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Full-Text Articles in Applied Mathematics

Stack For Computational Science, Mathematics And Engineering E-Learners, Idrissa S. Amour Feb 2024

Stack For Computational Science, Mathematics And Engineering E-Learners, Idrissa S. Amour

Tanzania Journal of Engineering and Technology (TJET)

Petroleum economic evaluation involves estimating revenues from forecasted production profiles and field costs including capital expenditures (CAPEX), drilling expenses (DRILLEX), and operating expenses (OPEX). The existing cost-estimating tool requires several inputs making it time-intensive and difficult to use with few data during the early stages of projects. Majority of the previously developed time saving cost estimations proxy models rely on unrealistic assumptions that include uniform operational costs for different fields with a different number of wells, casings, and drilled depths. This work focused at developing proxy models that consider the variability of the development costs with different parameters. The developed …


Transfer Learning In The Era Of Foundational Models: Application To Diagnosis In Rheumatology, Prashant Shekhar Feb 2024

Transfer Learning In The Era Of Foundational Models: Application To Diagnosis In Rheumatology, Prashant Shekhar

Math Department Colloquium Series

Problems with current synovitis grading procedures

  • There has been a lack of reliability in grading these images in the medical community due to a lack of universally accepted diagnostic criteria [Momtazmanesh et al., 2022]
  • The human/machine variability creates an additional challenge in an efficient automated scoring system [Ranganath et al., 2022]
  • There is a lack of consistency between doctors in grading these images [Momtazmanesh et al., 2022]


New Algorithmic Support For The Fundamental Theorem Of Algebra, Vitaly Zaderman Feb 2024

New Algorithmic Support For The Fundamental Theorem Of Algebra, Vitaly Zaderman

Dissertations, Theses, and Capstone Projects

Univariate polynomial root-finding is a venerated subjects of Mathematics and Computational Mathematics studied for four millenia. In 1924 Herman Weyl published a seminal root-finder and called it an algorithmic proof of the Fundamental Theorem of Algebra. Steve Smale in 1981 and Arnold Schonhage in 1982 proposed to classify such algorithmic proofs in terms of their computational complexity. This prompted extensive research in 1980s and 1990s, culminated in a divide-and-conquer polynomial root-finder by Victor Pan at ACM STOC 1995, which used a near optimal number of bit-operations. The algorithm approximates all roots of a polynomial p almost as fast as one …


Characterizing Linearizable Qaps By The Level-1 Reformulation-Linearization Technique, Lucas Waddell, Warren Adams Feb 2024

Characterizing Linearizable Qaps By The Level-1 Reformulation-Linearization Technique, Lucas Waddell, Warren Adams

Faculty Journal Articles

The quadratic assignment problem (QAP) is an extremely challenging NP-hard combinatorial optimization program. Due to its difficulty, a research emphasis has been to identify special cases that are polynomially solvable. Included within this emphasis are instances which are linearizable; that is, which can be rewritten as a linear assignment problem having the property that the objective function value is preserved at all feasible solutions. Various known sufficient conditions for identifying linearizable instances have been explained in terms of the continuous relaxation of a weakened version of the level-1 reformulation-linearization-technique (RLT) form that does not enforce nonnegativity on a subset …


Cognitive Load Scale In Learning Formal Definition Of Limit: A Rasch Model Approach, Rina Oktaviyanthi, Ria Noviana Agus, Mark Lester B. Garcia, Kornkanok Lertdechapat Feb 2024

Cognitive Load Scale In Learning Formal Definition Of Limit: A Rasch Model Approach, Rina Oktaviyanthi, Ria Noviana Agus, Mark Lester B. Garcia, Kornkanok Lertdechapat

Mathematics Faculty Publications

Constructing proofs for the limit using the formal definition induces a high cognitive load. Common assessment tools, like cognitive load scales, lack specificity for the concept of limits. This research aims to validate an instrument tailored to assess cognitive load in students focused on the formal definition of limits, addressing the need for diverse strategies in education. The research employs a quantitative survey design with a Rasch model approach, utilizing a data collection instrument in the form of a questionnaire. Subsequently, the data are analyzed by focusing on three aspects: (1) item fit to the Rasch model, (2) unidimensionality, and …


Total Variation Flow In R^N Dimensions With Examples Relating To Perimeters Of Level Sets, Luis Schneegans, Victoria Shumakovich Jan 2024

Total Variation Flow In R^N Dimensions With Examples Relating To Perimeters Of Level Sets, Luis Schneegans, Victoria Shumakovich

Undergraduate Research Symposium

In this project, we explore radial solutions to the Total Variation Flow (TVF) equation with the help of the Sign Fast Diffusion Equation (SFDE) and prior results in the 1-dimensional case. Specifically for radial solutions, we derive equations and explicit solutions relating to the n-dimensional case. Lastly, we look at how level sets and (time) profiles change.


