Medical Specialties Commons^™

Medical Education In The United States: Some Current Problems And An Uncertain Future, Richard J. Reitemeier

Henry Ford Hospital Medical Journal

No abstract provided.

An Overview Of The Newer Antibiotics, Ramon Del Busto

Henry Ford Hospital Medical Journal

The introduction of a large number of new antibiotics has made selecting the one most appropriate for treatment a confusing task for the practicing physician. One problem is that the differences in pharmacokinetics, in vitro activity, and clinical indications between some of these agents may be relatively minor; this is especially true of the new cephalosporins. Another problem is that the generic names of the cephalosporins are so similar that it is impractical, even for the infectious diseases specialist, to be familiar with all of them. This review attempts to summarize the most important characteristics of these new antibiotics and …

Viral Hepatitis: Update On Prevention, Miriam J. Alter

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Infectious Diseases And The Persisting Microbial Challenge, Louis D. Saravolatz

Henry Ford Hospital Medical Journal

No abstract provided.

Prospects For The Medical Use Of Interferon In 1984, Bosko Postic, Julio C. Arroyo

Henry Ford Hospital Medical Journal

Interferon, a natural and wide spectrum antiviral polypeptide that was discovered in 1957, has been extensively described. In addition to its antiviral effect, interferon has been found to suppress tumor growth and modulate the immune response. Until 1980, interferon was primarily prepared for clinical trials in human leukocytes derived from the buffy coat of whole blood. A major breakthrough occurred in the late 1970s when human interferon was produced by DNA recombinant methods in such heterologous cells as bacteria (genetic engineering). Interferon is not commercially available in 1984, but it may, based on clinical trials in humans, become part of …

Congenital Seminal Vesicle Cyst: A Specific Diagnosis By Computed Tomography, Leo Drolshagen, Michael A. Sandler

Henry Ford Hospital Medical Journal

Computed tomography (CT) has been shown to be of great value in the assessment of the urinary tract. However, this modality has been primarily used in the evaluation of renal masses and the staging of urinary tract carcinomas. It may also be useful in less common abnormalities, such as mesonephric duct anomalies including congenital seminal vesicle cysts. These lesions are associated with renal agenesis and may produce urinary tract symptoms, or be discovered incidentally. We present a case of a congenital vesicle cyst associated with ipsilateral renal agenesis with characteristic CT findings allowing for a specific diagnosis.

A Case Of Ige Myeloma: Methodology And Review Of The Literature, Pat A. Allevato, Michael J. Deegan, Jau-Wen Chu, Mary B. Perry, Carolyn L. Barth

Henry Ford Hospital Medical Journal

A 56-year-old man presented with a one-year history of progressive weakness predominantly affecting his extremities and persistent low back pain. Ouchterlony immunodiffusion of the concentrated urine detected a marked increase in lambda light chains. A sternal bone marrow documented a diagnosis of multiple myeloma. Screening high resolution agarose gel electrophoresis revealed diffuse hypogammaglobulinemia and, retrospectively, an equivocal, faint band which migrated in the fast gamma region. By using a combination of Immunoelectrophoresis and immunofixation electrophoresis, this questionable band was determined to represent an IgE lambda monoclonal protein. Radioimmunoassay for IgE documented a serum concentration of 50.6 mg/dl. No intact IgE …

Rapidly Progressive Pancytopenia, Hepatomegaly, And Abnormal Lung Uptake Of Colloid In Systemic Lupus Erythematosus: Possible Saturation Of Reticuloendothelial System With Blood Elements, Tetsushi Sakurai, Kiyoshi Fukuda, Ichiro Kono, Teizo Kabashima, Kazuhide Yamane, Heihachiro Kashiwagi

Henry Ford Hospital Medical Journal

A patient with systemic lupus erythematosus developed severe abdominal pain and tender hepatomegaly associated with progressive pancytopenia and elevated serum levels of circulating immune complexes. Liver scintigram demonstrated extreme hepatomegaly with poor colloid uptake and splenomegaly with increased colloid uptake. An unusual accumulation of colloid in the lungs was also noted. Subsequent clinical and laboratory studies raised the possibility of saturation of the reticuloendothelial system in the liver by circulating immune complexes and blood cells, a condition demonstrated in experimental animals, but not hitherto well documented in the human immune complex disorder.

Tubal Lavage In The Management Of Ectopic Pregnancy, Samuel A. Motanya, William H. Pfeffer, Emile Sandelin, C. James Chuong

Henry Ford Hospital Medical Journal

No abstract provided.

