Dentistry Commons^™

Tumor Implantation Site Of Syngeneic Oral Cancer Models Differentially Induces Site-Dependent Local And Systemic Immunosuppression

Faculty, Staff and Student Publications

Background/objectives: Preclinical studies of head and neck squamous cell carcinoma (HNSCC) commonly use subcutaneous heterotopic (flank) tumor models for simplicity; however, orthotopic models may better reflect the native tumor environment. Direct comparisons of the tumor immune microenvironments (TIME) and tumor-draining lymph nodes (tdLNs) between these models remain limited. Better understanding of site-specific immune differences could improve model selection and interpretation of translational HNSCC studies.

Methods: ROC1 tumors were established in murine heterotopic and orthotopic sites, followed by assessment of tumor growth kinetics, survival, and the tumor microenvironment. Immune composition of tumors, blood, tdLNs, and spleen was evaluated at three tumor …

Exploring Spike-Dependent And Ace2-Independent Sars-Cov-2 Interactions With Salivary Epithelial Cells In The Absence Of Ace2

Faculty, Staff and Student Publications

Salivary gland infection by SARS-CoV-2 requires viral entry via routes and mechanisms that remain unresolved. This study examined the expression of the angiotensin-converting enzyme 2 (ACE2) receptor in salivary tissues and basal cell-derived human salivary progenitor cells (hS/PCs), an unstudied potential entry point for SARS-CoV-2. Multiple detection modalities, including immunocytochemistry, Western blotting, flow cytometry and RT-PCR, demonstrated a consistent lack of ACE2 protein and transcript in both tissue specimens and primary salivary epithelial cells. Antigen retrieval at pH 9 was determined to be optimal for immunodetection protocols, yet ACE2 remained undetectable. Small intestine tissue served as a positive control, confirming …

Wnt-Dependent Ontogeny Of Acellular Cementum-Forming Cementoblasts On The Tooth Root Surface

Faculty, Staff and Student Publications

Cementum is a specialized mineralized tissue that covers the tooth root surface and anchors the tooth to the surrounding periodontal ligament. The cervical acellular cementum (AC) is indispensable for periodontal attachment and represents a key target for periodontal regenerative therapies. However, the developmental origin and molecular identity of AC-forming cementoblasts remain poorly understood. Here, through an integrated spatial and single-cell transcriptomic analysis, we identify AC-forming cementoblasts as a distinct population of noncanonical mineralizing cells enriched for cell-matrix organization and Wnt signaling signatures, distinguishing them from cellular cementum-forming cementoblasts localized in the apical portion. Lineage tracing using a Wnt inhibitory factor …

Asymmetric Maxillary Molar Distalization And Guided Canine Eruption Using Temporary Anchorage Devices And Super-Elastic Niti Wire, Kah-Ying Yim, Huei-Mei Tsai, Yu-Ling Cheng, Ming-Jeaun Su, Yi-Min Liu

Taiwanese Journal of Orthodontics

An adult female patient presented with a pronounced maxillary dental midline deviation and localized crowding in the upper right quadrant, particularly involving the canine and second molar. The maxillary right canine was buccally erupted and overlapped the lateral incisor and first premolar due to insufficient arch space and unfavorable root proximity. The mandibular arch exhibited mild anterior crowding with a flat curve of Spee. Orthodontic treatment was initiated using preadjusted fixed appliances. Extraction of the maxillary right third molar was performed to allow immediate sequential distalization of the maxillary right molars. A bypassed-canine main archwire in combination with a temporary …

Management Of Lower Incisor Protrusion In An Angle Class Iii Malocclusion Using Improved Super-Elastic Ti-Ni Alloy Wire, Jr-Wei Jian, Yu-Hsiang Chang, Yi-Mien Cheng, Ming-Han Cheng, Jian-Hong Yu

Taiwanese Journal of Orthodontics

A 16-year-old adolescent female presented with the chief complaint of poor dental alignment and protrusion of the lower teeth. Clinical examination revealed Angle Class III malocclusion accompanied by lower anterior crowding and a protrusive lip profile involving both the upper and lower lips. Cephalometric analysis demonstrated a skeletal Class I relationship with a normal mandibular plane angle. To facilitate anterior retraction, four premolars (15, 24, 34, and 45) were extracted. Following extraction, Improved Super-elastic Ti-Ni alloy wire (ISW) was employed to relieve lower anterior crowding. Canine distalization and anterior retraction were subsequently performed. Elastic chains were used to assist midline …

