Chemistry | Open Access Articles | Digital Commons Network™

Measurement Of Protein And Drug Adsorption On Nanoparticles By Competition With Dyes, Ashleigh Carroll, Jason Mcneill

Chemistry Summer Research Program

No abstract provided.

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Using Alginate Beads Modified With Graphite As An Effective Electrode, Madeline Mchugh, Barbara G. S. Guinati, Carlos D. Garcia

Chemistry Summer Research Program

No abstract provided.

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Polymersomes As Chemotherapeutic Agents For Non-Invasive Treatment Of Glioblastoma, Tj Fletcher, Molli Garifo, Jessica Larsen, Jessica Larsen

Chemistry Summer Research Program

No abstract provided.

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Accessing Rare Heterocycles From Alkynyl Ethers And Nitrogenous Electrophiles & The Development Of Small Molecule Inhibitors Against Naegleria Fowleri Infection, James W. D. Morris, Samuel Kwain, Daniel C. Whitehead

Chemistry Summer Research Program

No abstract provided.

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Combining Alginate Beads With Methylene To Create A Biosensor To Assess The Quality Of Milk, Vivien Zheng, Barbara Guinati, Carlos D. Garcia

Chemistry Summer Research Program

No abstract provided.

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Multi-Catalysis: Trifluoromethylation Of Amides, Ethan Apsley, Jason Wilt, Giovani Gutierrez, Byoungmoo Kim

Chemistry Summer Research Program

No abstract provided.

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Cryogrinding And Physical Analysis Of A Thermoplastic Polyurethane Elastomer, Timothy E. Whitesell, Marcia Reeves, David L. Helm, Joseph S. Thrasher

Chemistry Summer Research Program

No abstract provided.

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Stimuli-Responsive Self-Folding Bilayer Polymer Thin Films, Astrid Garcia, Dimuthu Edirisinghe, Bogdan Oliy, George Chumanov

Chemistry Summer Research Program

No abstract provided.

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Tuning Oxo Formation Energies Using Spectator Ligands In The Mil-100 Metal Organic Framework, Victoria E. Lee, Stephen P. Vicchio, Rachel B. Getman

Chemistry Summer Research Program

No abstract provided.

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Effects Of Low-Energy X-Rays And Uv Radiation On Fibroblast Cells, Michelle Gorodisky, Congyue Peng, Arianna Csiszer, Delphine Dean

Chemistry Summer Research Program

No abstract provided.

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Successes In Antiviral Drug Discovery: A Tribute To Nick Meanwell, David P. Rotella

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

Drug discovery is a difficult task, and is even more challenging when the target evolves during therapy. Antiviral drug therapy is an excellent example, exemplified by the evolution of therapeutic approaches for treatment of hepatitis C and HIV-1. Nick Meanwell and his colleagues made important contributions leading to molecules for treatment of hepatitis C and HIV-1, each with distinct mechanisms of action. This review summarizes the discovery and impact of these drugs, and will highlight, where applicable, the broader contributions of these discoveries to medicinal chemistry and drug discovery.

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Dynamics Of Ionizable Polymers In Ionic Liquid (Il) Using Nuclear Magnetic Resonance Spectroscopy, Sophie Ntipouna, Hayden Sasko, Shalika D. K. Meedin, Dvora Perahia

Chemistry Summer Research Program

No abstract provided.

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Halogen Bonding In Nitrogen And Iodine Compounds To Form Novel Cocrystals, Dahlia Griffin, Ann Jiang, Colin D. Mcmillen, William T. Pennington

Chemistry Summer Research Program

No abstract provided.

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Scope And Mechanistic Studies Of Ruthenium Catalyzed C-C And C-N Bond Activation Reactions, Dulanjali Thennakoon

Dissertations (1934 -)

Transition metal catalyzed selective C–C and C–N bond activation reactions emerged as an effective synthetic tool in organic chemistry. Reorganization of these bond connections allows access to complex molecular scaffolds from readily available starting materials which are immensely useful for organic synthesis of pharmaceutical agents. While enormous progress has been achieved to date, major challenges still remain in desigining broad applicable catalytic bond activation methods. The well-defined cationic Ru–H complex with a benzoquinone ligand was found to be an effective catalytic system for the deaminative coupling reaction of enones with amines which enable regioselective cleavage of unstrained Cα–Cβ bond of …

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Long-Term Monitoring Of Clodronate In Equine Hair Using Liquid Chromatography-Tandem Mass Spectrometry, Heather K. Knych, D. S. Mckemie, S. Yim, S. D. Stanley, R. M. Arthur

