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Vital Signs, June 1981, Boonshoft School Of Medicine

Vital Signs

A sixteen page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

The Evolution Of Prenatal Care In The United States : The Formative Years, Cristina M. Thomsen

Loma Linda University Electronic Theses, Dissertations & Projects

In the early decades of the twentieth century prenatal care became an accepted part of routine obstetrical care. This thesis is a description of the evolution of the prenatal care idea in the United States during these years. Two approaches are used in this description. An internal approach to prenatal care notes the maturation of procedure and technique. An external approach notes the inpatient and outpatient suggestions for providing prenatal care, the suggestions for educating the public to value and expect prenatal care and the medical profession to provide such care, and the varied promoters of such care, with their …

Environmental Enrichment And Nursing Therapy With Comatose Patients : Two Case Studies, Marilyne R. Sayler

Loma Linda University Electronic Theses, Dissertations & Projects

As a part of a larger research project with comatose patients the problem stated for this portion of the research study was to investigate the potential for identifying whether or not the quality of nursing care for comatose patients could be improved by nursing therapy with environmental enrichment and meaningful systematic orienting stimuli given by professional nurse clinicians and a patient's significant others. The effects of the orienting stimuli were measured by observable changes in arousal patterns in serial electroencephalograms (EEGs) , level of arousal as scored on the Glasgow Coma Scale (GCS), and selected measures of recovery outcome (RO). …

Correspondence, J. Jerry Rodos, D.O. To William Bergen, D.O., 1981 May 11, J. Jerry Rodos D.O.

William F. Bergen, D.O. Collection

Letter from J. Jerry Rodos, D.O., Dean of the New England College of Osteopathic Medicine to William Bergen regarding his appointment as Associate Clinical Professor in the Department of Internal Medicine.

New Hampshire Osteopathic Association: Meeting Minutes 1981-5-2, New Hampshire Osteopathic Association

William Kirmes, D.O. Collection

Meeting minutes from the New Hampshire Osteopathic Association meeting May 2, 1981 in Durham, NH.

Intestinal Bicarbonate Secretion In Amphiuma Measured By Ph Stat In Vitro: Relationship With Metabolism And Transport Of Sodium And Chloride Ions, Michael A. Imon, John F. White

Department of Anesthesia Faculty Articles

1. Isolated Amphiuma small intestine exposed on both surfaces to buffered or unbuffered media generated gradients of pH under short-circuited conditions consistent with secretion of HCO3(-). 2. When unbuffered mucosal medium was maintained at pH 7.4 by addition of acid, alkalinization of the mucosal medium occurred at a rate of 1-2 microequiv/hr cm2 under short-circuit conditions (Isc) and was reduced by anoxia, acetazolamide or removal of CO2. 3. The rate of HCO3(-) secretion (JHCO3(-)) was reduced at a mucosal pH above or below 7.4 and was proportional to serosal HCO3(-). 4. JHCO3(-) was reduced in Na+-free (choline) and Cl-free (SO4(2-) …

Vital Signs, May 1981, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Newsletter, Volume 26, Number 03, May - June 1981

Newsletter: A Report to Physicians of Texas Archives

• Cyclotron Will Provide New Research and Treatment Opportunities
• Conference Focuses on Nursing and Cooperation Among Disciplines in Pediatric Oncology
• Scientists Investigate the Links Between Nutrition and Cancer at 34th Symposium
• Two New Books Published
• UT MDAH Announces New Referral Guide
• Louise C. Strong Appointed to Killam Professorship
• Nationwide Hotline Offers Oncology Nursing Expertise
• New Professorship Named in Honor of R. Lee Cark

Vital Signs, April 1981, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Social Commentary: Values And Legal Personhood, Jeffrey A. Parness

West Virginia Law Review

No abstract provided.

