Chemistry Commons^™

Seasonal Variation Of Microbiota In Shank Acanthopagrus Latus Living In Both Brackish And Fresh Water, Ali A. Al-Hisnawi Ph.D., Jassim M. Mustafa, Yass K. Yasser, Khalid A. Hussain, Ameera M. Jabur

Karbala International Journal of Modern Science

The present study was conducted to monitor the microbiota in the posterior intestine of Shank fish living in the river (fresh water) and Al-Razzaza lake (salt or brackish water) in Kerbala, Iraq. Cultivable bacteria were calculated and identified from specimens obtained from the posterior intestine of mucosa (PM) and digesta (PD) during summer and winter seasons. The total culturable bacteria (TCB) of bacteria isolated from both intestinal regions from fresh water fish during summer time were higher than counterparts in winter time. In contrast, the TVC of bacteria isolated from the PM from salt water fish during winter time were …

Evaluation Of The Healing Activity Of Cucurbita Spp. Leaf And Seed Extracts On Experimental Thermal Burns, Sanaa Jameel Thamer Ph.D., Prof. Maha Khalil Ibrahim, Dr. Khalid Shanshal Alnema

Karbala International Journal of Modern Science

Burns are the most common skin injuries associated with many complications and high incidences of wound infections. Many compounds of plant products have been assessed to accelerate wound healing or reduce contamination. The possible healing effect of two Cucurbita spp. in skin burns was investigated. Cucurbita maxima and Cucurbita pepo leaves and seeds were extracted using ethanol and analyzed by gas chromatography–mass spectrometry. Second-degree burn wounds were made on laboratory rats, and the burn wounds were applied topically with extracts for 14 days and silver sulfadiazine (SS) for comparison. Serum vascular endothelial growth factor (VEGF) was analyzed post-treatment. Hydroxyproline content …

Energy Conservation Approach Of Wireless Sensor Networks For Iot Applications, Suha Abdulhussein Abdulzahra Msc, Ali Kadhum M. Al-Qurabat Ph.D., Prof. Dr. Ali Kadhum Idrees

Karbala International Journal of Modern Science

Wireless Sensor Network is one of the most important contributors to IoT and performs significant role in people's lives due to its extensive use in many applications. Energy-saving is essential since sensor nodes are working by their restricted battery. In this article, data reduction method proposed to work at Gateway level of network. In GW, proposed method works as filtering via enabling GW to identify, then remove, sets of data that are redundant and produced by neighboring nodes. Principle idea of method recommended at this level is to exploit the advantage of spatial correlation between sensors to minimize energy depletion.

Biosynthesis, Characterization And Antiproliferative Activity Of Green Synthesized Gold Nanoparticles Using Lantadene A Extracted From Lantana Camara, Dawood Ali Salim Dawood, Lee Suan Chua Ph.D, Tian Swee Tan Ph.D, Ahmed F. Alshemary Ph.D

Karbala International Journal of Modern Science

This study was focused on the biosynthesis of gold nanoparticles loaded with lantadene A (LA-AuNPs) from Lantana camara extract and the antiproliferative effects on prostate cancer cells (LNCaP). The synthesized LA-AuNPs had smooth surface, and nearly spherical in shape (67.94 nm) with the zeta potential (-30.11±0.83 mV). LAAuNPs showed a dose dependent cytotoxic activity with IC50, 126.82 µg/mL against LNCaP, but non-cytotoxic to normal prostate cells. The intrinsic pathway of apoptosis was caused by the increase of caspases-3/7 and -9 activity and cell cycle arrest at the G0/G1 phase. Therefore, LA-AuNPs could be a potent lead to inhibit LNCaP

An Online E-Voting System Based On An Adaptive Ledger With Singular Value Decomposition Technique, Rihab Habeeb Sahib, Prof. Dr. Eman Salih Al-Shamery

