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Articles 9421 - 9450 of 33219

Full-Text Articles in Chemistry

Evaluation Of Carbonic Anhydrase And Paraoxonase Inhibition Activities And Molecular Docking Studies Of Highly Water-Soluble Sulfonated Phthalocyanines, Emre Güzel, Fati̇h Sönmez, Sultan Erkan, Kübra Çikrikci, Adem Ergün, Nahi̇t Gençer, Oktay Arslan, Makbule Koçak Jan 2020

Evaluation Of Carbonic Anhydrase And Paraoxonase Inhibition Activities And Molecular Docking Studies Of Highly Water-Soluble Sulfonated Phthalocyanines, Emre Güzel, Fati̇h Sönmez, Sultan Erkan, Kübra Çikrikci, Adem Ergün, Nahi̇t Gençer, Oktay Arslan, Makbule Koçak

Turkish Journal of Chemistry

The investigation of carbonic anhydrase and paraoxonase enzyme inhibition properties of water-soluble zinc and gallium phthalocyanine complexes (1 and 2) are reported for the first time. The binding of p-sulfonylphenoxy moieties to the phthalocyanine structure favors excellent solubilities in water, as well as providing an inhibition effect on carbonic anhydrase (CA) I and II isoenzymes and paraoxonase (PON1) enzyme. According to biological activity results, both complexes inhibited hCA I, hCA II, and PON1. Whereas 1 and 2 showed moderate hCA I and hCA II (off-target cytosolic isoforms) inhibitory activity (Ki values of 26.09 μM and 43.11 μM for hCA I …

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Catalytic Activity Of Novel Thermoplastic/Cellulose-Au Nanocomposites Prepared By Cryomilling, Joanna Kwiczak Yigitbasi Jan 2020

Catalytic Activity Of Novel Thermoplastic/Cellulose-Au Nanocomposites Prepared By Cryomilling, Joanna Kwiczak Yigitbasi

Turkish Journal of Chemistry

Due to environmental concerns, increasing attention has been focused on the application and preparation of biobased polymers and their blends. In this study, cellulose, the most spread biopolymer on Earth, was used in the preparation of novel cotton/polypropylene- Au and cotton/polyethylene-Au nanocomposites via a green mechanochemical approach. First, mechanoradicals were generated by ball milling of the cotton and thermoplastics under cryo conditions, and then, these radicals were used in the reduction of Au ions to Au nanoparticles (Au NPs). Nanocomposites were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The application of mechanochemistry in …

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Effect Of Ph On Lipid Oxidation Of Red Onion Skin Extracts Treated With Washed Tilapia (Oreochromis Niloticus) Muscle Model Systems, Senem Güner, Yavuz Yağiz, Zeynal Topalcengi̇z, Hordur G. Kristinsson, George Baker, Paul Sarnoski, Bruce A. Welt, Amarat Simonne, Maurice M. Marshall Jan 2020

Effect Of Ph On Lipid Oxidation Of Red Onion Skin Extracts Treated With Washed Tilapia (Oreochromis Niloticus) Muscle Model Systems, Senem Güner, Yavuz Yağiz, Zeynal Topalcengi̇z, Hordur G. Kristinsson, George Baker, Paul Sarnoski, Bruce A. Welt, Amarat Simonne, Maurice M. Marshall

Turkish Journal of Chemistry

The aim of the study was to investigate the effect of pH on the lipid oxidation of red onion skin extracts (ROSEs) treated with washed tilapia muscle model systems (WTMS). Minced and buffered washed samples were prepared at pH 6.3 and 6.8. The WTMS were treated with2 different concentrations of red onion skin prior to storage for 5 days. Lipid oxidation was investigated via peroxide values (PVs), thiobarbituric acid reactive substances (TBARS), and the formation of volatile compounds. Fatty acid profiles of the samples were also identified. The ROSEs were able to significantly suppress the PV (~71%) and TBARS (~42%) …

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Design Of Novel Substituted Phthalocyanines; Synthesis And Fluorescence, Dft,Photovoltaic Properties, Mehmet Sali̇h Ağirtaş, Derya Güngördü Solğun, Ümi̇t Yildiko, Abdullah Özkartal Jan 2020

Design Of Novel Substituted Phthalocyanines; Synthesis And Fluorescence, Dft,Photovoltaic Properties, Mehmet Sali̇h Ağirtaş, Derya Güngördü Solğun, Ümi̇t Yildiko, Abdullah Özkartal

Turkish Journal of Chemistry

The 4-(2-[3,4-dimethoxyphenoxy] phenoxy) phthalonitrile was synthesized as the starting material of new syntheses. Zinc, copper, and cobalt phthalocyanines were achieved by reaction of starting compound with Zn(CH3COO)2, CuCl2, and CoCl2 metal salts. Basic spectroscopic methods such as nuclear magnetic resonance electronic absorption, mass and infrared spectrometry were used in the structural characterization of the compounds. Absorption, excitation, and emission measurements of the fluorescence zinc phthalocyanine compound were also investigated in THF. Then, structural, energy, and electronic properties for synthesized metallophthalocyanines were determined by quantum chemical calculations, including the DFT method. The bandgap of HOMO and LUMO was determined to be …