Infusing Quantitative Reasoning Skills Into A Differential Equation Class In An Urban Public Community College, Tanvir Prince Jan 2024

Infusing Quantitative Reasoning Skills Into A Differential Equation Class In An Urban Public Community College, Tanvir Prince

Numeracy

This research centers on implementing Quantitative Reasoning (QR) within a differential equations course at an urban public community college. As a participant in the Numeracy Infusion for College Educators (NICE) faculty development program, I sought to integrate QR skills into my curriculum. Students in the course were introduced to QR goals using real-world data sets, particularly those related to population growth, which aim to enhance their understanding, sharpen their problem-solving abilities, and cultivate a positive perspective on the real-world relevance of mathematics. Preliminary findings indicate varied levels of QR skill development among students. These results underscore the potential benefits of …


Model Selection Through Cross-Validation For Supervised Learning Tasks With Manifold Data, Derek Brown Jan 2024

Model Selection Through Cross-Validation For Supervised Learning Tasks With Manifold Data, Derek Brown

The Journal of Purdue Undergraduate Research

No abstract provided.


Machine Learning Of Big Data: A Gaussian Regression Model To Predict The Spatiotemporal Distribution Of Ground Ozone, Jerry Gu Jan 2024

Machine Learning Of Big Data: A Gaussian Regression Model To Predict The Spatiotemporal Distribution Of Ground Ozone, Jerry Gu

The Journal of Purdue Undergraduate Research

Tracking pollution levels on the ground is important to the environment and public health. One of the pollutants of concern is ozone, which, at high concentrations, can cause respiratory and cardiovascular problems. The National Center for Atmospheric Research (NCAR) has published valuable ozone data obtained from ground-based sensors installed at selected locations. Because it is unfeasible to measure the exact ozone levels everywhere at any time, it would be valuable to predict the temporal-spatial distributions of ozone concentration based on existing data. This would help us better understand the patterns and trends in the data and make better decisions to …


A Tale Of Two Viruses: Why Smallpox Was Eradicated And Polio Persists, Katherine G. Mcgough, Erin N. Bodine Jan 2024

A Tale Of Two Viruses: Why Smallpox Was Eradicated And Polio Persists, Katherine G. Mcgough, Erin N. Bodine

Spora: A Journal of Biomathematics

The smallpox and poliomyelitis (polio) viruses were, at a time, one of the largest threats to global public health killing millions until global eradication campaigns were put into effect. Vaccination led to the eradication of smallpox and the elimination of polio for most of the world. However, polio continues to persist at endemic levels in Pakistan and Afghanistan. We developed ODE models of smallpox and polio to explore differences in transmission dynamics and determine if the underlying biology has made poliomyelitis more difficult to eradicate. Our model analysis shows there are multiple factors which should allow polio to have a …


A Coupled Model Of Population, Poaching, And Economic Dynamics To Assess Rhino Conservation Through Legal Trade, Henry Doyle, Kylie Champagne, Ditto Rajpal, Grace Seebeck, David J. Gerberry Jan 2024

A Coupled Model Of Population, Poaching, And Economic Dynamics To Assess Rhino Conservation Through Legal Trade, Henry Doyle, Kylie Champagne, Ditto Rajpal, Grace Seebeck, David J. Gerberry

Spora: A Journal of Biomathematics

Rhinoceros populations in Africa are in peril largely due to the high value of their horns and the poaching that ensues. The strategy of legalizing the international trade of rhino horn is receiving increased support among both the people and government officials in Africa. Many in the international conservation community remain opposed to the idea. The legalization strategy is straightforward in theory: legalizing the trade of rhino horn will introduce a large quantity of horn to the market, the increased supply will lead to lower prices for rhino horn, and lower prices will reduce the overall poaching pressure these animals …


The Influence Of Green Building Design On Tourists' Intention To Stay In Eco-Friendly Hotels: A Study On Perceptions And Preferences, Enas Al Sayed Salama Dr., Gehad Nasr Abdelsalam Dr. Jan 2024

The Influence Of Green Building Design On Tourists' Intention To Stay In Eco-Friendly Hotels: A Study On Perceptions And Preferences, Enas Al Sayed Salama Dr., Gehad Nasr Abdelsalam Dr.