Karbala International Journal of Modern Science

Regular E-voting systems for elections may count the votes in less time,less cost,save the privacy of citizens,but still considered risky as votes can be tampered.E-voting systems based on a network distributed ledger show fast results,more trusted,save privacy,cannot be tampered,and distributed in which no central organization controls the system.This paper illustrate an e-voting system to solve the challenge of a massive ledger that is distributed among network-nodes using a data reduction technique as a security-matching-tool,singular value decomposition(SVD) that handle a copy of election results in another form and matched with the SQL-database results to announce a successful election-event representing a transparency-powerful-secured-system

Detecting Malicious Dns Queries Over Encrypted Tunnels Using Statistical Analysis And Bi-Directional Recurrent Neural Networks, Mohammad Al-Fawa'reh, Zain Ashi, Mousa Tayseer Jafar

Karbala International Journal of Modern Science

The exponential rise in the number of malicious threats targeting computer networks and digital services puts network infrastructure in jeopardy. Domain name protocol attacks are one of the most pervasive network attacks posing a threat to networks, whereby attackers send harmful information to the network; this type of threat is identified as DNS tunneling. The DNS protocol has recently gained increased attention from cyber-attackers, targeting organizations with a web presence or reliance on e-commerce businesses. Cyber-attackers can subtly exploit the contents of encrypted DNS packets that are sent across covert network tunnels, which are difficult for firewalls and blacklist detection …

Artificial Intelligence For Para Rubber Identification Combining Five Machine Learning Methods, Chairote Yaiprasert Ph.D.

Karbala International Journal of Modern Science

This study aims to identify Para rubber species using a combination of five machine learning techniques to classify leaf images. The learning process is defined using a dataset for each classification method. Approximately 1,472 leaf images are prepared consisting of various sizes, shapes, quality provided for the model. The classification indicators are defined with the help of an algorithm to identify at least three of the top five potential classification outcomes. The algorithm accurately predicts 100% of the five classification methods. Methods can provide precise and rapid classification of large quantities, without the need for image preprocessing prior to classification.

Synergistic Extraction Of Silver From Nitric Acid Medium With Dithizone In The Presence Of A Secondary Amine- Amberlite La-2 Using 110mag-Radioisotope, Madhusudan Mandal Ph.D.

Karbala International Journal of Modern Science

Synergistic extraction of silver has been investigated in the presence of two different kinds of extractants, one of which is a chelating ligand, dithizone and the other is a long-chain secondary amine amberlite LA-2 at pH 3.0 using a radiotracer technique. The apparent formation constant, overall equilibrium constant and adduct formation constants were calculated from distribution coefficients. Interestingly, it was observed that the adduct formation constant is too high when the ligand concentration is increased by keeping the amine concentration fixed at 0.044 M compared to that obtained when the ligand concentration is kept fixed at 8.74×10^-4 M.

Editorial Board

Karbala International Journal of Modern Science

No abstract provided.

Metal Release From A Biomedical Cocrmo Alloy In Mixed Protein Solutions Under Static And Sliding Conditions: Effects Of Protein Aggregation And Metal Precipitation, Zheng Wei, Valentine Romanovski, Luimar Filho, Cecilia Persson, Yolanda S. Hedberg

Chemistry Publications

Biomedical materials made of cobalt-chromium-molybdenum (CoCrMo) alloys are commonly used in artificial prostheses and dental implants, which are exposed to friction and load. The release of Co, Cr, and Mo from these surfaces is governed by physical and chemical processes. The extent of measured metal release from biomedical CoCrMo alloys into mixed protein solutions may be influenced by protein aggregation and metal precipitation effects. Metal release from, and the surface composition of, a CoCrMo alloy was investigated in physiological relevant solutions (phosphate buffered saline, PBS, with varying concentrations of fibrinogen from bovine plasma and/or bovine serum albumin) at pH 7.3 …

A Modular Strategy For Expanding Electron-Sink Capacity In Noncanonical Cluster Assemblies, Yume Mai, Alexandria K. Balzen, Rebecca K. Torren, Michael P. Callahan, Adam C. Colson