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Computational And Biological Studies Of Novel Thiazolyl Coumarin Derivatives Synthesized Through Suzuki Coupling, Shaista Parveen, Saima Kalsoom, Rifhat Bibi, Ambreen Asghar, Abdul Hameed, Waqar Ahmed, Abbas Hassan Jan 2020

Computational And Biological Studies Of Novel Thiazolyl Coumarin Derivatives Synthesized Through Suzuki Coupling, Shaista Parveen, Saima Kalsoom, Rifhat Bibi, Ambreen Asghar, Abdul Hameed, Waqar Ahmed, Abbas Hassan

Turkish Journal of Chemistry

The current investigation presents the synthesis, computational molecular-docking and biological activity studies of arylated thiazole coumarins. Aryl substituted thiazolyl coumarin derivatives were synthesized via Suzuki cross-coupling reaction. A detailed reaction condition optimization revealed that the Pd-PEPPSI-IPent precatalyst in only 2 mol% loading resulted in the desired product with high yield. The aim of this study was to examine the antimicrobial behavior of thiazole coumarin derivatives through in vitro and in silico studies. All the compounds showed activity against both antibacterial strains, Staphylococcus aureus and Escherichia coli, except 5d. Similarly, the compounds 5a, 5b, and 5d were found to be active …

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Synthesis And Pharmacological Effects Of Novel Benzenesulfonamides Carryingbenzamide Moiety As Carbonic Anhydrase And Acetylcholinesterase Inhibitors, Mehtap Tuğrak, Hali̇se İnci̇ Gül, Bariş Anil, İlhami̇ Gülçi̇n Jan 2020

Synthesis And Pharmacological Effects Of Novel Benzenesulfonamides Carryingbenzamide Moiety As Carbonic Anhydrase And Acetylcholinesterase Inhibitors, Mehtap Tuğrak, Hali̇se İnci̇ Gül, Bariş Anil, İlhami̇ Gülçi̇n

Turkish Journal of Chemistry

N-(1-(4-Methoxyphenyl)-3-oxo-3-((4-(N-(substituted)sulfamoyl)phenyl)amino)prop-1-en-1-yl)benzamides 3a - g were designed since sulfonamide and benzamide pharmacophores draw great attention in novel drug design due to their wide range of bioactivities including acetylcholinesterase (AChE) and human carbonic anhydrase I and II (hCA I and hCA II) inhibitory potencies. Structure elucidation of the compounds was carried out by 1H NMR, 13C NMR, and HRMS spectra. In vitro enzyme assays showed that the compounds had significant inhibitory potential against hCA I, hCA II, and AChE enzymes at nanomolar levels. Ki values were in the range of 4.07 ± 0.38 - 29.70 ± 3.18 nM for hCA I and …

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Processing Impact On Tocopherols And Triglycerides Composition Of Soybean Oil And Its Deodorizer Distillate Evaluated By High-Performance Liquid Chromatography, Zahid Hussain Laghari, Syed Tufail Hussain Sherazi, Hami̇de Fi̇li̇z Ayyildiz, Mustafa Topkafa, Hüseyi̇n Kara, Sarfaraz Ahmed Mahesar, Siraj Uddin Jan 2020

Processing Impact On Tocopherols And Triglycerides Composition Of Soybean Oil And Its Deodorizer Distillate Evaluated By High-Performance Liquid Chromatography, Zahid Hussain Laghari, Syed Tufail Hussain Sherazi, Hami̇de Fi̇li̇z Ayyildiz, Mustafa Topkafa, Hüseyi̇n Kara, Sarfaraz Ahmed Mahesar, Siraj Uddin

Turkish Journal of Chemistry

In the present study, high-performance liquid chromatography (HPLC) was used for the separation of tocopherols and triglycerides of processed soybean oil and deodorizer distillate (DD). The results of normal and reversed-phase modes of HPLC revealed that concentrations of tocopherols and triglycerides content were decreased during the neutralization, bleaching, and deodorization processes. The loss of individual tocopherols ranged between 55.16% and 63.25%. During processing, triglycerides containing stearic-oleic-linoleic (SOL) moieties and palmitic-palmitic-linoleic (PPL) fragments showed greater reduction up to 38.14% and 37.69%, respectively. Among tocopherols and triglycerides; γ-tocopherol and oleic-oleic-oleic (OOO) were found to be in greater concentrations 5.53% and 19.78%, respectively …

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Chemical Composition, Antimicrobial, And Lipase Enzyme Activity Of Essential Oil And Solvent Extracts From Serapias Orientalis Subsp. Orientalis, İshak Eri̇k, Gözde Kiliç, Eli̇f Öztürk, Şengül Alpay Karaoğlu, Nuretti̇n Yayli Jan 2020

