Chemistry Commons^™

Ambient Processed Rgo/Ti3cntx Mxene Thin Film With High Oxidation Stability, Photosensitivity, And Self-Cleaning Potential, Muhammad Abiyyu Kenichi Purbayanto, Dominika Bury, Madhurya Chandel, Zhila Dehghan Shahrak, Vadym Mochalin, Anna Wójcik, Dorota Moszczyńska, Anita Wojciechowska, Anika Tabassum, Michael Naguib, Agnieszka Maria Jastrzębska

Chemistry Faculty Research & Creative Works

Solution-Based Processing Offers Advantages for Producing Thin Films Due to Scalability, Low Cost, Simplicity, and Benignity to the Environment. Here, We Develop Conductive and Photoactivated Self-Cleaning Reduced Graphene Oxide (RGO)/Ti₃CNT_x MXene Thin Films Via Spin Coating under Ambient Conditions. the Addition of a Thin RGO Layer on Top of Ti₃CNT_x Resulted in Up to 45-Fold Improvement in the Environmental Stability of the Film Compared to the Bare Ti₃CNT_x Film. the Optimized RGO/Ti₃CNT_x Thin Film Exhibits an Optical Transmittance of 74% in the Visible Region of the Spectrum and …

Hydrogen Peroxide Disproportionation Activity Is Sensitive To Pyridine Substitutions On Manganese Catalysts Derived From 12-Membered Tetra-Aza Macrocyclic Ligands, David M. Freire, Hannah M. Johnston, Katherine J. Smith, Kristof Pota, Magy A. Mekhail, Sugam Kharel, Kayla N. Green

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The abundance of manganese in nature and versatility to access different oxidation states have made manganese complexes attractive as catalysts for oxidation reactions in both biology and industry. Macrocyclic ligands offer the advantage of substantially controlling the reactivity of the manganese center through electronic tuning and steric constraint. Inspired by the manganese catalase enzyme, a biological catalyst for the disproportionation of H₂O₂ into water and O₂, the work herein employs 12-membered tetra-aza macrocyclic ligands to study how the inclusion of and substitution to the pyridine ring on the macrocyclic ligand scaffold impacts the reactivity of …

Approaches To Assessing Nutrient Coupling In Open Ocean Datasets, James M. Moore, Claire P. Till

IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt

Nutrient coupling describes a process where the biogeochemical cycles of two elements are linked by being incorporated similarly into biomass. This paper uses data from the GEOTRACES GP16 cruise (Eastern Pacific Zonal Transect) to investigate the relationship between certain macronutrients generally coupled to trace elements in terms of their oceanic distributions with the notable exception of in an oxygen minimum zone: cadmium-phosphate and zinc-silicate. There are many methods applied to oceanographic data to correlate analyte concentrations; while they are often presented independently in literature, here we attempt to use them in conjunction for a more thorough interpretation. By compiling 1) …

Development Of Single-Crystalline And 3d-Printable Porous Organic Materials, Mingshi Zhang

Dartmouth College Ph.D Dissertations

Porous organic materials with designable structures, large surface areas, low densities, and unique electronic and optical properties have found widespread applications in adsorption, separation, energy storage, and catalysis. However, the majority of organic porous materials are synthesized as fluffy powders, which poses two fundamental challenges for them. Firstly, they lack a single-crystal structure at the microscopic scale, making it difficult to study the specific pore size, shape, and potential substrate binding sites at the atomic level and further establish the structure-property relationship. Secondly, they lack the general processing method and macroscopic shape design, making it difficult to manufacture suitable components …

Protocol For Purification And Enzymatic Characterization Of Members Of The Human Macrophage Migration Inhibitory Factor Superfamily, Andrew Parkins, Georgios Pantouris