Clinical Trials: I. Design And Ethical Issues, Barbara Tilley

Henry Ford Hospital Medical Journal

No abstract provided.

Editorial, Raymond C. Mellinger

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Temporomandibular Joint Relations Of Bone And Lateral Pterygoid Muscle : A Computerized Tomography Study, Duane K. Yamashiro

Loma Linda University Electronic Theses, Dissertations & Projects

This study utilized the imaging technique of computerized tomography (CT). Scans taken with a GE CT/N 8800 scanner of an adult cadaver and a 12-patient group were obtained through the Loma Linda University School of Dentistry, TMJ Department, and Loma Linda University Medical Center, Department of Neuroradiology.

The lateral scout image and a lateral cephalogram of the cadaver were compared using six angular measurements for facial type from Ricketts' Cephalometric Analysis. The six measurements, Maxillary Depth, Facial Depth, Mandibular Arc, Mandibular Plane, Lower Face Height and Facial Axis, were found to be similar. This allowed the investigator to rely exclusively …

Third Molar Eruption Prediction, Michael L. Jacobsen

Loma Linda University Electronic Theses, Dissertations & Projects

The diagnosis and treatment of third molars has often been cited as a special problem to the orthodontist. If the prognosis of third molars could be determined, orthodontic treatment could progress on a more positive basis.

This study was designed to provide a method of deciding whether developing third molars will erupt or become impacted.

Records from 130 orthodontically treated cases of Dr. Fredsall⁸ were studied. Several factors were evaluated and measured using the patients' cephalometric radiographs.

The actual fate of the third molars were recorded in the hope it could be used to predict what to expect from …

How Registered Nurses In Skilled Nursing Facilities Rate The Importance Of And The Frequency Engaged In Specific Nursing Behaviors Related To Their Role, Christine Anne Heine

Ellmer School of Nursing Theses & Dissertations

Registered nurses in skilled nursing facilities were surveyed using the Six-Dimension Scale of Nursing Performance to determine: (1) how they rated the importance of specific nursing behaviors related to their role, (2) how they rated the frequency engaged in the same specific nursing behaviors related to their role, and (3) if there was a relationship between how they rated the specific nursing behaviors for importance and frequency. There were five subgroups of nursing behaviors: (a) leadership, (b) nursing process, (c) teaching and collaboration, (d) interpersonal relations and communication, and (e) professional development. Registered nurses rated all of the behaviors as …

Inhibition Of Growth Of Toxoplasma Gondii In Cultured Fibroblasts By Human Recombinant Gamma Interferon., E. R. Pfefferkorn, Paul M. Guyre

Dartmouth Scholarship

The growth of Toxoplasma gondii in cultured human fibroblasts was inhibited by recombinant human gamma interferon at concentrations of 8 to 16 U/ml. The interferon was titrated by observing a total inhibition of parasite plaque formation 7 days after infection. Inhibition of the growth of T. gondii in the early days after infection was measured by marked reductions in the incorporation of radioactive uracil, a precursor that can only be used by the parasites. This assay showed that when cells were pretreated with gamma interferon for 1 day and then infected, inhibition of T. gondii growth could be readily detected …

Vital Signs, Spring 1984, Boonshoft School Of Medicine

Vital Signs

A twenty eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Intracranial Tumour In An Infant Presenting As Iron Deficiency Anaemia, Rashid Jooma, D N. Grant

Section of Neurosurgery

No abstract provided.

Screening Of Patients At High Risk For Cancer, Robert M. O'Bryan

Henry Ford Hospital Medical Journal

A cancer other than non-melanoma skin cancer will occur in one of every seven persons. Individuals with higher risks for cancer are those with increasing age, hereditary disorders, and a family history of cancer. Lifestyle, especially the use of tobacco and alcohol, diet, and perhaps behavioral patterns influence the risk. Less well understood but clearly pertinent risk factors include environmental and occupational exposures. The risk factors specific for breast cancer include a positive family history of breast cancer, history of mastopathy, age at first pregnancy greater than 35 years, early menarche with late menopause, and history of carcinoma of the …

Brief Communication: Streptokinase For Deep Venous Thrombosis, Barry Lesser, Maria A. Sawdyk

Henry Ford Hospital Medical Journal

No abstract provided.

Pericardial Tamponade In Acute Myeloid Leukemia, R. P. Warrier, K. R. Kini, R. Singh, K. Maeda, I. Barr, F. M. Jara

Henry Ford Hospital Medical Journal

We are reporting a case of acute myeloid leukemia in a child with pericardial effusion and cardiac tamponade, with a review of the literature. Morphologic and cytochemical evidence was used to diagnose acute myeloid leukemia, and radiologic, electrocardiographic, echocardiographic, cytologic, and histologic evidence confirmed the diagnosis of tamponade and pericardial leukemic involvement. Pericardiotomy and pericardial window drainage successfully relieved the tamponade, and conventional chemotherapy was used to induce a remission.