Chemical Composition, Antimicrobial, And Lipase Enzyme Activity Of Essential Oil And Solvent Extracts From Serapias Orientalis Subsp. Orientalis, İshak Eri̇k, Gözde Kiliç, Eli̇f Öztürk, Şengül Alpay Karaoğlu, Nuretti̇n Yayli

Turkish Journal of Chemistry

The volatile components of essential oil (EO), SPME, and SPME of solvent extracts (n-hexane, methanol, and water) obtained from fresh Serapias orientalis subsp. orientalis(Soo) were analyzed by GC-FID/MS. EO of Soo gave 11 compounds in the percentage of 99.97%; capronaldehyde (37.01%), 2-(E)-hexenal (23.19%), and n-nonanal (19.05%) were found to be major constituents. SPME GC-FID/MS analyses of fresh plant and solvent extracts of Soo revealed 7, 12, 7, and 4 compounds within the range of 99.7% to 99.9%. Limonene (76.5%, 41.7%, and 61.3%) was the major compound in SPMEs of the n-hexane and methanol extracts. α-Methoxy-p-cresol (52.9%) was the main component …

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Comparison Of Antioxidant Capacities And Antioxidant Components Of Commercial Bitter Melon (Momordica Charantia L.) Products, Esi̇n Akyüz, Sercan Türkoğlu, Kevser Sözgen Başkan, Esma Tütem, Mustafa Reşat Apak Jan 2020

Comparison Of Antioxidant Capacities And Antioxidant Components Of Commercial Bitter Melon (Momordica Charantia L.) Products, Esi̇n Akyüz, Sercan Türkoğlu, Kevser Sözgen Başkan, Esma Tütem, Mustafa Reşat Apak

Turkish Journal of Chemistry

In this study, the total phenolic contents and total antioxidant capacities of some commercial bitter melon products (powder, packaged powder, capsule, paste in olive oil), and of unripe and ripe fruits were determined by spectrophotometric and chromatographic methods. The total antioxidant capacities of unripe and ripe bitter melon samples, determined by using the CUPRAC (cupric reducing antioxidant capacity assay) and ABTS (2,2'-Azinobis-(3-Ethylbenzthiazolin-6-Sulfonic Acid)/HRP (horseradish peroxidase) methods, were 42.5 and 36.3 μmol TRE (Trolox equivalent) g-1, and 8.7 and 7.0 μmol TRE g-1, respectively. The TAC (total antioxidant capacity) order of the studied samples using the same 2 methods were determined …

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Biosynthesis Of Silver Nanoparticles Using Onosma Sericeum Willd. And Evaluation Oftheir Catalytic Properties And Antibacterial And Cytotoxic Activity, Selda Doğan Çalhan, Mustafa Gündoğan Jan 2020

Biosynthesis Of Silver Nanoparticles Using Onosma Sericeum Willd. And Evaluation Oftheir Catalytic Properties And Antibacterial And Cytotoxic Activity, Selda Doğan Çalhan, Mustafa Gündoğan

Turkish Journal of Chemistry

In this study, silver nanoparticle (AgNP) synthesis was carried out using Onosma sericeum Willd. aqueous extract for the first time, with a simple, economical, and green method without the need for any other organic solvent or external reducing or stabilizing agent. A variety of AgNPs, all of different particle sizes, were synthesized by controlling the silver ion concentration, extract volume, temperature, and pH. It was determined that the optimum conditions for AgNP synthesis were 1 mM AgNO3, pH 8, 25 °C, 20 g/200 mL extract, silver nitrate, and extract ratio 5:1 (v/v). The AgNPs were defined using UV-Vis spectroscopy, field …

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Design, Synthesis, Cytotoxic Activity, And Apoptosis Inducing Effects Of 4- And N-Substituted Benzoyltaurinamide Derivatives, Özlem Akgül, Mümi̇n Alper Erdoğan, Dervi̇ş Bi̇ri̇m, Çağla Kayabaşi, Cumhur Gündüz, Güli̇z Armagan Jan 2020

Design, Synthesis, Cytotoxic Activity, And Apoptosis Inducing Effects Of 4- And N-Substituted Benzoyltaurinamide Derivatives, Özlem Akgül, Mümi̇n Alper Erdoğan, Dervi̇ş Bi̇ri̇m, Çağla Kayabaşi, Cumhur Gündüz, Güli̇z Armagan

Turkish Journal of Chemistry

In this study, a group of 4-substituted benzoyltaurinamide derivatives were designed, synthesized, and investigated for their anticancer activity against three cancer cell lines and one nontumorigenic cell line by MTT assay. Among the final compounds, methoxyphenyl derivatives 14, 15, 16 were found to be effective against all the tested cancerous cell lines with promising selectivity. The most active compounds were further evaluated to determine the molecular mechanism of their anticancer activity by using western blot assay and the Annexin V-FITC/PI test. Compound 14 (in SH-SY5Y and MDA-MB-231 cell lines) and 15 (in SH-SY5Y cell line) were found to induce intrinsic …