Pacific Faculty Work

Macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT or MIF-2) are two proteins serving a key role in the pathogenesis of multiple disorders, including cancer.¹ Here, we present a protocol for the purification and enzymatic characterization of MIF and D-DT using keto-enol tautomerase activity. This approach measures enzymatic activity through the formation of an enol-borate complex. We describe steps for expressing and purifying proteins, preparing the 96-well microplate, and assay implementation including monitoring of keto-enol tautomerase activity. For complete details on the use and execution of this protocol, please refer to Parkins et al.^2,3

Microplastics In Water, Their Effects On The Aquatic Ecosystem And Human Public Health, And The Proposed Solutions, Mohanad Abouserie

The Undergraduate Research Journal

We could be swallowing a credit card's weight in plastic every week. Microplastic water pollution is becoming a threat to both humans and aquatic creatures. In this research, microplastic water contamination is discussed, and divergent solutions are proposed. This paper attempts to investigate the causes and effects of such pollution and analyze the current solutions for this issue. The adopted research method is secondary research, where several studies are explored and analyzed. This study explains numerous causes for this issue like cosmetics, cleaning products, factories, and sewage. Consequently, this contamination can negatively impact the organs and metabolisms of the living …

Phenyl Acrylate-Based Cross-Linked Anion Exchange Membranes For Non-Aqueous Redox Flow Batteries, Md Motiur R. Mazumder, Rohit G. Jadhav, Shelley D. Minteer

Chemistry Faculty Research & Creative Works

Redox flow batteries (RFBs) are of recent interest to store harvested renewable energy for improving grid reliability and utilization. in this study, we synthesized and characterized a series of phenyl acrylate-Based UV-cross-linked anion exchange membranes (AEMs) and explored the performance of these AEMs in a model non-aqueous RFB under model conditions. Infrared spectroscopy was utilized to confirm the incorporation of ion carriers in the phenyl acrylate backbone. the electrochemical performance was compared with the commercial Fumasep membrane Fuma-375 based on high stability in non-aqueous solvents, high permeability to the charge-carrying ion, low resistance, low crossover of the redox-active molecules, and …

Solvatochromic And Aggregation-Induced Emission Active Nitrophenyl-Substituted Pyrrolidinone-Fused-1,2-Azaborine With A Pre-Twisted Molecular Geometry, Albert D. Campbell Jr., Kaia Ellis, Lyric K. Gordon, Janiyah E. Riley, Robert B. Hughley, Adeline M. Boswell, Ophelia Adjei-Sah, Prioska D. Baruah, Ra’Nya Malone, Carl Saint-Louis

Faculty Articles

Boron–nitrogen-containing heterocycles with extended conjugated π-systems such as polycyclic aromatic 1,2-azaborines, hold the fascination of organic chemists due to their unique optoelectronic properties. However, the majority of polycyclic aromatic 1,2-azaborines aggregate at high concentrations or in the solid-state, resulting in aggregation-caused quenching (ACQ) of emission. This practical limitation poses significant challenges for polycyclic aromatic 1,2-azaborines’ use in many applications. Additionally, only a few solvatochromic polycyclic aromatic 1,2-azaborines have been reported and they all display minimal solvatochromism. Therefore, the scope of available polycyclic 1,2-azaborines needs to be expanded to include those displaying fluorescence at high concentration and in the solid-state as …

From Random To Rational: Improving Enzyme Design Through Electric Fields, Second Coordination Sphere Interactions, And Conformational Dynamics, Shobhit S. Chaturvedi, Daniel Bím, Christo Christov, Anastassia N. Alexandrova

Michigan Tech Publications

Enzymes are versatile and efficient biological catalysts that drive numerous cellular processes, motivating the development of enzyme design approaches to tailor catalysts for diverse applications. In this perspective, we investigate the unique properties of natural, evolved, and designed enzymes, recognizing their strengths and shortcomings. We highlight the challenges and limitations of current enzyme design protocols, with a particular focus on their limited consideration of long-range electrostatic and dynamic effects. We then delve deeper into the impact of the protein environment on enzyme catalysis and explore the roles of preorganized electric fields, second coordination sphere interactions, and protein dynamics for enzyme …