Comparative Effectiveness Of Single Versus Two Miniscrews For Maxillary Incisor Intrusion In Gummy Smile: A Systematic Review And Meta-Analysis, Vaibhav Sunil Zanwar, Santosh Jetu Chavan, Jyoti Sunny Manchanda, Sakshi Santoshkumar Jain, Vedant S, Rishika Arya

Taiwanese Journal of Orthodontics

Background: Orthodontic intrusion of maxillary incisors is commonly used to treat gummy smiles in deep bite patients. The effectiveness of using one versus two miniscrews for this purpose remains debated. This systematic review and meta-analysis aimed to compare the dental effects of one versus two miniscrews for maxillary incisor intrusion.

Materials and Methods: A literature search was conducted across multiple databases for studies published up to December 31, 2024. Five studies (four randomized controlled trials and one non-randomized study) met the inclusion criteria. Risk of bias was assessed using the RoB 2 and ROBINS-I tools.

Results: Intrusion was greater in …

Correlation Between Maxillary Incisor Inclination And Buccopalatal Alveolar Bone Thickness Assessed By Cbct: A Retrospective Observational Study, Raee Korgaonkar, Nandini Kamat

Taiwanese Journal of Orthodontics

Purpose: This retrospective study aimed to evaluate the correlation between buccal and palatal alveolar bone thickness and the degree of maxillary incisor inclination. The objective was to derive clinically relevant insights for orthodontic treatment planning and controlled tooth movement. Materials and Methods: Sixty-one maxillary central incisors from cone-beam computed tomography (CBCT) scans of thirty-four subjects were retrospectively evaluated and grouped as proclined, upright, and retroclined incisors. Buccal and palatal thicknesses of cortical and cancellous alveolar bone were measured at various levels of the incisor root. The correlation between bone thickness and incisor angulation was investigated using Spearman’s correlation test. Results: …

Evaluation Of Mandibular Buccal Shelf Bone Thickness And Height For Miniscrew Placement Using Cone-Beam Computed Tomography, Roji Shrestha, Rabindra Man Shrestha, Jyoti Dhakal, Sujita Shrestha

Taiwanese Journal of Orthodontics

Introduction: Buccal shelf area (BSA) is a recommended anatomic site for mini-screw insertion. Stability of miniscrew is determined by quantity of bone available in the region.

Objective: To determine bone thickness and height of BSA for optimum placement of miniscrew.

Materials and Methods: This cross-sectional observational study included 40 cone-beam computed tomography (CBCT) scans (23 males, 17 females) of patients aged 19-38 years. Patients were further divided into two age groups 19-28 years and 29-38 years. Measurements were made at 4 different sites: mandibular first molar mesial root (M6) and distal root (D6), second molar mesial root …

The Influence Of Prosthetic Obturators On Quality Of Life In Individuals With Maxillectomy Defects, Minseok Kim

Oral Health

Abstract

Introduction: In recent years, there has been a growing focus on understanding the impact of oral cancer on patients' quality of life. Prosthetic rehabilitation techniques, such as maxillary obturators, often in conjunction with reconstructive surgery, have emerged as interventions to address the challenges posed by post-maxillectomy abnormalities.

Objective: This study aims to systematically review and evaluate the effectiveness of maxillofacial prosthetic rehabilitation using obturators in enhancing the quality of life of patients following maxillectomy.