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Structural Insights Of Two Novel N-Acetyl-Glucosaminidase Enzymes Through In Silico Methods, Ari̇f Sercan Şahutoğlu, Hati̇ce Duman, Steven Alex Frese, Sercan Karav Jan 2020

Structural Insights Of Two Novel N-Acetyl-Glucosaminidase Enzymes Through In Silico Methods, Ari̇f Sercan Şahutoğlu, Hati̇ce Duman, Steven Alex Frese, Sercan Karav

Turkish Journal of Chemistry

EndoBI-1 and EndoBI-2 are two endo-β-N-acetylglucosaminidase isoenzymes that cleave N-N'-diacetylchitobiosyl moieties found in various types of native N-glycans. These N-glycans are indigestible by human infants and adults due to the lack of responsible glycosyl hydrolases and they act as selective prebiotics for a probiotic microorganism, Bifidobacterium longum subsp. infantis, in the large intestine. The selectivity and the thermostability of EndoBI-1 and EndoBI-2 suggest that these enzymes may be useful for many scientific and industrial applications. In this study, the growing numbers of homologous sequences in different databases were exploited in a comparative approach to investigate structural properties of EndoBI-1 and …

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Fabrication And Characterization Of Boric Acid-Crosslinked Ethyl Cellulose And Polyvinyl Alcohol Films As Potential Drug Release Systems For Topical Drug Delivery, Nasrin Aliasgharlou, Farzin Asghari Sana, Saba Khoshbakht, Pezhman Zolfaghari, Hamed Charkhian Jan 2020

Fabrication And Characterization Of Boric Acid-Crosslinked Ethyl Cellulose And Polyvinyl Alcohol Films As Potential Drug Release Systems For Topical Drug Delivery, Nasrin Aliasgharlou, Farzin Asghari Sana, Saba Khoshbakht, Pezhman Zolfaghari, Hamed Charkhian

Turkish Journal of Chemistry

In this study, boric acid (BA) is employed as a crosslinking agent to improve the characteristics of two commonly used polymeric films, ethyl cellulose (EC) and polyvinyl alcohol (PVA), for topical drug delivery applications. The developed films are characterized by FTIR spectroscopy and SEM analysis. The results show that the surfaces of the prepared films are even and transparent, except for the BA-modified EC sample. The initial cumulative release for erythromycin (EM) is found to be 0.30 and 0.36 mg/mL for EC and PVA films, which drops to 0.25 and 0.20 mg/mL after BA crosslinking, respectively, after 1 h at …

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Highly Luminescent Water-Dispersed Silicon Quantum Dots For Fluorometric Determination Of Oxytetracycline In Milk Samples, Hayri̇ye Eda Şatana Kara, Burak Demi̇rhan, Buket Er Demi̇rhan Jan 2020

Highly Luminescent Water-Dispersed Silicon Quantum Dots For Fluorometric Determination Of Oxytetracycline In Milk Samples, Hayri̇ye Eda Şatana Kara, Burak Demi̇rhan, Buket Er Demi̇rhan

Turkish Journal of Chemistry

A fluorescent probe based on silicon quantum dots (SiQDs) was developed for the selective and sensitive detection of oxytetracycline (OTC) via the inner filter effect (IFE). The water-soluble fluorescent SiQD was synthesized based on the reaction of 3-Aminopropyltriethoxysilane (APTES) and sodium citrate as precursors by the one-pot hydrothermal process. The strong fluorescence emission of quantum dots (QDs) was obtained at 440 nm when excited at 350 nm and OTC had a broad absorption band between 200 and 400 nm. The excitation spectrum of SiQDs was completely overlapped with the absorption spectrum of OTC. The light at an excitation wavelength of …

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Synthesis, Antioxidant And Antimicrobial Properties Of Novel Pyridyl-Carbonyl Thiazoles As Dendrodoine Analogs, Zafer Şahi̇n, Sevde Nur Bi̇lteki̇n, Leyla Yurttaş, Şeref Demi̇rayak Jan 2020

Synthesis, Antioxidant And Antimicrobial Properties Of Novel Pyridyl-Carbonyl Thiazoles As Dendrodoine Analogs, Zafer Şahi̇n, Sevde Nur Bi̇lteki̇n, Leyla Yurttaş, Şeref Demi̇rayak

Turkish Journal of Chemistry

Marine compound dendrodoine was first obtained from tunicate species (Dendrodo grossularia). It has a five-membered ring, namely, it is a heterocycle thiadiazole, which is found rarely in natural sources. Following its biological activities, novel analogs have been investigated recently. Synthesis of the analogs for this study is realized with uncommon thiazole closure, including methylene-carbonyl condensation. Structures are elucidated by NMR (1H, 13C) and HRMS spectrums. As an alkaloid derivative, antioxidant properties were evaluated with DPPH and FRAP assays and antimicrobial effect with microdilution method. Among the series, 3bc-3cf showed higher antioxidant activity than those having 3 or 4-pyridyl substituents. There …