The Structure Of A Lactobacillus Helveticus Chlorogenic Acid Esterase And The Dynamics Of Its Insertion Domain Provide Insights Into Substrate Binding, Kellie K. Omori, Charles T. Drucker, Tracie L. S. Okumura, Nathaniel B. Carl, Brianna T. Dinn, Destiny Ly, Kylie N. Sacapano, Allie Tajii, Cedric P. Owens

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Chlorogenic acid esterases (ChlEs) are a useful class of enzymes that hydrolyze chlorogenic acid (CGA) into caffeic and quinic acid. ChlEs can break down CGA in foods to improve their sensory properties and release caffeic acid in the digestive system to improve the absorption of bioactive compounds. This work presents the structure, molecular dynamics, and biochemical characterization of a ChlE from Lactobacillus helveticus (Lh). Molecular dynamics simulations suggest that substrate access to the active site of LhChlE is modulated by two hairpin loops above the active site. Docking simulations and mutational analysis suggest that two residues within …

Poly(Propylene Glycol)-Based Non-Isocyanate Polyurethane Ionenes: Thermal, Morphological And Conductive Properties, Jordan C. Pierce, George M. Timmermann, Creston Singer, David Salas-De La Cruz, Kevin Miller

Faculty & Staff Research and Creative Activity

The synthesis and characterization of a series of polyurethane ionenes using a non-isocyanate approach is disclosed. Imidazole-capped, urethane-containing prepolymers are prepared by first reacting carbonyl diimidazole (CDI) with several poly(propylene glycol) (PPG) diols with variable molecular weight, followed by subsequent reaction with 3-aminopropylimidazole (API). Polymerization with 1,4-dibromomethylbenzene followed by anion exchange resulted in the desired polyurethane ionenes bearing the [NTf2] counteranion as a series of viscous liquids. NMR and FTIR spectroscopy are used to characterize the intermediates and final ionenes, including molecular weight determination by end-group analysis. A single glass transition temperature (Tg), as determined by differential scanning …

Multiple Structural And Functional Annotations Based In-Silico Characterization Of Q9brx8 Protein, Eiman Zahid, Muhammad Farhan Sarwar

Karbala International Journal of Modern Science

Numerous proteins found in humans are poorly understood because there is a dearth of experimental evidence. Hypothetical proteins (HPs) or uncharacterized proteins are the terms used to describe these proteins. In this work, one of these proteins, Q9BRX8, is investigated using in-silico or bioinformatics tools to reveal its significant properties. In this regard, NCBI for the sequence retrieval, ProtParam tool for analysis of physiochemical properties, SOPMA for secondary structure prediction, SWISS-Model for homology modelling, STRING for protein-protein interaction and HDOCK for protein-protein docking analysis among other tools, were incorporated. The physiochemical characteristics indicated that Q9BRX8, which has an instability score …

Investigations On Copper Assisted Oxidative Transformations For The Construction Of Diverse C-C/C-N(O) Bonds, Prasanna Kumari S

Theses and Dissertations

Copper catalyzed C-C, C-N/C-O bond formation reactions are a prominent tool to access diverse biologically relevant molecules. Herein, we present the copper- catalyzed diverse C-C/C-N(O) bond forming reactions. In Chapter-I (introduction), we briefly discussed the various copper mediated organic transformations with appropriate examples.