Methodology: Systematic review of identified literature spanning the timeframe from 2000 to 2020 was used. The comprehensive search encompassed widely recognized databases including PubMed, …

Periodontal Disease In A Classic Maya Population From Ambergris Caye, Belize: A Cej-Ac Analysis, Avery R. Mcneil

Honors Theses

Dental remains provide a durable and information-rich record of biological, dietary, and health-related processes in past populations. This study examines periodontal disease, dental wear, and morphometric variation in a Classic period Maya population from coastal Belize (ca. A.D. 700-900) using cementoenamel junction-alveolar crest (CEJ-AC) distance as one measure of periodontal health. Dental remains were assessed using standardized bioarchaeological methods, including tooth identification, crown measurements, and periodontal scoring based on mean CEJ-AC distances recorded at preserved surfaces. The results indicate widespread mild to moderate periodontal disease across the sample, with posterior teeth exhibiting greater alveolar bone loss than anterior dentition. These …

Trauma-Informed Care (Tic) In Dental Settings, Kristi M. Soileau, Angeline Lee

New Orleans Dental Association News

Trauma-Informed Care (TIC) is an approach that recognizes the impact of trauma on patients, considering trauma to better utilize methods for more effective patient care. This approach contains the following ten implementation domains that serve as a guide in organizational change:

1. Governance and Leadership
2. Policy
3. Physical Environment
4. Engagement and Involvement
5. Cross-sector Collaboration
6. Screening, Assessment, and Treatment Services
7. Training and Workforce Development
8. Progress Monitoring and Quality Assurance
9. Financing
10. Evaluation

Implementing TIC will ensure that patients feel safe and autonomous in dental clinics, which results in increased trust between patient and provider, reduced patient anxiety during office visits, and therefore better oral …

Special Care Clinic At Lsu School Of Dentistry, Francis Martello Dds

New Orleans Dental Association News

The new LSU Special Care Clinic is fully functioning and helping to train dental and dental hygiene students in how to best care for patients with intellectual and developmental disabilities.

The clinic is located on the second floor of the Administration Building, thanks to new dean, Dr. John Gallo. A soft (and snowy!) opening in January 2025 was followed by a grand opening on May 9th. The clinic is staffed by first through fourth-year dental students, with leadership from members of the Special Care Dentistry Association (SCDA) student chapter.

Noda News April 2026

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

Examining The Rural Workforce: Comparing Admissions Strategies And Training Pathways In U.S. Medical And Dental Education, Charolyn A. Harris

Honors Theses

Access to healthcare in rural and underserved communities remains a significant challenge in the United States, particularly in dental care, where workforce shortages are more pronounced. This study examines how medical and dental education programs develop rural healthcare providers, focusing on admissions strategies and training pathways. Using a structured scoping review and secondary data analysis, this research compares how each field incorporates known predictors of rural practice, such as rural background and training experiences, into workforce pipeline development. Findings indicate that while both medical and dental education recognize rural background as a strong predictor of rural practice, medical education more …

Discrepancies In Pediatric Oral Health, Tyler B. Truong

Student Scholar Symposium Abstracts and Posters

In 2024, data was collected by the CDC on untreated tooth decay. From that data, children living in low-income households had an estimated 18.8% of tooth decay untreated, almost triple the amount when compared to children from middle to high income households (6.6%). As the income disparity continues to grow in the US, it is critical that we implement strategies to aid lower income communities in providing their children with proper oral hygiene tactics. In order to understand how communities can help promote healthy oral hygiene for their children, a survey of dentists from various areas was conducted to see …

Development Of A Unique Surgical Implant To Address The Development Of Iatrogenic Trigeminal Neuralgia Following Maxillomandibular Advancement Surgery For Osa, Erika L. Manning, Kun Yoon, Robert Diecidue, Joseph Harrington

Department of Oral and Maxillofacial Surgery Faculty Papers

A 58 y/o male with no significant past medical history presented in 2021 with obstructive sleep apnea (OSA), including trouble breathing through his nose due to hypoplastic maxilla, retrognathic mandible and chin, and microgenia. He underwent a LeFort 1 maxillary osteotomy, bilateral sagittal split osteotomy (BSSO), and genioplasty with fat graft on 2/10/2022. Postoperatively, the patient developed moderate pain and facial edema, which progressed into hypoesthesia with pain in the face with a sensation of fullness in the left ear and left masseter tightness. He also developed a positive Tinel sign in the left mandibular area and was diagnosed with …

Malignant Habits: An Addiction With Potentially Fatal Consequences, Marvin E. Pizer Dds, Ms, Ma, Ficd, Kenneth E. Danty

Virginia Dental Journal

No abstract provided.

