Medical Specialties Commons^™

Vital Signs, Fall 2003, Boonshoft School Of Medicine

Vital Signs

A twenty-eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, faculty profiles, and more.

Diagnosis Of Pulmonary Embolism With Helical Ct Scan, M U. Usman, V Bari, Javed Yakoob, Murad M. Khan Dr.

Department of Radiology

Objective: To determine the role of helical C.T. scan in the diagnosis of pulmonary embolism.SETTING: Radiology department, Aga Khan University Hospital. One year prospective study May 2001 to May 2002.Methods: Sixty patients suspected of having pulmonary embolism were included in this study. Helical C.T. scan chest was performed from aortic arch to lung bases with intravenous contrast medium. Images were acquired in mediastinal and lung windows. Image interpretation was performed on the console and hard copies for main branch and segmental thrombus.Results: Fifteen patients were diagnosed of having pulmonary embolism on C.T. scan. Clinical correlation and follow up with pulmonary …

Isolated Congenital Bilateral Absence Of Vas Deferens (Cbavd): A Rare Anomaly And Diagnostic Dilemma, M Moazzam, Syed Raziuddin Biyabani, C K. Jadoon

Section of Urology

No abstract provided.

What Is Wrong With Medical Audit?, J H. Rizvi

Department of Obstetrics & Gynaecology

No abstract provided.

Ccr5 Mediates Specific Migration Of Toxoplasma Gondii—Primed Cd8+ Lymphocytes To Inflammatory Intestinal Epithelial Cells, Souphalone Luangsay, Lloyd H. Kasper, Nicolas Rachinel, Laurie A. Minns

Dartmouth Scholarship

Toxoplasma gondii, an obligate intracellular parasite, can invade intestinal epithelial cells and elicit a robust Th1 immune response. In this model of intestinal inflammation, CD8⁺ intraepithelial lymphocytes (IELs) secrete transforming growth factor (TGF)-β, which appears necessary for the maintenance of homeostasis in the intestine. However, the mechanism responsible for the IEL migration to the inflamed intestine is still unclear.An in vitro coculture cell system was used to quantify the IEL attraction by an infected intestinal epithelial cell line (m-IC_cl2). We used CCR5-deficient mice to determine which chemokine receptor—chemokine interaction could be responsible for the recruitment of …

Genetic Polymorphisms Of The Interleukin-1 Gene And Early Marginal Bone Loss Around Endosseous Dental Implants, Hitomi Shimpuku, Yasuhiro Nosaka, Tatsuya Kawamura, Yoichi Tachi, Mitsuko Shinohara, Kiyoshi Ohura

Faculty, Staff and Student Publications

Dental implant surgery commonly proceeds in two stages. It is generally accepted that bone loss around implants does not occur at stage-II surgery because implants do not receive mechanical loading. However, early marginal bone loss around implants occasionally does occur during the healing period. Genetic polymorphisms in the interleukin-1 (IL-1) gene have been reported to be important for bone homeostasis and susceptibility to bone disease. We therefore investigated whether the idiopathic early marginal bone loss around implants is related to polymorphisms in the IL-1 gene. We performed a case-control study. Patients demonstrating marginal bone loss around implants at stage-II surgery …

Medical Education Digest, Vol. 5 No. 4 (July 15, 2003), Nova Southeastern University

Medical Education Digest

No abstract provided.

Adjusting For Non-Ignorable Verification Bias In Clinical Studies For Alzheimer’S Disease, Xiao-Hua Zhou, Pete Castelluccio

UW Biostatistics Working Paper Series

A common problem for comparing the relative accuracy of two screening tests for Alzheimer’s disease (D) in a two-stage design study is verification bias. If the verification bias can be assumed to be ignorable, Zhou and Higgs (2000) have proposed a maximum likelihood approach to compare the relative accuracy of screening tests in a two-stage design study. However, if the verification mechanism also depends on the unobserved disease status, the ignorable assumption does not hold. In this paper, we discuss how to use a profile likelihood approach to compare the relative accuracy of two screening tests for AD without assuming …

Use Of In Vivo-Induced Antigen Technology (Iviat) To Identify Genes Uniquely Expressed During Human Infection With Vibrio Cholerae, Long Hang, Manohar John, Muhammad Asaduzzaman, Emily A. Bridges, Cecily Vanderspurt, Thomas J. Kirn, Ronald K. Taylor

Dartmouth Scholarship

In vivo-induced antigen technology is a method to identify proteins expressed by pathogenic bacteria during human infection. Sera from 10 patients convalescing from cholera infection in Bangladesh were pooled, adsorbed against in vitro-grown El Tor Vibrio cholerae O1, and used to probe a genomic expression library in Escherichia coli constructed from El Tor V. cholerae O1 strain N16961. We identified 38 positive clones in the screen, encoding pili (PilA and TcpA), cell membrane proteins (PilQ, MshO, MshP, and CapK), methyl-accepting chemotaxis proteins, chemotaxis and motility proteins (CheA and CheR), a quorum-sensing protein (LuxP), and four hypothetical proteins. Analysis of immune …

