Engineering Commons^™

Improved Virus Isoelectric Point Estimation By Exclusion Of Known And Predicted Genome-Binding Regions, Joe Heffron, Brooke K. Mayer

Civil and Environmental Engineering Faculty Research and Publications

Knowledge of the isoelectric points (pIs) of viruses is beneficial for predicting virus behavior in environmental transport and physical/chemical treatment applications. However, the empirically measured pIs of many viruses have thus far defied simple explanation, let alone prediction, based on the ionizable amino acid composition of the virus capsid. Here, we suggest an approach for predicting the pI of nonenveloped viruses by excluding capsid regions that stabilize the virus polynucleotide via electrostatic interactions. This method was applied first to viruses with known polynucleotide-binding regions (PBRs) and/or three-dimensional (3D) structures. Then, PBRs were predicted in a group of 32 unique viral …

Seismic Performance Of Chevron-Configured Special Concentrically Braced Frames With Yielding Beams, Hayato Asada, Andrew D. Sen, Tao Li, Jeffrey W. Berman, Dawn E. Lehman, Charles W. Roeder

Civil and Environmental Engineering Faculty Research and Publications

Current seismic design requirements for special concentrically braced frames (SCBFs) in chevron configurations require that the beams supporting the braces be designed to resist the demands resulting from the simultaneous yielding of the tension brace and degraded, post-buckling strength of the compression brace. Recent research, including large-scale experiments and detailed finite-element analyses, has demonstrated that limited beam yielding is not detrimental to chevron braced frame behavior and actually increases the story drift at which the braces fracture. These findings have resulted in new expressions for computing beam demands in chevron SCBFs that reduce the demand in the tension brace to …

The Bridge Newsletter Winter 2020, Missouri University Of Science And Technology

The Bridge Newsletter

-Kummers give largest single gift in the history of Missouri higher education
-$1M gift from the Sunderland Foundation completes ACML lab
-Miner alumni step up
-Academy of Civil Engineers inducts 11 new members

Quantification Of Nitric Oxide Via Single-Walled Carbon Nanotubes, Jakob Meier

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Nitric oxide (NO), a free radical present in biological systems, can have many beneficial and detrimental effects on the body. Due to NO’s short half-life, its detection and quantification is difficult. This inability to quantify NO has hindered researchers that are trying to understand NO’s impact in healthy and diseased conditions. Single-walled carbon nanotubes (SWNT), can become selective to various analytes when wrapped in specific single-stranded DNA strands. The presence of the analyte of interest can change the wavelength and/or intensity of the SWNT’s fluorescence, allowing the SWNT to be used as a sensor. One type of SWNT sensor, 6,5 …

The Effects Of Solution Condition On Virus Filtration Performance, Fnu Namila

Graduate Theses and Dissertations

Virus filtration is an integral part of the downstream purification of mammalian cell culture-derived biotherapeutics to assure the viral safety of the products. Virus filtration membranes remove viruses based on a size-exclusion mechanism. Commercial parvovirus filers possess unique membrane structure and are designed to remove smaller non-enveloped parvoviruses with size 18-26 nm. However, some filters face issues, such as pre-mature fouling, the decline of filtrate flux, and reduction in virus retention. This doctoral dissertation focused on identifying the factors that influence the filtrate flux and the virus retention capability of commercial virus filters. The effects of solution pH and ionic …

Projecting Water Available For Irrigation Use And Identifying Water Supply Stress Under Climate Change Scenarios In Selected U.S. Fruit And Vegetable Production Regions, Andrew Shaw

Graduate Theses and Dissertations

Climate change affects water resources differently across geospatial regions in the United States (U.S). There is a concern of how water availability will be affected by changes in long-term temperature and precipitation patterns, specifically in major production regions for eight fruit and vegetable crops. The effects on surface water available for irrigation use and supply stress in five regions containing 31 Agricultural Statistics Districts (ASDs) were assessed. The Water Supply Stress Index Model was used and modified to project water available for irrigation use across nine climate scenarios driven by historical data, five General Circulation Models, two population scenarios, and …

Imparting 3d Representations To Artificial Intelligence For A Full Assessment Of Pressure Injuries., Sofia Zahia