Artificial Intelligence In Dental Education: A Literature Review Of Global Adoption, Pedagogical Outcomes, And Ethical Implications, Betti Shahin, Jeremiah D. Ghodsi, Toleen Mazloum, Denise Hale

Journal of Educational Leadership in Action

Background: Artificial intelligence (AI) is revolutionizing many fields by enabling machines to accomplish tasks that previously required human intelligence, such as learning, decision-making, and problem-solving. In dentistry, AI is increasingly applied to diagnostics, treatment planning, and clinical training. Its integration enhances educational experiences for students while supporting more accurate and efficient patient care.

Objective: This review synthesizes recent research on AI in dental education, highlighting global adoption trends and key pedagogical, ethical, and practical considerations.

Conclusion: AI has significant potential to enhance dental education through innovative teaching, clinical training, and data-driven decision-making. Effective integration depends on institutional …

Dental Rehabilitation With General Anesthesia And Analysis Of Waiting Time Periods, Hannah Shelton, Bethany Castro, Neena Patel, Robin Onikul, Amy Burleson, Jenna Sparks

Posters

Purpose: The aim of this research project is to understand how long patients are waiting to be seen to have dental rehabilitation completed under general anesthesia at Children’s Mercy Hospital. The data will help determine if additional surgical blocks are needed for dental providers to serve the patient population in a more reasonable time frame. Methods: A retrospective review of all appointments in the CMH dental clinic was conducted for all patients referred for general anesthesia. Data collected included patient wait times, patient age, ASA (American Society of Anesthesiologists) classification, type of appointment in which GA referral was made, and …

Dental Wear In Medieval Hungarian Populations, Sutton Walters

Honors College Theses

Dental wear can reveal past human behavior, offering insight into diet, daily activities and cultural practices (Berbesque et al., 2012; Deter, 2009; Estalrrich & Rosas, 2015; Górka, 2016; Molnar, 2008; Smith, 1984; Watson, 2014). Dental wear can reconstruct past life when other evidence is limited. This paper will address whether dental wear patterns observed in two medieval Hungarian populations, Kiskundorozsma–Kettőshatár I (KK) and SárrétudvariHízóföld (S), reflect sexual dimorphism patterns seen in hunter-gatherer vs. agriculturalist populations. Previous research demonstrates clear differences in wear between high- and lowwear subsistence strategies, whereas other studies report minimal or no sexual dimorphism and little variation …

Dental Findings Associated With Dandy Walker And Orofacial Digital Syndrome, Cailey C. Schell, Robin Onikul, Neena Patel, Jenna Sparks, Amy Burleson

Posters

Dandy Walker Syndrome is a rare congenital brain malformation in which the cerebellum does not fully develop. The cerebellum is responsible for controlling movement and balance and is located at the back of the brain1. Clinical symptoms associated with this syndrome include developmental delays, hydrocephalus, eye abnormalities and dental abnormalities including malformed or missing teeth1. Orofacial Digital Syndrome is another rare genetic disorder characterized by a combination of abnormalities affecting the face, mouth, hands and feet2. Clinical features of this syndrome include cleft lip, cleft palate, syndactyly, polydactyly, hypodontia and supernumerary teeth2. This presentation discusses a 9-year-old female patient who …

Dental Therapy: From Resistance To Responsibility, Chris Gorecki Dds

Journal of the Macomb Dental Society

This article features a monthly column from the Macomb Dental Society Executive Director, Dr. Christopher Gorecki.

Macomb Dental Society Journal Spring 2026

Journal of the Macomb Dental Society

In the Spring 2026 issue, the reader will find the following feature articles:

• MDS General Meeting

• Defever Seminar

• Ski Seminar

Also included are regular columns from the President, Executive Director and Editor, as well as news shorts and information on upcoming events.