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1981), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1981 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• President's Page
• Report of the Capital Campaign
• Neurosensory Diagnostic Center
• Faculty Notes
• News from the College
• News from the Hospital
• Tour of 4190
• Nurses Alumnae Banquet
• Bookstore
• Synapsis '82
• Spring Sports
• Worth Mentioning
• New Appointments
• From the Alumni Office
• Alumni News Briefs
• In Memoriam
• Founders Day Schedule

Clinical Thermoradiotherapy, H. I. Bicher, T. S. Sandhu, F. W. Hetzel

Henry Ford Hospital Medical Journal

A clinical trial is currently in progress to determine the efficacy of combined fractions of hyperthermia and radiation. The protocol consists of two parts. First, four fractions of microwave-induced hyperthermia (45.0° ± 0.5°C) are applied for 1 1/2 hours to the volume encompassing the tumor, each separated by 72 hours. After a one-week rest, a second series of four fractions is administered again at 72- hour intervals. Each fraction consists of a 400 rad dose of radiation followed within 20 minutes by hyperthermia (42.5 ± 0.5°C) for 1 1/2 hours. Currently, we have treated 62 patients with 82 fields with …

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Clinical Hyperthermia And Irradiation: Pilot Studies, John Fazekas, Ted Nerlinger

Henry Ford Hospital Medical Journal

Phase / (February 1979-May 1980) of our hyperthermia pilot study involved 26 carcinoma patients who participated in two treatment protocols: 20 patients received electron beam x-ray therapy plus an average of eight hyperthermia sessions (twice weekly at 42.5°-43.5°C intralesional temperatures for 40 minutes); 17 patients were heated with a 3450 microwave MHz generator in conjunction with surface heating (circulating water bag at 45°C). AGA thermograms assessed superficial blood flow to document heating patterns and forewarned of potential overheating as manifested by superficial burns (blisters). Although our study Is nonrandomized and our patient numbers are small, we noted a complete response …

Local Hyperthermia And Radiation: A Biologically-Oriented Clinical Scheduling, G. Arcangeli, A. Cividalli

Henry Ford Hospital Medical Journal

In a series of animal tumor studies, heat was directly delivered into the tumor mass with an interstitial applicator. After hyperthermia (44°-45°C for 45 minutes) or radiation alone (3x10 Gy), only a slight delay in tumor growth was observed, while the combined treatment, either simultaneous or sequential (i.e., heat delivered four hours after irradiation), appeared to be the most effective. The cure rate in the two combined treatment groups was 100%, in contrast to the lack of cure in the first two groups. The simultaneous use of heat and x-ray appeared to be slightly more effective than the sequential schedule; …

Glucose Metabolism In Mouse Tumor And Liver With And Without Hyperthermia, Christian Streffer, Siegelinde Hengstebeck, Peter Tamulevicius

Henry Ford Hospital Medical Journal

We measured levels of glycolytic metabolites in mouse tumor and liver after administering a glucose load of 6 mg/g of body weight and after hyperthermia for one hour at 43°C. Metabolites included glucose, glucose-6-phosphate, fructose-1.6-diphosphate, dihydroxyacetone-phosphate, glycerol-3-phosphate, pyruvate, and lactate, as well as acetoacetate and β-hydroxybutyrate. The combined treatment led to an increase of the lactate level and apparently enhanced glucose degradation. The redoxequilibria states were shifted to the reduced metabolites. It is possible that hypoxia was induced or enhanced, which could have significance for tumor therapy. At later periods after hyperthermia, metabolic alterations occurred that have also been observed …

Hyperthermia, F. K. Storm

Henry Ford Hospital Medical Journal

This report describes the history of hyperthermia and reviews current forms of treatment at both low (42°-43°C) and higher (<45°C) temperatures. Hyperthermia treatment at low temperatures includes fluid immersion and irrigation, regional perfusion with heated fluids, and electromagnetic radiofrequency waves. Low-temperature hyperthermia has also been combined with radiation therapy and with chemotherapy in recent clinical trials. At higher temperatures, we and other investigators have also had promising, preliminary results in treating tumors safely. With the specialized radiofrequency instrumentation we have developed to apply hyperthermia at any depth without preferential surface tissue heating, further clinical investigation of both superficial and deep internal solid tumors is now possible. Recent data suggest that hyperthermia may be an especially effective form of therapy for larger tumors that resist standard forms of treatment. Clinical trials are now underway to determine the most therapeutic dose/time regimen, to determine toxicity and therapeutic enhancement ratios of combined chemotherapy and x-irradiation with hyperthermia, and to evaluate any changes in the host immune system with such therapies.