Electronic Theses and Dissertations

During recent decades, researches have shown great interest to machine learning techniques in order to extract meaningful information from the large amount of data being collected each day. Especially in the medical field, images play a significant role in the detection of several health issues. Hence, medical image analysis remarkably participates in the diagnosis process and it is considered a suitable environment to interact with the technology of intelligent systems. Deep Learning (DL) has recently captured the interest of researchers as it has proven to be efficient in detecting underlying features in the data and outperformed the classical machine learning …

Fly-In Visualization Of Tubular Objects: Theory And Application In Virtual Colonoscopy., Mostafa Mohamed

Electronic Theses and Dissertations

In this dissertation, visualization for tubular objects, i.e., projecting 2D images from 3D inner surfaces of tubular objects, is investigated. Given surface points on 3D objects, an approach that most accurately and effectively projects 2D images from the 3D surface with minimal loss of information is desired. A new visualization method for tubular surfaces is proposed, denoted by "Fly-In". The approach uses a virtual camera ring that moves along the inner surface's centerline, obtaining projections of the surrounding views, forming small 3D topological rings within the tube rendered as a 2D rectangular image. A new visualization loss measure is also …

Modeling And Analysis For Unit Cell Size, Material Anisotropy And Material Imperfection Effects Of Cellular Structures Fabricated By Powder Bed Fusion Additive Manufacturing., Yan Wu

Electronic Theses and Dissertations

Cellular structures are networks of interconnected struts or walls with porosities and are widely found in many natural load-bearing structures such as plants and bones. Cellular structures offer unique functional characteristics such as high stiffness to weight ratio, tailorable heat transfer coefficient, and enhanced mechanical energy absorption, which makes them highly attractive in various engineering disciplines such as biomedical implants, electrodes, heat exchangers, and lightweight structures. There exists an abundance of literatures that have investigated various mechanical properties of various cellular structures such as Poisson’s ratio, elastic modulus, ultimate strength, yield strength, and failure characteristics. Based on the classic cellular …

Development Of A Pediatric Cardiac Assist Maglev Pump For Use With A Universal Driver System., Landon Heath Tompkins

Electronic Theses and Dissertations

Heart failure (HF) remains the leading cause of death, affecting 26 million adults worldwide and 6.5 million adults in the United States. Pediatric HF patients have been a historically underserved population with few options for mechanical circulatory support (MCS) therapy, a leading treatment as an alternative to heart transplantation. To address this clinical need, the Inspired Universal MagLev System is being developed; a low cost, universal magnetically levitated extracorporeal MCS system with interchangeable single-use pumps that will ultimately provide adult and pediatric patients ventricular and respiratory assist therapies. The Inspired Pediatric VAD is the first single-use pump application for this …

Hydration, Shrinkage, Cracking, And Mechanical Properties Of Cementitious Materials With Lignocellulosic Biomass Wastes., Aofei Guo

Electronic Theses and Dissertations

The disposal of lignocellulosic biomass wastes imposes a huge economic and environmental burden on this society. Recycling lignocellulosic biomass wastes and applying them to cementitious materials provides a sustainable and value-added way for both agriculture and concrete industries. To comprehensively identify the effect of lignocellulosic biomass wastes at different scales on cementitious materials, the hydration, shrinkage, cracking, and mechanical properties of cementitious materials with lignocellulosic biomass wastes were studied. Given the three different forms (powders, chips, and fibers) of lignocellulosic biomass wastes in this study, the research was implemented in three stages. In the first stage, hemp powders were collected …

Aldosterone Up-Regulates Voltage-Gated Potassium Currents And Nkcc1 Protein Membrane Fractions, Parveen Bazard, Bo Ding, Harish K. Chittam, Xiaoxia Zhu, Thomas A. Parks, Thomas E. Taylor-Clark, Venkat R. Bhethanabotla, Robert D. Frisina, Joseph P. Walton

Chemical and Biochemical Engineering Faculty Research & Creative Works

Na+–K+–2Cl− Cotransporter (NKCC1) is a protein that aids in the active transport of sodium, potassium, and chloride ions across cell membranes. It has been shown that long-term systemic treatment with aldosterone (ALD) can enhance NKCC1 protein expression and activity in the aging cochlea resulting in improved hearing. In the present work, we used a cell line with confirmed NKCC1 expression to demonstrate that in vitro application of ALD increased outward voltage-gated potassium currents significantly, and simultaneously upregulated whole lysate and membrane portion NKCC1 protein expression. These ALD-induced changes were blocked by applying the mineralocorticoid receptor antagonist eplerenone. However, application of …