Com Outlook Summer 2003, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Compromised Constitutions: The Iranian Experience With The 1918 Influenza Pandemic., Amir Afkhami

Psychiatry and Behavioral Sciences Faculty Publications

The global demographic impact of the 1918-19 influenza pandemic continues to fascinate researchers and scholars. This paper examines the social and demographic effects of this outbreak on Iranian society, through a comprehensive investigation of the modes of transmission and propagation, mortality rates, and other distinctive features of the region, and reveals the importance of taking a country's unique sociopolitical settings into account. Iran was one of the regions hit hardest by the pandemic, with mortality rates significantly higher than in most regions of the world. Though globally the victims of influenza lived primarily in urban areas, it was Iran's rural …

Tuberculosis Diagnosis And Treatment Practices Of Private Physicians In Karachi, Pakistan, J Khan, A Malik, H Hussain, N K. Ali, F Akbani, S J. Hussain, G N. Kazi, S F. Hussain

Section of Pulmonary & Critical Care

In a densely populated urban area of Karachi, Pakistan, a questionnaire survey was made of the knowledge and practices of 120 private general practitioners about the diagnosis and treatment of tuberculosis (TB). The majority knew that cough, fever and weight loss were the main symptoms of TB, but less than half knew that blood in sputum, poor appetite and chest pain were associated with the disease. Only 58.3% of physicians used sputum microscopy for diagnosing TB and 35.0% used it as a follow-up test. Only 41.7% treated TB patients themselves, the remaining referring their patients to specialists. Around 73.3% of …

Psychosocial Stress And Cervical Neoplasia Risk, Ann L. Coker, Sharon M. Bond, Margaret M. Madeleine, Kathryn J. Luchok, Lucia Pirisi

CRVAW Faculty Journal Articles

OBJECTIVE: We assessed the association between psychosocial stress and preinvasive cervical neoplasia development controlling for HR-HPV infection.

METHODS: This case-control study enrolled low-income women receiving family planning services at health department clinics. There were 59 cases with biopsy confirmed HSIL and 163 with low-grade SIL and 160 controls with normal cervical cytology. A modified SLE scale was used to measure stressful events and the perceived impact of the event in the prior 5 years. Unconditional logistic regression was used to assess SIL risk and stressful events scores and by subscales.

RESULTS: After adjusting for age, HR-HPV infection, and lifetime number …

Oncolog, Volume 48, Number 07/08, July/August 2003, Ann Sutton, Karen Stuyck, Gayle Nesom

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Researchers Explore Possible Applications of Nanotechnology in Cancer Treatment
• Sharing the Burden: Palliative Care Team Helps Patients, Families Through Difficult Times
• UPDATE: Study of Tamoxifen and Raloxifene (STAR) Nearing Completion Recruitment Efforts Focus on Women in Minority, Medically Underserved Populations
• House Call: Getting the Best Treatment

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 2003), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 2003 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates
• The Doctor is out!
• Cover Story: Taking a Closer Look at Forensic Medicine
• Osteopathic Manipulative Medicine Research Center
• Class Notes
• Computer Age Meets Office Hours…The Doctor is a Click Away
• In Memoriam
• My Turn
• Andrew Taylor Still Legacy Society
• PCOM Events

Effectiveness Of A Practice Regimen For Decreasing Floor Rise Time In Older Adults, Deborah Waldschmidt Gibbs

Human Movement Studies & Special Education Theses & Dissertations

Some older adults experience extended periods of time lying on the floor waiting for help to arrive because they can not rise up independently (Campbell et al., 1990; Nevitt, Cummings, and Hudes, 1991). In many of these cases the older adults are not seriously injured, yet they lack the ability to rise up (Tinetti and Speechley, 1989; Vellas, Cayla, Bocquet, Pemille, and Albarede, 1987). Body Recall, an exercise program that teaches floor rising to older adults, advocates practicing getting up from the floor as a method for retaining this ability. The benefit of Body Recall is only anecdotal and has …

Adolescent Violence Prevention: A Case Presentation, Hatim A. Omar, Joan Griffith

Pediatrics Faculty Publications

Violence in adolescence has seen an increase since the 1990s with dramatic statistics on violent death and risk behaviors. School violence has been focused upon by a huge media coverage of especially violent cases that could have had some endemic consequences worldwide. We present a case of a 14 year old white male with change in school behavior, strategies for the case investigation, its results, and long term prevention. Other research has shown that preventive measures during pregnancy, infancy and childhood can prevent adolescent and adult delinquency.