Hyperthermic Perfusion 16 Years After Its First Clinical Applications, R. Cavaliere, G. Moricca, F. Di Filippo, L. Aloe, G. Monticelli, F. S. Sartori

Henry Ford Hospital Medical Journal

It is known that above-normal temperatures (42°-42.5°C) provoke selective damage to neoplastic cells. We used heated circulating blood as a method for heat transfer on patients with limb tumors. From October 1964 to December 1979, we treated a total of 198 patients with hyperthermic perfusion for melanoma of the limbs (91), osteosarcoma (57), and soft tissue sarcoma (50). For melanoma patients, the five-year survival rate, excluding Stage IV, was 60%. For patients with soft tissue sarcoma, the five-year survival rates were 53% and 56% for hyperthermic perfusion and hyperthermic antiblastic perfusion. respectively. For 29 patients with osteosarcoma, hyperthermic perfusion was …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Local Microwave Hyperthermia In Cancer Therapy: Preliminary Report, Carlos A. Perez, Walter Kopecky, Robert Baglan, D. Venkata Rao, Richard Johnson

Henry Ford Hospital Medical Journal

This report summarizes our preliminary experience at the Mallinckrodt Institute of Radiology treating 26 patients with metastatic tumors with hyperthermia and irradiation. Patients received 400 rad fractions given every 72 hours (twice weekly) for a total of 2400, 2800, 3200, or 4000 rad followed by hyperthermia. In addition, 18 lesions were treated according to a protocol designed by the Radiation Therapy Oncology Group (RTOG) for superficial measurable tumors to receive three doses of 500 rad followed by hyperthermia (six lesions) or irradiation alone (three doses of 600, 700, or 800 rad) every 72 hours. Hyperthermia was administered with 2450 MHz …

Microwave Hyperthermia At 2450 And 915 Megahertz Frequencies, Kenneth H. Luk

Henry Ford Hospital Medical Journal

Microwave hyperthermia at frequencies of 2450 and 915 megahertz (MHz) was used to treat superficial measurable tumors of different histopathologies at various sites. Forty-seven patients received 59 courses of treatment; they were able to tolerate temperatures up to 42.5X1. Although hyperthermia alone (40°-42.5°C) did not produce an effective response, hyperthermia and radiation together (up to 2700 rad in nine fractions over three weeks) produced complete and partial responses in three-fourths of the treatment courses. The combination of hyperthermia and chemotherapy may have great potential, but confirmation of these clinical impressions will depend on a much larger series of patient data. …

Hyperthermia Treatment Of Experimental Tumors, J. Denekamp, S. A. Hill, F. A. Stewart

Henry Ford Hospital Medical Journal

The therapeutic advantage of combining hyperthermia with x-irradiation to treat tumors depends on whether or not it is possible to achieve greater thermal sensitization of tumors than of normal tissues. To determine such therapeutic gain factors (TGE), we assessed the response of mouse skin and seven transplantable mouse tumors to graded x-ray doses given alone or combined with moderate heat (42.5°C for 60 minutes). We constructed dose response curves for the average early skin reaction and for the induced delay in tumor regrowth to an arbitrarily chosen size. We studied the following areas: 1) the therapeutic gain of combining heat …

Vital Signs, March 1981, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Newsletter, Volume 26, Number 02, March - April 1981, Raymond Alexanian Md, Walter J. Pagel, Diane Culhane

Newsletter: A Report to Physicians of Texas Archives

• New Books Help Pediatric Patients and Their Parents Cope with Cancer
• Eight Patients Receiving Synthetic Interferon
• Center Helps Recovering Cancer Patients
• Routine Machine Solves the Problem of Transfusions for Jehovah’s Witnesses
• Noteworthy
• Treatment for Multiple Myeloma Reviewed, Raymond Alexanian, MD
• Smith Delivers 18th Mike Hogg Lecture, Walter J. Pagel
• 1979 Clinical Conference Book Reviewed, Diane Culhane
• National Large Bowel Cancer Project Holds Workshop