Attitude Determination And Control Of Arksat-1, Jared Gilliam

Mechanical Engineering Undergraduate Honors Theses

ARKSAT-1 is a nanosatellite developed at the University of Arkansas as part of NASA’s CubeSat Launch Initiative (CSLI). The goal of ARKSAT-1 is to utilize an LED emitter paired with a ground-based tracking system to perform measurements of the composition of the atmosphere using spectroscopy. As part of its function, it is imperative that the satellite is able to control its orientation so that the emitter is aligned as closely as possible with the ground tracker. To do this, the attitude control system of ARKSAT-1 uses magnetic actuators to create a torque on the satellite by interacting with Earth’s magnetic …

Towards Sensorimotor Coupling Of A Spiking Neural Network And Deep Reinforcement Learning For Robotics Application, Kashu Yamazaki

Mechanical Engineering Undergraduate Honors Theses

Deep reinforcement learning augments the reinforcement learning framework and utilizes the powerful representation of deep neural networks. Recent works have demonstrated the great achievements of deep reinforcement learning in various domains including finance,medicine, healthcare, video games, robotics and computer vision.Deep neural network was started with multi-layer perceptron (1stgeneration) and developed to deep neural networks (2ndgeneration)and it is moving forward to spiking neural networks which are knownas3rdgeneration of neural networks. Spiking neural networks aim to bridge the gap between neuroscience and machine learning, using biologically-realistic models of neurons to carry out computation. In this thesis, we first provide a comprehensive review …

Optical Properties Of Ultrathin In(Ga)As/Gaas And In(Ga)N/Gan Quantum Wells, Yurii Maidaniuk

Graduate Theses and Dissertations

Recently, structures based on ultrathin quantum wells (QWs) began to play a critical role in modern devices, such as lasers, solar cells, infrared photodetectors, and light-emitting diodes. However, due to the lack of understanding of the formation mechanism of ultrathin QWs during the capping process, scientists and engineers cannot fully explore the potential of such structures. This study aims to investigate how structural parameters of ultrathin QWs affect their emission properties by conducting a systematic analysis of the optical properties of In(Ga)As/GaAs and In(Ga)N/GaN ultrathin QWs. Specifically, the analysis involved photoluminescence measurements combined with effective bandgap simulation, x-ray diffraction, and …

Optimal Onboard Renewable Energy Charging Method To Improve Micro-Autonomous Underwater Vehicle Deployment Life, Brooklynn Dawn Byford

Theses and Dissertations

This study is an investigation of various methods for recharging a micro autonomous underwater vehicle (μAUV) onboard using renewable energy sources while deployed at sea. The goal of this project is to determine the optimal onboard renewable energy design method to be used to prolong the deployment life of a μAUV. This project specifically targeted vehicles specifications and designs similar to the Riptide Autonomous Solutions’ μAUV[1], which was used for this study. Concluding results are based on the following factors: power generation versus time, structural integrity, and design complexity. The three design method categories investigated are as follows: solar energy, …

Real-Time Intelligent And Multi-Spectral Inspection Of Structural Components, Mst Mousumi Rizia

Open Access Theses & Dissertations

Conventional, manual inspection methods are the most commonly used inspection approaches to this day; that cause downtime and can be erroneous due to their repetitive nature, heavy workload, and human error. The overarching goal of this work is to advance structural inspection with intelligent and autonomous techniques across infrastructures. In particular, this project will develop path-planning schemes for close navigation around the structures and intelligent algorithms for crack and corrosion detection.

The introduced novel navigation method uses advanced manufacturing techniques to generate aerial inspection trajectories in GPS-denied areas. The proposed method is validated using the `Gazebo' robotics simulator; the results …

Emocolor : Fine-Grained Emotion Recognition From Skin Color Information, Maria Guadalupe Jimenez Velasco

Open Access Theses & Dissertations

In everyday human-to-human communication, emotions play a fundamental role. Emotions represent the affective behavior of humans that is multi-modal, subtle, and complex. Previous approaches based on conventional computer vision explicitly used shape information. Modern approaches based on deep learning implicitly exploit all information available in the image, but by their nature make it difficult to assess the contributions of each source of information. In addition, skin color as a unimodal technique to recognize emotions has been explored to recognize only three coarse-grained emotions in valence space.To the best of our knowledge, this work presents the first approach to fine-grained emotion …

An Analysis Of Wildlife Strikes To Aircraft In Brazil: 2011-2018, Flavio A. C. Mendonca, Julius Keller, Chenyu Huang Ph.D.