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Selective Modifications At The Different Positions Of Cyclodextrins: A Review Of Strategies, Jia Yue Liu, Xiao Zhang, Bingren Tian Jan 2020

Selective Modifications At The Different Positions Of Cyclodextrins: A Review Of Strategies, Jia Yue Liu, Xiao Zhang, Bingren Tian

Turkish Journal of Chemistry

Cyclodextrins (CDs) are natural, nontoxic, and biodegradable macrocyclic oligosaccharides. As supramolecular hosts, CDs have numerous applications in many aspects. However, nonsubstituted CDs have the disadvantages of solubility, unspecific recognition sites, and weak interactions with guest molecules. Therefore, new CD-based derivatives are successfully designed, synthesized, and widely used in various fields. This contribution outlines the research progress in CD derivatives. In particular, this review emphasizes the synthesis and application of CDs modified through functionalization in definite positions, random substitution, and reconstruction of the skeleton. At the end of this review, a summary and future directions are presented.

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Proline-Based Organocatalyst-Mediated Asymmetric Aldol Reaction Of Acetone With Substituted Aromatic Aldehydes: An Experimental And Theoretical Study, Nevi̇n Arslan, Selami̇ Ercan, Necmetti̇n Pi̇ri̇nççi̇oğlu Jan 2020

Proline-Based Organocatalyst-Mediated Asymmetric Aldol Reaction Of Acetone With Substituted Aromatic Aldehydes: An Experimental And Theoretical Study, Nevi̇n Arslan, Selami̇ Ercan, Necmetti̇n Pi̇ri̇nççi̇oğlu

Turkish Journal of Chemistry

This work involves a facile synthesis of three (S)-proline-based organocatalysts with C$_{2}$ symmetry and their effects in enantioselective aldol reaction of acetone with substituted aromatic aldehydes. Moderate enantioselectivities (up to 61% ee) were obtained depending on the nature of the substituents on the aryl ring. Computational calculations at HF/6-31 + G(d) level were employed to underline the enantioselectivity imposed by all the organocatalysts. Higher calculations at B3LYP/6-311 ++ G(d,p) scrf=(solvent=dichloromethane)//B3LYP/6-31 + G(d) levels of theory were also performed for the aldol reaction of acetone with benzaldehyde and 4-nitrobenzaldehyde catalyzed by 1. The computationaloutcomeswereconsistentwiththoseproducedbyexperimentalresultsandtheywerevaluabletoelucidate the mechanism for the observed stereoselectivity.

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Gc-Ms Analysis Of The Methanolic Extracts Of Smilax China And Salix Alba And Their Antioxidant Activity, Abdul Qadir, Mohd Aqil, Athar Ali, Farhan J. Ahmad, Sayeed Ahmad, Muhammad Arif, Nausheen Khan Jan 2020

Gc-Ms Analysis Of The Methanolic Extracts Of Smilax China And Salix Alba And Their Antioxidant Activity, Abdul Qadir, Mohd Aqil, Athar Ali, Farhan J. Ahmad, Sayeed Ahmad, Muhammad Arif, Nausheen Khan

Turkish Journal of Chemistry

Smilax china L.(familySmilacaceae) and Salix alba L.(familySalicaceae)areplantsthathavebeentraditionally used to treat various ailments in Indian and Chinese medicine. A quantitative estimation of the methanolic extracts of these plants was performed by GC-MS analysis to obtain insight into its phytoconstituents responsible for therapeutic action. Theantioxidantpotentialofthemethanolextractsof Smilax china (MESC) and Salix alba (MESA) wereassessed with DPPH by using a UV spectrophotometer at a wavelength of 517 nm. The prevailing compounds found in MESC were lactam sugars including 2,5-dimethyl-2,4-dihydroxy-3(2H)-furanon (1.40%), 1,5-anhydro-6-deoxyhexo-2,3-diulose (4.33%), and alpha-methyl-1-sorboside (1.80%); the two alkaloids found were 1,4-methane-4,4a,5,6,7,8,9,9a-octahydro10,10-dimethyl cyclohepta[d] pyridazine (0.87%) and 1,3,7-trimethyl-2,6-dioxopurine(0.54%); terpenes included deltacadinene (0.39%), terpineol, (+)-cedrol (22.13%), 3-thujanol …

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Effect Of Various G-C3n4 Precursors On The Catalytic Performance Of Alkylorganotin-Based Catalysts In Acetylene Hydrochlorination, Yibo Wu, Fuxiang Li, Jianwei Xue, Zhiping Lv Jan 2020