Vital Signs, February, 1981, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

Oxidation Of Native And Modified Hemoglobin And Myoglobin By Sodium Nitrate. Effect Of Inositol Hexaphosphate, Ali Mansouri

Journal of the Arkansas Academy of Science

Native and modified hemoglobin, myoglobin and a and phemoglobin subunits were oxidized by sodium nitrite at pH 6. The experiments were carried out under oxy and deoxy conditions with and without inositol hexaphosphate (IHP). It is shown (a) that under oxy condition low concentration of IHP inhibits the oxidation of native hemoglobin only. However, high concentration of IHP inhibits the oxidation of both myoglobin and modified hemoglobin (digested or 0-93-SH groups blocked). This inhibition is partially counteracted by high oxygen pressure, (b) Under deoxy condition the oxidation rates of all hemeproteins studied are significantly faster than that of native hemoglobin. …

Namru-3 Translations Of Parasite Literature From Russian, French, Japanese, Etc. Into English (1921-1981) T1401-T1500, United States Naval Medical Research Unit Number Three, Cairo, Medical Zoology Department

United States Naval Medical Research Unit 3: Publications

T1401. TRANSLATION FROM RUSSIAN. L'VOV, D. K., GROMASHEVSKY, V. L., SIDOROVA, G. A., TSIRKIN, Yu. M. CHERVONSKY, V. L. GOSTINSHCHIKOVA, G. V. and ARISTOVA, V. A. (1971). Isolation of a new arbovirus Baku of Kemerovo group from argasid ticks Ornithodoros coniceps. in Azerbaijan. Vop. Virus., 16(4):434-437.

T1402. TRANSLATION FROM RUSSIAN. ALEKSANDROV, Yu. V., KORYAGIN, V. L. and YOVAL'CHUK, Zh. T. (1970). Observations on ecological biological properties of Hyalomma plumbeum ticks in eastern Crimea. Tezisy Dokl. 2. Akarol. Soveshch., (1):22-24.

T1403. TRANSLATION FROM RUSSIAN. MATEVOSYAN, K. Sh., KARASEVA, P. S. and SEMENOV, B. F. (1974). Study of potential arbovirus foci in …

Role Of The Arachidonic Acid Metabolites, Thromboxane A2 And Prostacyclin, In Shock Induced By Intraabdominal Sepsis, Robert Raymond Butler