Chemistry and Biochemistry Faculty Publications and Presentations

A modular synthetic strategy is described whereby organometallic complexes exhibiting considerable electron-sink capacity may be assembled by using only a few simple molecular components. The Fe₂(PPh₂)₂(CO)₅ fragment was selected as a common electroactive component and was assembled around aromatic cores bearing one, two, or three isocyanide functional groups, with the resultant complexes possessing electron-sink capacities of two, four, and six electrons, respectively. The latter complex is noteworthy in that its electron-sink capacity was found to rival that of large multinuclear clusters (e.g., [Ni₃₂C₆(CO)₃₆]^6– and [Ni_{38 …}

Single-Variable Porous Nanomaterial Series From Polymer Structure-Directing Agents, Morgan Stefik

Faculty Publications

Block polymer structure-directing agents (SDA) enable the production of porous nanoscale materials. Most strategies rely upon polymer equilibration where diverse morphologies are realized in porous functional materials. This review details how solvent selectivity determines the polymer SDA behaviors, spanning from bulk-type to solution-type. Equilibrating behavior of either type, however, obscures nanostructure cause-and-effect since the resulting sample series convolve multiple spatial variations. Solution-type SDA behaviors include both dynamic and persistent micelles. Persistent micelle templates (PMT) use high solvent selectivity for kinetic entrapment. PMTs enable independent wall thickness control with demonstrated 2 Å precision alterations. Unimodal PMT pore size distributions have spanned …

Activation Of Prp28 Atpase By Phosphorylated Npl3 At A Critical Step Of Spliceosome Remodeling, F.-L. Yeh, S.-L. Chang, G. R. Ahmed, H.-I. Liu, L. Tung, C.-S. Yeh, L. S. Lanier, Corina Maeder, C.-M. Lin, S.-C. Tsai, W.-Y. Hsiao, W.-H. Chang, T.-H. Chang

Chemistry Faculty Research

Splicing, a key step in the eukaryotic gene-expression pathway, converts precursor messenger RNA (pre-mRNA) into mRNA by excising introns and ligating exons. This task is accomplished by the spliceosome, a macromolecular machine that must undergo sequential conformational changes to establish its active site. Each of these major changes requires a dedicated DExD/H-box ATPase, but how these enzymes are activated remain obscure. Here we show that Prp28, a yeast DEAD-box ATPase, transiently interacts with the conserved 5' splice-site (5'SS) GU dinucleotide and makes splicing-dependent contacts with the U1 snRNP protein U1C, and U4/U6.U5 tri-snRNP proteins, Prp8, Brr2, and Snu114. We further …

Chapter 3.1: Visualization Of The Nernst Equation Via 3-D Topo Surfaces: E⁰ Plateaus, Left-Hand Bluffs, Front Cliffs And Reaction Paths, Garon C. Smith, Md Mainul Hossain

Water Topos: A 3-D Trend Surface Approach to Viewing and Teaching Aqueous Equilibrium Chemistry

A new 3-D graphical representation of oxidation–reduction (redox) processes in aqueous solutions has been developed utilizing a composition grid for which the x-axis carries the activity of the reduced form of the redox couple and the y-axis carries the activity of the oxidized form. The Nernst equation potential corresponding to the redox couple’s activities at each grid point is plotted above it as a z-coordinate. This creates a 3-D trend surface (a topo) over the grid. The topos typically have a steep left-hand bluff and a precipitous front cliff that are encountered when one or the other …

Synthesis Of Molecular Probes For The Detection Of Toxic Analytes, Rashid Mia

Dissertations

Two different types of molecular probes have been synthesized. The first family of probes is the coumarin class of compounds. These chemodosimters are referred to as Low Molecular Weight Fluorescent probes (LMFP). The other type of molecular probe is a macrocycle known as a pillar[5]arene receptor.