Journal of Engineering Research

Green building design involves integrating sustainable and environmentally friendly practices into the construction and operation of buildings, including hotels, with the goal of minimizing the adverse impact on the environment. This paper delves into the pivotal role of green building design and eco-service provision within the context of green hotels. The aim is to investigate the interconnections among tourists' environmental concerns, their perceived significance of green building design, and their intention to choose green hotels.

To enhance the understanding of tourist behavior and its implications for tourism in Egypt, a questionnaire was administered in Sharm El Sheikh, a prominent Egyptian …


Experimental Study Of Bent Glass Curtain Walls., Sarah Said Abd El Kariem, Moustafa El Shami, Mahmoud El Nagar Jan 2024

Experimental Study Of Bent Glass Curtain Walls., Sarah Said Abd El Kariem, Moustafa El Shami, Mahmoud El Nagar

Journal of Engineering Research

A Bent Laminated Glass is commonly used in the residential and commercial structures, its methodology is not present in the curves and tables at the ASTM E1300. Therefore, it has become a need for architects to use basis for this type of glass. To the best of authors ‘knowledge, no one study the bent laminated glass in details. A variety of safety glass that has lately gained popularity in the construction sector is modern laminated glass. Given that it offers a safe failover capability, it is perfect for the automotive industry. Double-lite glass is produced using two or more …


Market Analysis And Bidding Strategy Of Hybrid Renewable Energy Systems Considering Emissions, Fatma Elzahraa, Mohamed Elnemr, Samir Dawoud Jan 2024

Market Analysis And Bidding Strategy Of Hybrid Renewable Energy Systems Considering Emissions, Fatma Elzahraa, Mohamed Elnemr, Samir Dawoud

Journal of Engineering Research

The competition in the electricity markets makes it difficult to choose a suitable strategy for maximizing profit while reducing harmful emissions. To have an adequate energy price for consumers while minimizing the harmful emissions to the atmosphere and maximizing profits of all participants in the electricity market needs an aggressive bidding strategy. Developing these bidding strategies with the integration of renewable energy (RE) in the electricity market became important. This research studies various bidding strategies for maximizing profits in the deregulated energy market since participants are keen on developing bidding strategies considering emissions. These bidding strategies will consider the integration …


Effects Of Fuel Equivalence Ratio And Swirl Vane Angles On Premixed Burner Turbulent Flame Combustion Characteristics, Medhat Elkelawy Prof. Dr. Eng., E. A. El Shenawy Prof. Dr., Hagar Alm-Eldin Bastawissi Prof. Dr. Eng., Ibrahim Ali Mousa Eng., Mohamed M. Abdel-Raouf Ibrahim Dr. Eng. Jan 2024

Effects Of Fuel Equivalence Ratio And Swirl Vane Angles On Premixed Burner Turbulent Flame Combustion Characteristics, Medhat Elkelawy Prof. Dr. Eng., E. A. El Shenawy Prof. Dr., Hagar Alm-Eldin Bastawissi Prof. Dr. Eng., Ibrahim Ali Mousa Eng., Mohamed M. Abdel-Raouf Ibrahim Dr. Eng.

Journal of Engineering Research

A turbulent flow field has a major effect on the premixed flame structure and temperature distribution that specifically determines the effectiveness of the burned fuel and the amounts of produced emissions. However, the premixed flame tangential and axial velocity distribution through the flame length help to predict the combustion and emissions attributes of the burned fuel. In this regard, an experimental and analytical investigation on premixed turbulent burners at different equivalence fuel-air ratios with different swirl vane angles has been achieved in the present work to assess the combustion performance and emissions characteristics. A theoretical methodology was carried out to …


Enhancing The Performance Of Conventional Solar Still Using The Nano-Doped Paint (Ndp) Coating, Hagar Alm-Eldin Bastawissi Prof.Dr, Nermin Elgendy Engineer, Ayman R. El-Tohamy Jan 2024

Enhancing The Performance Of Conventional Solar Still Using The Nano-Doped Paint (Ndp) Coating, Hagar Alm-Eldin Bastawissi Prof.Dr, Nermin Elgendy Engineer, Ayman R. El-Tohamy

