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Decreasing Selenium Levels Andglutathione Peroxidase Activity In Patientswith Cutaneous Leishmaniasis, Abdurrahi̇m Koçyi̇ği̇t, Özcan Erel, Mehmet Sali̇h Gürel, Adnan Seyrek, Necmeddi̇n Aktepe, Selahatti̇n Gür, Senel Avci
Decreasing Selenium Levels Andglutathione Peroxidase Activity In Patientswith Cutaneous Leishmaniasis, Abdurrahi̇m Koçyi̇ği̇t, Özcan Erel, Mehmet Sali̇h Gürel, Adnan Seyrek, Necmeddi̇n Aktepe, Selahatti̇n Gür, Senel Avci
Turkish Journal of Medical Sciences
For most infectious diseases, increased formation of reactive oxygen species is secondary to the primary disease process. Some microorganisms are highly susceptible to exogenous reactive oxygen species such as hydrogen peroxide. Glutathione peroxidase (GSH-Px) remove H 2 O 2 , and selenium is requird for the activity of GSH-Px. Therefore, to assess the status of GSH-Px and selenium in cutaneous leishmaniasis (CL), we determined serum selenium concentration and blood GSH-Px activity in 52 patients with CL and in 38 healthy controls. Selenium concentrations and GSH-Px activities were found to be lower in the patient group than in the controls (p
The In Vitro Effects Of The Antimalarial Drug Primaquine, On The Activities Of Some Enzymes In Human Erythrocyte Lyzates, Meltem Müftüoğlu, Nazmi̇ Özer
The In Vitro Effects Of The Antimalarial Drug Primaquine, On The Activities Of Some Enzymes In Human Erythrocyte Lyzates, Meltem Müftüoğlu, Nazmi̇ Özer
Turkish Journal of Medical Sciences
The effect of primaquine on the enzymatic antioxidant defence mechanisms of erythrocytes were determined by measuring the activities of the below enzymes, before and after 30 minutes of incubation of hemolyzates with 1 mM primaquine at 37°C. Among the enzymes studied glucose-6- phosphate dehydrogenase seemed the most sensitive enzyme; 57 % and 78 % inhibition at zero (due to the binding of primaquine to NADP binding site) and 30 minutes of incubation (due to the reactive oxygen species), respectively. Catalase, superoxide dismutase, and glutathione-S-transferase were less sensitive to primaquine-derived reactive oxygen species: 33, 11, and 0 % inhibition at the …