Exploring Stem Cell-Based Approaches To Ameloblast-Like Cell Development: Progress And Limitations In Enamel Formation, Ava L. Abruzzese

Honors Scholar Theses

Enamel is one of the most critical structural components of the tooth. As the outermost layer, it serves as a protective barrier, shielding the underlying dentin and dental pulp from physical trauma and mechanical forces. The formation and mineralization of enamel are regulated by specialized cells known as ameloblasts. Once enamel maturation is complete, these cells undergo apoptosis. Consequently, enamel lacks the capacity for natural regeneration after damage or erosion, which can result from various environmental factors. When enamel is compromised, current clinical interventions focus on preventing further deterioration rather than true regeneration. These approaches include the use of remineralizing …

Dental Rehabilitation Of Pediatric Patient With Ellis-Van Creveld Syndrome: Case Report, Emma Kojima Dds, Robin Onikul, Neena Patel, Jenna Sparks, Amy Burleson

Posters

Ellis-van Creveld Syndrome, also known as Chondroectodermal dysplasia, is a rare autosomal recessive disorder caused by mutations in the EVC and EVC2 genes4. This syndrome is characterized by polydactyly of the hands, short limbs, ectodermal dysplasia, and congenital heart defects. Because Ellis–van Creveld syndrome affects all three embryonic layers, it presents with a range of oral manifestations, including absence of the mucobuccal fold, a serrated alveolar ridge, multiple labial frenula, abnormalities in tooth morphology, and congenitally missing teeth1. This report details a 20-month-old female who presented to the Children’s Mercy Dental Clinic in May 2019 for comprehensive dental care. The …

Evaluation And Treatment Of Pediatric Pre-Eruptive Intracoronal Resorption, Sophia Rosen, Robin Onikul, Neena Patel, Jenna Sparks, Amy Burleson

Posters

Pre- eruptive intracoronal resorption (PEIR), also known as “pre-eruptive caries,” is a dental condition characterized by the resorption of dental tissue prior to the eruption of the tooth.1PIER is typically found adjacent to the dentin-enamel junction, within the occlusal dentin of the tooth.2PIER may be referred to as “occult” or hidden caries due to the presence of sound enamel and is often an incidental finding on routine radiographs.3PEIR is often misinterpreted as traditional caries due to its radiographic appearance,3however requires careful evaluation for determination of treatment and long term success. Case report: This case report details a 13 year old …

The Future Of Dentistry In Macomb County, Kyle Katynski Dds

Journal of the Macomb Dental Society

This article features a monthly column from the Macomb Dental Society President, Dr. Kyle Katynski.

The Effect Of Two Desensitizing Agents In Treatment Of Dentin Hypersensitivity In Cervical Lesions (A Randomized Clinical Trial), Hend Sayed Ahmed, Mohamed Fouad Haridy, Hoda Fouda, Sara Katarya, Youssef M. Haridy

Dentistry

No abstract provided.

Improving Dimensional Stability Of Irreversible Hydrocolloid By Condensation Silicone Incorporation

Faculty, Staff and Student Publications

Background: Irreversible hydrocolloid (alginate) is widely used for dental impressions, but its poor dimensional stability over time limits accuracy when delays in pouring occur. Enhancing its stability through material modification, such as incorporating condensation silicone, may improve clinical outcomes.

Materials and methods: Three groups (n = 10) were evaluated: Group I (conventional alginate, Avagel), Group II (extended-pour alginate, Hydrogum 5), and Group III (alginate modified with condensation silicone). Specimens were fabricated using standardized molds and stored under controlled humidity. Dimensional stability was assessed at five time points (immediate, 24, 48, 72, and 120 h) by measuring mass and linear dimensions. …

Ultrasonic Cavity Preparation With Cvd Diamond Tips: A Scanning Electron Microscopy Study Of Dentin Surface Morphology And Smear Layer Formation

Faculty, Staff and Student Publications

Background: Minimally invasive dentistry has driven the development of alternative cavity preparation techniques aimed at preserving tooth structure and improving biological outcomes. Ultrasonic systems associated with chemical vapor deposition (CVD) diamond tips have emerged as a potential alternative to conventional rotary instruments; however, evidence regarding their effects on dentin surface morphology and smear layer characteristics under SEM remains limited. This study aimed to evaluate the morphological characteristics of dentin surfaces after cavity preparation using ultrasonic and conventional rotary techniques.

Materials and methods: Twenty extracted human teeth were sectioned longitudinally to obtain standardized specimens. Samples were assigned to ultrasonic preparation using …