Journal of Engineering Research

Nations are throughout the entire globe continuously confronting the problem of potable water shortage. Recently, it has been thought that using solar energy to desalinate brackish water offers a practical answer to the world's water crises. The output of these stills, is meager, and academics haven't done much to boost it in any way. Solar distillers have been proposed as an efficient method to produce potable water. In recent years, saltwater has produced drinking water by various ways. The efficiency of a solar distiller is significantly influenced by various factors, most important factor of them is the absorber surface. In …


Engine Performance And Emissions Improvement Study On Direct Injection Of Diesel/Ammonia Dual Fuel By Adding Cng As Partially Premixed Charge, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi Prof. Dr., Mohammed Osama Elsamadony Dr. Eng., Abdallah Salem Abdalhadi Eng. Jan 2024

Engine Performance And Emissions Improvement Study On Direct Injection Of Diesel/Ammonia Dual Fuel By Adding Cng As Partially Premixed Charge, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi Prof. Dr., Mohammed Osama Elsamadony Dr. Eng., Abdallah Salem Abdalhadi Eng.

Journal of Engineering Research

Researchers have recently moved on in their studies to find a solution to prevent or reduce this problem. There have been directions taken by researchers to solve the problem, including, replacing fossil fuels with environmentally friendly types or by combining two or more types of fuel. This is by modifying fuel injection systems as appears in the PCCI, RCCI, or HCCI systems, or working to integrate the two trends by using new injection systems and burning alternative fuels with fossil fuels. Therefore, the trend has good results on the specific consumption of fuel, raising thermal efficiency, and working to reduce …


Experimental Study On The Impact Of Secondary Air Injection And Different Swirl Van Angles On Premixed Turbulent Flame Propagation And Emission Behaviors, Medhat Elkelawy Prof. Dr. Eng., E. A. El Shenawy Prof. Dr., Hagar Alm-Eldin Bastawissi Prof. Dr. Eng., Ibrahim Ali Mousa Eng., Mohamed M. Abdel-Raouf Ibrahim Dr. Eng. Jan 2024

Experimental Study On The Impact Of Secondary Air Injection And Different Swirl Van Angles On Premixed Turbulent Flame Propagation And Emission Behaviors, Medhat Elkelawy Prof. Dr. Eng., E. A. El Shenawy Prof. Dr., Hagar Alm-Eldin Bastawissi Prof. Dr. Eng., Ibrahim Ali Mousa Eng., Mohamed M. Abdel-Raouf Ibrahim Dr. Eng.

Journal of Engineering Research

The objective of the present paper is to investigate experimentally the flame characteristics utilizing different secondary air inlet direction for different primary air swirl numbers and equivalence fuel-air ratios. In this study, an experimental test rig was carried out to investigate the flame temperature and emission behavior with flame length at the equivalence fuel-air ratios taken0.96, 0.80, 0.70, and 0.60, and swirl vane angles were varied as 20, 30, 45, and 60° to generate different swirl numbers of 0.26, 0.416, 0.71 and 1.23, respectively. In addition to the introduction of secondary air in test combustor, whereas the primary air and …


The Effect Of An Existing Tunnel And A Newly Excavated Tunnel On Ground Loss Beneath Sand Slope-3d Numerical Study, Ashraf Nazir, Ahmed Nasr, Asmaa Saeed Jan 2024

The Effect Of An Existing Tunnel And A Newly Excavated Tunnel On Ground Loss Beneath Sand Slope-3d Numerical Study, Ashraf Nazir, Ahmed Nasr, Asmaa Saeed

Journal of Engineering Research

Abstract- Most researchers perform their numerical models for tunnels by modeling perfectly horizontal ground surfaces above the tunnels. The prediction of surface settlement of a sandy slope due to the interaction mechanism between the slope and the tunnels is one of the critical problems in urban areas. As a result, in this work, a numerical analysis using PLAXIS 3D TUNNEL has been performed to investigate the effect of tunnel excavation on the deformation of a shallow sandy slope, and empirically by the Herzog method. The study also assesses the influence of parameters on slope deformation that have not been …


Compartmental Modeling For The Neophyte: An Application Of Berkeley Madonna, Olcay Akman, Siddharth Bhumpelli, Cody Cline, Christopher Hay-Jahans Jan 2024

Compartmental Modeling For The Neophyte: An Application Of Berkeley Madonna, Olcay Akman, Siddharth Bhumpelli, Cody Cline, Christopher Hay-Jahans

Spora: A Journal of Biomathematics

Compartmental modeling serves as a necessary framework in many fields, especially biomathematics and ecology. This article introduces readers to a user-friendly approach to constructing compartmental models and solving the resulting systems of differential equations to simulate real-world applications. The platform used is Berkeley Madonna, a software package that has an intuitive graphical interface which empowers users—even those with limited mathematical and programming backgrounds—to focus on modeling concepts rather than mathematical or programming intricacies. This makes Berkeley Madonna an ideal platform for students, educators, and researchers.