UK CARES Faculty Publications

Given the potential for long-term inhibition of bone remodeling/healing and detrimental effects to horses in training, bisphosphonates are tightly regulated in horseracing. Hair has proven to be an effective matrix for detection of drug administration to horses and has been particularly effective in detecting drugs for a long period of time post administration. Thus, hair may prove to be a useful matrix for detection of administration of this class of drugs. The objective of the current study was to develop an assay and assess the usefulness of hair as a matrix for long-term detection of clodronate to horses. Seven horses …

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Elucidating The Structure And Regulatory Interactions Of The Hotair Non-Coding Rna And The Bacterial Rnase P. Holoenzyme, Ainur Abzhanova

Dissertations (1934 -)

RNA structures and RNA-protein interactions are studied as potential drug targets, biomarkers in cancer, and can be administered as vaccines. The cancer associated HOTAIR (HOX transcript antisense RNA) exists in higher vertebrates and interacts with chromatin remodeling enzymes. We examined the thermodynamic folding properties and structural propensity of the exonic regions of HOTAIR using biophysical methods and NMR spectroscopy. Different exons of HOTAIR contain variable degrees of structural heterogeneity. We identify one exonic region, exon 4, that adopts a stable and compact fold under low magnesium concentrations. Close agreement of NMR spectroscopy and chemical probing confirm conserved base pair interactions …

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Dynamics Of Diffusion, Evaporation, And Retention Of Organic Solvents In Paints By Unilateral Nmr And Hr-Mas Nmr Spectroscopy, Valeria Di Tullio, Roberta Pigliapochi, Nicholas Zumbulyadis, Silvia A. Centeno, Jaclyn Catalano, Molly Wagner, Cecil Dybowski

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

Transport of organic solvents in polymeric matrices plays a central role in many processes of interest to the coatings industry. Previous studies have focused on individual processes taking place in the solvent-paint system. In the present study, we report results on the molecular dynamics in a solvent/paint system during the entire sequence of absorption, diffusion, swelling, and evaporation processes, obtained non-invasively, in situ, and in real time using unilateral NMR relaxometry. The associated chemical structures were investigated using HR-MAS NMR spectroscopy. Four distinct ranges of molecular motion in the solvent/paint film were identified based on proton NMR transverse relaxation time …

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Clear As Glass: Novel Antibiotic Glasses Vitrified From Solution, Claire Lamberti

Chemistry Theses and Dissertations

The World Health Organization (W.H.O.) has maintained a list of essential medicines since 1977 (1). This list contains the medications considered to be the most effective and of the utmost importance to the needs of worldwide healthcare systems. If new forms of these drugs can be created, they can be studied for potential stability and transportation purposes, as well as drug delivery mechanisms. There are strategies to try and improve the physicochemical properties including forming polymorphs, salts, cocrystals, and amorphous formulations. There are issues with these techniques, and a large one is that in most cases the crystal structures of …

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The Decomposition Of Normal Vibrational Modes In Different Chemistry Problems, Mateus Macedo Quintano

Chemistry Theses and Dissertations

The least action principle yields the Euler-Lagrange equations, which explain molecular vibrations in minimizing action. Subsequently, the Lagrangian gives rise to the equations of motion using the Euler-Lagrange equations. We can then solve the characteristic value problem to obtain normal vibrational modes. Ultimately, the vibrational spectrum of a molecule can be extracted from the characteristic values. Normal coordinates are linear combinations of internal or Cartesian coordinates. However, the delocalization of normal vibrational modes across the molecule restricts the direct use of normal mode frequencies and force constants for measuring bond strength. From the force constant matrix and the normal mode …

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Understanding Mitochondrial Dysfunction In Neurodegenerative Diseases Using Novel Neuron Cell Models, Amy Apfelbaum, Anthony Grillo Phd, Raghav Dutta Phd, Alaa Hassan

Annual Student Research Poster Session

This past summer I worked Dr. Anthony Grillo’s lab under my mentors Raghav Dutta and Alaa Hassan at the University of Cincinnati. The Grillo Lab is focused on understanding the mechanisms of mitochondrial complex 1 dysfunction in neurodegenerative diseases. It has been shown that an early feature of neurodegeneration is complex 1 dysfunction; we were trying to determine if this is a cause or an effect of these diseases. This summer, we focused on identifying different types of neuron subtypes in brain tissue samples, isolating primary neurons by first identifying and visualizing the types of brain cells present in brain …

