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Full-Text Articles in Medicine and Health Sciences
An Immunohistochemical Study Of Gastricneuroendocrine Tumors: Expression Ofproliferating Cell Nuclear Antigen Andp53 Oncoprotein, Gülen Doğusoy, Süha Göksel, Işil Paki̇ş, Haydar Durak, Gökhan Ersoy, Selda Göçener
An Immunohistochemical Study Of Gastricneuroendocrine Tumors: Expression Ofproliferating Cell Nuclear Antigen Andp53 Oncoprotein, Gülen Doğusoy, Süha Göksel, Işil Paki̇ş, Haydar Durak, Gökhan Ersoy, Selda Göçener
Turkish Journal of Medical Sciences
The aim of this study is to examine expression of Proliferating cell nuclear antigen (PCNA) and p53 oncoprotein in gastric neuroendocrine tumors. 35 gastric neuroendocrine tumors were analyzed for first histopathologic features and then, immunohistochemical study was done to detect labeling index of PCNA and accumulation of p53 protein by using monoclonal antibodies and the Labeled strepavidin-biotin method. PCNA labeling index and p53 protein expression were compared with histopatholoic features in statistical methods of Fisher's exact, chi square and logistic regression tests. No significant correlation was found between them except PCNA score and depth of invasion. In conclusion, our findings …
Agnors, Pcna And Histologic Activity Index Inchronic Liver Disease, Koray Ceyhan, İlkser Akpolat, İbrahim Kobat, Nazan Bozdoğan, Selim Erekul
Agnors, Pcna And Histologic Activity Index Inchronic Liver Disease, Koray Ceyhan, İlkser Akpolat, İbrahim Kobat, Nazan Bozdoğan, Selim Erekul
Turkish Journal of Medical Sciences
Chronic hepatitis is a clinical and pathological syndrome, which has several causes and it is characterized by varying degrees of hepatocellular necrosis and inflammation. Several systems have been proposed to evaluate the diagnosis, grading and staging of chronic hepatitis. A histologic activity index (HAI) has been developed which generates a numerical score for liver biopsy specimens obtained from patients with chronic hepatitis. The aim of this study was to evaluate the correlation between HAI and proliferative activity markers, such as PCNA and AgNORs in biopsy specimens obtained from patients with chronic liver disease including chronic hepatitis and cirrhosis. Mean AgNOR …