Homeland (In)Security : Roots And Displacement, From New York, To Toronto, To Salt Lake City, Marusya Bociurkiw

Reconstruction: Studies in Contemporary Culture

[First paragraph]

On September 11, 2001, broadcast and print media around the world narrated the destruction of New York City's World Trade Center and the deaths of thousands of its occupants. This paper will examine the ways in which television and its appendages (the telephone, the internet, the newspaper) operated to organize the discursive meanings of this traumatic event. I will propose that between September 11 and February 2002's Winter Olympics in Salt Lake City, Utah, ideas about home, roots and rootedness (and their Others: foreignness, homelessness, nomadicism) operated as a discursive mapping of that which could otherwise not be …

The Frequency Of Iga Nephropathy At A Single Center In Pakistan, S. Muzaffar, N. S. Azad, N. Kayani, Shahid Pervaz, A. Ahmed, S. H. Hasan

Department of Pathology and Laboratory Medicine

Objectives: To detect the prevalence of IgA nephropathy in Pakistani patients, as no significant published data from this part of the developing world is available in the international literature for reference.

Method: The study was conducted in a university hospital on 105 consecutive renal biopsy specimens. Direct immunofluorescence microscopy was performed using antibodies specific for the heavy chains of IgG, IgA, IgM, C3 and fibrinogen.

Results: Seventy-nine (79) cases were classified as glomerulopathies, out of which 10 cases (12.65%) were diagnosed as IgA nephropathy, among which one case was that of Henoch- Schonlein purpura. The age range was 6 to …

Prediction Of 1976 Diabetes Incidence From 1960 Animal Product Consumption Among California Seventh-Day Adventists, Arnold Vang

Loma Linda University Electronic Theses, Dissertations & Projects

The prevalence of diagnosed and undiagnosed diabetes in the US has been estimated at more than 16 million individuals (King, 1998). This has led to research into lifestyle practices (Astrup, 2001; Touomilehto, 2001), which has identified several of primary prevention. High fat diet and type 2 diabetes has been attributed to the wellareas known mechanisms of hyperglycemia, hyperinsulinaemia and insulin resistance (Ferrannini, 1999; Reaven, 1988).

We examined the association between all animal product consumption, specific animal product consumption and diabetes incidence among California Seventh-day Adventists who were cohort members of the Adventist Mortality Study (Kahn, 1984) and the Adventist Health …

Requirement For The Betai And Betaiv Tubulin Isotypes In Mammalian Cilia., Heather C Jensen-Smith, Richard F Ludueña, Richard Hallworth

Journal Articles: Eppley Institute

Nielsen et al., [2001: Curr Biol 11:529-533], based on studies in Drosophila, have proposed that beta tubulin in axonemal microtubules must contain a specific acidic seven amino acid sequence in its carboxyl terminus. In mammals, the two betaIV isotypes (betaIVa and betaIVb) contain that sequence. In order to test the application of this hypothesis to mammals, we have examined the expression of beta tubulin isotypes in four different ciliated tissues (trachea, ependyma, uterine tube, and testis) using isotype-specific antibodies and indirect immunofluorescence. We find that betaIV tubulin is present in all ciliated cell types examined, but so is betaI tubulin. …

Alginate Is Not A Significant Component Of The Extracellular Polysaccharide Matrix Of Pa14 And Pao1 Pseudomonas Aeruginosa Biofilms, Daniel J. Wozniak, Timna J. O. Wyckoff, Melissa Starkey, Rebecca Keyser, Parastoo Azadi, George A. O'Toole, Matthew R. Parsek

Dartmouth Scholarship

The bacterium Pseudomonas aeruginosa causes chronic respiratory infections in cystic fibrosis (CF) patients. Such infections are extremely difficult to control because the bacteria exhibit a biofilm-mode of growth, rendering P. aeruginosa resistant to antibiotics and phagocytic cells. During the course of infection, P. aeruginosa usually undergoes a phenotypic switch to a mucoid colony, which is characterized by the overproduction of the exopolysaccharide alginate. Alginate overproduction has been implicated in protecting P. aeruginosa from the harsh environment present in the CF lung, as well as facilitating its persistence as a biofilm by providing an extracellular matrix that promotes adherence. Because of …

Probucol Prevents Early Coronary Heart Disease And Death In The High-Density Lipoprotein Receptor Sr-Bi/Apolipoprotein E Double Knockout Mouse, Anne Braun, Songwen Zhang, Helena E. Miettinen, Shamsah Ebrahim, Teresa M. Holm, Eliza Vasile, Mark J. Post