Publications

Purpose: Aircraft accidents due to wildlife hazards have become a growing safety and economic problem to the Brazilian and international aviation industries. These safety occurrences have resulted in significant direct and indirect economic losses as well injuries and fatalities worldwide. The purpose of this study was to develop empirical information obtained from the analysis of wildlife strike and aircraft operations data in Brazil that could be used for accident prevention efforts.

Design/methodology: The research team collected and analyzed aircraft operations as well as wildlife strike data from the 32 busiest commercial airports in Brazil, from 2011 through 2018. …

Utilizing A New Eco-Friendly Drilling Mud Additive Generated From Wastes To Minimize The Use Of The Conventional Chemical Additives, Abo Taleb T. Al-Hameedi, Husam H. Alkinani, Mohammed M. Alkhamis, Shari Dunn-Norman

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

The cost of the drilling operation is very high. Drilling fluid presents 15 to 30% of the entire expense of the drilling process. Ordinarily, the major drilling fluids additives are viscosity modifiers, filtration control agents, and partial loss treatments. In this experimental work, full-set measurements under fresh and aged conditions, as well as high-temperature and high-pressure (HTHP) API filtration, were conducted to study the impacts of adding 0.5%, 1.5%, 2.5%, and 3.5% of black sunflower seeds’ shell powder (BSSSP) to spud mud. BSSSP of various grain sizes showed their ability to be invested for viscosity modifying, seepage loss controlling, and …

Polyrad -- Protection Against Free Radical Damage, Hannah Kim, Yin Tse, Andrew Webb, Ethan Mudd, Muhammad Raisul Abedin, Melanie R. Mormile, Subhadeep Dutta, Kaushal Rege, Sutapa Barua

Biological Sciences Faculty Research & Creative Works

The effects of elevated levels of radiation contribute to the instability of pharmaceutical formulations in space compared to those on earth. Existing technologies are ineffective at maintaining the therapeutic efficacies of drugs in space. Thus, there is an urgent need to develop novel space-hardy formulations for preserving the stability and efficacy of drug formulations. This work aims to develop a novel approach for the protection of space pharmaceutical drug molecules from the radiation-induced damage to help extend or at least preserve their structural integrity and potency. To achieve this, free radical scavenging antioxidant, Trolox was conjugated on the surface of …

An Analysis Of The Benefits And Difficulties Of Aerial Magnetic Vector Navigation, Aaron J. Canciani, Christopher J. Brennan

Faculty Publications

Recent successful flight tests have demonstrated scalar magnetic anomaly navigation to be a viable GPS-alternative navigation system. These flight tests matched magnetic field measurements to maps of the Earth's crustal magnetic field in order to navigate. Scalar magnetic navigation uses only the magnetic field intensity, not direction, in order to navigate. While it appears obvious to extend aerial magnetic navigation to use the full vector field, in practice there are substantial obstacles to doing so. This article explores the key challenges of magnetic vector navigation including current sensor limitations, lack of high frequency magnetic vector maps of the Earth's crust, …

Optimization And Characterization Of Novel Injection Molding Process For Metal Matrix Syntactic Foams, Myranda Spratt, Joseph William Newkirk

Materials Science and Engineering Faculty Research & Creative Works

Metal matrix syntactic foams are particulate composites comprised of hollow or porous particles embedded in a metal matrix. These composites are difficult to manufacture due primarily to the lightweight, relatively fragile filler material. In this work, an injection molding process was developed for metal matrix syntactic foams. First, an aqueous binder was optimized for low-pressure injection molding. A mixture model was used to optimize the composition of the binder to achieve the highest relative density. The model predicted the maximum relative density was at a binder composition (in vol.%) of 7% agar, 4% glycerin, and 89% water. Second, this binder …