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The Sound Of Geological Targets On Mars From The Absolute Intensity Of Laser-Induced Sparks Shock Waves, C. Alvarez-Llamas, J. Laserna, J. Moros, P. Purohit, L. García-Gómez, S. M. Angel Ph.D., P. Bernardi, B. Bousquet, A. Cadu, E. Dauson, O. Forni, T. Fouchet, O. Gasnault, X. Jacob, G. Lacombe, N. L. Lanza, C. Larmat, J. Lasue, R. D. Lorenz, P. Y. Meslin, D. Mimoun, F. Montmessin, N. Murdoch, A. M. Ollila, P. Pilleri, N. Randazzo, A. L. Reyes-Newell, S. Schröder, A. Stott, J. Ten Cate, A. Udry, D. Vogt

Faculty Publications

Inspection of geological material is one of the main goals of the Perseverance rover during its journey across the landscape of the Jezero crater in Mars. NASA's rover integrates SuperCam, an instrument capable of performing standoff characterization of samples using a variety of techniques. Among those tools, SuperCam can perform laser-induced breakdown spectroscopy (LIBS) studies to elucidate the chemical composition of the targets of interest. Data from optical spectroscopy can be supplemented by simultaneously-produced laser-produced plasma acoustics in order to expand the information acquired from the probed rocks thanks to the SuperCam's microphone (MIC) as it can be synchronized with …

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Amyloid-Beta Protein Concentration Dependence Of Reversible Aggregation Using Gold Colloid Particles, Renee Spencer, Lila Kocieniewski, Bryan Martinez, Kazushige Yokoyama

McNair Scholars Program

Although Alzheimer’s and COVID-19 are different diseases, the commonality between them is during the process of them developing in a person by fibrillogenesis. The product of fibrillogenesis results in the development of these diseases. We study the first stage of fibrillogenesis where the amyloid-beta peptide monomers are assembled into an oligomer. We want to isolate this oligomer using gold colloids because this step can be reversed. Utilizing gold colloids allows us to freeze fibrillogenesis in the first step by folding and unfolding the protein repeatedly through a series of pH changes from 4 or below to 10 or higher. At …

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Study Of Non-Covalent Interactions Using Molecular Rotors And Balances, Daniel Onyekachi Madukwe

Theses and Dissertations

The main focus of this dissertation is on the quantification of non-covalent interactions using molecular rotors and balances. While molecular rotors were used to measure kinetic effects of weak non-covalent interactions, molecular balances were used to measure their thermodynamic effects. Chapters 1 and 2 focus on the use of molecular rotors in measuring and studying the kinetic effects of the hydrogen bonding interaction on the bond rotation transition states. Chapters 3 and 4 focus on the quantification of lone pair – lone pair and sp²-CH/π interactions respectively, using molecular balances. These studies were carried out in the …

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Expanding On The Solid State Chemistry Of F-Element Chalcogenides, Logan Skyler Breton

Theses and Dissertations

An overarching goal in solid state chemistry is to achieve predictability regarding the synthesis of compounds with desired properties. While this goal is far from being reached, solid state chemists are hard at work synthesizing and characterizing new materials to further our understanding of structure-property relationships, and to expand our fundamental knowledge to rationalize the outcomes of solid-state syntheses. With the advent of new solid state synthetic methods, novel compounds exhibiting exciting properties are still being discovered today. The infancy of these synthetic methods promises a myriad of undiscovered compounds with potentially interesting properties which has resulted in a recent …

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Photophysical And Photocatalytic Properties Of Covalent Organic Frameworks, Daniel Streater H.

Dissertations (1934 -)

This dissertation is most interested in how a class of materials known as covalent organic frameworks (COFs) can be designed to capture photon energy to initiate chemical reactions. Different COF designs change how long the energy is held, how it migrates, and how it is dispersed – and these differences can be used to change their performance as artificial photosynthesis platforms. Thus, it is helpful to have an informative discussion about the processes behind natural photosynthesis, that is, nature’s light harvesting strategies and photocatalytic schemes (Section 1.2) and will lead into an introduction of COFs and why they possess unique …

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Identification Of The Autoregulatory Properties And Molecular Interactions Of The Lysine-Specific Histone Demethylase 1 Enzyme, Dulmi Senanayaka

Dissertations (1934 -)

The conserved chromatin-remodeling enzyme, Lysine-Specific histone1/2 Demethylase 1 (LSD1) primarily demethylates Histone H3K4me , acting as a transcriptional repressor. It plays pivotal roles in various physiological processes including cancer and interacts with many regulatory proteins, non-coding RNAs, and small metabolites. However, little biochemical information is known about LSD1’s N-terminal intrinsically disordered region (IDR) and how LSD1 interacts with various biomolecules in the context of nucleosome. I present evidence that the IDR of LSD1, containing multiple post translational modifications (PTMs) and a nuclear localization signal (NLS), can act as a reversible competitive autoinhibitor of LSD1’s activity. This autoinhibition can be relieved …