In Chapter II, we report a one-pot methodology for the vicinal aminoalkylation of naphthoquinone through a direct C(sp2)-H functionalization reaction. Through this method, readily available planar naphthoquinone substrates were transformed into three-dimensional molecular scaffolds through the formation of one C(sp2)-C(sp2) and two C(sp2)-N bonds. The indole fused nitrogen heterocyclic products were obtained in good yields. Apart from …

Development Of Bioactive Peptidomimetics, Lei Wang

USF Tampa Graduate Theses and Dissertations

In the past two decades, a lot of different peptidomimetics, such as β-peptides, oligoureas, azapeptides, peptoids, aromatic oligoamides, and others, have been developed. These peptidomimetics with distinctive scaffolds have shown potential in protein surface recognition and mimicry, PPI regulation, catalysis, etc. Moreover, these bioactive peptidomimetics demonstrate much better bioavailability and biostability than the bioactive peptides. To expand the application of peptidomimetics, our group have developed a new sequence-specific peptidomimetics- γ-AApeptide, which is derived from chiral γ-PNA. It shows excellent advantages including highly resistant to various proteolytical degradations and has the potential to increase chemodiversity. γ-AApeptide also exhibits remarkable biomedical applications, …

Mechanistic Insights Into Electrocatalytic Carbon−Bromine Bond Cleavage In Polybrominated Phenols, Eric C.R. Mckenzie, Seyyedamirhossein Hosseini, Mayank Tanwar, Matthew Neurock, Shelley D. Minteer, Stephen C. Jacobson

Chemistry Faculty Research & Creative Works

Carbon−halogen bond cleavage has been studied extensively for many years as a simple electrosynthesis step in the formation of more complex natural products. Reduction of halogenated phenols has received less attention, in part, due to the lowered faradaic efficiency resulting from the competing hydrogen evolution reaction. Herein, we report the electroreduction of a series of brominated phenols through a homogeneous electrocatalytic (EC′) mechanism. Beginning with the structurally simple 2-bromophenol, we use foot-of-the-wave analysis to determine optimal catalysts. Nickel (II) salen requires the lowest overpotential for C−Br reduction and was used across all substrates. Chronoamperometric studies and density functional theory calculations …

Dipole Effects In The Angular Distributions Of Photoelectron Spectroscopy, C. Annie Hart

Arts & Sciences Graduate Student Theses and Dissertations

Comparing experimental photoelectron angular distributions to theoretical predictions for direct detachment is a valuable tool for indicating more complex detachment pathways, such as those which access temporary anion states. This is exemplified by resonance mediated detachment from NiO2−. The presence of forbidden transitions and deviations in photoelectron angular distribution and relative transition intensities indicate a resonance, which is further supported with multireference calculations. In detachment processes that produce a neutral molecule with a permanent dipole, the quality of angular distribution predictions suffer by treating the outgoing electron as a free particle. To improve upon this issue, angular distribution prediction methods …

Strengthening Brain Research In Africa, Abdullahi Tunde Aborode, Nike Jesutofunmi Idowu, Samuel Tundealao, Joseph Jaiyeola, Ogunware Adedayo Emmanuel

Department of Chemistry: Faculty Publications

This paper explores the emerging field of neuroscience in Africa, considering the unique genetic diversity, sociocultural determinants, and health inequalities in the continent. It presents numerous brain research initiatives, such as ABDRN, AMARI, APCDR, and H3Africa, aimed at understanding genetic and environmental factors influencing brain disorders in Africa. Despite numerous challenges like the brain drain phenomenon, inadequate infrastructure, and scarce research expertise, significant progress has been achieved. The paper proposes solutions, including international collaboration, capacity-building efforts, and policies to promote neuroscience research, to enhance the understanding of brain function and address brain-related health issues within the African context.