An Overview Of Ceramic Molds For Investment Casting Of Nickel Superalloys, Janos E. Kanyo, Stefan Schafföner, R. Sharon Uwanyuze, Kaitlynn S. Leary

Materials Science and Engineering Faculty Research & Creative Works

Accelerating advancements in technological systems have demonstrated a need for alloys with drastically improved thermomechanical and chemical properties, called superalloys. Ceramic molds are typically used in near-net shape investment casting processes of superalloy components due to their chemical inertness and high-temperature capabilities. Ceramic molds, however, often suffer from shortcomings in vital properties including flexural strength, thermal shock resistance, permeability, dimensional stability, corrosion resistance, and leachability, which have restricted their ability to adequately process modern alloy castings. This study analyses these limitations and illustrates how to address them, particularly regarding ceramic mold and slurry design, processing of shells and cores, material …

Reintroduction Of Skilled Trade Programs For High School Students, Cristian Ayala-Quirino

Construction Management

The curriculum that incorporated skilled trades has vanished from many high schools, and more students are encouraged to attend college instead of pursuing trades. People view construction labor positions as jobs instead of careers. The construction industry is facing a substantial labor shortage amongst skilled laborers throughout the whole industry. Not enough people know how beneficial a career in the construction labor force can be. If more people knew about these career opportunities, they might have a greater interest in pursuing a career as a skilled tradesperson. To comprehend students’ understanding of the construction industry and examine where we can …

Should Teamwork-Based Content Be Taught In The Cal Poly Construction Management Curriculum?, Matthew J. Sharman

Construction Management

At California Polytechnic State University, San Luis Obispo (Cal Poly), in the Construction Management (CM) curriculum, there is a lack of teamwork-based content. This content includes negotiation, conflict resolution, and fundamental skills for working collaboratively with others such as social-emotional intelligence, empathy, and communication. The nature of the Cal Poly CM Program is to teach students about the aspects of the construction process, however what is missed is teaching how to work effectively in teams. They fail to teach this because of the strict curriculum of focusing on learning objectives rather than teaching individuals how to be effective construction managers. …

Blockchain Technology In The Construction Industry, Marco C. Reza

Construction Management

The construction industry has not advanced as quickly as other industries in the aspects of time, cost, and quality; but Blockchain could be the solution. While there have been improvements in the construction sector such as BIM or Prefabrication, nothing compares to those in other industries. This brings the search for a new technology that would boost construction to a new level of productivity. One technology that could potentially do this is Blockchain. Blockchain, defined in a big picture, is like a shared google sheet where anybody could add information but nobody could delete it. This technology could change the …

Online Platform For Construction Management Internship Reviews - Continued, Michael F. Dunne Iii

Construction Management

The purpose of this paper is to outline and explain the origin, process and outcome of my goal to create a website where Construction Management students have the capability to review their internships. The aim was to continue to progress Cal Poly alumna Erica Zetterquist’s senior project and her idea to create an online platform similar to “PolyRatings”, a website where Cal Poly students are able to review and rate their professors. This website is essentially the same thing as “Polyratings”, but for internships instead of professors, hoping to help students with their job search process. Based off a series …

The Discipleship Home Pergola And Firepit Area, Andreas V. Rasmussen

Construction Management

This report illustrates the complete process of the implementation of an outdoor space consisting of a hardscaped firepit area covered by a pergola in the backyard of the Discipleship Home in Oceano, CA. This project was carried out by two construction management students, Andreas Rasmussen and Logan Smith. Logan Smith’s primary focus was the pergola while I was in charge of the hardscaping and natural gas firepit directly underneath the structure. The project was completed in December of 2020 with the use of quality materials purchased from local businesses and the help of local equipment rental store, Grover Tool & …

Oasis Church: Designing And Building A Pergola For The Discipleship Home, Logan Keil Smith

Construction Management

The senior project idea for building a pergola, fire-pit, and paver hardscape was designed and executed by Andreas Rasmussen and Logan Smith. With the necessary background knowledge in landscape construction and the required funding, the Discipleship Home in Oceano, California, gave these two construction management students the opportunity to build an outdoor aesthetic area for residents of the Discipleship Home. This document provides information regarding the design, acquired funding, construction process, lessons learned and conclusion after the project was finished. The purpose of the project is to provide a peaceful place in which the residents of the Discipleship Home can …