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The Synthesis Of Novel Rare Earth Thiosilicates Using The Boron Chalcogen Mixture Method For An Interest In Their Magnetic And Optical Properties, Adam Alexander King

Theses and Dissertations

The chalcogens or the group sixteen elements excluding oxygen, are of interest due to their wide variety of structures and compositions, which gives the potential for a plethora of desired physical properties. This is due to their increased ability to catenate, forming stable chalcogen-chalcogen bonds. When the chalcogens combine with certain main group elements and transition metals they form anionic framework building blocks known as chalcometallates. One such chalcometallate of interest is the thiosilicates, compounds containing Si-S bonds as the anionic frameworks. These compounds are of interest due to their potentials in both their optical and magnetic properties. However, traditional …

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Cadmium And Salinity Stressor Antagonism On Vallisneria Neotropicalis, Christopher P. Mikolaitis

Graduate Theses and Dissertations (2019 - present)

Submerged macrophytes form the foundation of freshwater ecosystems. These organisms are sessile and are very susceptible to shifts in their environment. Heavy metals are of particular concern as they can be sequestered indefinitely in sediments and are readily taken up by rooted vegetation. In the presence of saltwater intrusions, these metals can interact with salt ions potentially changing their availability to submerged vegetation. In this study a freshwater macrophyte, Vallisneria neotropicalis, was used as a test species for interactive effects between Cd, a non-essential heavy metal, and salt stress. The metrics used to establish the individual as well as …

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Study Of Digital Algan Alloy Based Heterostructures Using Aln/Gan Short Period Superlattice, Mohammad Kamal Hussain

Theses and Dissertations

Ultrawide Bandgap (UWBG) and Extreme Bandgap (EBG) AlxGa1-xN (x > 0.40) alloys with EG > 4.2 eV are potential candidates for high temperature and high voltage applications, compared to Wide Bandgap (WBG) GaN-based lateral channel devices. Since critical electric field (Ec) scales as (Eg)^2.5, theoretically AlGaN alloys can sustain large electric field before breaking down. However, achieving linear ohmic contacts to the 2-dimensional electron gas (2DEG) formed at the interface of AlyGa_1-xN/ Al_xGa_1-xN (y – x ≥ 0.20) High Electron Mobility Transistors (HEMTs) is challenging. Direct contact through the AlGaN barrier is difficult due …

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Identification Of New Disinfection Byproducts In Drinking Water And Impacts Of Algae, Md. Tareq Aziz

Theses and Dissertations

The disinfection of water has been hailed as one of the most important triumphs for public health in the 20th century. Drinking water treatment plants produce safe drinking water by inactivating microorganisms through the use of disinfectants, including chlorine, chloramine, chlorine dioxide, UV irradiation, and ozone. However, these disinfectants also produce toxic disinfection by-products (DBPs), through reactions with natural organic matter and anthropogenic pollutants, as well as bromide and iodide present in source waters. The presence of bromide and iodide results in the formation of bromo- and iodo-DBPs which are much more toxic than DBPs containing chlorine. DBPs are always …

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Full-Text Articles in Chemistry

Measurement Of Protein And Drug Adsorption On Nanoparticles By Competition With Dyes, Ashleigh Carroll, Jason Mcneill

Chemistry Summer Research Program

Using Alginate Beads Modified With Graphite As An Effective Electrode, Madeline Mchugh, Barbara G. S. Guinati, Carlos D. Garcia

Chemistry Summer Research Program

Polymersomes As Chemotherapeutic Agents For Non-Invasive Treatment Of Glioblastoma, Tj Fletcher, Molli Garifo, Jessica Larsen, Jessica Larsen

Chemistry Summer Research Program

Accessing Rare Heterocycles From Alkynyl Ethers And Nitrogenous Electrophiles & The Development Of Small Molecule Inhibitors Against Naegleria Fowleri Infection, James W. D. Morris, Samuel Kwain, Daniel C. Whitehead

Chemistry Summer Research Program

Combining Alginate Beads With Methylene To Create A Biosensor To Assess The Quality Of Milk, Vivien Zheng, Barbara Guinati, Carlos D. Garcia

Chemistry Summer Research Program

Multi-Catalysis: Trifluoromethylation Of Amides, Ethan Apsley, Jason Wilt, Giovani Gutierrez, Byoungmoo Kim