Development Of Antiviral Peptidomimetics, Songyi Xue

USF Tampa Graduate Theses and Dissertations

Protein-protein interactions (PPIs) are essential for biological processes and are associated with a number of diseases, including cancer, infectious diseases, and neurodegenerative diseases. As a result, modulation of PPIs has been recognized as one of the most promising strategies to develop the novel drugs. Peptide modulators always exhibit higher specificity and affinities with targets than small compounds or monoclonal antibodies, but their broad medicinal effectiveness is constrained by their poor bioavailability and biostability. Peptidomimetics, which have been developed to mimic the structure as well as function of bioactive peptides and proteins, have shown excellent potential in protein surface mimicry and …

Streamlined Synthesis Of Potential Dual-Emissive Fluorescent Silicon Quantum Dots (Siqds) For Cell Imaging, Di Sun, Steven Wu, Jeremy P. Martin, Kirati Tayutivutikul, Guodong Du, Colin Combs, Diane Darland, Julia Zhao

Biology Faculty Publications

One of the current challenges of working with nanomaterials in bioapplications is having a tool that is biocompatible (non-toxic) and produces stable, intense fluorescence for bioimaging. To address these challenges, we have developed a streamlined and one-pot synthetic route for silicon-based quantum dots (SiQDs) using a hydrothermal method. Part of our unique approach for designing the SiQDs was to incorporate (3-aminopropyl) triethoxysilane (APTES), which is an amphipathic molecule with hydroxyl and amine functional groups available for modification. In order to reduce the toxicity of APTES, we chose glucose as a reducing agent for the reaction. The resulting SiQDs produced potent, …

In Vitro Antioxidant, Anti-Inflammatory, And Photoprotective Activities Of Aqueous Extract Of The Endemic Plant Hammada Scoparia L. From Algeria, Benine Chaima, Djahra Ali Boutlelis, Laiche Ammar Touhami, Tlili Hajer, Tliba Ali, Ben Arfa Abdelkarim, Najjaa Hanen

Karbala International Journal of Modern Science

This study aimed to analyze the chemical profile and evaluate the biological activities of the aqueous extract of H. Scoparia, an endemic plant found in Southeastern Algeria. The aqueous extract was subjected to phytochemical screening, RP-HPLC, and FT-IR analysis. The anti-inflammatory activity was examined using the protein denaturation method, and the photoprotective activity was evaluated using UV-Visible spectrophotometry. The antioxidant activity was assessed using ABTS, DPPH, and FRAP assays. The study found the presence of various secondary metabolites such as polyphenols, tannins, and saponins. This study suggests that H. Scoparia extract has the potential as a natural source of bio-actives …

B/Lv Laboratory Accessibility Technology Adapted For Neurodiverse Chemistry Students, Christin B. Monroe

Journal of Science Education for Students with Disabilities

Text-to-speech technology is a common accommodation available for students with disabilities. Despite the ubiquitous nature of text-to-speech, this technology has not been explored in laboratory settings for neurodiverse college students. This study explores the adaptability of laboratory accessible text-to-speech technology (originally developed for blind/low vision (B/LV) students) for neurodiverse students. Students were asked to provide general feedback about the usability and effectiveness of the technology using Likert surveys. The students also answered open-ended questions about how the technology could be adapted to be more neurodiverse friendly. Overall, more than 50% of the students found the technology useful but had specific …

Equine In Vivo Metabolite Profiling Of The Selective Androgen Receptor Modulator Lgd-3303 For Doping Control, Malin Nilsson Broberg, Heather Knych, Ulf Bondesson, Curt Pettersson, Börje Tidstedt, Scott Stanley, Mario Thevis, Mikael Hedeland

UK CARES Faculty Publications

LGD-3303 is a Selective Androgen Receptor Modulator (SARM) that is prohibited in both equine and human sports due to its anabolic properties. The aim of this study was to investigate the equine in vivo metabolite profile of LGD-3303 and identify drug metabolites that can be suitable as new and improved analytical targets for equine doping control. This was performed by an oral administration of 0.05 mg⋅kg 1 LGD-3303 to horses, where blood and urine samples were collected up to 96 h after administration. The in vivo samples consisting of plasma, urine and hydrolyzed urine were analyzed utilizing ultra-high performance liquid …

Syntheses And Characterization Of Photoactive Ruthenium And Iron Polypyridyl Complexes, Rajani Thapa Magar

Chemistry and Chemical Biology ETDs

Within this dissertation, two distinct classes of metal complexes have been discussed that bear significance in the field of solar energy conversion, photo redox catalysis and memory devices. The first class of the metal complexes is a series of photochromic Ruthenium polypyridyl N-heterocyclic carbene tethered sulfoxide complexes that are reported to undergo unusually slow isomerization from S-bonded to O-bonded and unusually fast thermal reversion from O-bonded to S-bonded configuration. The role of NHC in the excited state dynamics of these complexes have been discussed in detail in Chapter 3.