The chemodosimters (2.12a-c and 3.12a) were synthesized in four to five steps. The photophysical properties were extensively studied in various solvent systems (DMSO, CH₃CN, DMF, MeOH, EtOH, Me₂CO, MeCO₂Et, CHCl₃, C₆H₅Me, and C₆H₆). Dimethyl sulfoxide (DMSO) …

Anharmonic Vibrational Frequencies Of Water Borane And Associated Molecules, Brent R. Westbrook, Ryan C. Fortenberry

Faculty and Student Publications

Water borane (BH3 OH2 ) and borinic acid (BH2 OH) have been proposed as intermediates along the pathway of hydrogen generation from simple reactants: water and borane. However, the vibrational spectra for neither water borane nor borinic acid has been investigaged experimen-tally due to the difficulty of isolating them in the gas phase, making accurate quantum chemical predictions for such properties the most viable means of their determination. This work presents theoretical predictions of the full rotational and fundamental vibrational spectra of these two poten-tially application-rich molecules using quartic force fields at the CCSD(T)-F12b/cc-pCVTZ-F12 level with additional corrections included for …

Formation Of Reactive Nitrogen Species During Dichloramine Decay And Their Impact On N Nitrosodimethylamine Formation Under Drinking Water Conditions, Huong Thu Pham

Graduate Theses and Dissertations

NDMA occurrence and formation pathways in drinking water systems are reviewed and NDMA yields are compared on the basis of disinfectant type, water chemistry, and precursor category. In chloramination, despite monochloramine being the predominant species between pH 7-9, evidence suggests that dichloramine is the primary species involved in NDMA formation. This is somewhat confounding as NDMA yields are maximal at pH 9, yet at pH 9 dichloramine decays faster than it forms and hence is present at trace levels; additionally, the proposed mechanism involves a spin-forbidden incorporation of dissolved oxygen as a triplet, which is presumably kinetically slow. This review …

Aqueous-Based Associated Solvents For Protein And Peptide Fractionation And Protein Purification, Sajad Tasharofi

Chemistry & Biochemistry Dissertations - Archive

The focus of this dissertation is studying capabilities of a novel two-phase system in enhancing protein identification in the whole-cell proteomics studies. In this document, two types of biphasic systems have been used for two different purposes. The first type of biphasic system is formed by the addition of 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) to the aqueous solutions of water-miscible organic solvents. A combination of HFIP, organic solvent, and water forms a two-phase system in spite of the fact that every solvent pair in the three-component system is miscible and forms homogeneous solutions in water. This biphasic system is called Fluoroalcohol-Organic Associated Solvent …

Total Synthesis Of Imidazole-Containing Β-Carboline Alkaloids And Pyrrole-Imidazole Alkaloids, Moumita Singha Roy

Chemistry & Biochemistry Dissertations - Archive

The first part in this dissertation focuses on the development of an enantioselective total synthesis of villagorgin A, from another natural product haploscleridamine. Haploscleridamine was targeted first as it was thought that a successful approach to this family member would permit access to the other congeners through minor modifications, including conversion to villagorgin A. Moreover, villagorgin A has just one additional carbon atom compared to haploscleridamine, the introduction of which can be envisioned through a Pictet-Spengler reaction with formaldehyde. On completion of the haploscleridamine synthesis, attention was turned to the brominated congener, lissoclin C. Lissoclin C can be accessed from …

Mif But Not Mif-2 Recruits Inflammatory Macrophages In An Experimental Polymicrobial Sepsis Model, Pathricia Veronica Tilstam, Wibke Schulte, Thomas Holowka, Bong-Sung Kim, Jessica Nouws, Maor Sauler, Marta Piecychna, Georgios Pantouris, Elias Lolis, Lin Leng, Jürgen Bernhagen, Günter Fingerle-Rowson, Richard Bucala

Pacific Faculty Work

Excessive inflammation drives the progression from sepsis to septic shock. Macrophage migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict mortality in different infections, and anti-MIF antibody improves survival in experimental models when administered 8 hours after infectious insult. The recent description of a second MIF superfamily member, D-dopachrome tautomerase (D-DT/MIF-2), prompted closer investigation of MIF-dependent responses. We subjected Mif^-/- and Mif-2^-/- mice to polymicrobial sepsis and observed a survival benefit with Mif but not Mif-2 deficiency. Survival was associated with reduced numbers of small peritoneal macrophages (SPMs) that, in contrast to large peritoneal macrophages …