Chemistry Summer Research Program

Cryogrinding And Physical Analysis Of A Thermoplastic Polyurethane Elastomer, Timothy E. Whitesell, Marcia Reeves, David L. Helm, Joseph S. Thrasher

Chemistry Summer Research Program

Stimuli-Responsive Self-Folding Bilayer Polymer Thin Films, Astrid Garcia, Dimuthu Edirisinghe, Bogdan Oliy, George Chumanov

Chemistry Summer Research Program

Tuning Oxo Formation Energies Using Spectator Ligands In The Mil-100 Metal Organic Framework, Victoria E. Lee, Stephen P. Vicchio, Rachel B. Getman

Chemistry Summer Research Program

Effects Of Low-Energy X-Rays And Uv Radiation On Fibroblast Cells, Michelle Gorodisky, Congyue Peng, Arianna Csiszer, Delphine Dean

Chemistry Summer Research Program

Successes In Antiviral Drug Discovery: A Tribute To Nick Meanwell, David P. Rotella

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

Dynamics Of Ionizable Polymers In Ionic Liquid (Il) Using Nuclear Magnetic Resonance Spectroscopy, Sophie Ntipouna, Hayden Sasko, Shalika D. K. Meedin, Dvora Perahia

Chemistry Summer Research Program

Halogen Bonding In Nitrogen And Iodine Compounds To Form Novel Cocrystals, Dahlia Griffin, Ann Jiang, Colin D. Mcmillen, William T. Pennington

Chemistry Summer Research Program

Scope And Mechanistic Studies Of Ruthenium Catalyzed C-C And C-N Bond Activation Reactions, Dulanjali Thennakoon

Dissertations (1934 -)

Long-Term Monitoring Of Clodronate In Equine Hair Using Liquid Chromatography-Tandem Mass Spectrometry, Heather K. Knych, D. S. Mckemie, S. Yim, S. D. Stanley, R. M. Arthur

UK CARES Faculty Publications

Elucidating The Structure And Regulatory Interactions Of The Hotair Non-Coding Rna And The Bacterial Rnase P. Holoenzyme, Ainur Abzhanova

Dissertations (1934 -)

Dynamics Of Diffusion, Evaporation, And Retention Of Organic Solvents In Paints By Unilateral Nmr And Hr-Mas Nmr Spectroscopy, Valeria Di Tullio, Roberta Pigliapochi, Nicholas Zumbulyadis, Silvia A. Centeno, Jaclyn Catalano, Molly Wagner, Cecil Dybowski

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

Clear As Glass: Novel Antibiotic Glasses Vitrified From Solution, Claire Lamberti

Chemistry Theses and Dissertations

The Decomposition Of Normal Vibrational Modes In Different Chemistry Problems, Mateus Macedo Quintano

Chemistry Theses and Dissertations

Understanding Mitochondrial Dysfunction In Neurodegenerative Diseases Using Novel Neuron Cell Models, Amy Apfelbaum, Anthony Grillo Phd, Raghav Dutta Phd, Alaa Hassan

Annual Student Research Poster Session

Faculty Publications

Amyloid-Beta Protein Concentration Dependence Of Reversible Aggregation Using Gold Colloid Particles, Renee Spencer, Lila Kocieniewski, Bryan Martinez, Kazushige Yokoyama

McNair Scholars Program

Study Of Non-Covalent Interactions Using Molecular Rotors And Balances, Daniel Onyekachi Madukwe

Theses and Dissertations

Expanding On The Solid State Chemistry Of F-Element Chalcogenides, Logan Skyler Breton

Theses and Dissertations

Photophysical And Photocatalytic Properties Of Covalent Organic Frameworks, Daniel Streater H.

Dissertations (1934 -)

Identification Of The Autoregulatory Properties And Molecular Interactions Of The Lysine-Specific Histone Demethylase 1 Enzyme, Dulmi Senanayaka

Dissertations (1934 -)

The Synthesis Of Novel Rare Earth Thiosilicates Using The Boron Chalcogen Mixture Method For An Interest In Their Magnetic And Optical Properties, Adam Alexander King

Theses and Dissertations

Cadmium And Salinity Stressor Antagonism On Vallisneria Neotropicalis, Christopher P. Mikolaitis

Graduate Theses and Dissertations (2019 - present)

Study Of Digital Algan Alloy Based Heterostructures Using Aln/Gan Short Period Superlattice, Mohammad Kamal Hussain

Theses and Dissertations

Identification Of New Disinfection Byproducts In Drinking Water And Impacts Of Algae, Md. Tareq Aziz

Theses and Dissertations