For the first time in two decades, structural information of the …

Comparative Efficacy Of Systemic And Combination Fungicides For The Control Of Alternaria Leaf Spot Of Cabbage, Patience U. Ishieze, Chinedu F. Amuji, Kevin I. Ugwuoke, Paul K. Baiyeri, Michael O. Eze

Chemistry Faculty Research & Creative Works

Alternaria leaf spot of cabbage, caused by the Alternaria brassicicola, affects leaves of cabbages and often results in head rots causing severe decline in yield. in this work, the effects of systemic and combination fungicides on A. brassicicola mycelia growth in vitro and disease severity in field trials were investigated. the results of in vitro evaluation revealed that both fungicides significantly inhibited (p < 0.05) the growth of A. brassicicola under in vitro conditions. However, metal Axyl-M 6% was less effective with 100 μg/mL having only 30 ± 3.5% inhibition. on the other hand, 100 μg/mL of mancozeb 63% + carbendazim 12% had 94 ± 3.5% growth inhibition of A. brassicicola, respectively, under the same conditions. Dose-response analysis of the efficacy of the two fungicides showed that the LC50 of metal Axyl-M 6% and mancozeb 63% + carbendazim 12% were 125.52 ppm and 57.22 ppm, respectively, indicating the superiority of combination fungicide over systemic fungicide alone. Field studies showed that while manure type significantly impacted on biomass production (p < 0.001), it did not significantly affect disease severity. on the other hand, the frequency of fungicide application impacted on disease severity, with biweekly application leading to a significant reduction in disease severity after 10 weeks.

Development Of An Enhanced Hybrid Bi-Catalytic Electrode Containing Bimetallic Composite Catalyst And Immobilized Enzyme For Complete Glucose Electrooxidation, Jefferson Honorio Franco, João Victor Bonaldo, Rodrigo Garcia Da Silva, Shelley D. Minteer, Adalgisa R. De Andrade

Chemistry Faculty Research & Creative Works

We describe an enzymatic fuel cell (EFC) that can electrooxidize glucose completely. the EFC contains the hybrid Ni@Pt-CNT/OxOx bioanode, composed of a bimetallic composite catalyst (Ni@Pt-CNT) and the enzyme oxalate oxidase (OxOx), which can cleave carbon-carbon bonds. Ni@Pt-CNT/OxOx displayed 3-fold higher catalytic activity in the presence than in the absence of glucose (1.3 and 0.4 mA cm−2, respectively), indicating that Ni@Pt-CNT and OxOx acted synergistically. Electrochemical impedance spectroscopy showed that Ni@Pt-CNT/OxOx had higher charge transfer resistance and double layer capacitance than Ni@Pt-CNT. Long-term bulk electrolysis (18 h) revealed that the EFC operating with Ni@Pt-CNT/OxOx presented better current density and stability …

Alkaline Pretreatment And Air Mixing For Improvement Of Methane Production From Anaerobic Co-Digestion Of Poultry Litter With Wheat Straw, Yuanhang Zhan, Jun Zhu, Yiting Xiao, Leland C. Schrader

