Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons™

Open Access. Powered by Scholars. Published by Universities.®

1999

Medical Sciences

Institution
Keyword
Publication
Publication Type
File Type

Articles 211 - 217 of 217

Full-Text Articles in Medicine and Health Sciences

Cloning And Transcriptional Activation Of Thevitamin D Receptor (Amphibians)1, Meral Güzey Jan 1999

Cloning And Transcriptional Activation Of Thevitamin D Receptor (Amphibians)1, Meral Güzey

Turkish Journal of Medical Sciences

The vitamin D receptor (VDR), a member of the nuclear receptor superfamily, is an integral part of the body's calcium regulatory system. Mammalian and avian VDR genes were isolated, sequenced and characterized. In this study we cloned the vitamin D receptor from amphibians. We received a cDNA library prepared from amphibian (frog) tissues and prepared a cDNA probe based on the avian VDR. We screened the library and located the positive clones. Complete structure of VDR gene has been compared with other species and concluded that it shares 79%, 73%, 73% and 75% identity at the aminoacid level with the …

Go to article

Characterization Of Catalytic Phenotype Of \Beta-Galactosidasefrom Laci Mutant, E. Coli Csh-36,As A Tool For The Management Of Lactoseintolerance, Ayşegül Ayyildiz Jan 1999

Characterization Of Catalytic Phenotype Of \Beta-Galactosidasefrom Laci Mutant, E. Coli Csh-36,As A Tool For The Management Of Lactoseintolerance, Ayşegül Ayyildiz

Turkish Journal of Medical Sciences

Objectives: Lactose intolerance is a common public health problem with 5-100% prevalance among different populations of the world. Use of \beta-galactosidase to reduce the lactose content in food or consumption of special products of milk or exogeneous lactase enzyme are among the approaches taken to manage lactose intolerance. Recombinant \beta -galactosidase as well as \beta -galactosidase derived from different sources have variances in their bioefficiency. Thermodynamic properties of \beta -galactosidase determines the industrial efficiency. In this \beta -galactosidase from E. coli CSH-36, a constitutive expressor of enzyme was investigated for enzyme biofunctionality. Methods: The enzyme was purified by cell lysis, …

Go to article

Proximal Rectal Stenosis, Mehmet Demi̇rcan, M. Harun Gürsoy, Sema Uğuralp, Mustafa Aydinç, Murat Mutuş Jan 1999

Proximal Rectal Stenosis, Mehmet Demi̇rcan, M. Harun Gürsoy, Sema Uğuralp, Mustafa Aydinç, Murat Mutuş

Turkish Journal of Medical Sciences

No abstract provided.

Go to article

The Relationship Between Reactivity Of Metabolites Of Pyrrolizidine Alkaloids And Extrahepatic Toxicity, R. A. Cooper, R. J. Huxtable Dec 1998

The Relationship Between Reactivity Of Metabolites Of Pyrrolizidine Alkaloids And Extrahepatic Toxicity, R. A. Cooper, R. J. Huxtable

Roland A. Cooper

Pyrrolizidine alkaloids (PAs) are a large group of structurally similar toxins. In animals, including man, they are hepatotoxic and in some cases pneumo- and neurotoxic. PAs are metabolized by the liver P450 system to reactive dehydroalkaloid (DHA) intermediates. PA toxicity is a result of alkylation of macromolecules by DHAs. We have measured the relative reactivity of a series of semi-synthetic DHAs by recording the rate at which they alkylate a model nucleophile, 4-(p-nitrobenzyl)pyridine. Rate data fit mono- or biexponential equations. Rank order of reactivity for the macrocyclic and open ester DHAs was the same as those measured for DHA hydrolysis. …

Go to article

Factors Affecting The Circumcision Decision, Jeffrey D. Tiemstra Md Dec 1998

Factors Affecting The Circumcision Decision, Jeffrey D. Tiemstra Md

Jeffrey Tiemstra, MD, FAAFP

BACKGROUND: Studies from more than 10 years ago have shown that most parents choose circumcision for their infant sons for nonmedical reasons. Since then a wealth of data has accumulated on the relative risks and benefits of the procedure, although the medical community remains divided on the appropriateness of the procedure. Whether the ongoing research effort and medical debate have had an effect on parental decision making is unknown.

METHODS: A survey of parents of 55 male infants was conducted to determine when the parents made their decision regarding circumcision, whether discussions with providers affected their decisions, and what the …

Go to article

Ampa Receptors In Epilepsy And As Targets For Antiepileptic Drugs, Michael A. Rogawski, Sean D. Donevan Dec 1998

Ampa Receptors In Epilepsy And As Targets For Antiepileptic Drugs, Michael A. Rogawski, Sean D. Donevan

Michael A. Rogawski

No abstract provided.

Go to article

Lateral Hypothalamic Nmda Receptor Subunits Nr2a And/Or Nr2b Mediate Eating: Immunochemical/Behavioral Evidence, Arshad Khan, Margarita C. Curras, Jennifer Dao, Faizi A. Jamal, Rishi K. Goel, Elizabeth R. Gillard, Stefany D. Wolfsohn, B. Glenn Stanley Dec 1998

Lateral Hypothalamic Nmda Receptor Subunits Nr2a And/Or Nr2b Mediate Eating: Immunochemical/Behavioral Evidence, Arshad Khan, Margarita C. Curras, Jennifer Dao, Faizi A. Jamal, Rishi K. Goel, Elizabeth R. Gillard, Stefany D. Wolfsohn, B. Glenn Stanley

Arshad M. Khan, Ph.D.

No abstract provided.

Go to article

First Prev