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Time Dependent Changes In The Cristaneuroepithelium Resulting From Gentamicinototoxicity In The Chinchilla, Hasan Tanyeri̇, Ivan Lopez, Larry Hoffman
Time Dependent Changes In The Cristaneuroepithelium Resulting From Gentamicinototoxicity In The Chinchilla, Hasan Tanyeri̇, Ivan Lopez, Larry Hoffman
Turkish Journal of Medical Sciences
This experiment was conducted to investigate the time-dependent effects of gentamicin (GM) on the neuroepithelial morphology of the posterior crista ampullares (PCA) of the adult chinchilla. The time course of GM-induced HC pathology was documented through measurements of HC density as well as through HC morphologic evaluation. HC morphology was examined under light microscopy and HC density measurements were documented as a function of the time course of GM-induced ototoxicity. Six groups of animals (n=12) were treated with daily injections of 30 mg/kg of GM subcutaneously (SC) for six days and were sacrificed 1, 2, 3, 4, 6 and 8 …
Dose Dependent Changes In The Cristaneuroepitheium Resulting From Gentamicinototoxicity In The Chinchilla, Hasan Tanyeri̇, Ivan Lopez, Larry Hoffman
Dose Dependent Changes In The Cristaneuroepitheium Resulting From Gentamicinototoxicity In The Chinchilla, Hasan Tanyeri̇, Ivan Lopez, Larry Hoffman
Turkish Journal of Medical Sciences
This experiment was conducted to investigate the dose-dependent effects of gentamicin (GM) on the neuroepithelial morphology of the posterior crista ampullares (PCA) of the adult chinchilla. The experiment focused on hair cell (HC) morphology to monitor GM's dose-dependent effects and also to define an ototoxically-efficient and safe dose what would subsequently be used in a time course study. Chinchillas (n=13) were treated with subcutaneous (SC) daily doses of 120 mg/kg, 60 mg/kg, and 30 mg/kg GM, respectively, for six days. Light microscopy observations were made from the excised PCA of two animals from each group that survided the complete treatment …