Effect Of Various G-C3n4 Precursors On The Catalytic Performance Of Alkylorganotin-Based Catalysts In Acetylene Hydrochlorination, Yibo Wu, Fuxiang Li, Jianwei Xue, Zhiping Lv

Turkish Journal of Chemistry

A series of alkylorganotin-based catalysts (Sn-g-C$_{3}$N$_{4}$/AC) was prepared by wet impregnation in ethanol using different g-C$_{3}$N$_{4}$ precursors and alkylorganotin compounds. The structure, texture, surface composition, and adsorption properties of the as-prepared catalysts were extensively characterized. Then, the obtained samples were evaluated for their catalytic performance in hydrochlorination of acetylene. The results provided by the X-ray photoelectron spectroscopy, acetylene temperature-programmed desorption, and HCl adsorption confirmed the nature of the active sites (i.e. Sn-N$_{x}$ ) involved in the reactant adsorption, and hence in the improved catalytic performance. These active sites were also related to the improved lifetime of alkylorganotin-based catalysts in the …

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Hydrotalcite Framework Stabilized Ruthenium Nanoparticles (Ru/Htal): Efficient Heterogeneous Catalyst For The Methanolysis Of Ammonia-Borane, İsmai̇l Burak Bağuç, Mehmet Yurderi̇, Gülşah Saydan Kanberoğlu, Ahmet Bulut Jan 2020

Hydrotalcite Framework Stabilized Ruthenium Nanoparticles (Ru/Htal): Efficient Heterogeneous Catalyst For The Methanolysis Of Ammonia-Borane, İsmai̇l Burak Bağuç, Mehmet Yurderi̇, Gülşah Saydan Kanberoğlu, Ahmet Bulut

Turkish Journal of Chemistry

Ruthenium nanoparticles stabilized by a hydrotalcite framework (Ru/HTaL) were prepared by following a 2-step procedure comprising a wet-impregnation of ruthenium(III) chloride precatalyst on the surface of HTaL followed by an ammonia-borane (NH$_{3}$BH$_{3}$) reduction of precatalyst on the HTaL surface all at room temperature. The characterization of Ru/HTaL was done by using various spectroscopic and visualization methods including ICP-OES, P-XRD, FTIR, $^{11}$B NMR, XPS, BFTEM, and HRTEM. The sum of the results gained from these analyses has revealed the formation of well-dispersed and highly crystalline ruthenium nanoparticles with a mean diameter of 1.27 ± 0.8 nm on HTaL surface. The catalytic …

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The Single Nucleotide Ss-Arrestin2 Variant, A248t, Resembles Dynamical Properties Of Activated Arrestin, Özge Şensoy Jan 2020

The Single Nucleotide Ss-Arrestin2 Variant, A248t, Resembles Dynamical Properties Of Activated Arrestin, Özge Şensoy

Turkish Journal of Chemistry

ß-arrestins are responsible for termination of G protein-coupled receptor (GPCR)-mediated signaling. Association of single nucleotide variants with onset of crucial diseases has made this protein family hot targets in the field of GPCR-mediated pharmacology. However, impact of these mutations on function of these variants has remained elusive. In this study, structural and dynamical properties of one of ß-arrestin2 (arrestin 3) variants, A248T, which has been identified in some cancer tissue samples, were investigated via molecular dynamics simulations. The results showed that the variant underwent structural rearrangements which are seen in crystal structures of active arrestin. Specifically, the "short helix" unravels …

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Preparation And Catalytic Evaluation Of Au/ Γ-Al2o3nanoparticles For The Conversion Of 4-Nitrophenol To 4-Aminophenol By Spectrophotometric Metho, Farhat Saira, Naveeda Firdous, Rumana Qureshi, Ayesha Ihsan Jan 2020

Preparation And Catalytic Evaluation Of Au/ Γ-Al2o3nanoparticles For The Conversion Of 4-Nitrophenol To 4-Aminophenol By Spectrophotometric Metho, Farhat Saira, Naveeda Firdous, Rumana Qureshi, Ayesha Ihsan

Turkish Journal of Chemistry

A set of catalysts having gold nanoparticles deposited on γ-Al$_{2}$O$_{3}$ ( Au/ γ-Al2O3) with lowest effective amount of gold content were prepared by successive impregnation and hydrogen reduction method. The structural featuresof prepared catalysts were analysed byX-ray diffraction(XRD), N2 physisorption, scanning electron microscopy (SEM), and Fourier transform infrared (FTIR). The catalytic activity was evaluated for the reduction of an organic pollutant 4-nitrophenol (4NP) to 4-aminophenol (4AP) by spectrophotometric analysis. Supported catalyst presented excellent catalytic ability to convert 4NP to 4AP in the presence of sodium borohydride (SBH) due to synergistic effect of Au NPs and mesoporous γ-Al$_{2}$O$_{3}$ support. The reduction …