Cushing's Disease Due To Pituitary Carcinoma, M. Saeed Zafar, R. C. Mellinger, J. L. Chason

Henry Ford Hospital Medical Journal

Criteria for the diagnosis of pituitary carcinoma are subject to controversy. Some authors do not accept the demonstration of cellular anaplasia alone as sufficient to establish the diagnosis but require evidence of metastatic disease in order to label a pituitary tumor as malignant. However, pituitary tumors can metastasize even in the absence of anaplasia. The present case of Cushing's disease and pituitary carcinoma had no clinical evidence of metastases when first reported. Partial surgical removal of the tumor followed by irradiation resulted in clinical remission of the Cushing's syndrome, but two years later progressive uncontrollable recurrence of the disease ended …

Peritoneal Lavage Red Blood Cell And White Blood Cell Count: A Prospective Comparison Of Usefulness, Eugene Meyer, James C. Gruenberg

Henry Ford Hospital Medical Journal

Prospectively, 637 patients with blunt or penetrating trauma to the lower chest or abdomen had quantitative peritoneal lavage red blood cell (RBC) and white blood cell (WBC) counts as part of their initial diagnostic evaluation. Statistically, the lavage RBC count (error rate: 6.8%) was a superior test to the lavage WBC count (error rate: 9.7%) (chi sq=9.2564, p=0.0024). See Appendix. When the lavage RBC and WBC tests agreed, the predictive value was high: 94% (46/49) when both were positive and 95% (521/549) when both were negative. When the lavage RBC test was positive and the lavage WBC test was negative, …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Why Cancer?, Angelos A. Kambouris

Henry Ford Hospital Medical Journal

No abstract provided.

Family History As A Marker For Increased Risk Of Breast Cancer And Colon Cancer, Robert A. Norum

Henry Ford Hospital Medical Journal

Cancer of the breast and colon are well known to occur with high frequency in families with certain inherited cancer syndromes. These cancers also occur with increased frequency in families which do not have a recognizable genetic cancer syndrome. The fact of familial occurrence can be used to identify people with increased risk of cancer. In high-risk people methods for early detection can be developed which may reduce morbidity and mortality from these cancers, as has been done for certain inherited cancer syndromes.

External Beam Treatment Of Inoperable Non-Small Cell Carcinoma Of The Lung, H. Gunter Seydel

Henry Ford Hospital Medical Journal

External beam radiation therapy for unresectable non-small cell carcinoma of the lung has produced significant survival in patients with disease limited to one hemithorax. New approaches to improve the results of radiation treatment of these patients include interstitial implantation, the use of hypoxic cell sensitizers, biologic response modifiers, as well as changes in the technique of radiation therapy. This includes the use of modern computerized tomographic scanning technology for better definition of tumor volume as well as the use of two fractions per day in the treatment of non-small cell carcinoma of the lung. Initial results of these studies are …

The Spectrum Of B Cell Neoplasia, Michael J. Deegan

Henry Ford Hospital Medical Journal

Recent progress in our understanding of the immune system and the development of new techniques that permit the precise identification of lymphocytes have permitted a reexamination of lymphoid neoplasms. Most of the non-Hodgkin's lymphomas and lymphocytic leukemias have been characterized as T or B cell neoplasms and have been shown to possess features similar to those expressed by normal lymphoid cells at different stages of maturation. The clinical significance and therapeutic implications of these discoveries are now being explored. This paper presents a concise overview of the differentiation of human B lymphocytes, the surface and cytoplasmic markers that permit their …

Preoperative Chemotherapy And Irradiation In The Treatment Of Soft Tissue Sarcomas Of The Lower Extremities: Preliminary Report Of Experience At Henry Ford Hospital, S. David Nathanson

Henry Ford Hospital Medical Journal

The development of effective chemotherapy and improved techniques of radiation therapy offer the possibility of managing soft tissue sarcomas so that surgery may need to be less radical than in the past and amputation can be avoided. The low rates of local-regional and systemic recurrence that have resulted from using innovative combinations of chemotherapy, radiation therapy, and conservative surgery encouraged us to use preoperative intraarterial adriamycin (doxorubicin) with or without radiation therapy for three cases of soft tissue sarcomas of the lower extremities. The rationale for this therapy is also discussed.