics, growth stages, etc. – have not been fully realized.

Using the root-phenotyping platform RhizoVision Explorer, several root traits of soybean plants treated ...


Development Of The Ark Assay For Quantitating Dna- Protein Crosslink Accumulation And Fanconi Anemia Pathway Involvement In The Repair Process, Naeh Klages-Mundt 2022 The Texas Medical Center Library

Development Of The Ark Assay For Quantitating Dna- Protein Crosslink Accumulation And Fanconi Anemia Pathway Involvement In The Repair Process, Naeh Klages-Mundt

The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Dissertations and Theses (Open Access)

DNA-protein crosslinks (DPCs) are a common DNA lesion naturally arising in cells, wherein protein becomes covalently and irreversibly bound to the DNA. Given their excessive size, these adducts present a significant challenge to replication and transcription, thus requiring timely and efficient repair. However, the precise mechanisms involved with processing DPC removal remain unclear. Moreover, current methodologies to quantitate DPC accumulation and removal are restrained by a range of limitations. Here, we describe and discuss a new DPC detection assay – the ARK assay – capable of overcoming the limitations incurred by prior assays. The design, which uses dual chaotropic lysis and anionic ...


Identification Of Genetic Variants Underlying Maxillary Canine-Tooth Mesioversion And Small Body Size In Shetland Sheepdogs, Sydney R. Abrams 2022 Clemson University

Identification Of Genetic Variants Underlying Maxillary Canine-Tooth Mesioversion And Small Body Size In Shetland Sheepdogs, Sydney R. Abrams

All Theses

The domesticated dog (Canis lupus familiaris) exhibits a unique population structure, with high levels of genetic homogeneity within breeds due to selective breeding. These closed breeding populations can result in breed-specific inherited disorders. Maxillary canine-tooth mesioversion (MCM) is a genetically complex dental anomaly observed nearly exclusively in the small Shetland Sheepdog breed. Here, we utilized a genome-wide approach to discover a locus of major effect on chromosome 9. Using whole-genome resequencing data from a bilaterally affected dog, we identified variants in two genes: FTSJ3, encoding an RNA methyltransferase, and GH1, encoding growth hormone. Independent genome-wide association studies of height and ...


Digital Commons powered by bepress