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Full-Text Articles in Medicine and Health Sciences
Uwomj Volume 69, No 2, Spring 1999, Western University
Uwomj Volume 69, No 2, Spring 1999, Western University
University of Western Ontario Medical Journal
An interdisciplinary medical science publication; established 1930.
Comparative Genomic Hybridization (Cgh) Incancer Research, İbrahi̇m Keser
Comparative Genomic Hybridization (Cgh) Incancer Research, İbrahi̇m Keser
Turkish Journal of Medical Sciences
Cancer is a multifactorial and multistep process. Conventional cytogenetics has become a major working field in cancer research. Chromosome rearrangements are recognized as critical in the pathogenesis of human cancer. Molecular biology and molecular cytogenetics technology have increased our ability to identify genetic alterations in cancer cells. Polymerase chain reaction (PCR), fluorescence in situ hybridization (FISH), oligonucleotide-primed in situ DNA synthesis (PRINS) are the most common molecular cytogenetic procedures in cancer research but they have limits with precise localization in their principles in cancer researching. However, comparative genomic hybridization (CGH) is a powerful molecular cytogenetic technique which allows the analysis …