Training Data Augmentation With Data Distilled By Principal Component Analysis, Nikolay Metodiev Sirakov, Tahsin Shahnewaz, Arie Nakhmmani Jan 2024

Training Data Augmentation With Data Distilled By Principal Component Analysis, Nikolay Metodiev Sirakov, Tahsin Shahnewaz, Arie Nakhmmani

Faculty Publications

This work develops a new method for vector data augmentation. The proposed method applies principal component analysis (PCA), determines the eigenvectors of a set of training vectors for a machine learning (ML) method and uses them to generate the distilled vectors. The training and PCA-distilled vectors have the same dimension. The user chooses the number of vectors to be distilled and augmented to the set of training vectors. A statistical approach determines the lowest number of vectors to be distilled such that when augmented to the original vectors, the extended set trains an ML classifier to achieve a required accuracy. …


Odes And Mandatory Voting, Christoph Borgers, Natasa Dragovic, Anna Haensch, Arkadz Kirshtein, Lilla Orr Jan 2024

Odes And Mandatory Voting, Christoph Borgers, Natasa Dragovic, Anna Haensch, Arkadz Kirshtein, Lilla Orr

CODEE Journal

This paper presents mathematics relevant to the question whether voting should be mandatory. Assuming a static distribution of voters’ political beliefs, we model how politicians might adjust their positions to raise their share of the vote. Various scenarios can be explored using our app at https: //centrism.streamlit.app/. Abstentions are found to have great impact on the dynamics of candidates, and in particular to introduce the possibility of discontinuous jumps in optimal candidate positions. This is an unusual application of ODEs. We hope that it might help engage some students who may find it harder to connect with the more customary …


Raising Student Awareness Of Environmental Issues Via Writing Assignments With Differential Equations, Michelle L. Ghrist Jan 2024

Raising Student Awareness Of Environmental Issues Via Writing Assignments With Differential Equations, Michelle L. Ghrist

CODEE Journal

In this paper, I discuss two environmentally-focused writing assignments that I developed and implemented in recent integral calculus and differential equations courses. These models of carbon storage and PCB’s in a river provide interesting applications of one-compartment mixing problems. The assignments were intended to focus student attention on sustainability concerns while also developing other essential skills. I discuss these assignments and their effect on my students’ technical writing and environmental awareness. Detailed introductory instructions and mostly complete solutions to these assignments appear in the appendices, to include sample student work.


Using A Sand Tank Groundwater Model To Investigate A Groundwater Flow Model, Christopher Evrard, Callie Johnson, Michael A. Karls, Nicole Regnier Jan 2024

Using A Sand Tank Groundwater Model To Investigate A Groundwater Flow Model, Christopher Evrard, Callie Johnson, Michael A. Karls, Nicole Regnier

CODEE Journal

A Sand Tank Groundwater Model is a tabletop physical model constructed of plexiglass and filled with sand that is typically used to illustrate how groundwater water flows through an aquifer, how water wells work, and the effects of contaminants introduced into an aquifer. Mathematically groundwater flow through an aquifer can be modeled with the heat equation. We will show how a Sand Tank Groundwater Model can be used to simulate groundwater flow through an aquifer with a no flow boundary condition.