Identification Of Disease-Linked Hyperactivating Mutations In Ube3a Through Large-Scale Functional Variant Analysis, Kellan P. Weston, Xiaoyi Gao, Jinghan Zhao, Kwang Soo Kim, Susan E. Maloney, Jill Gotoff, Sumit Parikh, Yen Chen Leu, Kuen Phon Wu, Marwan Shinawi, Joshua P. Steimel, Joseph S. Harrison, Jason J. Yi

College of the Pacific Faculty Articles

The mechanisms that underlie the extensive phenotypic diversity in genetic disorders are poorly understood. Here, we develop a large-scale assay to characterize the functional valence (gain or loss-of-function) of missense variants identified in UBE3A, the gene whose loss-of-function causes the neurodevelopmental disorder Angelman syndrome. We identify numerous gain-of-function variants including a hyperactivating Q588E mutation that strikingly increases UBE3A activity above wild-type UBE3A levels. Mice carrying the Q588E mutation exhibit aberrant early-life motor and communication deficits, and individuals possessing hyperactivating UBE3A variants exhibit affected phenotypes that are distinguishable from Angelman syndrome. Additional structure-function analysis reveals that Q588 forms a regulatory site …

Theoretical Investigation Of The Co-C Bond Activation In Methylcobalamin And Adenosylcobalamin-Dependent Systems: Mechanistic Insights., Arghya Pratim Ghosh

Electronic Theses and Dissertations

The vitamin B₁₂ derivates, otherwise known as cobalamin (Cbl), are ubiquitous organometallic cofactors. The biologically active forms of Cbl, such as methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl), act as cofactors in different physiological reactions for both prokaryotes and eukaryotes. A crucial aspect of the Cbl-mediated systems is the activation of the organometallic Co-C bond that plays a critical role in its catalytic activity. One of the most remarkable features of this Co-C bond is its unusual activation in AdoCbl-dependent enzymatic reactions, where a trillion-fold rate acceleration of the Co-C bond cleavage is observed inside the enzyme compared to the isolated …

Understanding Students’ Global Interdependence In Science Instruction, Walter S. Smith

Journal of Global Education and Research

Multiple American educational organizations such as the National Education Association, Association for Supervision and Curriculum Development, and the Council of Chief State School Officers have advocated for globalizing the K-12 curriculum. The National Science Teaching Association (NSTA) in a position statement on international education and the Next Generation Science Standards have produced goals and standards for internationalizing the science curriculum by addressing topics such as climate change, environment, and disease that cross borders. In contrast to those pronouncements on the curriculum, this article views global science education through an instructional lens that focuses on a students’ global interdependence in science …

Headspace-Solid Phase Micro Extraction – Gas Chromatography – Mass Spectrometry (Hs-Spme-Gc-Ms) Analysis For Oak Barrel Flavor Compounds In Whiskey, Hailey F. Jarzynka

Chemistry & Biochemistry Theses - Archive

This study presents a method to simultaneously detect both fault compounds and oak barrel flavor compounds in whiskey using headspace-solid phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS). A major contaminant in whiskey is geosmin and an array of oak barrel compounds includes 2-methoxy-4-methylphenol, 5-methylfurfural, guaiacol, trans-whiskey lactone, 2-methoxy-4-vinylphenol, 4-ethylguaiacol, eugenol, vanillin, and 4-ethylphenol. Geosmin is a fault compound that produces a musty or moldy taste to the whiskey and the other compounds originate from the barrels in which the whiskey is aged in and transfer to the whiskey in the aging process. Each compound was quantitated and 15 different whiskies were compared …

Volatiles Characterization During Whiskey Production Using Headspace - Solid Phase Microextraction - Gas Chromatography - Mass Spectrometry, Robert H. Magnuson

Chemistry & Biochemistry Theses - Archive

Whiskey is the second most consumed distilled alcoholic beverage type, by brand, on the planet behind Chinese Baijiu. A prominent component in many varieties of whiskey, maize, contributes a wide profile of compounds that undergo modification in the production pathway, ultimately influencing the final flavor profile. In this study, headspace/solid phase microextraction-gas chromatography/mass spectrometry (HS/SPME-GC/MS) was used to characterize the volatile profile of 5 different maize varieties, mashes produced from each, and 4 post-fermentation mixtures. Headspace sampling was performed using a high capacity SPME Arrow device, in an effort maximize the species detected. Compound identification was supplied by matches within …

