Medical Specialties Commons^™

Simulated Science: Clinical Microbiology Lessons With Operation Outbreak, Melissa Poua

Open Educational Resources

This resource includes suggested teaching materials, posters and other visual aids, and two worksheets in epidemiology and virology, respectively. The target audience for this resource is healthcare majors in clinical microbiology courses. The laboratory activities are adapted to work with a free hands-on teaching phone application (Operation Outbreak) that models an outbreak in real-time, allowing the students to explore interventions and mitigation strategies.

Further details and instructions.

Proptosis Of Eye: An Atypical Presentation Of Prostatic Malignancy., Amna Amjad, Asif Husain Osmani, Ghulam H

Section of Pulmonary & Critical Care

Orbital metastasis is a rare occurrence found only in about 3 - 10% of all prostate cancers. A 72 years male presented with proptosis of the left eye associated with pain, blurred vision and frequent headaches for the past 8 months. Past medical history had symptoms of bladder outflow obstruction for 3 years. MRI brain and orbit with contrast was consistent with a large soft tissue mass in the left frontal region. The mass was surgically excised in order to achieve palliation. Histopathology revealed poorly differentiated malignant neoplasm with immunohistochemistry favoring metastatic prostate carcinoma. Postoperative radiotherapy was administered with a …

Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Head-to-head comparisons of conventional influenza vaccines with adenovirus (Ad) gene-based vaccines demonstrated that these viral vectors can mediate more potent protection against influenza virus infection in animal models. In most cases, Ad vaccines are engineered to be replication-defective (RD-Ad) vectors. In contrast, replication-competent Ad (RC-Ad) vaccines are markedly more potent but risk causing adenovirus diseases in vaccine recipients and health care workers. To harness antigen gene replication but avoid production of infectious virions, we developed “single-cycle” adenovirus (SC-Ad) vectors. Previous work demonstrated that SC-Ads amplify transgene expression 100-fold and produce markedly stronger and more persistent immune responses than RD-Ad vectors …