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Development Of A Biosensor Platform Based On Ito Sheets Modified With 3-Glycidoxypropyltrimethoxysilane For Early Detection Of Trap1, Berfi̇n Vural, Meltem Çalişkan, Mustafa Kemal Sezgi̇ntürk Jan 2020

Development Of A Biosensor Platform Based On Ito Sheets Modified With 3-Glycidoxypropyltrimethoxysilane For Early Detection Of Trap1, Berfi̇n Vural, Meltem Çalişkan, Mustafa Kemal Sezgi̇ntürk

Turkish Journal of Chemistry

The aim of this research was to design an electrochemical immunosensor for determination of tumour necrosis factor receptor-associated protein-1(TRAP1) antigen, a heat shock protein linked to tumour necrosis factor. The indium-tin oxide covered polyethylene terephthalate (ITO-PET) electrode surface was cleaned and was prepared for the introduction of hydroxyl groups on its surface by using NH$_{4}$ OH/H$_{2}$O$_{2}$/H$_{2}$O. As a silanization agent for covalent attachment of anti-TRAP1 on the surface of the ITO working electrode, 3-glycidoxypropyltrimethoxysilane (3-GOPS) was used. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to characterize the immobilization steps. A variety of parameters, 3-GOPS and anti-TRAP1 concentrations, …

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Preparation And Characterization Of Form-Stable Phase Change Material/End-Of-Life Tires Composites For Thermal Energy Storag, Yeli̇z Konuklu Jan 2020

Preparation And Characterization Of Form-Stable Phase Change Material/End-Of-Life Tires Composites For Thermal Energy Storag, Yeli̇z Konuklu

Turkish Journal of Chemistry

The management of end-of-life tires (ELT) waste gains importance in aspect of possible environmental and economic issues so the waste recycling becomes unavoidable. This study describes the fabrication and characterization of a new phase changing material (PCM)/ELT microcomposites that could be used in thermal energy storage. Paraffin together with the 4 fatty acids and ELT rubber powder are used as PCMs and as the supporting material, respectively. Paraffin/ELT composites are fabricated, as well, by the vacuum impregnation method in order to investigate the effect of the preparation method. The thermal, morphological, and chemical properties of the prepared PCM/ELT rubber microcomposites …

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Sensitive Determination Of Hydrogen Peroxide In Real Water Samples By High Spin Peroxo Complex, Tuğba Yavuz, Levent Peli̇t Jan 2020

Sensitive Determination Of Hydrogen Peroxide In Real Water Samples By High Spin Peroxo Complex, Tuğba Yavuz, Levent Peli̇t

Turkish Journal of Chemistry

In this paper, a fast, cheap, simple, sensitive and selective spectrophotometric method based on high spin peroxo-Fe(III)-EDTAcomplexinthealkalinemediumwasdevelopedforthedeterminationofhydrogenperoxide(H$_{2}$O$_{2}$) in real water samples. The purple-coloured complex with a maximum absorbance at a wavelength of 525 nm was formed. Various parameters such as type of stabilizer reagent and its concentration, reaction time, Fe(III), EDTA and NH3 concentration were optimized. The method was confirmed with the Beer?s law with a molar absorption coefficient of267.36Lmol$^{-1}$ cm$^{-1}$ in the 8.3×10$^{-6}$ -4.08×10$^{3}$ mol/L concentrationrange. Sandell's sensitivityoftheproposed method was also calculated as 0.188 µg/cm2. LOD and LOQ were determined as 2.5 ×10$^{-6}$ and 8.3 ×10$^{-6}$ mol/L, respectively. Intraday …

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Combined Computational And Experimental Studies On Cysteine-Sulfadiazine Adduct Formation, Nursel Açar Selçuki̇, Emi̇ne Coşkun, Ender Bi̇çer Jan 2020

Combined Computational And Experimental Studies On Cysteine-Sulfadiazine Adduct Formation, Nursel Açar Selçuki̇, Emi̇ne Coşkun, Ender Bi̇çer

Turkish Journal of Chemistry

The electrochemical characterization of sulfadiazine-cysteine (SD-CYS) adduct formation was performed in phosphatebuffer(pH7)onthebasisofvoltammetriccurrentandpeakpotentialmeasurements. Duetotheassociationof cysteine with sulfadiazine, the reduction peak currents of mercuric and mercurous cysteine thiolates decreased and their peak potentials simultaneously shifted to less negative potentials. By using the current changes of mercurous cysteine thiolate, it was determined that cysteine and sulfadiazine are associated with a 1:1 stoichiometry with a conditional association constant of 1.99 ×10$^{4}$ M$^{-1}$. In addition to experimental studies, a computational approach was carried out to study the geometrical parameters, electron densities, and UV-Vis absorption spectra of sulfadiazine and SDCYS adduct in water. Calculated (B3LYP/6-311++G(d,p) level) …