Biological and Agricultural Engineering Faculty Publications and Presentations

Alkaline pretreatment (AL) and air mixing (air) both have the potential to improve anaerobic co-digestion (Co-AD) of poultry litter with wheat straw for methane production. In this study, the effects of the combination of AL (pH 12 for 12 h) and air mixing (12 mL·d⁻¹) on the Co-AD process were investigated. The substrate hydrolysis was enhanced by AL, with soluble chemical oxygen demand increased by 4.59 times and volatile fatty acids increased by 5.04 times. The cumulative methane yield in the group of Co-AD by AL integrated with air (Co-(AL + air)), being 287 mL·(g VS_added) …

Reproducibly Defining Electrode Area Of Carbon Paper Electrodes Via Machine Cutting And High-Throughput Waxing, Rokas Gerulskis, Shelley D. Minteer

Chemistry Faculty Research & Creative Works

Carbon paper is one of the most common carbon electrode materials employed in electrochemical research due to its low cost, disposability, and controllable dimensions and scaling. Carbon paper is usually hand cut, and a variety of strategies are used to define electrode area. This procedure is tedious, imprecise, and inaccurate, yielding coefficients of variation in peak current output as high as 20%. Imprecision in hand-preparation translates directly to poor reproducibility in electrochemical data leading to challenges in directly comparing data across research groups and research fields. This work introduces an inexpensive and precise method to automatically cut and rapidly wax …

Straight Out-Of-The-Tube: Analysis And Conservation Of George Mathieu’S Pour Une Aliénation Définitive Du Logos, Christy H. Mccutchen

Art Conservation Master's Projects

Pour une aliénation définitive du logos (96.5 cm × 195.6 cm, Buffalo AKG Art Museum, Acc.1971:7), painted in 1955 by French artist Georges Mathieu (1921-2012) is an iconic example of Lyrical Abstraction. Mathieu launched this European counterpart to Abstract Expressionism in the post-war upheaval of 1947. His unorthodox methods present a unique combination of aesthetic concerns and intrinsic material instability. Mathieu’s technique involved squeezing oil paints out-of-the-tube directly onto his canvas with rapid and spontaneous calligraphic motions. The primary condition issue for Pour une aliénation définitive du logos was the failing adhesion between this thickly applied paint and the primed …

Optimizing Mn-Al Permanent Magnet Performance Through Control Of The Phase Transformation, Ternary Element Addition, And Advanced Processing, Thomas R. Keller

Dartmouth College Ph.D Dissertations

The growing need for electrical power in machines and vehicles brings with it a growing need for critical materials. The current high-performance permanent magnets (PMs) based on rare-earth (RE) elements Nd and Sm cannot escape the problem of raw material cost, geographic scarcity in the earth’s crust, and lack of circular global supply chains. This poses a problem of industrial ecology: can PMs be made from inexpensive, more abundant materials while still meeting sufficient performance criteria? PMs based on the magnetic τ phase of Mn-Al offer a possible alternative to REPMs. However, years of innovation have not yet achieved real-world …

Guar-Based Injectable Hydrogel For Drug Delivery And In Vitro Bone Cell Growth, Humandra Poudel, Ambar R. Rangumagar, Pooja Singh, Adeolu Oluremi, Nawab Ali, Fumiya Watanabe, Joseph Batta-Mpouma, Jin-Woo Kim, Ahona Ghosh, Anindya Ghosh

Chemistry & Biochemistry Faculty Publications and Presentations

Injectable hydrogels offer numerous advantages in various areas, which include tissue engineering and drug delivery because of their unique properties such as tunability, excellent carrier properties, and biocompatibility. These hydrogels can be administered with minimal invasiveness. In this study, we synthesized an injectable hydrogel by rehydrating lyophilized mixtures of guar adamantane (Guar-ADI) and poly-β-cyclodextrin (p-βCD) in a solution of phosphate-buffered saline (PBS) maintained at pH 7.4. The hydrogel was formed via host-guest interaction between modified guar (Guar-ADI), obtained by reacting guar gum with 1-adamantyl isocyanate (ADI) and p-βCD. Comprehensive characterization of all synthesized materials, including the hydrogel, was performed using …