Dartmouth Scholarship

Mice with homozygous null mutations in the high-density lipoprotein receptor SR-BI (scavenger receptor class B, type I) and apolipoprotein E genes fed a low-fat diet exhibit a constellation of pathologies shared with human atherosclerotic coronary heart disease (CHD): hypercholesterolemia, occlusive coronary atherosclerosis, myocardial infarctions, cardiac dysfunction (heart enlargement, reduced systolic function and ejection fraction, and ECG abnormalities), and premature death (mean age 6 weeks). They also exhibit a block in RBC maturation and abnormally high plasma unesterified-to-total cholesterol ratio (0.8) with associated abnormal lipoprotein morphology (lamellar/vesicular and stacked discoidal particles reminiscent of those in lecithin/cholesterol acyltransferase deficiency and cholestasis). Treatment …

General Physicians' Perspective Of Sleep Apnea From A Developing Country, Syed Fayyaz Hussain, Sumaiya Zahid, Raana Haqqee, Javaid Ahmed Khan

Section of Pulmonary & Critical Care

To assess the knowledge of general physicians about the diagnosis and management of obstructive sleep apnea (OSA), a self-administered questionnaire, containing 15 questions, was distributed to 160 doctors attending a pulmonary CME program in March 2002. After 15 minutes of response time, the questionnaires were collected. The data were entered and analyzed using SPSS (Version 10.0) software. One hundred and twenty (75%) questionnaires were returned. Only 41% of responders had ever read an article about OSA and 36% had suspected it at least once in their practice. The majority (61-77%) of responders were aware of the common symptoms of OSA, …

Athletic Trainers' Perceptions Of Competence In Therapeutic Exercise, Christopher J. Jones

Masters Theses

As the athletic training profession continues to expand, it is necessary to evaluate the preparedness of the entry-level certified athletic trainer (ATC). The purpose of this research is to determine if entry-level certified athletic trainers perceive that they have the knowledge and skills necessary to perform specific tasks related to therapeutic exercise.

An online questionnaire was sent out to 450 entry-level certified athletic trainers in District Four. A total of 69 subjects returned the survey for a response rate of 15.3%. The questionnaire utilized a Likert-type scale consisting of questions derived in the area of therapeutic exercise of the NATA …

Experience In 118 Consecutive Patients Undergoing Ct-Guided Stereotactic Surgery Utilizing The Cosman-Robert-Wells (Crw) Frame, G. R. Sharma, H. Siddiqui, Rashid Jooma

Section of Neurosurgery

Aims: To evaluate the efficacy of CT-guided neurosurgical procedures done on patients operated by this modality.
Methods: Between January 1997 and March 2000, 118 patients undergoing CT-guided stereotactic procedures were recruited to the study. The CRW III stereotactic system (Radionics, USA) and the TSX-00ZA CT Scanner (Toshiba, Japan) were used for all the procedures in the series. These procedures were directed to symptomatic brain lesions or for the treatment of Parkinsonian tremor.
Results: Of 118 patients, 109 had intra-cranial lesions and 9 had Parkinson's Disease. The stereotactic procedures performed on these patients were: biopsies in 62, guided mini-craniotomies in 22, …

Oncolog, Volume 48, Number 06, June 2003, Dawn Chalaire, Sunni Hosemann, Kate O'Suilleabhain, Kerry L. Wright, Daniel J. Booser Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Largest-Ever NCI Trial to Study Lung Cancer Screening
• “What Choices Do I Have?” Breast Reconstruction Book and CD-ROM Help Patients Make Complicated Decisions
• House Call: Coping with the Adverse Effects of Cancer Treatment
• New Proton Therapy Center to Deliver Radiation with Precision, Few Side Effects
• DiaLog: Treating Breast Cancer with Hormone Therapy: Past, Present, and Future, by Daniel J. Booser, MD, FRCPC, Associate Professor, Department of Breast Medical Oncology

Systemic Sclerosis: Current Views Of Its Pathogenesis., Chris T. Derk, Sergio A. Jimenez

Department of Medicine Faculty Papers

Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by severe and often progressive cutaneous and visceral fibrosis, pronounced alterations in the microvasculature, and numerous cellular and humoral immune abnormalities. Clinically, SSc is very heterogeneous, encompassing a spectrum ranging from mild limited forms of skin sclerosis with minimal internal organ involvement to severe skin and multiple internal organ fibrosis. Mortality and morbidity in SSc are very high and are directly related to the extent of the fibrotic and microvascular alterations. A better understanding of the pathogenesis of this incurable disorder will help to better target and design effective …

Residency Program At Michael E Debakey Department Of Surgery, Baylor College Of Medicine, F Charles Brunicardi

Faculty, Staff and Students Publications

No abstract provided.

Commencement, Philadelphia (2003), Philadelphia College Of Osteopathic Medicine

Commencements

Philadelphia Campus D.O. Commencement Program, 112th Class. Degrees include Doctor of Osteopathic Medicine.

Commencement Speaker: Edward G. Rendell, Governor, Commonwealth of Pennsylvania.