Modeling Aircraft Takeoffs, Catherine Cavagnaro Jan 2024

Modeling Aircraft Takeoffs, Catherine Cavagnaro

CODEE Journal

Real-world applications can demonstrate how mathematical models describe and provide insight into familiar physical systems. In this paper, we apply techniques from a first-semester differential equations course that shed light on a problem from aviation. In particular, we construct several differential equations that model the distance that an aircraft requires to become airborne. A popular thumb rule that pilots have used for decades appears to emanate from one of these models. We will see that this rule does not follow from a representative model and suggest a better method of ensuring safety during takeoff. Aircraft safety is definitely a matter …


Fitting A Covid-19 Model Incorporating Senses Of Safety And Caution To Local Data From Spartanburg County, South Carolina, D. Chloe Griffin, Amanda Mangum Jan 2024

Fitting A Covid-19 Model Incorporating Senses Of Safety And Caution To Local Data From Spartanburg County, South Carolina, D. Chloe Griffin, Amanda Mangum

CODEE Journal

Common mechanistic models include Susceptible-Infected-Removed (SIR) and Susceptible-Exposed-Infected-Removed (SEIR) models. These models in their basic forms have generally failed to capture the nature of the COVID-19 pandemic's multiple waves and do not take into account public policies such as social distancing, mask mandates, and the ``Stay-at-Home'' orders implemented in early 2020. While the Susceptible-Vaccinated-Infected-Recovered-Deceased (SVIRD) model only adds two more compartments to the SIR model, the inclusion of time-dependent parameters allows for the model to better capture the first two waves of the COVID-19 pandemic when surveillance testing was common practice for a large portion of the population. We find …


Inhabiting Numbers: Weaving, Polyphony, And Embodied Mathematics, Kristine Barrett Jan 2024

Inhabiting Numbers: Weaving, Polyphony, And Embodied Mathematics, Kristine Barrett

Textile Society of America: Symposium Proceedings

Inhabiting Numbers: Polyphony as Woven Sound explores connections between vocal polyphony and textile practices, specifically weaving and spinning. Rather than consider music and weaving as separate from one another, the following paper presents the ways in which they are deeply intertwined and mutually constitutive forms of cultural expression. The technical modes of thinking produced through repetition inherent in both—particularly as practices utilizing complex mathematical structures—produce ways of thinking unique to each. Through practice, I suggest these technical modes of making transit across different materials and mediums—in both explicit and implicit ways. The music created through the interweaving of multiple voices …


Human System Composite Performance Measures: General Systems Performance Theory Insights, Lawrence Disalvi Jan 2024

Human System Composite Performance Measures: General Systems Performance Theory Insights, Lawrence Disalvi

Bioengineering Dissertations - Archive

Composite Performance Measures (CPMs) of human performance are widely employed in applications that range from mundane to life-changing, yet they are frequently presented without explanation or reference to theoretical underpinnings. The conceptual soundness of a widely used CPM approach, based on additive combination of constituent components, has been called into question by Kondraske. He argues the relevance of General Systems Performance Theory (GSPT) and performance capacity envelope concepts when applied to multidimensional CPM measures.

To obtain evidence-based answers to assertions regarding CPM types and rationale employed in medical and non-medical contexts, a Systematic Descriptive Review was conducted. Separately, the GSPT-based …


Mathematical Modeling Of Microscale Biology In Polyelectrolyte Brushes, William J. Ceely Jan 2024

Mathematical Modeling Of Microscale Biology In Polyelectrolyte Brushes, William J. Ceely

CGU Theses & Dissertations

Biological macromolecules including nucleic acids, proteins, and glycosaminoglycans are typically anionic and can span domains of up to hundreds of nanometers and even micron length scales. The structures exist in crowded environments that are dominated by multivalent electrostatic interactions that can be modeled using mean-field continuum approaches that represent underlying molecular nanoscale biophysics. In this thesis, we develop such models for polyelectrolyte brushes using both steady state modified Poisson-Boltzmann models and transient modified Poisson-Nernst-Planck models that incorporate important ion-specific (Hofmeister) effects. The transient model enables observation of the relative physical effects as an initial non-equilibrium state relaxes to the steady …


Optimal Control Frameworks For A Class Of Epidemiological And Oncological Models, Asma Ali H Alghamdi Jan 2024

Optimal Control Frameworks For A Class Of Epidemiological And Oncological Models, Asma Ali H Alghamdi

Mathematics Dissertations - Archive

In this thesis, we employ optimal control frameworks in two distinct contexts: Human immunodeficiency virus (HIV) and esophageal cancer. For HIV, we introduce a comprehensive data-driven nonlinear optimization framework designed for personalized therapies. This framework utilizes a deterministic in-host nonlinear ordinary differential equation (ODE) model and formulates two optimization problems using individual patient data. The first problem focuses on estimating patient-specific parameters through constrained optimization, while the second problem determines optimal combination therapies to reduce viral load to undetectable levels. Several numerical experiments suggest that our framework can provide a robust and effective optimal dosages with lower toxicity levels to …