Utilizing High Throughput Computing Techniques For The Predictions Of Spectroscopic Properties Of Astrophysically Relevant Molecules, Brian Ferrari

Electronic Theses and Dissertations, 2020-2023

Here, we utilize Quantum Chemistry (QC) approaches to predict the structures, vibrational frequencies, infrared intensities and Raman activities of unusual molecular species using the General Atomic and Molecular Structure System (GAMESS(US)) package. A Python-based software, AutoGAMESS, was developed to automate the workflow and take advantage of High Throughput Computing (HTC) techniques enabling the automated generation of spectroscopic data from hundreds of calculations. This approach was utilized to determine these properties for a series of carbon oxides (C2On; n = 3 to 4), anticipated to be produced during the radiation of pure carbon dioxide ices, under conditions relevant to the interstellar …

Genetically Engineered Thermosynechococcus Elongatus Bp1: Assessment Of Potential Biorisks And Biofuel Production, Thu Ho Anh Nguyen-Jones

Chemistry & Biochemistry Theses & Dissertations

According to the International Energy Outlook 2019, released by the U.S. Energy Information Administration, it is projected that the energy consumption will increase up to 50% between 2018 and 2050 worldwide. As fossil fuel being a finite source of energy with the risk of depletion, many countries are now facing an energy security crisis. Therefore, it is important to develop other renewable and sustainable energy sources that will allow countries to shift away from depending on fossil fuels. Among several types of renewable energy, biofuel production using genetically engineered cyanobacteria is capturing much interest due to its many advantages. Different …

College Of Natural Sciences Newsletter, December 2021, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Volume 2, Issue 12

Page 1 Dean's Message
Page 2 Awards & Recognition
Page 2 Media Coverage of CNS
Page 3 Media Coverage Cont.
Page 4 Science as Art Competition
Page 5 Open PRAIRIE Data
Page 5 Grants Awarded in CNS

Super-Adsorbent Hydrogels For Removal Of Methylene Blue From Aqueous Solution: Dye Adsorption Isotherms, Kinetics, And Thermodynamic Properties, Buddhabhushan Salunkhe, Thomas P. Schuman

Chemistry Faculty Research & Creative Works

Removal of dyes through adsorption from wastewater has gained substantial interest in recent years, especially in development of hydrogel-based adsorbents, owing to their easy use and economical nature. The aim of the present study was to design a super-adsorbent hydrogel based on sodium styrene sulfonate (NaSS) monomer for removal of dyes like methylene blue (MB). NaSS displays both an aromatic ring and strongly ionic group in its monomer structure that can enhance adsorption capacity. Poly (sodium styrene sulfonate-co-dimethylacrylamide) hydrogels were prepared by solution free radical polymerization using gelatin meth acryloyl (GelMA) as crosslinker, creating a highly porous, three-dimensionally crosslinked polymer …

Spectroscopic Studies Of The Interaction Between Phosphorus Heterocycles And Cytochrome P450, Dumei Ma, Libo Zhang, Yingwu Yin, Yuxing Gao, Qian Wang

Faculty Publications

P450 fatty acid decarboxylase OleT from Staphylococcus aureus (OleT_SA) is a novel cytochrome P450 enzyme that catalyzes the oxidative decarboxylation of fatty acids to yield primarily terminal alkenes and CO₂ or minor α- and β-hydroxylated fatty acids as side-products. In this work, the interactions between a series of cycloalkyl phosphorus heterocycles (CPHs) and OleT_SA were investigated in detail by fluorescence titration experiment, ultraviolet–visible (UV–vis) and ³¹P NMR spectroscopies. Fluorescence titration experiment results clearly showed that a dynamic quenching occurred when CPH-6, a representative CPHs, interacted with OleT_SA with a binding constant value of 15.2 …