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Fabrication And Biocompatibility Assessment Of Polypyrrole/Cobalt(Ii) Metal-Organic Frameworks Nanocomposite, Mehrnaz Mehrabani, Zeinab Ansari Asl, Farzaneh Rostamzadeh, Saeideh Jafarinejad Farsangi, Mahnaz Sadat Hashemi, Mozhgan Sheikholeslami, Zeinab Neisi Jan 2020

Fabrication And Biocompatibility Assessment Of Polypyrrole/Cobalt(Ii) Metal-Organic Frameworks Nanocomposite, Mehrnaz Mehrabani, Zeinab Ansari Asl, Farzaneh Rostamzadeh, Saeideh Jafarinejad Farsangi, Mahnaz Sadat Hashemi, Mozhgan Sheikholeslami, Zeinab Neisi

Turkish Journal of Chemistry

Nowadays, metal-organic frameworks (MOFs) have emerged as promising tools for different biological applications and therefore, efforts are ongoing to develop more biocompatible MOFs-based nanocomposites. We aimed to fabricate some new conductive nanocomposites of polypyrrole and cobalt-MOF with different weight percentages (PPy/x%Co-MOF)usingthesolutionmixingmethodandcharacterizethemthroughFT-IR(Fourier-transforminfrared), PXRD (powder X-ray diffraction), SEM (scanning electron microscope), and TEM (transmission electron microscope) techniques. The biocompatibility of nanocomposites was assessed by haemolytic, cytotoxic, and quantitative reverse transcription PCR (qRT-PCR) assays. FT-IR and PXRD results revealed that nanocomposites consisted of pure MOFs and PPy. Moreover, SEM results indicated their spherical morphology along with an average diameter of 190 nm. (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium …

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Bioreduction: The Biological Activity, Characterization, And Synthesis Of Silver Nanoparticles, Nesri̇n Korkmaz Jan 2020

Bioreduction: The Biological Activity, Characterization, And Synthesis Of Silver Nanoparticles, Nesri̇n Korkmaz

Turkish Journal of Chemistry

Today, nanoparticles are effectively used in different areas. Initially, physical and chemical methods were used in the synthesis of nanoparticles. Biosynthesis (green synthesis) has emerged as an alternative to overcome the toxic effects of chemically synthesized nanoparticles. In this study, green synthesis of silver nanoparticles (AgNPs) with the leaf extract of Anthurium andraeanum was performed. UV-Vis spectrophotometry, scanning transmission electron microscopy, and XRD were applied to characterize the biosynthesized nanoparticles. As a result of the characterization, the spectra showed that a spectrum at a wavelength of about 419 nm and a spherical size of 38 nm nanoparticles was formed. Antibacterial …

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Design Of An Amphiphilic Hyperbranched Core/Shell-Type Polymeric Nanocarrier Platform For Drug Delivery, Ayça Bal Öztürk, Nesri̇n Oğuz, Hande Tekarslan Şahi̇n, Serkan Emi̇k, Emi̇ne Alarçi̇n Jan 2020

Design Of An Amphiphilic Hyperbranched Core/Shell-Type Polymeric Nanocarrier Platform For Drug Delivery, Ayça Bal Öztürk, Nesri̇n Oğuz, Hande Tekarslan Şahi̇n, Serkan Emi̇k, Emi̇ne Alarçi̇n

Turkish Journal of Chemistry

An amphiphilic core/shell-type polymer-based drug carrier system (HPAE- PCL-b-MPEG), composed of hyperbranched poly(aminoester)-based polymer (HPAE) as the core building block and poly(ethylene glycol)-bpoly(ε-caprolactone) diblock polymers (MPEG-b-PCL) as the shell building block, was designed. The synthesized polymers were characterized with FTIR, $^{1}$H NMR, $^{13}$C NMR, and GPC analysis. Monodisperse HPAE-PCL-bMPEG nanoparticles with dimensions of

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Arene Diazonium Saccharin Intermediates: A Greener And Cost-Effective Alternative Method For The Preparation Of Aryl Iodide, Lia Zaharani, Nader Ghaffari Khaligh, Zohreh Shahnavaz, Mohd Rafie Johan Jan 2020

Arene Diazonium Saccharin Intermediates: A Greener And Cost-Effective Alternative Method For The Preparation Of Aryl Iodide, Lia Zaharani, Nader Ghaffari Khaligh, Zohreh Shahnavaz, Mohd Rafie Johan

Turkish Journal of Chemistry

In the current protocol, the arene diazonium saccharin derivatives were initially produced from various substituted aromatic amines; subsequently, these intermediates were treated with a greener organic iodide for the preparation of the aryl iodide. We tried to choose low-cost, commercially available, biodegradable, recoverable, ecofriendly, and safe reagents and solvents. The arene diazonium saccharin intermediates could be stored in the liquid phase into a refrigerator for a long time with no significant loss activity. The outstanding merits of the current protocol (a) included the partial recovering of saccharin and tetraethylammonium salt, (b) reduce the use of solvents and the reaction steps …

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