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Full-Text Articles in Medicine and Health Sciences
Cartilage Regeneration On A Large Articular Surface Facilitated By Stress Shielding, Charles L. Mcdowell, Jennifer S. Wayne, Robert Tuten, Hunter H. Mcguire Jr.
Cartilage Regeneration On A Large Articular Surface Facilitated By Stress Shielding, Charles L. Mcdowell, Jennifer S. Wayne, Robert Tuten, Hunter H. Mcguire Jr.
Virginia Journal of Science
An animal model for the study of articular cartilage regeneration in-vivo facilitated by stress-shielding is introduced. The object of the model is to test the hypothesis that some form of cartilaginous tissue will grow upon a large joint surface in vivo with the joint in normal motion. The model utilizes the known capability of immature cells to differentiate. The source of cells is bleeding subchondral bone. In addition, the model provides a mechanically shielded environment in which cell differentiation and maturation can occur. The study showed that a substantial amount of tissue will grow in the animal model only when …
Effects Of Surgical Trauma On Articular Cartilage, Di̇lek Taşkiran, Emi̇n Taşkiran, Hakan Özsoy, Veli̇ Lök
Effects Of Surgical Trauma On Articular Cartilage, Di̇lek Taşkiran, Emi̇n Taşkiran, Hakan Özsoy, Veli̇ Lök
Turkish Journal of Medical Sciences
This study was designed to evaulate the effects of reconstruction of anterior cruciate ligament on cartilage collagen and proteoglycan metabolism. Proteoglycan fragments (PF) and matrix metalloproteinase-1 (MMP-1) levels were assessed in synovial fluids aspirated from 17 patients preoperatively and at 1 st month postoperatively. Synovial fluids of 10 healthy knee served as controls. Both MMP-1 and proteoglycan fragments were found significantly elevated in pathological knees preoperatively with compare to control. The postoperative levels of MMP-1 and proteoglycans were also significantly higher than preoperative and control values. These findings suggest that surgical trauma may have detrimental effects on cartilage matrix metabolism …