MUSC Theses and Dissertations

A rat fecal peritonitis model of acute intraabdominal sepsis was investigated in order to evaluate the potential role of arachidonic acid metabolites in septic shock. Immunoreactive (i) Thromboxane (Tx) B2, the stable metabolite of TXA2' and i6-keto-PGF1α, the stable metabolite of prostacyclin, were measured by radioimmuonassay. plasma levels of iTXB2 rapidly increased from non-detectable (ND< 200 pg/ml) to 1,066 -/+ 194 pg/ml (N=14) 1 hour after feces injection. iTxB2 then increased to 1,695 -/+ 218 pg/ml (N=16) at 4 hours and remained unchanged through 6 hours. Plasma i6-keto-PGF1α increased from ND to 3,777 -/+ 414 pg/ml (N=16) at 1 hour. Four hours after feces, i6-keto-PGF1α levels rose to 6,945 -/+ 732 pg/ml (N=16) then continued to rise to 9,465 -/+ 792 pg/ml (N=7) at 6 hours. Either essential fatty acid deficiency (arachidonic acid depletion) or indomethacin pretreatment (cyclooxygenase inhibition) significantly decreased (P< 0.01) the elevations of plasma iTxB2 and i6-keto-PGF1α associated with fecal peritonitis. Thrombocytopenia occurred within 6 hours after injection of feces and was significantly improved (P< 0.05) by indomethacin. Elevated fibrin degradation products at 6 hours (18 -/+ 3 µg/ml) were significantly reduced in essential fatty acid deficient (7 -/+ 2 µg/ml; P< 0.05) and indomethacin treated (4 -/+ 0.7 µg/ml; P< 0.01) rats. Survival time (8.6 -/+ 0.2 hours) was significantly enhanced by essential fatty acid deficiency (10.2 -/+ 0.4 hrs; P< 0.01) or indomethacin pretreatment (13.3 -/+ 0.6 hrs; P< 0.01). These studies show that fecal peritonitis is associated with increased synthesis of thromboxane A2 and prostacyclin and suggest that these arachidonic acid metabolites may play a role in the pathophysiology of septic shock. To evaluate the pathogenic role of thromboxane (Tx) and prostacyclin (PGI2) in septic shock, the protective efficacy of the Tx synthetase inhibitor, 7(l-imidazolyl) heptanoic acid (7-IHA) and the cyclooxygenase inhibitor, ibuprofen, were assessed during fecal peritonitis in the rat. 7-IHA (60 mg/kg) administered ip 30 minutes prior to feces significantly reduced the plasma level of iTxB2 to ND (P< 0.01) at 1 hour and to 508 -/+ 56 pg/ml (P< 0.01) at 4 hours after injection of feces. In contrast, the levels of i6-keto-PGF1α, the stable metabolite of PGI2 were significantly elevated by 7-IHA pretreatment from septic control levels to 5,185 -/+ 467 pg/ml (P< 0.05) at 1 hour. Plasma i6-keto-PGF1α at 4 hours in 7-IHA treated rats (5,503 -/+ 665 pg/ml) was not different from untreated controls. Ibuprofen (5 mg/kg) administered ip 30 minutes prior to feces significantly decreased both iTxB2 and i6-keto-PGF1α plasma levels to 729 -/+ 99 pg/ml and 1,327 -/+ 251 pg/ml, respectively (P< 0.05) at 4 hours. Survival associated with fecal peritonitis was not altered by 7-IGA pretreatment, but was significantly improved (P< 0.05) in ibuprofen treated rates. Fibrin degradation products were also significantly decreased (P< 0.05) by 7-IHA pretreatment. These results suggest that TxA2 may contribute to the coagulopathies seen in septic shock and that PGI2 may be associated with terminal pathophysiologic events. The final phase of this project investigated the possible synergistic benefit between an antibiotic, gentamicin (GENT), and reduction of arachidonic acid metabolism by pre-administration of indomethacin (INDO) or essential fatty acid (EFA) deficiency. GENT significantly increased mean survival time to 23.8 -/+ 2.6 hours (N=16; P< 0.01). GENT + INDO or GENT + EFA deficiency further improved mean survival time and produced long term survivals (>48 hrs) of 35% (N=17) and 30% (N=7) respectively (P< 0.01 compared to GENT). GENT pretreatment did not significantly alter plasma iTxB2 levels, however, it selectively decreased i6-keto-PGF1α. For example, i6-keto-PGF1α decreased from 9,465 -/+ 792 pg/ml (N=7) to 2,096 -/+ 1174 pg/ml (N=5; P< 0.01) at 6 hours after induction of fecal peritonitis. GENT + INDO pretreatment significantly decreased both iTxB2 and i6-keto-PGF1α to ND (P< 0.01). Pretreatment with GENT alone did not reduce fibrin degradation products. These findings are consistent with the concept that TxA2 may play a role in consumptive coagulopathies and PGI2 may be associated with the terminal hypotension seen during septic shock. The effect of GENT on TxA2 and PGI2 production was investigated further. GENT had no observable effect on in vitro endotoxin stimulated production of these arachidonic acid metabolites by cultured rat peritoneal macrophages. GENT significantly reduced the plasma levels of iTxB2 and i6-keto-PGF1α during endotoxin induced shock in rats. These observations support a complex interaction of bacteria, endotoxin, host tissues, and gentamicin with the possible involvement of undescribed mediated factors.

The University Of Health Sciences Journal, Vol.1 No.1: Winter-Spring 1981, University Of Health Sciences College Of Osteopathic Medicine, James F. Ryan

University of Health Sciences Journal (1981-1985)

Contents: Winter Festival: Beginning of a Tradition... -- Campus Roundup: Growth and Change Continues -- Commencement 1981: Sights and Sounds of Happiness -- Editorial Directions -- In Memoriam -- News Briefs -- Alumni News -- Medical Library Information.

Vital Signs, January, 1981, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.